Rrs1 (ribosome biogenesis regulator 1 homolog) - Rat Genome Database

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Gene: Rrs1 (ribosome biogenesis regulator 1 homolog) Rattus norvegicus
Analyze
Symbol: Rrs1
Name: ribosome biogenesis regulator 1 homolog
RGD ID: 1311403
Description: Predicted to enable 5S rRNA binding activity. Predicted to be involved in several processes, including mitotic metaphase chromosome alignment; protein localization to nucleolus; and ribosome biogenesis. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in condensed nuclear chromosome; endoplasmic reticulum; and nucleoplasm. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Orthologous to human RRS1 (ribosome biogenesis regulator 1 homolog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC297784; ribosome biogenesis regulator homolog; ribosome biogenesis regulatory protein homolog; RRS1 ribosome biogenesis regulator homolog; RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8514,516,303 - 14,517,936 (-)NCBIGRCr8
mRatBN7.259,733,486 - 9,735,119 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl59,733,091 - 9,735,140 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx511,887,332 - 11,888,962 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0513,518,830 - 13,520,460 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0513,222,009 - 13,223,639 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.059,430,710 - 9,432,343 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl59,430,728 - 9,432,343 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0514,229,588 - 14,231,221 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.459,304,448 - 9,306,081 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.159,304,894 - 9,350,347 (-)NCBI
Celera59,242,443 - 9,244,076 (-)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
amphetamine  (EXP)
antimycin A  (ISO)
Archazolid B  (ISO)
Aroclor 1254  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
N-nitrosodiethylamine  (EXP)
ochratoxin A  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc dichloride  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:19433866   PMID:19465021   PMID:22658674   PMID:22681889   PMID:24029230   PMID:24120868  


Genomics

Comparative Map Data
Rrs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8514,516,303 - 14,517,936 (-)NCBIGRCr8
mRatBN7.259,733,486 - 9,735,119 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl59,733,091 - 9,735,140 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx511,887,332 - 11,888,962 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0513,518,830 - 13,520,460 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0513,222,009 - 13,223,639 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.059,430,710 - 9,432,343 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl59,430,728 - 9,432,343 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0514,229,588 - 14,231,221 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.459,304,448 - 9,306,081 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.159,304,894 - 9,350,347 (-)NCBI
Celera59,242,443 - 9,244,076 (-)NCBICelera
Cytogenetic Map5q11NCBI
RRS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38866,429,014 - 66,430,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl866,429,014 - 66,430,733 (+)EnsemblGRCh38hg38GRCh38
GRCh37867,341,249 - 67,342,968 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36867,503,817 - 67,505,522 (+)NCBINCBI36Build 36hg18NCBI36
Build 34867,503,816 - 67,505,520NCBI
Celera863,332,964 - 63,334,669 (+)NCBICelera
Cytogenetic Map8q13.1NCBI
HuRef862,831,252 - 62,832,957 (+)NCBIHuRef
CHM1_1867,395,947 - 67,397,652 (+)NCBICHM1_1
T2T-CHM13v2.0866,854,584 - 66,856,303 (+)NCBIT2T-CHM13v2.0
Rrs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3919,615,633 - 9,617,680 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl19,615,633 - 9,617,680 (+)EnsemblGRCm39 Ensembl
GRCm3819,545,408 - 9,547,455 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl19,545,408 - 9,547,455 (+)EnsemblGRCm38mm10GRCm38
MGSCv3719,535,489 - 9,537,536 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3619,530,656 - 9,532,669 (+)NCBIMGSCv36mm8
Celera19,519,571 - 9,521,618 (+)NCBICelera
Cytogenetic Map1A2NCBI
cM Map12.08NCBI
Rrs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495544412,740,172 - 12,751,674 (-)NCBIChiLan1.0ChiLan1.0
RRS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2782,166,690 - 82,168,475 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1857,806,089 - 57,808,056 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0862,972,274 - 62,974,004 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1864,638,584 - 64,640,311 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl864,638,713 - 64,639,810 (+)Ensemblpanpan1.1panPan2
RRS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12916,016,134 - 16,018,046 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2916,016,189 - 16,017,286 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2916,330,843 - 16,332,570 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02916,094,741 - 16,096,468 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2916,094,823 - 16,097,669 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12916,127,207 - 16,128,934 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02916,226,551 - 16,228,278 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02916,482,576 - 16,484,301 (+)NCBIUU_Cfam_GSD_1.0
Rrs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530367,219,794 - 67,221,536 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364967,564,459 - 7,565,556 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364967,563,989 - 7,565,663 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RRS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl468,285,803 - 68,288,195 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1468,285,803 - 68,288,213 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2474,453,947 - 74,455,657 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RRS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1862,297,483 - 62,299,194 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl862,297,608 - 62,298,705 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603979,206,829 - 79,208,531 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rrs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474424,915,703 - 24,916,800 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474424,914,717 - 24,916,940 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rrs1
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:40
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000009482
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)5818750118616199Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 37 29 17 29 67 27 34 9
Low 8 20 12 2 12 8 11 7 8 7 2 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000009482   ⟹   ENSRNOP00000009482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl59,733,091 - 9,735,140 (-)Ensembl
Rnor_6.0 Ensembl59,430,728 - 9,432,343 (-)Ensembl
RefSeq Acc Id: NM_001079699   ⟹   NP_001073167
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8514,516,303 - 14,517,936 (-)NCBI
mRatBN7.259,733,486 - 9,735,119 (-)NCBI
Rnor_6.059,430,710 - 9,432,343 (-)NCBI
Rnor_5.0514,229,588 - 14,231,221 (-)NCBI
RGSC_v3.459,304,448 - 9,306,081 (-)RGD
Celera59,242,443 - 9,244,076 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001073167 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A1A5P2 (Get FASTA)   NCBI Sequence Viewer  
  AAI28747 (Get FASTA)   NCBI Sequence Viewer  
  EDM11566 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009482
  ENSRNOP00000009482.3
RefSeq Acc Id: NP_001073167   ⟸   NM_001079699
- UniProtKB: A1A5P2 (UniProtKB/Swiss-Prot),   A6JFH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009482   ⟸   ENSRNOT00000009482

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1A5P2-F1-model_v2 AlphaFold A1A5P2 1-365 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693538
Promoter ID:EPDNEW_R4063
Type:initiation region
Name:Rrs1_1
Description:ribosome biogenesis regulator homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.059,432,363 - 9,432,423EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311403 AgrOrtholog
BioCyc Gene G2FUF-42194 BioCyc
Ensembl Genes ENSRNOG00000007240 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009482 ENTREZGENE
  ENSRNOT00000009482.6 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7098944 IMAGE-MGC_LOAD
InterPro Ribosom_reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:297784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156696 IMAGE-MGC_LOAD
NCBI Gene 297784 ENTREZGENE
PANTHER PTHR17602 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBOSOME BIOGENESIS REGULATORY PROTEIN HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RRS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rrs1 PhenoGen
RatGTEx ENSRNOG00000007240 RatGTEx
UniProt A1A5P2 ENTREZGENE
  A6JFH0 ENTREZGENE, UniProtKB/TrEMBL
  RRS1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-03 Rrs1  ribosome biogenesis regulator 1 homolog  Rrs1  ribosome biogenesis regulator homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-30 Rrs1  ribosome biogenesis regulator homolog  Rrs1  RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Rrs1  RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)   Rrs1_predicted  RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rrs1_predicted  RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED