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Gene: Slc25a16 (solute carrier family 25 member 16) Rattus norvegicus

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Symbol:

Slc25a16

Name:

solute carrier family 25 member 16

RGD ID:

1311311

Description:

Predicted to enable several functions, including ATP hydrolysis activity; catalytic activity, acting on DNA; and coenzyme A transmembrane transporter activity. Predicted to be involved in DNA metabolic process; DNA replication checkpoint signaling; and mitochondrial coenzyme A transmembrane transport. Predicted to be located in membrane; mitochondrion; and nucleus. Predicted to be active in mitochondrial inner membrane. Orthologous to human SLC25A16 (solute carrier family 25 member 16); INTERACTS WITH (+)-schisandrin B; acetamide; acrylamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

GDC; graves disease carrier protein; LOC361836; mitochondrial solute carrier protein homolog; solute carrier family 25 (mitochondrial carrier), member 16; solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16; solute carrier family 25, member 16

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	25,659,847 - 25,717,080 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	25,660,339 - 25,689,285 (-)	Ensembl				GRCr8
GRCr8 Ensembl	20	25,690,252 - 25,715,959 (-)	Ensembl				GRCr8
mRatBN7.2	20	25,691,474 - 25,717,558 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	25,662,055 - 25,716,319 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	26,385,022 - 26,409,844 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	25,738,050 - 25,762,873 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	26,324,094 - 26,348,852 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	27,283,383 - 27,308,069 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	27,254,984 - 27,308,069 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	29,124,026 - 29,147,931 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	25,259,020 - 25,287,344 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	26,987,115 - 27,012,429 (-)	NCBI		Celera
RGSC_v3.1	20	25,272,066 - 25,299,061 (+)	NCBI
Cytogenetic Map	20	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cerebral Visual Impairment and Intellectual Disability (ISO)

nonsyndromic congenital nail disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acrylamide (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

ciguatoxin CTX1B (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

formaldehyde (ISO)

glafenine (EXP)

hydrogen peroxide (ISO)

isotretinoin (ISO)

lead diacetate (EXP)

methapyrilene (EXP)

methidathion (ISO)

methyl methanesulfonate (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

progesterone (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

testosterone enanthate (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

valproic acid (ISO)

vancomycin (ISO)

vitamin E (ISO)

vorinostat (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

base-excision repair (IEA,ISS)

coenzyme A transport (IEA,ISO)

DNA damage response (IEA)

DNA double-strand break processing (IEA,ISS)

DNA repair (IEA)

DNA replication (IEA,ISS)

DNA replication checkpoint signaling (IEA,ISS)

DNA replication, Okazaki fragment processing (IEA,ISS)

DNA replication, removal of RNA primer (IEA)

mitochondrial coenzyme A transmembrane transport (IBA,IEA,ISO,ISS)

mitochondrial DNA repair (IEA)

mitochondrial DNA replication (IEA)

mitotic telomere maintenance via semi-conservative replication (IEA)

positive regulation of DNA replication (IEA)

replication fork reversal (IBA)

telomere maintenance (IEA)

telomere maintenance via semi-conservative replication (IEA)

transmembrane transport (IEA)

Cellular Component

chromosome, telomeric region (IEA)

cytoplasm (IBA)

membrane (IEA)

mitochondrial inner membrane (IBA,IEA,ISO,ISS)

mitochondrial nucleoid (IEA)

mitochondrion (IEA)

nucleus (IEA)

Molecular Function

4 iron, 4 sulfur cluster binding (IEA)

5'-3' DNA helicase activity (IEA,ISS)

5'-flap endonuclease activity (IBA,IEA,ISS)

ATP binding (IEA)

ATP hydrolysis activity (IEA,ISS)

catalytic activity (IEA)

coenzyme A transmembrane transporter activity (IBA,IEA,ISO,ISS)

deoxyribonuclease (pyrimidine dimer) activity (IEA)

DNA binding (IEA,ISS)

DNA helicase activity (IEA,ISS)

endonuclease activity (IEA)

helicase activity (IEA)

hydrolase activity (IEA)

iron-sulfur cluster binding (IEA)

metal ion binding (IEA)

nuclease activity (IEA,ISS)

nucleotide binding (IEA)

RNA binding (IBA)

single-stranded DNA helicase activity (IEA,ISS)

transmembrane transporter activity (IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2575220	PMID:12477932	PMID:14651853	PMID:18614015

Genomics

Comparative Map Data

Slc25a16
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	25,659,847 - 25,717,080 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	25,660,339 - 25,689,285 (-)	Ensembl				GRCr8
GRCr8 Ensembl	20	25,690,252 - 25,715,959 (-)	Ensembl				GRCr8
mRatBN7.2	20	25,691,474 - 25,717,558 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	25,662,055 - 25,716,319 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	26,385,022 - 26,409,844 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	25,738,050 - 25,762,873 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	26,324,094 - 26,348,852 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	27,283,383 - 27,308,069 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	27,254,984 - 27,308,069 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	29,124,026 - 29,147,931 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	25,259,020 - 25,287,344 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	26,987,115 - 27,012,429 (-)	NCBI		Celera
RGSC_v3.1	20	25,272,066 - 25,299,061 (+)	NCBI
Cytogenetic Map	20	q11	NCBI

SLC25A16
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	68,477,998 - 68,527,523 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	68,473,079 - 68,527,523 (-)	Ensembl			hg38	GRCh38
GRCh37	10	70,237,755 - 70,287,280 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	69,912,103 - 69,957,590 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	69,912,103 - 69,957,590	NCBI
Celera	10	63,517,479 - 63,563,049 (-)	NCBI		Celera
Cytogenetic Map	10	q21.3	NCBI
HuRef	10	64,241,842 - 64,288,560 (-)	NCBI		HuRef
CHM1_1	10	70,524,338 - 70,569,332 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	69,347,236 - 69,396,739 (-)	NCBI		T2T-CHM13v2.0

Slc25a16
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	62,756,454 - 62,782,278 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	62,756,412 - 62,782,277 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	62,920,632 - 62,946,494 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	62,920,633 - 62,946,498 (+)	Ensembl			mm10	GRCm38
MGSCv37	10	62,383,381 - 62,409,242 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	62,315,990 - 62,341,851 (+)	NCBI		MGSCv36	mm8
Celera	10	64,021,749 - 64,047,627 (+)	NCBI		Celera
Cytogenetic Map	10	B4	NCBI
cM Map	10	32.5	NCBI

Slc25a16
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955425	20,707,006 - 20,739,455 (-)	Ensembl
ChiLan1.0	NW_004955425	20,705,758 - 20,739,692 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC25A16
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	80,577,072 - 80,691,127 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	80,582,391 - 80,696,447 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	64,898,024 - 64,956,541 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	67,207,261 - 67,264,257 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	67,506,006 - 67,549,308 (-)	Ensembl			panPan2	panpan1.1
PanPan1.1 Ensembl	10	67,207,261 - 67,264,257 (-)	Ensembl			panPan2	panpan1.1

SLC25A16
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	19,695,305 - 19,738,832 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	19,697,034 - 19,738,834 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	19,826,297 - 19,870,093 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	19,966,484 - 20,010,542 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	19,967,641 - 20,010,559 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	19,868,192 - 19,911,728 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	20,071,276 - 20,114,631 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	20,413,440 - 20,457,128 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slc25a16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	61,300,357 - 61,340,497 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936521	9,793,038 - 9,834,973 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936521	9,793,088 - 9,834,972 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC25A16
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	71,612,278 - 71,651,059 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	71,612,273 - 71,651,341 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	77,648,575 - 77,715,804 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC25A16
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	62,871,828 - 62,926,759 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666048	23,629,311 - 23,675,003 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc25a16
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	2,800,350 - 2,837,918 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624754	2,800,432 - 2,837,910 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slc25a16
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	18	23,748,082 - 23,770,819 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slc25a16
146 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	546
Count of miRNA genes:	254
Interacting mature miRNAs:	300
Transcripts:	ENSRNOT00000056047
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	4189476	49189476	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	1	26925056	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1	33724594	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26128279	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8043920	29865039	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600300	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	1	34066551	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29193376	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	20745585	56021148	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	1	27341128	Rat
1598870	Bp289	Blood pressure QTL 289	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	8216359	53216359	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29193376	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29193376	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29193376	Rat
1598858	Cm61	Cardiac mass QTL 61	3.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	20	8216359	53216359	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29193376	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	12243242	49189476	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578510	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600300	Rat

Markers in Region

RH128448

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	25,692,082 - 25,692,283 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	27,283,901 - 27,284,101	NCBI	Rnor6.0
Rnor_5.0	20	29,124,544 - 29,124,744	UniSTS	Rnor5.0
RGSC_v3.4	20	25,286,626 - 25,286,826	UniSTS	RGSC3.4
Celera	20	26,987,633 - 26,987,833	UniSTS
Cytogenetic Map	20	p11	UniSTS

AU047875

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	25,716,823 - 25,717,042 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	27,308,574 - 27,308,792	NCBI	Rnor6.0
Rnor_5.0	20	29,148,436 - 29,148,654	UniSTS	Rnor5.0
RGSC_v3.4	20	25,258,297 - 25,258,515	UniSTS	RGSC3.4
Celera	20	27,012,934 - 27,013,152	UniSTS
Cytogenetic Map	20	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001429292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279286	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279287	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279288	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279289	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M32973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000438 ⟹ ENSRNOP00000000438

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	25,663,299 - 25,716,319 (-)	Ensembl
Rnor_6.0 Ensembl	20	27,254,984 - 27,301,952 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000056047 ⟹ ENSRNOP00000052899

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	25,690,252 - 25,715,959 (-)	Ensembl
mRatBN7.2 Ensembl	20	25,691,567 - 25,716,319 (-)	Ensembl
Rnor_6.0 Ensembl	20	27,283,385 - 27,308,069 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102171 ⟹ ENSRNOP00000077473

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	25,663,299 - 25,707,418 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103093 ⟹ ENSRNOP00000083522

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	25,660,339 - 25,689,285 (-)	Ensembl
mRatBN7.2 Ensembl	20	25,662,055 - 25,690,593 (-)	Ensembl

RefSeq Acc Id:

NM_001100860 ⟹ NP_001094330

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	25,690,252 - 25,715,007 (-)	NCBI
mRatBN7.2	20	25,691,565 - 25,716,319 (-)	NCBI
Rnor_6.0	20	27,283,383 - 27,308,069 (-)	NCBI
Rnor_5.0	20	29,124,026 - 29,147,931 (-)	NCBI
RGSC_v3.4	20	25,259,020 - 25,287,344 (+)	RGD
Celera	20	26,987,115 - 27,012,429 (-)	RGD

Sequence:

