Phpt1 (phosphohistidine phosphatase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Phpt1 (phosphohistidine phosphatase 1) Rattus norvegicus
Analyze
Symbol: Phpt1
Name: phosphohistidine phosphatase 1
RGD ID: 1311355
Description: Orthologous to human PHPT1 (phosphohistidine phosphatase 1); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; INTERACTS WITH 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 14 kDa phosphohistidine phosphatase; LOC296571
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,791,062 - 28,792,905 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.238,392,926 - 8,394,325 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx311,498,106 - 11,499,505 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,084,332 - 20,085,731 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,274,175 - 18,275,574 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,797,037 - 2,798,436 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,796,997 - 2,798,470 (-)Ensemblrn6Rnor6.0
Rnor_5.032,778,450 - 2,779,849 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,744,947 - 3,746,346 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,217,877 - 3,219,276 (-)NCBICelera
RGSC_v3.133,745,120 - 3,746,334 (-)NCBI
Cytogenetic Map3p13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
decabromodiphenyl ether  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
furfural  (ISO)
glafenine  (EXP)
hypochlorous acid  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
microcystin RR  (ISO)
Nutlin-3  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
tungsten  (ISO)
valproic acid  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells. Kamath V, etal., Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E276-86. doi: 10.1152/ajpendo.00091.2010. Epub 2010 May 25.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12383260   PMID:12477932   PMID:16219293   PMID:18656514   PMID:18796614   PMID:19056867   PMID:19138678   PMID:19344975   PMID:20110805   PMID:23376485  


Genomics

Comparative Map Data
Phpt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,791,062 - 28,792,905 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.238,392,926 - 8,394,325 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx311,498,106 - 11,499,505 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,084,332 - 20,085,731 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,274,175 - 18,275,574 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,797,037 - 2,798,436 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,796,997 - 2,798,470 (-)Ensemblrn6Rnor6.0
Rnor_5.032,778,450 - 2,779,849 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,744,947 - 3,746,346 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,217,877 - 3,219,276 (-)NCBICelera
RGSC_v3.133,745,120 - 3,746,334 (-)NCBI
Cytogenetic Map3p13NCBI
PHPT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,849,409 - 136,851,024 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,848,724 - 136,851,039 (+)Ensemblhg38GRCh38
GRCh379139,743,861 - 139,745,476 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,863,367 - 138,865,311 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349137,019,382 - 137,021,327NCBI
Celera9110,257,046 - 110,259,279 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,202,666 - 109,204,708 (+)NCBIHuRef
CHM1_19139,891,999 - 139,894,223 (+)NCBICHM1_1
T2T-CHM13v2.09149,083,591 - 149,085,206 (+)NCBIT2T-CHM13v2.0
Phpt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,463,442 - 25,465,528 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,463,442 - 25,465,236 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38225,573,430 - 25,575,514 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,573,430 - 25,575,224 (-)Ensemblmm10GRCm38
MGSCv37225,428,951 - 25,430,391 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36225,395,440 - 25,396,880 (-)NCBIMGSCv36mm8
Celera225,301,192 - 25,302,632 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.44NCBI
Phpt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,930,951 - 4,932,509 (+)Ensembl
ChiLan1.0NW_0049555134,930,951 - 4,932,509 (+)NCBIChiLan1.0ChiLan1.0
PHPT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,551,316 - 2,553,397 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,553,651 - 2,555,698 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09107,906,160 - 107,908,130 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19136,877,274 - 136,878,317 (+)NCBIPanPan1.1PanPan1.1panPan2
PHPT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,736,310 - 48,737,771 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,736,333 - 48,737,725 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha947,949,921 - 47,951,381 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0949,614,346 - 49,615,806 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,614,371 - 49,615,763 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,390,569 - 48,392,028 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,689,275 - 48,690,734 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,736,240 - 48,737,700 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Phpt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,307,826 - 202,309,158 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,065,900 - 1,067,214 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366691,065,901 - 1,067,214 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHPT1
(Sus scrofa - pig)		 No map positions available.
PHPT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,338,205 - 1,340,143 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,338,388 - 1,339,753 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660583,936,606 - 3,938,603 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phpt1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1511,603,745 - 11,605,644 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Phpt1
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:37
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000022495
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH137697  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,395,110 - 8,395,272 (+)MAPPERmRatBN7.2
Rnor_6.032,799,222 - 2,799,383NCBIRnor6.0
Rnor_5.032,780,635 - 2,780,796UniSTSRnor5.0
RGSC_v3.433,747,132 - 3,747,293UniSTSRGSC3.4
Celera33,220,062 - 3,220,223UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022495   ⟹   ENSRNOP00000022495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl32,796,997 - 2,798,470 (-)Ensembl
RefSeq Acc Id: NM_001106558   ⟹   NP_001100028
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,791,062 - 28,792,461 (-)NCBI
mRatBN7.238,392,926 - 8,394,325 (-)NCBI
Rnor_6.032,797,037 - 2,798,436 (-)NCBI
Rnor_5.032,778,450 - 2,779,849 (-)NCBI
RGSC_v3.433,744,947 - 3,746,346 (-)RGD
Celera33,217,877 - 3,219,276 (-)RGD
Sequence:
RefSeq Acc Id: XM_063283464   ⟹   XP_063139534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,791,070 - 28,792,905 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100028 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139534 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93563 (Get FASTA)   NCBI Sequence Viewer  
  EDL93564 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001100028   ⟸   NM_001106558
- UniProtKB: A6JT83 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022495   ⟸   ENSRNOT00000022495
RefSeq Acc Id: XP_063139534   ⟸   XM_063283464
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZP47-F1-model_v2 AlphaFold D3ZP47 1-124 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691884
Promoter ID:EPDNEW_R2408
Type:multiple initiation site
Name:Phpt1_1
Description:phosphohistidine phosphatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,798,439 - 2,798,499EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311355 AgrOrtholog
BioCyc Gene G2FUF-50439 BioCyc
Ensembl Genes ENSRNOG00000016723 Ensembl
Gene3D-CATH Janus/Ocnus UniProtKB/TrEMBL
InterPro Janus UniProtKB/TrEMBL
  Janus_sf UniProtKB/TrEMBL
KEGG Report rno:296571 UniProtKB/TrEMBL
NCBI Gene 296571 ENTREZGENE
PANTHER 14 KDA PHOSPHOHISTIDINE PHOSPHATASE UniProtKB/TrEMBL
  JANUS-A/JANUS-B UniProtKB/TrEMBL
Pfam Ocnus UniProtKB/TrEMBL
PhenoGen Phpt1 PhenoGen
RatGTEx ENSRNOG00000016723 RatGTEx
Superfamily-SCOP PHP14-like UniProtKB/TrEMBL
UniProt A6JT83 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Phpt1  phosphohistidine phosphatase 1   Phpt1_predicted  phosphohistidine phosphatase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Phpt1_predicted  phosphohistidine phosphatase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED