Lman2l (lectin, mannose-binding 2-like) - Rat Genome Database

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Gene: Lman2l (lectin, mannose-binding 2-like) Rattus norvegicus
Analyze
Symbol: Lman2l
Name: lectin, mannose-binding 2-like
RGD ID: 1311393
Description: Predicted to enable D-mannose binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein transport. Predicted to be located in Golgi apparatus. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 69 and autosomal recessive intellectual developmental disorder 52. Orthologous to human LMAN2L (lectin, mannose binding 2 like); INTERACTS WITH bisphenol A; leflunomide; thioacetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lectin, mannose binding 2 like; LOC120094667; LOC301343; VIP36-like protein
RGD Orthologs
Human
Mouse
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8946,157,596 - 46,181,151 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl946,157,596 - 46,181,207 (-)EnsemblGRCr8
mRatBN7.2938,661,709 - 38,685,244 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl938,661,712 - 38,685,337 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx947,165,415 - 47,188,981 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0952,280,511 - 52,304,041 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0950,562,410 - 50,585,939 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0943,020,940 - 43,023,015 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl942,999,229 - 43,022,999 (-)Ensemblrn6Rnor6.0
Rnor_5.0942,674,819 - 42,676,894 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4935,381,997 - 35,384,072 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera936,449,735 - 36,451,810 (-)NCBICelera
RGSC_v3.1935,366,221 - 35,385,543 (-)NCBI
Cytogenetic Map9q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12609988   PMID:12878160  


Genomics

Comparative Map Data
Lman2l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8946,157,596 - 46,181,151 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl946,157,596 - 46,181,207 (-)EnsemblGRCr8
mRatBN7.2938,661,709 - 38,685,244 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl938,661,712 - 38,685,337 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx947,165,415 - 47,188,981 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0952,280,511 - 52,304,041 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0950,562,410 - 50,585,939 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0943,020,940 - 43,023,015 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl942,999,229 - 43,022,999 (-)Ensemblrn6Rnor6.0
Rnor_5.0942,674,819 - 42,676,894 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4935,381,997 - 35,384,072 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera936,449,735 - 36,451,810 (-)NCBICelera
RGSC_v3.1935,366,221 - 35,385,543 (-)NCBI
Cytogenetic Map9q21NCBI
LMAN2L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38296,705,929 - 96,740,064 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl296,704,993 - 96,740,084 (-)Ensemblhg38GRCh38
GRCh37297,371,666 - 97,405,801 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36296,735,393 - 96,769,528 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34296,793,542 - 96,827,675NCBI
Celera291,812,913 - 91,845,986 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef291,332,308 - 91,366,499 (-)NCBIHuRef
CHM1_1297,376,571 - 97,410,719 (-)NCBICHM1_1
T2T-CHM13v2.0297,212,567 - 97,246,702 (-)NCBIT2T-CHM13v2.0
Lman2l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39136,458,274 - 36,484,352 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl136,458,952 - 36,484,352 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38136,418,900 - 36,445,271 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl136,419,871 - 36,445,271 (-)Ensemblmm10GRCm38
MGSCv37136,480,031 - 36,502,084 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36136,367,732 - 36,389,785 (-)NCBIMGSCv36mm8
Celera136,209,990 - 36,232,040 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map115.26NCBI
Lman2l
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14112,642,002 - 112,665,168 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lman2l
103 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:95
Count of miRNA genes:87
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000063781
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat

Markers in Region
RH141137  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2938,676,212 - 38,676,432 (+)MAPPERmRatBN7.2
Rnor_6.0943,013,979 - 43,014,198NCBIRnor6.0
Rnor_5.0942,667,858 - 42,668,077UniSTSRnor5.0
RGSC_v3.4935,375,036 - 35,375,255UniSTSRGSC3.4
RH 3.4 Map10529.09UniSTS
Cytogenetic Map9q21UniSTS
RH140151  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2938,662,037 - 38,662,229 (+)MAPPERmRatBN7.2
Rnor_6.0942,999,550 - 42,999,741NCBIRnor6.0
Rnor_5.0942,653,429 - 42,653,620UniSTSRnor5.0
RGSC_v3.4935,360,214 - 35,360,405UniSTSRGSC3.4
Celera936,429,214 - 36,429,405UniSTS
Cytogenetic Map9q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000063781   ⟹   ENSRNOP00000060837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl946,157,596 - 46,181,207 (-)Ensembl
mRatBN7.2 Ensembl938,661,722 - 38,685,337 (-)Ensembl
Rnor_6.0 Ensembl943,000,167 - 43,022,998 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089843   ⟹   ENSRNOP00000072506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl946,157,598 - 46,181,114 (-)Ensembl
mRatBN7.2 Ensembl938,661,717 - 38,685,233 (-)Ensembl
Rnor_6.0 Ensembl942,999,229 - 43,022,999 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117761   ⟹   ENSRNOP00000081479
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl946,157,596 - 46,181,207 (-)Ensembl
mRatBN7.2 Ensembl938,661,722 - 38,685,337 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119365   ⟹   ENSRNOP00000086744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl946,157,596 - 46,181,125 (-)Ensembl
mRatBN7.2 Ensembl938,661,712 - 38,685,192 (-)Ensembl
RefSeq Acc Id: NM_001402076   ⟹   NP_001389005
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,157,596 - 46,181,125 (-)NCBI
mRatBN7.2938,661,715 - 38,685,244 (-)NCBI
RefSeq Acc Id: XM_039084531   ⟹   XP_038940459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,157,596 - 46,179,540 (-)NCBI
mRatBN7.2938,661,709 - 38,683,659 (-)NCBI
RefSeq Acc Id: XM_039084532   ⟹   XP_038940460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,157,596 - 46,179,540 (-)NCBI
mRatBN7.2938,661,709 - 38,683,659 (-)NCBI
RefSeq Acc Id: XM_063266892   ⟹   XP_063122962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,157,596 - 46,181,151 (-)NCBI
RefSeq Acc Id: XR_010054583
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8946,158,847 - 46,181,151 (-)NCBI
Ensembl Acc Id: ENSRNOP00000060837   ⟸   ENSRNOT00000063781
Ensembl Acc Id: ENSRNOP00000072506   ⟸   ENSRNOT00000089843
Ensembl Acc Id: ENSRNOP00000086744   ⟸   ENSRNOT00000119365
Ensembl Acc Id: ENSRNOP00000081479   ⟸   ENSRNOT00000117761
RefSeq Acc Id: XP_038940460   ⟸   XM_039084532
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A4A4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940459   ⟸   XM_039084531
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A4A4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001389005   ⟸   NM_001402076
- Peptide Label: precursor
- UniProtKB: A6IND3 (UniProtKB/TrEMBL),   F7F3Z1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122962   ⟸   XM_063266892
- Peptide Label: isoform X1
- UniProtKB: A6IND4 (UniProtKB/TrEMBL),   A0A8I6G604 (UniProtKB/TrEMBL)
Protein Domains
L-type lectin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7F3Z1-F1-model_v2 AlphaFold F7F3Z1 1-349 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696615
Promoter ID:EPDNEW_R7126
Type:multiple initiation site
Name:Lman2l_1
Description:VIP36-like protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0943,023,012 - 43,023,072EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311393 AgrOrtholog
BioCyc Gene G2FUF-27811 BioCyc
Ensembl Genes ENSRNOG00000015699 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000063781 ENTREZGENE
  ENSRNOT00000063781.5 UniProtKB/TrEMBL
  ENSRNOT00000089843.3 UniProtKB/TrEMBL
  ENSRNOT00000117761 ENTREZGENE
  ENSRNOT00000117761.2 UniProtKB/TrEMBL
  ENSRNOT00000119365 ENTREZGENE
  ENSRNOT00000119365.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9025901 IMAGE-MGC_LOAD
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  Intracellular_Lectin-GPT UniProtKB/TrEMBL
  Lectin_leg UniProtKB/TrEMBL
MGC_CLONE MGC:187745 IMAGE-MGC_LOAD
NCBI Gene 301343 ENTREZGENE
PANTHER VESICULAR MANNOSE-BINDING LECTIN UniProtKB/TrEMBL
  VIP36-LIKE PROTEIN UniProtKB/TrEMBL
Pfam Lectin_leg-like UniProtKB/TrEMBL
PhenoGen Lman2l PhenoGen
PROSITE L_LECTIN_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015699 RatGTEx
Superfamily-SCOP SSF49899 UniProtKB/TrEMBL
UniProt A0A8I6A4A4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G604 ENTREZGENE, UniProtKB/TrEMBL
  A6IND3 ENTREZGENE, UniProtKB/TrEMBL
  A6IND4 ENTREZGENE, UniProtKB/TrEMBL
  B1WBZ8_RAT UniProtKB/TrEMBL
  F7F3Z1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-04 Lman2l  lectin, mannose-binding 2-like  LOC120094667  lectin, mannose binding 2 like  Data merged from RGD:41155346 737654 PROVISIONAL
2021-01-27 LOC120094667  lectin, mannose binding 2 like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Lman2l  lectin, mannose-binding 2-like   Lman2l_predicted  lectin, mannose-binding 2-like (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lman2l_predicted  lectin, mannose-binding 2-like (predicted)      Symbol and Name status set to approved 70820 APPROVED