Spock1 (sparc/osteonectin, cwcv and kazal like domains proteoglycan 1) - Rat Genome Database

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Gene: Spock1 (sparc/osteonectin, cwcv and kazal like domains proteoglycan 1) Rattus norvegicus
Analyze
Symbol: Spock1
Name: sparc/osteonectin, cwcv and kazal like domains proteoglycan 1
RGD ID: 1311496
Description: Predicted to enable calcium ion binding activity; cysteine-type endopeptidase inhibitor activity; and metalloendopeptidase inhibitor activity. Predicted to be involved in several processes, including generation of neurons; negative regulation of cell-substrate adhesion; and negative regulation of neuron projection development. Predicted to be located in neuromuscular junction; node of Ranvier; and sarcoplasm. Predicted to be active in extracellular space and postsynaptic density. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC102549404; LOC306759; sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1; sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1; testican-1; uncharacterized LOC102549404; uncharacterized protein LOC102549404
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8176,746,892 - 7,227,034 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl176,747,646 - 7,230,282 (+)EnsemblGRCr8
mRatBN7.2176,741,504 - 7,221,685 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl176,742,273 - 7,224,935 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx176,764,172 - 7,241,507 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0178,294,102 - 8,771,565 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,760,562 - 7,237,893 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0177,675,531 - 7,797,863 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl177,675,531 - 7,797,863 (+)Ensemblrn6Rnor6.0
Rnor_5.0179,833,535 - 9,981,069 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41713,198,069 - 13,213,055 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,844,778 - 7,323,370 (+)NCBICelera
RGSC_v3.11713,133,516 - 13,212,970 (+)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
mercury dichloride  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
nickel sulfate  (ISO)
ochratoxin A  (ISO)
paclitaxel  (ISO)
PCB138  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. MiR-139-5p, miR-940 and miR-193a-5p inhibit the growth of hepatocellular carcinoma by targeting SPOCK1. Li P, etal., J Cell Mol Med. 2019 Apr;23(4):2475-2488. doi: 10.1111/jcmm.14121. Epub 2019 Feb 1.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9323035   PMID:10640720   PMID:10842087   PMID:11751414   PMID:12477932   PMID:12853036   PMID:14511383   PMID:25931508  


Genomics

Comparative Map Data
Spock1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8176,746,892 - 7,227,034 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl176,747,646 - 7,230,282 (+)EnsemblGRCr8
mRatBN7.2176,741,504 - 7,221,685 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl176,742,273 - 7,224,935 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx176,764,172 - 7,241,507 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0178,294,102 - 8,771,565 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,760,562 - 7,237,893 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0177,675,531 - 7,797,863 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl177,675,531 - 7,797,863 (+)Ensemblrn6Rnor6.0
Rnor_5.0179,833,535 - 9,981,069 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41713,198,069 - 13,213,055 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,844,778 - 7,323,370 (+)NCBICelera
RGSC_v3.11713,133,516 - 13,212,970 (+)NCBI
Cytogenetic Map17p14NCBI
SPOCK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385136,975,298 - 137,499,326 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5136,975,298 - 137,598,379 (-)Ensemblhg38GRCh38
GRCh375136,310,987 - 136,835,015 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365136,338,886 - 136,862,917 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345136,338,887 - 136,862,894NCBI
Celera5132,435,878 - 132,959,945 (-)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5131,499,446 - 132,023,226 (-)NCBIHuRef
CHM1_15135,743,638 - 136,267,703 (-)NCBICHM1_1
T2T-CHM13v2.05137,497,979 - 138,022,024 (-)NCBIT2T-CHM13v2.0
Spock1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391357,569,008 - 58,056,194 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1357,569,008 - 58,056,146 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381357,421,195 - 57,908,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1357,421,195 - 57,908,332 (-)Ensemblmm10GRCm38
MGSCv371357,522,556 - 58,009,693 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361357,435,716 - 57,917,898 (-)NCBIMGSCv36mm8
