Frzb (frizzled-related protein) - Rat Genome Database

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Gene: Frzb (frizzled-related protein) Rattus norvegicus
Analyze
Symbol: Frzb
Name: frizzled-related protein
RGD ID: 1311315
Description: Predicted to enable Wnt-protein binding activity. Predicted to be involved in several processes, including Wnt signaling pathway; neural crest cell differentiation; and somite development. Predicted to act upstream of or within several processes, including cochlea morphogenesis; negative regulation of canonical Wnt signaling pathway; and negative regulation of cell differentiation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (frizzled related protein); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC295691; secreted frizzled-related protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8385,739,162 - 85,772,168 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl385,739,165 - 85,772,096 (-)EnsemblGRCr8
mRatBN7.2365,332,274 - 65,365,208 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl365,332,277 - 65,365,208 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx368,678,473 - 68,711,328 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0377,262,043 - 77,294,902 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0375,024,919 - 75,057,671 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0367,635,604 - 67,668,772 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl367,635,607 - 67,668,772 (-)Ensemblrn6Rnor6.0
Rnor_5.0374,196,163 - 74,229,331 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4363,350,504 - 63,383,436 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera364,780,097 - 64,813,027 (-)NCBICelera
RGSC_v3.1363,246,875 - 63,295,070 (-)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
chlorohydrocarbon  (EXP)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cytarabine  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
glycidol  (EXP)
GW 4064  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel subsulfide  (EXP)
niclosamide  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
organophosphorus compound  (EXP)
oxybenzone  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
retinyl acetate  (ISO)
rofecoxib  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
Theaflavin 3,3'-digallate  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Secreted and transmembrane wnt inhibitors and activators. Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Reduced skeletal muscle secreted frizzled-related protein 3 is associated with inflammation and insulin resistance. Pachori AS, etal., Obesity (Silver Spring). 2017 Apr;25(4):697-703. doi: 10.1002/oby.21787. Epub 2017 Feb 27.
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Epigenetic loss of putative tumor suppressor SFRP3 correlates with poor prognosis of lung adenocarcinoma patients. Schlensog M, etal., Epigenetics. 2018;13(3):214-227. doi: 10.1080/15592294.2016.1229730. Epub 2018 Apr 18.
Additional References at PubMed
PMID:9178261   PMID:10654605   PMID:12055200   PMID:12477932   PMID:17433286   PMID:17462603   PMID:17471511   PMID:18166153   PMID:18991062   PMID:19562671   PMID:19961844   PMID:20208569  
PMID:20551380   PMID:24006456   PMID:25046226  


Genomics

Comparative Map Data
Frzb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8385,739,162 - 85,772,168 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl385,739,165 - 85,772,096 (-)EnsemblGRCr8
mRatBN7.2365,332,274 - 65,365,208 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl365,332,277 - 65,365,208 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx368,678,473 - 68,711,328 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0377,262,043 - 77,294,902 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0375,024,919 - 75,057,671 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0367,635,604 - 67,668,772 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl367,635,607 - 67,668,772 (-)Ensemblrn6Rnor6.0
Rnor_5.0374,196,163 - 74,229,331 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4363,350,504 - 63,383,436 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera364,780,097 - 64,813,027 (-)NCBICelera
RGSC_v3.1363,246,875 - 63,295,070 (-)NCBI
Cytogenetic Map3q24NCBI
FRZB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382182,833,275 - 182,866,637 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2182,833,275 - 182,866,638 (-)Ensemblhg38GRCh38
GRCh372183,698,002 - 183,731,365 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362183,406,982 - 183,439,743 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342183,524,242 - 183,557,004NCBI
Celera2177,294,242 - 177,327,734 (-)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2175,555,371 - 175,588,842 (-)NCBIHuRef
CHM1_12183,703,943 - 183,737,410 (-)NCBICHM1_1
T2T-CHM13v2.02183,322,235 - 183,355,596 (-)NCBIT2T-CHM13v2.0
Frzb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39280,242,314 - 80,277,740 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl280,242,314 - 80,277,969 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38280,411,970 - 80,447,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl280,411,970 - 80,447,625 (-)Ensemblmm10GRCm38
MGSCv37280,252,127 - 80,287,553 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36280,212,809 - 80,248,235 (-)NCBIMGSCv36mm8
Celera282,075,833 - 82,112,383 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map248.13NCBI
Frzb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540314,598,765 - 14,631,154 (+)Ensembl
ChiLan1.0NW_00495540314,598,765 - 14,627,997 (+)NCBIChiLan1.0ChiLan1.0
FRZB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21385,492,596 - 85,525,895 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B85,507,574 - 85,540,875 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B70,106,378 - 70,139,333 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B187,915,579 - 187,948,855 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B187,915,579 - 187,948,855 (-)EnsemblpanPan2panpan1.1
FRZB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13625,884,557 - 25,907,436 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3625,884,557 - 25,907,369 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3625,782,614 - 25,812,978 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03626,038,918 - 26,069,318 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3626,039,164 - 26,076,017 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13626,165,036 - 26,195,383 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03626,095,997 - 26,126,346 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03626,237,636 - 26,268,037 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Frzb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303142,886,744 - 142,917,194 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650911,440,148 - 11,470,967 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650911,440,414 - 11,471,042 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FRZB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1588,332,860 - 88,377,247 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11588,332,856 - 88,377,275 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21597,838,143 - 97,881,633 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FRZB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11068,353,393 - 68,385,135 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1068,351,922 - 68,385,110 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040131,158,267 - 131,189,920 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Frzb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248444,608,016 - 4,643,141 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248444,608,016 - 4,639,582 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Frzb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1557,608,263 - 57,640,946 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Frzb
335 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:132
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000010247
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
RH132687  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2365,332,994 - 65,333,174 (+)MAPPERmRatBN7.2
Rnor_6.0367,636,325 - 67,636,504NCBIRnor6.0
Rnor_5.0374,196,884 - 74,197,063UniSTSRnor5.0
RGSC_v3.4363,351,225 - 63,351,404UniSTSRGSC3.4
Celera364,780,818 - 64,780,997UniSTS
Cytogenetic Map3q24UniSTS
RH134537  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2365,332,365 - 65,332,553 (+)MAPPERmRatBN7.2
Rnor_6.0367,635,696 - 67,635,883NCBIRnor6.0
Rnor_5.0374,196,255 - 74,196,442UniSTSRnor5.0
RGSC_v3.4363,350,596 - 63,350,783UniSTSRGSC3.4
Celera364,780,189 - 64,780,376UniSTS
Cytogenetic Map3q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 143 91 90 59 35 59 6 299 135 11 116 81 89 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000010247   ⟹   ENSRNOP00000010247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl385,739,165 - 85,772,096 (-)Ensembl
mRatBN7.2 Ensembl365,332,277 - 65,365,208 (-)Ensembl
Rnor_6.0 Ensembl367,635,607 - 67,668,772 (-)Ensembl
RefSeq Acc Id: NM_001100527   ⟹   NP_001093997
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,739,162 - 85,772,096 (-)NCBI
mRatBN7.2365,332,274 - 65,365,208 (-)NCBI
Rnor_6.0367,635,604 - 67,668,772 (-)NCBI
Rnor_5.0374,196,163 - 74,229,331 (-)NCBI
RGSC_v3.4363,350,504 - 63,383,436 (-)RGD
Celera364,780,097 - 64,813,027 (-)RGD
Sequence:
RefSeq Acc Id: XM_063283281   ⟹   XP_063139351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,739,162 - 85,772,168 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001093997 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139351 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98777 (Get FASTA)   NCBI Sequence Viewer  
  AAI66428 (Get FASTA)   NCBI Sequence Viewer  
  EDL79280 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010247
  ENSRNOP00000010247.5
RefSeq Acc Id: NP_001093997   ⟸   NM_001100527
- Peptide Label: precursor
- UniProtKB: B2GUW1 (UniProtKB/TrEMBL),   A6HMM9 (UniProtKB/TrEMBL),   F7F8N4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010247   ⟸   ENSRNOT00000010247
RefSeq Acc Id: XP_063139351   ⟸   XM_063283281
- Peptide Label: isoform X1
- UniProtKB: A6HMM9 (UniProtKB/TrEMBL),   B2GUW1 (UniProtKB/TrEMBL),   F7F8N4 (UniProtKB/TrEMBL)
Protein Domains
FZ   NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GUW1-F1-model_v2 AlphaFold B2GUW1 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692171
Promoter ID:EPDNEW_R2695
Type:single initiation site
Name:Frzb_1
Description:frizzled-related protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0367,667,987 - 67,668,047EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311315 AgrOrtholog
BioCyc Gene G2FUF-49225 BioCyc
Ensembl Genes ENSRNOG00000007765 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010247 ENTREZGENE
  ENSRNOT00000010247.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/TrEMBL
  2.40.50.120 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7106784 IMAGE-MGC_LOAD
  IMAGE:7374231 IMAGE-MGC_LOAD
InterPro Frizzled_dom UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/TrEMBL
  Frizzled_related UniProtKB/TrEMBL
  Netrin_domain UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/TrEMBL
  NTR_Sfrp3 UniProtKB/TrEMBL
  SFRP3_CRD UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
KEGG Report rno:295691 UniProtKB/TrEMBL
MGC_CLONE MGC:112808 IMAGE-MGC_LOAD
  MGC:187419 IMAGE-MGC_LOAD
NCBI Gene 295691 ENTREZGENE
PANTHER Fz_related UniProtKB/TrEMBL
  PTHR11309:SF97 UniProtKB/TrEMBL
Pfam NTR UniProtKB/TrEMBL
  PF01392 UniProtKB/TrEMBL
PhenoGen Frzb PhenoGen
PROSITE NTR UniProtKB/TrEMBL
  PS50038 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007765 RatGTEx
SMART C345C UniProtKB/TrEMBL
  FRI UniProtKB/TrEMBL
Superfamily-SCOP Frizzled_Cys-rich UniProtKB/TrEMBL
  TIMP_like UniProtKB/TrEMBL
UniProt A6HMM9 ENTREZGENE, UniProtKB/TrEMBL
  B2GUW1 ENTREZGENE
  F7F8N4 ENTREZGENE, UniProtKB/TrEMBL
  Q4G040_RAT UniProtKB/TrEMBL
UniProt Secondary B2GUW1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Frzb  frizzled-related protein  Frzb_predicted  frizzled-related protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Frzb_predicted  frizzled-related protein (predicted)      Symbol and Name status set to approved 70820 APPROVED