Advanced Search (OLGA)

Gene: Rasgef1c (RasGEF domain family, member 1C) Rattus norvegicus

Analyze

Symbol:

Rasgef1c

Name:

RasGEF domain family, member 1C

RGD ID:

1311549

Description:

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human RASGEF1C (RasGEF domain family member 1C); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC360519; ras-GEF domain-containing family member 1C

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RASGEF1C (RasGEF domain family member 1C)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Rasgef1c (RasGEF domain family, member 1C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rasgef1c (RasGEF domain family member 1C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RASGEF1C (RasGEF domain family member 1C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RASGEF1C (RasGEF domain family member 1C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rasgef1c (RasGEF domain family member 1C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RASGEF1C (RasGEF domain family member 1C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RASGEF1C (RasGEF domain family member 1C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rasgef1c (RasGEF domain family member 1C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rasgef1c (RasGEF domain family member 1C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RASGEF1C (RasGEF domain family member 1C)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rasgef1c (RasGEF domain family, member 1C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	R05G6.10	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG7369	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG7369	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	LTE1	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	34,728,573 - 34,794,763 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	34,728,573 - 34,794,763 (+)	Ensembl				GRCr8
mRatBN7.2	10	34,227,483 - 34,293,676 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	34,227,483 - 34,293,675 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	38,902,847 - 38,969,114 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	7,441,262 - 7,507,533 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	33,896,517 - 33,962,789 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	35,392,762 - 35,459,267 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	35,392,762 - 35,459,267 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	35,164,536 - 35,230,688 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	35,403,239 - 35,470,217 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	33,583,183 - 33,648,570 (+)	NCBI		Celera
RGSC_v3.1	10	35,404,270 - 35,471,266 (+)	NCBI
Cytogenetic Map	10	q21-q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP)

cadmium dichloride (EXP,ISO)

CGP 52608 (ISO)

chrysene (ISO)

Cuprizon (EXP)

decabromodiphenyl ether (EXP)

dorsomorphin (ISO)

ethanol (ISO)

genistein (EXP)

glyphosate (EXP)

lead(0) (ISO)

lipopolysaccharide (ISO)

methoxychlor (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N,N-diethyl-m-toluamide (EXP)

perfluorooctanoic acid (EXP)

permethrin (EXP)

phenylmercury acetate (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tetraphene (ISO)

thiram (ISO)

titanium dioxide (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Ras protein signal transduction (IBA)

small GTPase-mediated signal transduction (IEA)

Cellular Component

plasma membrane (IBA)

Molecular Function

guanyl-nucleotide exchange factor activity (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Rasgef1c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	34,728,573 - 34,794,763 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	34,728,573 - 34,794,763 (+)	Ensembl				GRCr8
mRatBN7.2	10	34,227,483 - 34,293,676 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	34,227,483 - 34,293,675 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	38,902,847 - 38,969,114 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	7,441,262 - 7,507,533 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	33,896,517 - 33,962,789 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	35,392,762 - 35,459,267 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	35,392,762 - 35,459,267 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	35,164,536 - 35,230,688 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	35,403,239 - 35,470,217 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	33,583,183 - 33,648,570 (+)	NCBI		Celera
RGSC_v3.1	10	35,404,270 - 35,471,266 (+)	NCBI
Cytogenetic Map	10	q21-q22	NCBI

RASGEF1C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	180,100,795 - 180,209,211 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	180,100,795 - 180,209,225 (-)	Ensembl			hg38	GRCh38
GRCh37	5	179,527,795 - 179,636,211 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	179,460,401 - 179,568,736 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	179,460,409 - 179,497,955	NCBI
Celera	5	175,153,213 - 175,262,098 (-)	NCBI		Celera
Cytogenetic Map	5	q35.3	NCBI
HuRef	5	174,252,451 - 174,290,610 (-)	NCBI		HuRef
CHM1_1	5	178,960,091 - 178,997,463 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	180,655,720 - 180,764,663 (-)	NCBI		T2T-CHM13v2.0

Rasgef1c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	49,791,996 - 49,871,050 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	49,792,662 - 49,871,821 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	49,901,169 - 49,980,223 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	49,901,835 - 49,980,994 (+)	Ensembl			mm10	GRCm38
MGSCv37	11	49,715,337 - 49,793,725 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	49,745,258 - 49,823,646 (+)	NCBI		MGSCv36	mm8
Celera	11	54,463,772 - 54,542,850 (+)	NCBI		Celera
Cytogenetic Map	11	B1.2- B1.3	NCBI
cM Map	11	30.02	NCBI

