Frzb (frizzled-related protein) - Rat Genome Database

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Gene: Frzb (frizzled-related protein) Rattus norvegicus
Analyze
Symbol: Frzb
Name: frizzled-related protein
RGD ID: 1311315
Description: Predicted to enable Wnt-protein binding activity. Predicted to be involved in several processes, including negative regulation of cell growth; neural crest cell differentiation; and somite development. Predicted to act upstream of or within several processes, including cochlea morphogenesis; negative regulation of canonical Wnt signaling pathway; and negative regulation of cell differentiation. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (frizzled related protein); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC295691; secreted frizzled-related protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8385,739,162 - 85,772,168 (-)NCBIGRCr8
mRatBN7.2365,332,274 - 65,365,208 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl365,332,277 - 65,365,208 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx368,678,473 - 68,711,328 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0377,262,043 - 77,294,902 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0375,024,919 - 75,057,671 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0367,635,604 - 67,668,772 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl367,635,607 - 67,668,772 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0374,196,163 - 74,229,331 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4363,350,504 - 63,383,436 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1363,246,875 - 63,295,070 (-)NCBI
Celera364,780,097 - 64,813,027 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FrzbRatlung adenocarcinoma severityISOFRZB (Homo sapiens)9068941mRNA:decreased expression:lung (human)RGDPMID:27623992 and REF_RGD_ID:32716395
FrzbRatlung non-small cell carcinoma  ISOFRZB (Homo sapiens)32716395DNA:hypermethylation:exon 1RGD 
FrzbRatlung squamous cell carcinoma  ISOFRZB (Homo sapiens)32716395protein:decreased expression:lung (human)RGD 
FrzbRattype 2 diabetes mellitus  ISOFRZB (Homo sapiens)32716394protein more ...RGD 
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Original Reference(s)
FrzbRatosteoarthritis  ISOFRZB (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15210948 and PMID:25741868
FrzbRatOsteoarthritis, Hip  ISOFRZB (Homo sapiens)8554872ClinVar Annotator: match by term: OSTEOARTHRITIS OF HIP more ...ClinVarPMID:15210948
Object Symbol
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Term
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Evidence
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Reference
Notes
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Original Reference(s)
FrzbRatosteoarthritis  ISOFRZB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
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Original Reference(s)
FrzbRatosteoarthritis susceptibilityISOFRZB (Homo sapiens)7240710 OMIM 

1 to 20 of 122 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FrzbRat1,2-dimethylhydrazine multiple interactionsEXP 6480464[APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in increased expression of FRZB mRNACTDPMID:27840820
FrzbRat1,2-dimethylhydrazine increases expressionISOFrzb (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of FRZB mRNACTDPMID:22206623
FrzbRat17alpha-ethynylestradiol affects expressionISOFRZB (Homo sapiens)6480464Ethinyl Estradiol affects the expression of FRZB mRNACTDPMID:26865667
FrzbRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOFrzb (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of FRZB mRNACTDPMID:19933214
FrzbRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of FRZB mRNACTDPMID:34747641
FrzbRat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOFrzb (Mus musculus)64804642 more ...CTDPMID:38648751
FrzbRat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOFRZB (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of FRZB mRNACTDPMID:28628672
FrzbRat4,4'-diaminodiphenylmethane increases expressionISOFrzb (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of FRZB mRNACTDPMID:18648102
FrzbRat5-aza-2'-deoxycytidine decreases expressionISOFrzb (Mus musculus)6480464Decitabine results in decreased expression of FRZB mRNACTDPMID:27915011
FrzbRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of FRZB mRNACTDPMID:24780913
FrzbRatactinomycin D multiple interactionsISOFRZB (Homo sapiens)6480464[Dactinomycin co-treated with nutlin 3] results in increased expression of FRZB mRNACTDPMID:38460933
FrzbRataflatoxin B1 increases expressionISOFRZB (Homo sapiens)6480464Aflatoxin B1 results in increased expression of FRZB mRNACTDPMID:21641981 and PMID:22100608
FrzbRataflatoxin B1 increases expressionEXP 6480464Aflatoxin B1 results in increased expression of FRZB mRNACTDPMID:33354967
FrzbRatall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin results in decreased expression of FRZB mRNACTDPMID:20488242
FrzbRatall-trans-retinoic acid decreases expressionISOFRZB (Homo sapiens)6480464Tretinoin results in decreased expression of FRZB mRNACTDPMID:21934132 and PMID:23724009
FrzbRataristolochic acid A increases expressionISOFRZB (Homo sapiens)6480464aristolochic acid I results in increased expression of FRZB mRNACTDPMID:33212167
FrzbRatarsane affects expressionISOFRZB (Homo sapiens)6480464Arsenic affects the expression of FRZB proteinCTDPMID:24675094
FrzbRatarsenic atom affects expressionISOFRZB (Homo sapiens)6480464Arsenic affects the expression of FRZB proteinCTDPMID:24675094
FrzbRatatrazine multiple interactionsISOFRZB (Homo sapiens)6480464[Atrazine co-treated with Arsenates] results in increased expression of FRZB mRNACTDPMID:18585445
FrzbRatbenzo[a]pyrene increases expressionISOFRZB (Homo sapiens)6480464Benzo(a)pyrene results in increased expression of FRZB mRNACTDPMID:22316170

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Biological Process
1 to 20 of 41 rows

  
Object Symbol
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Source
Original Reference(s)
FrzbRatbiological_process  ND 159840707/2010: no relevant rat dataRGD 
FrzbRatcell differentiation involved_inIEAUniProtKB-KW:KW-02211600115GO_REF:0000043UniProtGO_REF:0000043
FrzbRatcochlea morphogenesis acts_upstream_of_or_withinISOFrzb (Mus musculus)1624291MGI:98958 PMID:17433286RGDPMID:17433286
FrzbRatcochlea morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P97401 and ensembl:ENSMUSP000000283891600115GO_REF:0000107EnsemblGO_REF:0000107
FrzbRatconvergent extension involved in organogenesis acts_upstream_of_or_withinISOFrzb (Mus musculus)1624291MGI:98958 PMID:17433286RGDPMID:17433286
FrzbRatconvergent extension involved in organogenesis acts_upstream_of_or_withinIEAUniProtKB:P97401 and ensembl:ENSMUSP000000283891600115GO_REF:0000107EnsemblGO_REF:0000107
FrzbRatdevelopmental process involved_inIEAARBA:ARBA000287391600115GO_REF:0000117UniProtGO_REF:0000117
FrzbRatepithelial cell development acts_upstream_ofISOFrzb (Mus musculus)1624291 PMID:19562671RGDPMID:19562671
FrzbRatepithelial cell development acts_upstream_ofIEAUniProtKB:P97401 and ensembl:ENSMUSP000000283891600115GO_REF:0000107EnsemblGO_REF:0000107
FrzbRathepatocyte differentiation acts_upstream_ofISOFrzb (Mus musculus)1624291 PMID:19562671RGDPMID:19562671
FrzbRathepatocyte differentiation acts_upstream_ofIEAUniProtKB:P97401 and ensembl:ENSMUSP000000283891600115GO_REF:0000107EnsemblGO_REF:0000107
FrzbRatinner ear morphogenesis acts_upstream_of_or_withinISOFrzb (Mus musculus)1624291MGI:98958 PMID:18991062RGDPMID:18991062
FrzbRatinner ear morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P97401 and ensembl:ENSMUSP000000283891600115GO_REF:0000107EnsemblGO_REF:0000107
FrzbRatnegative regulation of canonical Wnt signaling pathway involved_inISOFRZB (Homo sapiens)1624291 PMID:17471511RGDPMID:17471511
FrzbRatnegative regulation of canonical Wnt signaling pathway acts_upstream_of_or_withinISOFrzb (Mus musculus)1624291MGI:98956 PMID:19961844RGDPMID:19961844
FrzbRatnegative regulation of canonical Wnt signaling pathway involved_inIEAUniProtKB:Q92765 and ensembl:ENSP000002951131600115GO_REF:0000107EnsemblGO_REF:0000107
FrzbRatnegative regulation of canonical Wnt signaling pathway acts_upstream_of_or_withinIEAUniProtKB:P97401 and ensembl:ENSMUSP000000283891600115GO_REF:0000107EnsemblGO_REF:0000107
FrzbRatnegative regulation of cartilage development acts_upstream_of_or_withinIEAUniProtKB:P97401 and ensembl:ENSMUSP000000283891600115GO_REF:0000107EnsemblGO_REF:0000107
FrzbRatnegative regulation of cartilage development acts_upstream_of_or_withinISOFrzb (Mus musculus)1624291MGI:98958 PMID:18991062RGDPMID:18991062
FrzbRatnegative regulation of cell development acts_upstream_of_or_withinISOFrzb (Mus musculus)1624291 PMID:19562671RGDPMID:19562671
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Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FrzbRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
FrzbRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
FrzbRatWnt signaling, canonical pathway   ISOFRZB (Homo sapiens)7365107 RGD 