Celera1358,485,985 - 58,970,735 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.5NCBI
Spock1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540831,957,882 - 32,465,461 (-)Ensembl
ChiLan1.0NW_00495540831,954,622 - 32,465,463 (-)NCBIChiLan1.0ChiLan1.0
SPOCK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24132,267,651 - 132,785,725 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15130,407,210 - 130,925,284 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05132,372,283 - 132,890,168 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15138,512,523 - 138,730,331 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5138,512,523 - 138,797,416 (-)EnsemblpanPan2panpan1.1
SPOCK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11124,733,290 - 25,013,400 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1124,733,603 - 25,007,376 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1123,482,135 - 23,980,859 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01125,550,901 - 26,073,758 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1125,550,906 - 26,007,073 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11124,288,279 - 24,783,213 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01124,106,169 - 24,605,094 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01124,771,888 - 25,267,226 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spock1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213124,975,526 - 125,469,022 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365974,000,400 - 4,156,221 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365974,000,433 - 4,493,920 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPOCK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2139,018,179 - 139,522,593 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12139,018,177 - 139,523,601 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22144,718,318 - 145,255,866 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPOCK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12339,676,750 - 40,192,565 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2339,676,558 - 39,965,037 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603437,701,157 - 38,216,801 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spock1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247339,556,763 - 10,080,703 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247339,556,024 - 10,080,703 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Spock1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11480,207,983 - 80,681,222 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Spock1
3824 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:366
Count of miRNA genes:226
Interacting mature miRNAs:257
Transcripts:ENSRNOT00000061187
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat

Markers in Region
D17Got10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2176,808,272 - 6,808,369 (-)MAPPERmRatBN7.2
Rnor_6.0177,439,126 - 7,439,222NCBIRnor6.0
Rnor_5.0179,623,649 - 9,623,745UniSTSRnor5.0
RGSC_v3.41712,777,857 - 12,777,954RGDRGSC3.4
RGSC_v3.41712,777,858 - 12,777,954UniSTSRGSC3.4
Celera176,911,414 - 6,911,510UniSTS
RGSC_v3.11712,777,858 - 12,777,954RGD
RH 3.4 Map1761.5UniSTS
RH 3.4 Map1761.5RGD
RH 2.0 Map1750.4RGD
Cytogenetic Map17p14UniSTS
BE106256  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2176,953,694 - 6,953,875 (-)MAPPERmRatBN7.2
Rnor_6.0177,294,257 - 7,294,437NCBIRnor6.0
Rnor_6.0177,210,919 - 7,211,099NCBIRnor6.0
Rnor_5.0179,478,962 - 9,479,142UniSTSRnor5.0
Rnor_5.0179,397,171 - 9,397,351UniSTSRnor5.0
RGSC_v3.41712,926,208 - 12,926,388UniSTSRGSC3.4
Celera177,059,557 - 7,059,737UniSTS
RH 3.4 Map1769.5UniSTS
Cytogenetic Map17p14UniSTS
BE106955  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2176,868,300 - 6,868,457 (-)MAPPERmRatBN7.2
Rnor_6.0177,379,173 - 7,379,329NCBIRnor6.0
Rnor_5.0179,563,673 - 9,563,829UniSTSRnor5.0
RGSC_v3.41712,838,516 - 12,838,672UniSTSRGSC3.4
Celera176,975,024 - 6,975,180UniSTS
RH 3.4 Map1766.1UniSTS
Cytogenetic Map17p14UniSTS
AU048032  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,148,618 - 7,148,823 (+)MAPPERmRatBN7.2
mRatBN7.2177,148,706 - 7,148,823 (+)MAPPERmRatBN7.2
Rnor_6.0177,728,271 - 7,728,387NCBIRnor6.0
Rnor_6.0177,728,183 - 7,728,387NCBIRnor6.0
Rnor_5.0179,911,389 - 9,911,593UniSTSRnor5.0
Rnor_5.0179,911,477 - 9,911,593UniSTSRnor5.0
RGSC_v3.41713,142,703 - 13,142,819UniSTSRGSC3.4
RGSC_v3.41713,142,615 - 13,142,819UniSTSRGSC3.4
Celera177,252,866 - 7,253,065UniSTS
Cytogenetic Map17p14UniSTS
RH140414  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,218,819 - 7,218,951 (+)MAPPERmRatBN7.2
Rnor_6.0177,797,567 - 7,797,698NCBIRnor6.0
Rnor_5.0179,980,773 - 9,980,904UniSTSRnor5.0
RGSC_v3.41713,212,759 - 13,212,890UniSTSRGSC3.4
Celera177,323,074 - 7,323,205UniSTS
RH 3.4 Map1766.8UniSTS
Cytogenetic Map17p14UniSTS
MARC_8169-8170:996688351:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,217,474 - 7,218,567 (+)MAPPERmRatBN7.2
Rnor_6.0177,796,222 - 7,797,314NCBIRnor6.0
Rnor_5.0179,979,428 - 9,980,520UniSTSRnor5.0
RGSC_v3.41713,211,414 - 13,212,506UniSTSRGSC3.4
Celera177,321,729 - 7,322,821UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 64 163 91 90 59 54 59 6 310 150 11 142 77 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000061187   ⟹   ENSRNOP00000057901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl176,747,652 - 7,227,033 (+)Ensembl
mRatBN7.2 Ensembl176,742,273 - 7,219,116 (+)Ensembl
Rnor_6.0 Ensembl177,675,531 - 7,797,863 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104617   ⟹   ENSRNOP00000097993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl176,747,652 - 7,230,282 (+)Ensembl
mRatBN7.2 Ensembl176,742,273 - 7,224,935 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119234   ⟹   ENSRNOP00000086844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl176,747,646 - 7,226,812 (+)Ensembl
mRatBN7.2 Ensembl176,742,273 - 7,219,116 (+)Ensembl
RefSeq Acc Id: NM_001271297   ⟹   NP_001258226
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8176,746,892 - 7,224,466 (+)NCBI
mRatBN7.2176,741,513 - 7,219,116 (+)NCBI
Rnor_6.0177,675,531 - 7,797,863 (+)NCBI
Rnor_5.0179,833,535 - 9,981,069 (+)NCBI
Celera176,844,778 - 7,323,370 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063276334   ⟹   XP_063132404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,107,789 - 7,227,034 (+)NCBI
RefSeq Acc Id: XM_063276335   ⟹   XP_063132405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,109,049 - 7,227,034 (+)NCBI
RefSeq Acc Id: NP_001258226   ⟸   NM_001271297
- Peptide Label: precursor
- UniProtKB: A6KAL9 (UniProtKB/TrEMBL),   F1M6V6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057901   ⟸   ENSRNOT00000061187
Ensembl Acc Id: ENSRNOP00000086844   ⟸   ENSRNOT00000119234
Ensembl Acc Id: ENSRNOP00000097993   ⟸   ENSRNOT00000104617
RefSeq Acc Id: XP_063132404   ⟸   XM_063276334
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063132405   ⟸   XM_063276335
- Peptide Label: isoform X2
Protein Domains
Kazal-like   Thyroglobulin type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M6V6-F1-model_v2 AlphaFold F1M6V6 1-328 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311496 AgrOrtholog
BioCyc Gene G2FUF-10325 BioCyc
Ensembl Genes ENSRNOG00000012747 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061187 ENTREZGENE
  ENSRNOT00000061187.5 UniProtKB/TrEMBL
  ENSRNOT00000104617.2 UniProtKB/TrEMBL
  ENSRNOT00000119234.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.30 UniProtKB/TrEMBL
  4.10.800.10 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7312156 IMAGE-MGC_LOAD
InterPro EF-hand-like_dom UniProtKB/TrEMBL
  Kazal_dom UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
  SPARC/Testican_Ca-bd-dom UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/TrEMBL
  Thyroglobulin_1_sf UniProtKB/TrEMBL
KEGG Report rno:306759 UniProtKB/TrEMBL
MGC_CLONE MGC:109277 IMAGE-MGC_LOAD
NCBI Gene 306759 ENTREZGENE
PANTHER SPARC OSTEONECTIN UniProtKB/TrEMBL
  TESTICAN-1 UniProtKB/TrEMBL
Pfam Kazal_2 UniProtKB/TrEMBL
  SPARC_Ca_bdg UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/TrEMBL
PhenoGen Spock1 PhenoGen
PROSITE KAZAL_2 UniProtKB/TrEMBL
  THYROGLOBULIN_1_1 UniProtKB/TrEMBL
  THYROGLOBULIN_1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012747 RatGTEx
SMART KAZAL UniProtKB/TrEMBL
  SM00211 UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/TrEMBL
UniProt A0A8I6A6U2_RAT UniProtKB/TrEMBL
  A0A8I6ATZ8_RAT UniProtKB/TrEMBL
  A6KAL9 ENTREZGENE, UniProtKB/TrEMBL
  F1M6V6 ENTREZGENE, UniProtKB/TrEMBL
  Q562B0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Spock1  sparc/osteonectin, cwcv and kazal like domains proteoglycan 1  LOC102549404  uncharacterized LOC102549404  Data merged from RGD:7719129 737654 PROVISIONAL
2016-08-22 Spock1  sparc/osteonectin, cwcv and kazal like domains proteoglycan 1  Spock1  sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102549404  uncharacterized LOC102549404      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-18 Spock1  sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1  Spock1  sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Spock1  sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1  Spock1_predicted  sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Spock1_predicted  sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED