Il17f (interleukin 17F) - Rat Genome Database

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Gene: Il17f (interleukin 17F) Rattus norvegicus
Analyze
Symbol: Il17f
Name: interleukin 17F
RGD ID: 1311398
Description: Predicted to enable cytokine binding activity; protein dimerization activity; and signaling receptor binding activity. Predicted to be involved in several processes, including defense response to bacterium; interleukin-17-mediated signaling pathway; and regulation of cytokine production. Predicted to act upstream of or within positive regulation of cytokine production involved in inflammatory response and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17F (interleukin 17F); PARTICIPATES IN interleukin-23 signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IL-17F; interleukin-17F; LOC301291; MGC114402
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8930,686,532 - 30,697,918 (-)NCBIGRCr8
mRatBN7.2923,190,094 - 23,201,482 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,190,100 - 23,201,482 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx931,687,255 - 31,698,635 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0936,807,980 - 36,819,360 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,123,245 - 35,134,625 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0926,885,702 - 26,897,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,885,708 - 26,897,219 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0925,742,088 - 25,753,605 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4919,507,952 - 19,519,338 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1919,505,279 - 19,516,660 (-)NCBI
Celera920,765,976 - 20,777,363 (-)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11574464   PMID:11591732   PMID:16785495   PMID:16982811   PMID:17911633   PMID:17982105   PMID:19577259   PMID:20554964   PMID:24548428   PMID:28093217  


Genomics

Comparative Map Data
Il17f
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8930,686,532 - 30,697,918 (-)NCBIGRCr8
mRatBN7.2923,190,094 - 23,201,482 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,190,100 - 23,201,482 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx931,687,255 - 31,698,635 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0936,807,980 - 36,819,360 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,123,245 - 35,134,625 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0926,885,702 - 26,897,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,885,708 - 26,897,219 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0925,742,088 - 25,753,605 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4919,507,952 - 19,519,338 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1919,505,279 - 19,516,660 (-)NCBI
Celera920,765,976 - 20,777,363 (-)NCBICelera
Cytogenetic Map9q13NCBI
IL17F
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,236,681 - 52,245,689 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,236,681 - 52,245,689 (-)EnsemblGRCh38hg38GRCh38
GRCh37652,101,479 - 52,109,298 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,209,443 - 52,217,257 (-)NCBINCBI36Build 36hg18NCBI36
Build 34652,209,442 - 52,217,257NCBI
Celera653,762,606 - 53,770,421 (-)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef651,932,711 - 51,940,522 (-)NCBIHuRef
CHM1_1652,103,743 - 52,111,557 (-)NCBICHM1_1
T2T-CHM13v2.0652,075,437 - 52,084,442 (-)NCBIT2T-CHM13v2.0
Il17f
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39120,847,370 - 20,855,498 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl120,847,370 - 20,860,841 (-)EnsemblGRCm39 Ensembl
GRCm38120,777,146 - 20,785,274 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl120,777,146 - 20,790,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv37120,767,227 - 20,774,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36120,762,918 - 20,764,663 (-)NCBIMGSCv36mm8
Celera120,651,214 - 20,658,338 (-)NCBICelera
Cytogenetic Map1A4NCBI
cM Map16.49NCBI
Il17f
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554115,852,767 - 5,859,208 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554115,852,767 - 5,859,208 (+)NCBIChiLan1.0ChiLan1.0
IL17F
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2566,704,846 - 66,713,100 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1662,581,667 - 62,589,927 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0651,789,210 - 51,797,470 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1653,057,313 - 53,065,124 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl653,057,318 - 53,065,124 (-)Ensemblpanpan1.1panPan2
IL17F
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11219,904,283 - 19,908,497 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1219,904,126 - 19,908,619 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1219,801,660 - 19,805,553 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01220,403,156 - 20,407,042 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11219,909,305 - 19,913,193 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01220,012,473 - 20,016,364 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01220,150,933 - 20,154,815 (-)NCBIUU_Cfam_GSD_1.0
Il17f
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494655,379,286 - 55,380,920 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364768,574,387 - 8,580,916 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364768,579,282 - 8,580,916 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL17F
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl746,059,002 - 46,077,048 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1746,058,371 - 46,066,039 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,508,706 - 52,516,123 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL17F
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11720,263,252 - 20,272,234 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1720,264,481 - 20,271,982 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604452,133,830 - 52,147,127 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il17f
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248553,848,409 - 3,867,175 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248553,865,559 - 3,867,175 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il17f
63 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:144
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000016717
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system reproductive system respiratory system
High
Medium
Low 1
Below cutoff 1 2 7 4 3 4 4 6 1

Sequence


RefSeq Acc Id: ENSRNOT00000016717   ⟹   ENSRNOP00000016717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl923,190,100 - 23,201,482 (-)Ensembl
Rnor_6.0 Ensembl926,885,708 - 26,897,219 (-)Ensembl
RefSeq Acc Id: NM_001015011   ⟹   NP_001015011
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8930,686,532 - 30,697,918 (-)NCBI
mRatBN7.2923,190,094 - 23,201,482 (-)NCBI
Rnor_6.0926,885,702 - 26,897,219 (-)NCBI
Rnor_5.0925,742,088 - 25,753,605 (-)NCBI
RGSC_v3.4919,507,952 - 19,519,338 (-)RGD
Celera920,765,976 - 20,777,363 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001015011 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91568 (Get FASTA)   NCBI Sequence Viewer  
  EDM18651 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016717
  ENSRNOP00000016717.7
GenBank Protein Q5BJ95 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001015011   ⟸   NM_001015011
- Peptide Label: precursor
- UniProtKB: Q5BJ95 (UniProtKB/Swiss-Prot),   A0A0H2UHJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016717   ⟸   ENSRNOT00000016717

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BJ95-F1-model_v2 AlphaFold Q5BJ95 1-161 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311398 AgrOrtholog
BioCyc Gene G2FUF-28031 BioCyc
Ensembl Genes ENSRNOG00000012509 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016717 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000016717.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7443410 IMAGE-MGC_LOAD
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-17_chr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-17_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:301291 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114402 IMAGE-MGC_LOAD
NCBI Gene 301291 ENTREZGENE
Pfam IL17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il17f PhenoGen
PRINTS INTRLEUKIN17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012509 RatGTEx
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHJ7 ENTREZGENE, UniProtKB/TrEMBL
  A6JJ81_RAT UniProtKB/TrEMBL
  IL17F_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Il17f  interleukin 17F  Il17f_predicted  interleukin 17F (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Il17f_predicted  interleukin 17F (predicted)      Symbol and Name status set to approved 70820 APPROVED