Symbol:
Stxbp5l
Name:
syntaxin binding protein 5L
RGD ID:
1311561
Description:
Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Predicted to be involved in Golgi to plasma membrane transport; exocytosis; and regulation of synaptic vesicle exocytosis. Predicted to act upstream of or within glucose homeostasis; negative regulation of insulin secretion; and regulation of exocytosis. Predicted to be located in membrane and secretory granule. Predicted to be part of SNARE complex. Predicted to be active in neuromuscular junction; neuronal dense core vesicle; and plasma membrane. Orthologous to human STXBP5L (syntaxin binding protein 5L); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acetamide.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC288080; syntaxin binding protein 5-like; syntaxin-binding protein 5-like
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
STXBP5L (syntaxin binding protein 5L)
HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Stxbp5l (syntaxin binding protein 5-like)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Stxbp5l (syntaxin binding protein 5L)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
STXBP5L (syntaxin binding protein 5L)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
STXBP5L (syntaxin binding protein 5L)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Stxbp5l (syntaxin binding protein 5L)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
STXBP5L (syntaxin binding protein 5L)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
STXBP5L (syntaxin binding protein 5L)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Stxbp5l (syntaxin binding protein 5L)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Rattus rattus (black rat):
Stxbp5l (syntaxin binding protein 5L)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
EPHB4 (EPH receptor B4)
HGNC
OMA
Alliance orthologs 3
Homo sapiens (human):
STXBP5L (syntaxin binding protein 5L)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
STXBP5L (syntaxin binding protein 5L)
Alliance
DIOPT (HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Stxbp5l (syntaxin binding protein 5-like)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Stxbp5l (syntaxin binding protein 5-like)
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
stxbp5l (syntaxin binding protein 5-like)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
stxbp5l (syntaxin binding protein 5-like)
Alliance
DIOPT (Hieranoid|OMA|OrthoFinder|PANTHER|PhylomeDB)
Drosophila melanogaster (fruit fly):
Tomosyn
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Drosophila melanogaster (fruit fly):
Tomosyn
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):
SRO7
Alliance
DIOPT (Ensembl Compara|Hieranoid|OrthoFinder|PANTHER|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):
SRO77
Alliance
DIOPT (Ensembl Compara|Hieranoid|OrthoFinder|PANTHER|SonicParanoid)
Caenorhabditis elegans (roundworm):
tom-1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Caenorhabditis elegans (roundworm):
tom-1
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
stxbp5l
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Allele / Splice:
Stxbp5lTn(sb-T2/Bart3)2.202Mcwi
Genetic Models:
F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 11 76,838,839 - 77,167,852 (+) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 11 76,838,900 - 77,161,306 (+) Ensembl GRCr8 mRatBN7.2 11 63,334,667 - 63,654,270 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 11 63,334,667 - 63,657,014 (+) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 11 72,147,113 - 72,466,676 (+) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 11 64,809,343 - 65,128,900 (+) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 11 63,858,949 - 64,163,917 (+) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 11 66,246,624 - 66,566,331 (+) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 11 66,316,606 - 66,566,331 (+) Ensembl rn6 Rnor6.0 Rnor_5.0 11 69,337,663 - 69,661,463 (+) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 11 65,129,572 - 65,455,115 (+) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 11 62,831,916 - 63,131,512 (+) NCBI Celera RGSC_v3.1 11 65,147,137 - 65,512,704 (+) NCBI Cytogenetic Map 11 q21 NCBI
JBrowse:
Only show annotations with direct experimental evidence (0 objects hidden)
Stxbp5l Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Stxbp5l (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Stxbp5l Rat 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of STXBP5L mRNA CTD PMID:29097150 Stxbp5l Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Stxbp5l (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Stxbp5l Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Stxbp5l (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Stxbp5l Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Stxbp5l (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Stxbp5l Rat 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO STXBP5L (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... CTD PMID:28628672 Stxbp5l Rat 4,4'-sulfonyldiphenol multiple interactions ISO STXBP5L (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... CTD PMID:28628672 Stxbp5l Rat 4,4'-sulfonyldiphenol increases methylation ISO Stxbp5l (Mus musculus) 6480464 bisphenol S results in increased methylation of STXBP5L exon CTD PMID:33297965 Stxbp5l Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of STXBP5L mRNA CTD PMID:24780913 Stxbp5l Rat acetamide increases expression EXP 6480464 acetamide results in increased expression of STXBP5L mRNA CTD PMID:31881176 Stxbp5l Rat aflatoxin B1 decreases methylation ISO STXBP5L (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of STXBP5L gene CTD PMID:27153756 Stxbp5l Rat aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of STXBP5L mRNA CTD PMID:33354967 Stxbp5l Rat aflatoxin B1 increases methylation ISO STXBP5L (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of STXBP5L intron CTD PMID:30157460 Stxbp5l Rat aristolochic acid A increases expression ISO STXBP5L (Homo sapiens) 6480464 aristolochic acid I results in increased expression of STXBP5L mRNA CTD PMID:33212167 Stxbp5l Rat benzo[a]pyrene increases methylation ISO STXBP5L (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of STXBP5L 5' UTR; Benzo(a)pyrene results in increased methylation of more ... CTD PMID:27901495 Stxbp5l Rat benzo[a]pyrene affects methylation ISO STXBP5L (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of STXBP5L promoter CTD PMID:27901495 Stxbp5l Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of STXBP5L mRNA CTD PMID:25181051|PMID:34947998 Stxbp5l Rat bisphenol A decreases expression ISO Stxbp5l (Mus musculus) 6480464 bisphenol A results in decreased expression of STXBP5L mRNA CTD PMID:32156529 Stxbp5l Rat Brodifacoum increases expression EXP 6480464 bromfenacoum results in increased expression of STXBP5L protein CTD PMID:28903499 Stxbp5l Rat bromobenzene increases expression EXP 6480464 bromobenzene results in increased expression of STXBP5L mRNA CTD PMID:32479839 Stxbp5l Rat coumarin decreases phosphorylation ISO STXBP5L (Homo sapiens) 6480464 coumarin results in decreased phosphorylation of STXBP5L protein CTD PMID:35688186 Stxbp5l Rat dexamethasone multiple interactions ISO STXBP5L (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... CTD PMID:28628672 Stxbp5l Rat dorsomorphin multiple interactions ISO STXBP5L (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Stxbp5l Rat endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of STXBP5L mRNA CTD PMID:29391264 Stxbp5l Rat ethanol decreases expression ISO Stxbp5l (Mus musculus) 6480464 Ethanol results in decreased expression of STXBP5L mRNA CTD PMID:29018328 Stxbp5l Rat FR900359 affects phosphorylation ISO STXBP5L (Homo sapiens) 6480464 FR900359 affects the phosphorylation of STXBP5L protein CTD PMID:37730182 Stxbp5l Rat furan decreases expression EXP 6480464 furan results in decreased expression of STXBP5L mRNA CTD PMID:25539665 Stxbp5l Rat indometacin multiple interactions ISO STXBP5L (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... CTD PMID:28628672 Stxbp5l Rat levonorgestrel multiple interactions ISO STXBP5L (Homo sapiens) 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of STXBP5L mRNA CTD PMID:19074003 Stxbp5l Rat maneb multiple interactions ISO Stxbp5l (Mus musculus) 6480464 [Maneb co-treated with Paraquat] results in increased expression of STXBP5L mRNA CTD PMID:36117858 Stxbp5l Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of STXBP5L gene CTD PMID:35440735 Stxbp5l Rat okadaic acid decreases expression ISO STXBP5L (Homo sapiens) 6480464 Okadaic Acid results in decreased expression of STXBP5L mRNA CTD PMID:38832940 Stxbp5l Rat paraquat multiple interactions ISO Stxbp5l (Mus musculus) 6480464 [Maneb co-treated with Paraquat] results in increased expression of STXBP5L mRNA CTD PMID:36117858 Stxbp5l Rat PCB138 multiple interactions ISO Stxbp5l (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Stxbp5l Rat rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of STXBP5L mRNA CTD PMID:28374803 Stxbp5l Rat SB 431542 multiple interactions ISO STXBP5L (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Stxbp5l Rat silicon dioxide decreases expression ISO STXBP5L (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of STXBP5L mRNA CTD PMID:25895662 Stxbp5l Rat sodium arsenite decreases expression ISO STXBP5L (Homo sapiens) 6480464 sodium arsenite results in decreased expression of STXBP5L mRNA CTD PMID:29301061 Stxbp5l Rat testosterone undecanoate multiple interactions ISO STXBP5L (Homo sapiens) 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of STXBP5L mRNA CTD PMID:19074003 Stxbp5l Rat testosterone undecanoate increases expression ISO STXBP5L (Homo sapiens) 6480464 testosterone undecanoate results in increased expression of STXBP5L mRNA CTD PMID:19074003 Stxbp5l Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of STXBP5L mRNA CTD PMID:34492290 Stxbp5l Rat titanium dioxide decreases methylation ISO Stxbp5l (Mus musculus) 6480464 titanium dioxide results in decreased methylation of STXBP5L gene CTD PMID:35295148 Stxbp5l Rat triptonide increases expression ISO Stxbp5l (Mus musculus) 6480464 triptonide results in increased expression of STXBP5L mRNA CTD PMID:33045310 Stxbp5l Rat valproic acid affects expression ISO STXBP5L (Homo sapiens) 6480464 Valproic Acid affects the expression of STXBP5L mRNA CTD PMID:25979313 Stxbp5l Rat valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of STXBP5L mRNA CTD PMID:29427782 Stxbp5l Rat valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of STXBP5L mRNA CTD PMID:29427782 Stxbp5l Rat valproic acid multiple interactions ISO STXBP5L (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Stxbp5l Rat valproic acid increases expression ISO STXBP5L (Homo sapiens) 6480464 Valproic Acid results in increased expression of STXBP5L mRNA CTD PMID:23179753|PMID:24383497|PMID:24935251|PMID:26272509|PMID:27188386 Stxbp5l Rat vorinostat increases expression ISO STXBP5L (Homo sapiens) 6480464 vorinostat results in increased expression of STXBP5L mRNA CTD PMID:27188386 Stxbp5l Rat XL147 multiple interactions ISO Stxbp5l (Mus musculus) 6480464 [N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of STXBP5L mRNA CTD PMID:27935865