Rasgef1c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955408	482,107 - 515,132 (+)	NCBI	ChiLan1.0	ChiLan1.0

RASGEF1C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	175,048,959 - 175,232,161 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	173,193,659 - 173,396,241 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	175,277,643 - 175,313,874 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	182,596,743 - 182,632,099 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

RASGEF1C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	1,494,187 - 1,571,505 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	1,519,464 - 1,574,939 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	1,556,389 - 1,636,865 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	1,465,669 - 1,546,363 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	1,465,844 - 1,546,370 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	1,418,525 - 1,498,998 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	1,516,552 - 1,597,121 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	1,756,608 - 1,837,342 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rasgef1c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	119,402,068 - 119,484,234 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936739	611,686 - 694,443 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936739	611,845 - 694,011 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RASGEF1C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	78,414,860 - 78,501,807 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	78,414,861 - 78,503,557 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	79,900,046 - 79,968,563 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RASGEF1C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	81,839,211 - 81,945,983 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	81,838,441 - 81,878,740 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666075	13,221,040 - 13,331,817 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rasgef1c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	42,894,235 - 42,927,633 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624733	42,893,044 - 42,986,472 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rasgef1c
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	32,574,007 - 32,638,328 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rasgef1c
527 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	101
Count of miRNA genes:	76
Interacting mature miRNAs:	91
Transcripts:	ENSRNOT00000059277
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31796281	76796281	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15776754	60776754	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	27023535	98502431	Rat
2293669	Bmd33	Bone mineral density QTL 33	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	10	27443787	72443787	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1250554	64349221	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293679	Bmd30	Bone mineral density QTL 30	3.5	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6877142	51877142	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35730538	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	19939207	64939207	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	18035782	63035782	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	922197	45922197	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	2103708	47103708	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18668419	63668419	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21833758	61843633	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28950353	73950353	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29800910	64653589	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	27443787	72443787	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14991535	86964295	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5893811	50893811	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
2293652	Bmd22	Bone mineral density QTL 22	4.9	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22931373	91127454	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6660923	73950353	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5893811	50893811	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5893811	50893811	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	14653541	59653541	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15533012	73695498	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	24662123	73695339	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	27023535	61843633	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5893811	50893811	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29800910	91417879	Rat
2298495	Eae23	Experimental allergic encephalomyelitis QTL 23	16.93		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis duration (CMO:0001424)	10	16175525	61175525	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	20110614	65110614	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38832698	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	27587226	96099902	Rat
2289985	Bp305	Blood pressure QTL 305			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	29076978	74076978	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6661118	35509383	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	18035782	63035782	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293705	Bmd25	Bone mineral density QTL 25	7.1	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	27443787	72443787	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	29377046	52699134	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31129113	76129113	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	20110614	65110614	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	27023535	99451848	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
10	11	53	146	58	57	26	45	26	6	210	130	9	125	36	90	31	16	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000059277 ⟹ ENSRNOP00000056044

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	34,728,573 - 34,794,763 (+)	Ensembl
mRatBN7.2 Ensembl	10	34,227,483 - 34,293,675 (+)	Ensembl
Rnor_6.0 Ensembl	10	35,392,762 - 35,459,267 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098334 ⟹ ENSRNOP00000094236

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	34,729,376 - 34,794,763 (+)	Ensembl
mRatBN7.2 Ensembl	10	34,228,286 - 34,293,675 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112439 ⟹ ENSRNOP00000094068

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	34,772,170 - 34,794,763 (+)	Ensembl
mRatBN7.2 Ensembl	10	34,271,078 - 34,293,675 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000151333 ⟹ ENSRNOP00000112065

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	34,753,353 - 34,794,763 (+)	Ensembl

RefSeq Acc Id:

NM_001108273 ⟹ NP_001101743

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	34,728,573 - 34,794,763 (+)	NCBI
mRatBN7.2	10	34,227,483 - 34,293,675 (+)	NCBI
Rnor_6.0	10	35,392,762 - 35,459,267 (+)	NCBI
Rnor_5.0	10	35,164,536 - 35,230,688 (+)	NCBI
RGSC_v3.4	10	35,403,239 - 35,470,217 (+)	RGD
Celera	10	33,583,183 - 33,648,570 (+)	RGD

Sequence:

show sequence

TCGCGGCGGGCTGCGAGCGGGCGGGTAGGCAGCGCCCGGTCTACGGTGCAGCGGCTGGGGCGAG
CGCGGCGGGCGCTGCCGATGGGCCGGGCCCGGGCTGTCGGAGCGCCGGGAGCCGGCAGGCATGC
CCCGGACACTGACTGCCTCCGACATGGTCACCCCAGGCAGCCTCAGCCCGCCTCCCATAGACTC
CACAGAAGGAGAGCAGGCTGGGCAGCCCCTCCTGGACGGAGCTCCATCCTCAGCCTCTTTGGAG
ACCCTGATTCAGCACCTCGTGCCCACAGCCGATTACTATCCTGAGAAAGCCTACATCTTCACCT
TCCTGCTGAGCTCTCGTCTCTTCATCGAGCCCCGAGAGCTCCTGGCTCGTGTGTGTCACCTGTG
CATAGAGCAGCAACAGCTGGACAAGCCGGTGCTGGACAAGGCCCGAGTCCGGAAGTTTGGTGCC
AAATTGCTCCAGTTGTTAGCCGAGTGGACTGAAACCTTCCCACGGGACTTTGAAGAGGAGTCCA
CCATCGGACACCTGACAGACGTGGTGGGCCGCATCTCCCCATGTGACGAGACCTACGGAAACAG
GATGCACCAGCTCCTGCAGACTCTGCACCAGAAATTGGCATCACTTGGCCAGGGACCAGAAGGC
CTGGTAGGGGCGGACAAGCCCATCTCCTACAGGACCAAGCCTCCAGCCTCAATCCACAGGGAGC
TCCTGGGTGTCTGCAGTGACCCCTACACACTGGCCCAGCAACTGACCCATGTGGAGCTGGAGCG
GCTTAGGCACATTGGGCCCGAGGAGTTTGTCCAGGCTTTTGTGAACAAGGACCCCCTGGCAGGC
ACAAAGCCCCGCTTCAATGACAAGACAAACAACGTAGAGGCCTACGTGAAGTGGTTCAACAGAC
TATGCTACCTGGTAGCCACAGAAATCTGCATGCCAGCCAAGAAGAAACAGAGGGCACAGGTGAT
CGAGTTCTTCATTGACGTGGCCCGAGAGTGCTTCAACATCGGCAACTTCAACTCCCTCATGGCC
ATTATCTCCGGCATGAACATGAGTCCTGTCTCCAGGCTGAAGAAGACTTGGGCCAAAGTGAAAA
CAGCCAAGTTCTTCATTCTGGAGCACCAGATGGACCCAACAGGGAATTTCTGCAACTATAGGAC
AGCTCTGCGTGGGGCAGCCCACCGCTCACTGACTGCTCACAGCAGCAGGGAGAAGATTGTCATC
CCCTTCTTCAGCCTGCTCATCAAGGACATTTATTTCCTCAATGAGGGCTGCGCCAACCGCCTTC
CCAATGGACACGTCAATTTTGAGAAATTTCTGGAACTGGCCAAGCAGGTTGGAGAGTTCATTAC
TTGGAAACAAGTGGAATGTCCTTTCGAGCAAGATCCAAGCATCACCCATTACCTGTACACCGCA
CCCATCTTCAGCGAAGACGGTCTGTATTTGGCTTCCTATGAAAGCGAAAGTCCAGAGAACCAGA
CAGAAAAGGAGAGGTGGAAATCTCTAAGATCTTCTATTCTGGGGAAGACATGAGAAGCCCTGAG
ACAGAGGAAGAGGAAACATCGGAGCTGACACAGGCAGTCCCAACCCTGTCGCAGATGGCCCAAT
GGGTGGAGGTTGACGCAAAGCTTCTTTACTTTGTAAACCAGACGCTATGACCTGGTACCTGCCA
CAAAGGCCACATGGGCACGGGAAACCTTGCATAGGACCTCAGCCCTGGCTGACTTGTCAGGGCC
TCCAAGAGCATGGGGGACACGCCTTGGGCAAACATTGCCTTTATGACCAAGTGGGTCACATAGT
CAGTCTGTCCATTCTGGACAGGGACACAGTGTTACCCGGATAGCTGGGTGACTGCGATCATGTG
ATTTTGTTGAATGACCTGTGCTATGGAGAGTAACGCCACAGTCTGTCACCAGGTGGCTTGGGAG
CCTCTGTAACTGCAGCGGGCATCACGGTGCAACATGAGATGTCCCTGCACCAGGTCCGAGCCCA
CTCTAGCCCCTGGCATTCCGCTGACGGGCCCCAATCCCGTCCCTCCCAGCGGACTTGTTTCTGC
AGTCACCCATCTCCTTCTGCATCCTGCTGGTATCAGGATAGCCCCCTGGCGACTGCGGTGAAAC
AAGTCACTGAGACAAACCGGAGTCATGGAGTCAGCAATGTGTATATTACAACCTGCTGCCTAGC
TCCCTTGTAAACTTTAGAGTCGGAGTAAACTCATGTTTGTACGCCCATCCTGC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001101743	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM04243	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000056044
	ENSRNOP00000056044.2
	ENSRNOP00000094068.1
	ENSRNOP00000094236.1
	ENSRNOP00000112065.1

RefSeq Acc Id:

NP_001101743 ⟸ NM_001108273

- UniProtKB:

D3ZVN9 (UniProtKB/TrEMBL), A6HDY8 (UniProtKB/TrEMBL), A0A8I6AL57 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPRTLTASDMVTPGSLSPPPIDSTEGEQAGQPLLDGAPSSASLETLIQHLVPTADYYPEKAYIF
TFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGAKLLQLLAEWTETFPRDFEEE
STIGHLTDVVGRISPCDETYGNRMHQLLQTLHQKLASLGQGPEGLVGADKPISYRTKPPASIHR
ELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLAGTKPRFNDKTNNVEAYVKWFN
RLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV
KTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANR
LPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDPSITHYLYTAPIFSEDGLYLASYESESPEN
QTEKERWKSLRSSILGKT

hide sequence

Ensembl Acc Id:

ENSRNOP00000056044 ⟸ ENSRNOT00000059277

Ensembl Acc Id:

ENSRNOP00000094068 ⟸ ENSRNOT00000112439

Ensembl Acc Id:

ENSRNOP00000094236 ⟸ ENSRNOT00000098334

Ensembl Acc Id:

ENSRNOP00000112065 ⟸ ENSRNOT00000151333

Protein Domains

N-terminal Ras-GEF Ras-GEF

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZVN9-F1-model_v2	AlphaFold	D3ZVN9	1-466	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311549	AgrOrtholog
BioCyc Gene	G2FUF-25259	BioCyc
Ensembl Genes	ENSRNOG00000003005	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000059277	ENTREZGENE
	ENSRNOT00000059277.4	UniProtKB/TrEMBL
	ENSRNOT00000098334.2	UniProtKB/TrEMBL
	ENSRNOT00000112439.2	UniProtKB/TrEMBL
	ENSRNOT00000151333.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.840.10	UniProtKB/TrEMBL
	Son of sevenless (SoS) protein Chain: S domain 1	UniProtKB/TrEMBL
InterPro	Ras-like_GEF	UniProtKB/TrEMBL
	Ras-like_Gua-exchang_fac_N	UniProtKB/TrEMBL
	Ras_G-nucl-exch_fac_CS	UniProtKB/TrEMBL
	Ras_GEF_dom	UniProtKB/TrEMBL
	RASGEF_cat_dom_sf	UniProtKB/TrEMBL
	RasGRF_CDC25	UniProtKB/TrEMBL
KEGG Report	rno:360519	UniProtKB/TrEMBL
NCBI Gene	360519	ENTREZGENE
PANTHER	PTHR23113	UniProtKB/TrEMBL
	RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1C	UniProtKB/TrEMBL
Pfam	RasGEF	UniProtKB/TrEMBL
	RasGEF_N	UniProtKB/TrEMBL
PhenoGen	Rasgef1c	PhenoGen
PROSITE	RASGEF	UniProtKB/TrEMBL
	RASGEF_CAT	UniProtKB/TrEMBL
	RASGEF_NTER	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003005	RatGTEx
SMART	RasGEF	UniProtKB/TrEMBL
Superfamily-SCOP	Ras_GEF	UniProtKB/TrEMBL
UniProt	A0A8I6AL57	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ALC8_RAT	UniProtKB/TrEMBL
	A0ABK0LM75_RAT	UniProtKB/TrEMBL
	A6HDY8	ENTREZGENE, UniProtKB/TrEMBL
	D3ZVN9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Rasgef1c	RasGEF domain family, member 1C	Rasgef1c_predicted	RasGEF domain family, member 1C (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Rasgef1c_predicted	RasGEF domain family, member 1C (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message