Zfp474 (zinc finger protein 474) - Rat Genome Database

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Gene: Zfp474 (zinc finger protein 474) Rattus norvegicus
Analyze
Symbol: Zfp474
Name: zinc finger protein 474
RGD ID: 1311600
Description: Predicted to enable zinc ion binding activity. Orthologous to human ZNF474 (zinc finger protein 474); INTERACTS WITH bisphenol A; Cuprizon; fenvalerate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC307310; RGD1311600; similar to RIKEN cDNA 4933409D10; Znf474
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81848,239,557 - 48,269,831 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1848,239,466 - 48,303,589 (+)EnsemblGRCr8
mRatBN7.21846,041,224 - 46,071,502 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1846,041,218 - 46,100,751 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1848,092,043 - 48,122,307 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01848,803,891 - 48,834,170 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01846,597,948 - 46,628,211 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01847,577,566 - 47,607,512 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1847,577,566 - 47,634,127 (+)Ensemblrn6Rnor6.0
Rnor_5.01846,791,110 - 46,821,610 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41847,970,576 - 48,000,849 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1844,229,744 - 44,260,010 (+)NCBICelera
RGSC_v3.11847,944,059 - 48,037,924 (+)NCBI
Cytogenetic Map18q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp474
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81848,239,557 - 48,269,831 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1848,239,466 - 48,303,589 (+)EnsemblGRCr8
mRatBN7.21846,041,224 - 46,071,502 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1846,041,218 - 46,100,751 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1848,092,043 - 48,122,307 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01848,803,891 - 48,834,170 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01846,597,948 - 46,628,211 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01847,577,566 - 47,607,512 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1847,577,566 - 47,634,127 (+)Ensemblrn6Rnor6.0
Rnor_5.01846,791,110 - 46,821,610 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41847,970,576 - 48,000,849 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1844,229,744 - 44,260,010 (+)NCBICelera
RGSC_v3.11847,944,059 - 48,037,924 (+)NCBI
Cytogenetic Map18q11NCBI
ZNF474
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385122,129,546 - 122,153,569 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5122,129,546 - 122,182,658 (+)Ensemblhg38GRCh38
GRCh375121,465,241 - 121,489,264 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365121,493,114 - 121,517,165 (+)NCBIBuild 36Build 36hg18NCBI36
Celera5117,419,660 - 117,443,684 (+)NCBICelera
Cytogenetic Map5q23.2NCBI
HuRef5116,656,761 - 116,680,785 (+)NCBIHuRef
CHM1_15120,897,810 - 120,921,875 (+)NCBICHM1_1
T2T-CHM13v2.05122,646,426 - 122,670,425 (+)NCBIT2T-CHM13v2.0
Zfp474
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391852,748,979 - 52,772,904 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1852,748,987 - 52,772,902 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381852,615,906 - 52,639,832 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1852,615,915 - 52,639,830 (+)Ensemblmm10GRCm38
MGSCv371852,775,569 - 52,799,484 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361852,741,351 - 52,765,199 (+)NCBIMGSCv36mm8
Celera1853,929,192 - 53,956,795 (+)NCBICelera
Cytogenetic Map18D1NCBI
cM Map1828.24NCBI

Variants

.
Variants in Zfp474
162 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:131
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000025273
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat

Markers in Region
AW535970  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21846,070,193 - 46,070,359 (+)MAPPERmRatBN7.2
Rnor_6.01847,606,206 - 47,606,371NCBIRnor6.0
Rnor_5.01846,819,754 - 46,819,919UniSTSRnor5.0
RGSC_v3.41847,999,543 - 47,999,708UniSTSRGSC3.4
Celera1844,258,704 - 44,258,869UniSTS
Cytogenetic Map18q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
2 10 22 83 22 25 6 18 6 86 58 8 67 12 65 19

Sequence


Ensembl Acc Id: ENSRNOT00000025273   ⟹   ENSRNOP00000025273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1846,041,224 - 46,071,502 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091536   ⟹   ENSRNOP00000070630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1848,240,452 - 48,269,969 (+)Ensembl
mRatBN7.2 Ensembl1846,042,159 - 46,070,934 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116416   ⟹   ENSRNOP00000096492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1848,239,466 - 48,303,589 (+)Ensembl
mRatBN7.2 Ensembl1846,041,218 - 46,100,751 (+)Ensembl
RefSeq Acc Id: NM_001107380   ⟹   NP_001100850
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81848,239,557 - 48,269,831 (+)NCBI
mRatBN7.21846,041,224 - 46,071,502 (+)NCBI
Rnor_6.01847,577,566 - 47,607,512 (+)NCBI
Rnor_5.01846,791,110 - 46,821,610 (+)NCBI
RGSC_v3.41847,970,576 - 48,000,849 (+)RGD
Celera1844,229,744 - 44,260,010 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100850 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM14448 (Get FASTA)   NCBI Sequence Viewer  
  EDM14449 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070630
  ENSRNOP00000070630.3
  ENSRNOP00000096492.1
RefSeq Acc Id: NP_001100850   ⟸   NM_001107380
- UniProtKB: D4A016 (UniProtKB/TrEMBL),   A6IX17 (UniProtKB/TrEMBL),   A0A0G2JYF2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000096492   ⟸   ENSRNOT00000116416
Ensembl Acc Id: ENSRNOP00000025273   ⟸   ENSRNOT00000025273
Ensembl Acc Id: ENSRNOP00000070630   ⟸   ENSRNOT00000091536
Protein Domains
C2HC/C3H-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JYF2-F1-model_v2 AlphaFold A0A0G2JYF2 1-451 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700796
Promoter ID:EPDNEW_R11304
Type:initiation region
Name:Zfp474_2
Description:zinc finger protein 474
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11305  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01847,577,590 - 47,577,650EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311600 AgrOrtholog
BioCyc Gene G2FUF-7516 BioCyc
Ensembl Genes ENSRNOG00000018724 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091536 ENTREZGENE
  ENSRNOT00000091536.3 UniProtKB/TrEMBL
  ENSRNOT00000116416.2 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro ZC2HC1 UniProtKB/TrEMBL
  Znf_C2HC_C3H UniProtKB/TrEMBL
KEGG Report rno:307310 UniProtKB/TrEMBL
NCBI Gene 307310 ENTREZGENE
PANTHER PTHR13555 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 474 UniProtKB/TrEMBL
Pfam zf-C2HC_2 UniProtKB/TrEMBL
PhenoGen Zfp474 PhenoGen
PROSITE ZF_C2HC_C3H UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018724 RatGTEx
UniProt A0A0G2JYF2 ENTREZGENE, UniProtKB/TrEMBL
  A6IX17 ENTREZGENE, UniProtKB/TrEMBL
  D4A016 ENTREZGENE
UniProt Secondary D4A016 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-19 Zfp474  zinc finger protein 474  Znf474  zinc finger protein 474  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Znf474  zinc finger protein 474  Zfp474  zinc finger protein 474  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-27 Zfp474  zinc finger protein 474  RGD1311600_predicted  similar to RIKEN cDNA 4933409D10 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1311600_predicted  similar to RIKEN cDNA 4933409D10 (predicted)  LOC307310_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC307310_predicted  similar to RIKEN cDNA 4933409D10 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL