Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | ISO | Eif4g3 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of EIF4G3 mRNA | CTD | PMID:22206623 | 1-chloro-2,4-dinitrobenzene | affects binding | ISO | EIF4G3 (Homo sapiens) | 6480464 | Dinitrochlorobenzene binds to EIF4G3 protein | CTD | PMID:32991956 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EIF4G3 mRNA | CTD | PMID:11007951 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EIF4G3 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Eif4g3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of EIF4G3 mRNA | CTD | PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Eif4g3 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EIF4G3 mRNA | CTD | PMID:15328365 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | EIF4G3 (Homo sapiens) | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of EIF4G3 mRNA] | CTD | PMID:11007951 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Eif4g3 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of EIF4G3 mRNA | CTD | PMID:26251327 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Eif4g3 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of EIF4G3 promoter | CTD | PMID:33297965 | 4,4'-sulfonyldiphenol | increases methylation | ISO | EIF4G3 (Homo sapiens) | 6480464 | bisphenol S results in increased methylation of EIF4G3 gene | CTD | PMID:31601247 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of EIF4G3 mRNA | CTD | PMID:24780913 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of EIF4G3 mRNA | CTD | PMID:23630614 | aflatoxin B1 | increases methylation | ISO | EIF4G3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of EIF4G3 5' UTR | CTD | PMID:30157460 | aflatoxin B1 | decreases methylation | ISO | EIF4G3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of EIF4G3 gene | CTD | PMID:27153756 | all-trans-retinoic acid | increases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of EIF4G3 mRNA | CTD | PMID:23724009 | arsenite(3-) | multiple interactions | ISO | EIF4G3 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to EIF4G3 mRNA] | CTD | PMID:32406909 | auramine O | increases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Benzophenoneidum results in increased expression of EIF4G3 protein | CTD | PMID:28722353 | benzo[a]pyrene | decreases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of EIF4G3 mRNA | CTD | PMID:20064835 more ... | benzo[a]pyrene | affects methylation | ISO | EIF4G3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of EIF4G3 intron | CTD | PMID:30157460 | benzo[a]pyrene | increases methylation | ISO | Eif4g3 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of EIF4G3 exon and Benzo(a)pyrene results in increased methylation of EIF4G3 intron | CTD | PMID:27901495 | bisphenol A | increases expression | ISO | Eif4g3 (Mus musculus) | 6480464 | bisphenol A results in increased expression of EIF4G3 mRNA | CTD | PMID:26063408 | bisphenol A | multiple interactions | ISO | EIF4G3 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of EIF4G3 gene | CTD | PMID:31601247 | bisphenol A | increases methylation | ISO | EIF4G3 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of EIF4G3 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | Eif4g3 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of EIF4G3 mRNA | CTD | PMID:33221593 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of EIF4G3 mRNA | CTD | PMID:32145629 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of EIF4G3 mRNA | CTD | PMID:25181051 | cadmium atom | multiple interactions | ISO | EIF4G3 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of EIF4G3 mRNA | CTD | PMID:35301059 | cadmium atom | multiple interactions | ISO | Eif4g3 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of EIF4G3 mRNA | CTD | PMID:37325564 | cadmium dichloride | multiple interactions | ISO | EIF4G3 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of EIF4G3 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | Eif4g3 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of EIF4G3 mRNA | CTD | PMID:37325564 | carbamazepine | affects expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of EIF4G3 mRNA | CTD | PMID:24752500 | carbon nanotube | increases expression | ISO | Eif4g3 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of EIF4G3 mRNA | CTD | PMID:25620056 | chlorpyrifos | increases methylation | EXP | | 6480464 | Chlorpyrifos results in increased methylation of EIF4G3 gene | CTD | PMID:32905263 | choline | multiple interactions | ISO | Eif4g3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of EIF4G3 gene | CTD | PMID:20938992 | chrysene | increases expression | ISO | Eif4g3 (Mus musculus) | 6480464 | chrysene results in increased expression of EIF4G3 mRNA | CTD | PMID:26377693 | cisplatin | decreases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of EIF4G3 mRNA | CTD | PMID:19561079 and PMID:27594783 | cobalt dichloride | decreases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of EIF4G3 mRNA | CTD | PMID:19320972 and PMID:19376846 | copper(II) sulfate | increases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of EIF4G3 mRNA | CTD | PMID:19549813 | coumarin | increases phosphorylation | ISO | EIF4G3 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of EIF4G3 protein | CTD | PMID:35688186 | coumestrol | decreases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of EIF4G3 mRNA | CTD | PMID:19167446 | cycloheximide | multiple interactions | ISO | EIF4G3 (Homo sapiens) | 6480464 | Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of EIF4G3 mRNA] | CTD | PMID:11007951 | dexamethasone | increases expression | EXP | | 6480464 | Dexamethasone results in increased expression of EIF4G3 mRNA | CTD | PMID:20032058 | dexamethasone | multiple interactions | EXP | | 6480464 | Testosterone inhibits the reaction [Dexamethasone results in increased expression of EIF4G3 mRNA] | CTD | PMID:20032058 | diclofenac | affects expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Diclofenac affects the expression of EIF4G3 mRNA | CTD | PMID:24752500 | doxorubicin | decreases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of EIF4G3 mRNA | CTD | PMID:29803840 | enzyme inhibitor | multiple interactions | ISO | EIF4G3 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of EIF4G3 protein | CTD | PMID:23301498 | epoxiconazole | increases expression | ISO | Eif4g3 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of EIF4G3 mRNA | CTD | PMID:35436446 | ethanol | affects splicing | ISO | Eif4g3 (Mus musculus) | 6480464 | Ethanol affects the splicing of EIF4G3 mRNA | CTD | PMID:30319688 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of EIF4G3 mRNA | CTD | PMID:24136188 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of EIF4G3 mRNA | CTD | PMID:24136188 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of EIF4G3 mRNA | CTD | PMID:24793618 | folic acid | multiple interactions | ISO | Eif4g3 (Mus musculus) | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | formaldehyde | increases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of EIF4G3 mRNA | CTD | PMID:23649840 and PMID:27664576 | FR900359 | affects phosphorylation | ISO | EIF4G3 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of EIF4G3 protein | CTD | PMID:37730182 | fulvestrant | multiple interactions | ISO | EIF4G3 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of EIF4G3 gene | CTD | PMID:31601247 | hydralazine | multiple interactions | ISO | EIF4G3 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of EIF4G3 mRNA | CTD | PMID:17183730 | ivermectin | decreases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of EIF4G3 protein | CTD | PMID:32959892 | L-methionine | multiple interactions | ISO | Eif4g3 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of EIF4G3 gene | CTD | PMID:20938992 | leflunomide | decreases expression | ISO | Eif4g3 (Mus musculus) | 6480464 | leflunomide results in decreased expression of EIF4G3 mRNA | CTD | PMID:19751817 | methapyrilene | decreases methylation | EXP | | 6480464 | Methapyrilene results in decreased methylation of EIF4G3 gene | CTD | PMID:26431795 | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of EIF4G3 mRNA | CTD | PMID:30467583 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of EIF4G3 gene | CTD | PMID:35440735 | methylmercury chloride | increases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of EIF4G3 mRNA | CTD | PMID:28001369 | nickel atom | increases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Nickel results in increased expression of EIF4G3 mRNA | CTD | PMID:25583101 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of EIF4G3 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | Eif4g3 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of EIF4G3 mRNA | CTD | PMID:34911549 | paracetamol | affects expression | ISO | Eif4g3 (Mus musculus) | 6480464 | Acetaminophen affects the expression of EIF4G3 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of EIF4G3 mRNA | CTD | PMID:22230336 | paracetamol | decreases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of EIF4G3 mRNA | CTD | PMID:21420995 | pentachlorophenol | decreases expression | ISO | Eif4g3 (Mus musculus) | 6480464 | Pentachlorophenol results in decreased expression of EIF4G3 mRNA | CTD | PMID:23892564 | phosgene | affects expression | ISO | Eif4g3 (Mus musculus) | 6480464 | Phosgene affects the expression of EIF4G3 mRNA | CTD | PMID:16300373 | progesterone | affects expression | ISO | Eif4g3 (Mus musculus) | 6480464 | Progesterone affects the expression of EIF4G3 mRNA | CTD | PMID:17251523 | serpentine asbestos | decreases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Asbestos and Serpentine results in decreased expression of EIF4G3 mRNA | CTD | PMID:21148743 | sodium dichromate | decreases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | sodium bichromate results in decreased expression of EIF4G3 mRNA | CTD | PMID:17685462 | sunitinib | increases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of EIF4G3 mRNA | CTD | PMID:31533062 | testosterone | multiple interactions | EXP | | 6480464 | Testosterone inhibits the reaction [Dexamethasone results in increased expression of EIF4G3 mRNA] | CTD | PMID:20032058 | testosterone enanthate | affects expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | testosterone enanthate affects the expression of EIF4G3 mRNA | CTD | PMID:17440010 | tetrachloromethane | increases expression | ISO | Eif4g3 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of EIF4G3 mRNA | CTD | PMID:31919559 | titanium dioxide | increases expression | ISO | Eif4g3 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of EIF4G3 mRNA | CTD | PMID:29264374 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of EIF4G3 mRNA | CTD | PMID:25729387 | trichostatin A | decreases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of EIF4G3 mRNA | CTD | PMID:24935251 | tungsten | decreases expression | ISO | Eif4g3 (Mus musculus) | 6480464 | Tungsten results in decreased expression of EIF4G3 mRNA | CTD | PMID:30912803 | valproic acid | multiple interactions | ISO | EIF4G3 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of EIF4G3 mRNA | CTD | PMID:17183730 | valproic acid | increases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of EIF4G3 mRNA | CTD | PMID:29154799 | zinc atom | increases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of EIF4G3 mRNA | CTD | PMID:22171008 | zinc(0) | increases expression | ISO | EIF4G3 (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of EIF4G3 mRNA | CTD | PMID:22171008 | | 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