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#
Reference Title
Reference Citation
1. Secreted and transmembrane wnt inhibitors and activators. Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Reduced skeletal muscle secreted frizzled-related protein 3 is associated with inflammation and insulin resistance. Pachori AS, etal., Obesity (Silver Spring). 2017 Apr;25(4):697-703. doi: 10.1002/oby.21787. Epub 2017 Feb 27.
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Epigenetic loss of putative tumor suppressor SFRP3 correlates with poor prognosis of lung adenocarcinoma patients. Schlensog M, etal., Epigenetics. 2018;13(3):214-227. doi: 10.1080/15592294.2016.1229730. Epub 2018 Apr 18.
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PMID:9178261   PMID:10654605   PMID:12055200   PMID:12477932   PMID:17433286   PMID:17462603   PMID:17471511   PMID:18166153   PMID:18991062   PMID:19562671   PMID:19961844   PMID:20208569  
PMID:20551380   PMID:24006456   PMID:25046226  



Frzb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8385,739,162 - 85,772,168 (-)NCBIGRCr8
mRatBN7.2365,332,274 - 65,365,208 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl365,332,277 - 65,365,208 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx368,678,473 - 68,711,328 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0377,262,043 - 77,294,902 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0375,024,919 - 75,057,671 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0367,635,604 - 67,668,772 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl367,635,607 - 67,668,772 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0374,196,163 - 74,229,331 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4363,350,504 - 63,383,436 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1363,246,875 - 63,295,070 (-)NCBI
Celera364,780,097 - 64,813,027 (-)NCBICelera
Cytogenetic Map3q24NCBI
FRZB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382182,833,275 - 182,866,637 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2182,833,275 - 182,866,637 (-)EnsemblGRCh38hg38GRCh38
GRCh372183,698,002 - 183,731,365 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362183,406,982 - 183,439,743 (-)NCBINCBI36Build 36hg18NCBI36
Build 342183,524,242 - 183,557,004NCBI
Celera2177,294,242 - 177,327,734 (-)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2175,555,371 - 175,588,842 (-)NCBIHuRef
CHM1_12183,703,943 - 183,737,410 (-)NCBICHM1_1
T2T-CHM13v2.02183,322,235 - 183,355,596 (-)NCBIT2T-CHM13v2.0
Frzb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39280,242,314 - 80,277,740 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl280,242,314 - 80,277,969 (-)EnsemblGRCm39 Ensembl
GRCm38280,411,970 - 80,447,396 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl280,411,970 - 80,447,625 (-)EnsemblGRCm38mm10GRCm38
MGSCv37280,252,127 - 80,287,553 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36280,212,809 - 80,248,235 (-)NCBIMGSCv36mm8
Celera282,075,833 - 82,112,383 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map248.13NCBI
Frzb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540314,598,765 - 14,631,154 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540314,598,765 - 14,627,997 (+)NCBIChiLan1.0ChiLan1.0
FRZB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21385,492,596 - 85,525,895 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B85,507,574 - 85,540,875 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B70,106,378 - 70,139,333 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B187,915,579 - 187,948,855 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B187,915,579 - 187,948,855 (-)Ensemblpanpan1.1panPan2
FRZB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13625,884,557 - 25,907,436 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3625,884,557 - 25,907,369 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3625,782,614 - 25,812,978 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03626,038,918 - 26,069,318 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3626,039,164 - 26,076,017 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13626,165,036 - 26,195,383 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03626,095,997 - 26,126,346 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03626,237,636 - 26,268,037 (-)NCBIUU_Cfam_GSD_1.0
Frzb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303142,886,744 - 142,917,194 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650911,440,148 - 11,470,967 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650911,440,414 - 11,471,042 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FRZB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1588,332,860 - 88,377,247 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11588,332,856 - 88,377,275 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21597,838,143 - 97,881,633 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FRZB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11068,353,393 - 68,385,135 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1068,351,922 - 68,385,110 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040131,158,267 - 131,189,920 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Frzb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248444,608,016 - 4,643,141 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248444,608,016 - 4,639,582 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Frzb
212 total Variants

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:132
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000010247
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 54 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat

1 to 10 of 54 rows
RH132687  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2365,332,994 - 65,333,174 (+)MAPPERmRatBN7.2
Rnor_6.0367,636,325 - 67,636,504NCBIRnor6.0
Rnor_5.0374,196,884 - 74,197,063UniSTSRnor5.0
RGSC_v3.4363,351,225 - 63,351,404UniSTSRGSC3.4
Celera364,780,818 - 64,780,997UniSTS
Cytogenetic Map3q24UniSTS
RH134537  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2365,332,365 - 65,332,553 (+)MAPPERmRatBN7.2
Rnor_6.0367,635,696 - 67,635,883NCBIRnor6.0
Rnor_5.0374,196,255 - 74,196,442UniSTSRnor5.0
RGSC_v3.4363,350,596 - 63,350,783UniSTSRGSC3.4
Celera364,780,189 - 64,780,376UniSTS
Cytogenetic Map3q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 57 31



Ensembl Acc Id: ENSRNOT00000010247   ⟹   ENSRNOP00000010247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl365,332,277 - 65,365,208 (-)Ensembl
Rnor_6.0 Ensembl367,635,607 - 67,668,772 (-)Ensembl
RefSeq Acc Id: NM_001100527   ⟹   NP_001093997
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,739,162 - 85,772,096 (-)NCBI
mRatBN7.2365,332,274 - 65,365,208 (-)NCBI
Rnor_6.0367,635,604 - 67,668,772 (-)NCBI
Rnor_5.0374,196,163 - 74,229,331 (-)NCBI
RGSC_v3.4363,350,504 - 63,383,436 (-)RGD
Celera364,780,097 - 64,813,027 (-)RGD
Sequence:
RefSeq Acc Id: XM_063283281   ⟹   XP_063139351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8385,739,162 - 85,772,168 (-)NCBI
Protein RefSeqs NP_001093997 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139351 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98777 (Get FASTA)   NCBI Sequence Viewer  
  AAI66428 (Get FASTA)   NCBI Sequence Viewer  
  EDL79280 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010247
  ENSRNOP00000010247.5
RefSeq Acc Id: NP_001093997   ⟸   NM_001100527
- Peptide Label: precursor
- UniProtKB: B2GUW1 (UniProtKB/TrEMBL),   A6HMM9 (UniProtKB/TrEMBL),   F7F8N4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010247   ⟸   ENSRNOT00000010247
RefSeq Acc Id: XP_063139351   ⟸   XM_063283281
- Peptide Label: isoform X1
- UniProtKB: A6HMM9 (UniProtKB/TrEMBL),   B2GUW1 (UniProtKB/TrEMBL),   F7F8N4 (UniProtKB/TrEMBL)
FZ   NTR

Name Modeler Protein Id AA Range Protein Structure
AF-B2GUW1-F1-model_v2 AlphaFold B2GUW1 1-323 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692171
Promoter ID:EPDNEW_R2695
Type:single initiation site
Name:Frzb_1
Description:frizzled-related protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0367,667,987 - 67,668,047EPDNEW


1 to 37 of 37 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-49225 BioCyc
Ensembl Genes ENSRNOG00000007765 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010247 ENTREZGENE
  ENSRNOT00000010247.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/TrEMBL
  2.40.50.120 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7106784 IMAGE-MGC_LOAD
  IMAGE:7374231 IMAGE-MGC_LOAD
InterPro Frizzled_dom UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/TrEMBL
  Frizzled_related UniProtKB/TrEMBL
  Netrin_domain UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/TrEMBL
  NTR_Sfrp3 UniProtKB/TrEMBL
  SFRP3_CRD UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
KEGG Report rno:295691 UniProtKB/TrEMBL
MGC_CLONE MGC:112808 IMAGE-MGC_LOAD
  MGC:187419 IMAGE-MGC_LOAD
NCBI Gene 295691 ENTREZGENE
PANTHER Fz_related UniProtKB/TrEMBL
  PTHR11309:SF97 UniProtKB/TrEMBL
Pfam NTR UniProtKB/TrEMBL
  PF01392 UniProtKB/TrEMBL
PhenoGen Frzb PhenoGen
PROSITE NTR UniProtKB/TrEMBL
  PS50038 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007765 RatGTEx
SMART C345C UniProtKB/TrEMBL
  FRI UniProtKB/TrEMBL
Superfamily-SCOP Frizzled_Cys-rich UniProtKB/TrEMBL
  TIMP_like UniProtKB/TrEMBL
UniProt A6HMM9 ENTREZGENE, UniProtKB/TrEMBL
  B2GUW1 ENTREZGENE
  F7F8N4 ENTREZGENE, UniProtKB/TrEMBL
  Q4G040_RAT UniProtKB/TrEMBL
UniProt Secondary B2GUW1 UniProtKB/TrEMBL
1 to 37 of 37 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Frzb  frizzled-related protein  Frzb_predicted  frizzled-related protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Frzb_predicted  frizzled-related protein (predicted)      Symbol and Name status set to approved 70820 APPROVED