show sequence

AACAGCCATGGTGCTTCCTAGTGTTTTGTAAGTTGGCAGCGGAGGCTCGGGACGTGGCGCAGGT
CCGGATGGCGGCCCTGGTGGCTGCAGCGGCCCTGGCGGCGGCCGAGCCTCCACCCGCGGTGCCG
CAGGCGGCGGGGAGCGGGGGCCCGACCTCTCGCCGAGACTTCTACTGGCTGCGTTCCTTCTTAG
CCGGAGGTATTGCTGGATGCTGTGCCAAAACCACAGTTGCTCCCTTGGATCGAGTAAAGGTTTT
ATTACAAGCTCACAACCACCATTACAAACATTTAGGGGTACTTTCTGCACTGCGCGCTGTTCCC
CAAAAGGAAGGCTACCTTGGATTATATAAAGGAAACGGTGCAATGATGATTCGAATCTTTCCCT
ACGGTGCAATCCAGTTCATGGCCTTTGAGCATTATAAAACGTTCATTACTACAAAGCTGGGAGT
TTCTGGTCATGTGCATAGATTAATGGCTGGATCCATGGCAGGCATGACAGCAGTTATCTGCACT
TACCCTCTGGATGTGGTCAGGGTGCGCCTGGCCTTCCAAGTGAAAGGTGAACACACCTATTCAG
GGATCATCCATGCGTTCAAGACAATCTATGCCAAGGAAGGTGGTTTCCTTGGATTCTACAGAGG
TCTGATGCCTACTATATTAGGAATGGCTCCATATGCAGGTGTTTCCTTTTTTACCTTTGGTACC
TTGAAGAGTGTTGGGCTTTCCTATGCTCCCACCCTGCTTGGCCGACCATCGTCCGACAACCCCA
ACGTCTTAGTCTTGAAAACTCACATAAACTTACTTTGTGGTGGTGTTGCTGGAGCAATAGCACA
GACGATATCCTACCCATTTGATGTAACCCGTCGGAGAATGCAGTTGGGGGCAGTCCTACCGGAG
TTTGAGAAGTGCCTTACCATGAGGGAGACCATGAAGTATGTCTATGGACACCATGGGATTCGGA
GAGGATTGTACCGTGGCTTATCTCTGAACTACATCCGCTGTATTCCCTCTCAAGCTGTGGCTTT
CACAACATATGAACTTATGAAGCAATTTTTTCACCTTAACTAAAAGAAAAAAATCATGATTTGT
AGTTACTGTGCTCAGTAATTCTCGGAAGGATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGTGTGTATGAGTGACACCTTAATTGTGAGGGAAACGTTACTTGAAGGGG
ACGTTTGCCCTCACACAGGAACCACTGGTATTTTAATACTTGATTTCTTTCAGTTTTTAAATCA
TAGATCAAAAATGCTTAGCATAATTTGTTATTTTTCTTTTTGATGGGATCTCCATATGTTATCC
TGGCTGGCTTGGAACTCACTGTGAAGAGACCAGGCTACCCTCAGACTTGTAGCAATCCTCTTTC
CTCTGCTGCCCATTCCAGAGAATTGGAATCCCATGCCTGAGATTCCAGGCGTCAGCCATCATGC
TTCCTCTGACATACTTTTTAATGGCAAACATTATACCTTAAAACCCTGAAGAGCCATCTTGGGC
TGACTGTGGCTACCTGTTTGGTTATTTTAAAGTGTTAATAGGAAGGAAAAGAAAGTTCATATTT
GAGTTCAAGAGATTGTCATTAGTCCTACCATACCATTCCAAACTTCCCATTGTAACTGTGGTTA
CTGGGGGCGGAGGGACTGGAATCCAACCGAGGGCCTTTGCATGCCAAGCACATGTTGTACCCCC
TCACCACATCCCCAGCCTGCAAGCACCATAGCACTGAGCTATGTCACTGGCCCTTTTCTGTTTT
ATTGTGAAGCTGGGGATGGATCACACTCATGCATGACGATTGTGTAATTGCACACTGCCAATGG
CCCACACCCCCAGCCAACTAACCCCGCTCCTTATTTACCCCCTCCCACTCTGTCCTTTCTTTAC
TTCTTCTGGGGAGTAAACTCAGGGTCTCTCTTGCCTATCTTGCTAGATAAGTGCTCTACCTCTG
AACTACATCTCCAGCCTTTTAGCCTTGGGTAATGTTATTAAAATCAGCCGACTTCGTTTTATTG
TCGCAGAATGAGGACTGAATATTTAAGGTCTGTGAAACAGAGCCAGCAACAAAGTAGTGTTCTT
ATTATGTTTCACCTCATAATTCTGCTCCAGTTGATAAAAACAACACCTTTCCCTTCATTCGTTT
GAAAAGCAGACTGTCTGCCTGCCTGCCTGCCTTTCTTTCTTCCTTCCTTCCTTCCTTCCTTCCT
TCCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTTCTTTCTTTCTTT
CTTCTCTCTTTGGGGATTGAATCTAGGACCAGGCATGATGAGATCCCATCAGAAAACCAAGTGT
ACACTGAGGTACATCCCCAAATGTCTTTCACTCTCAATAAAATTAGTGCTGAATTTTAAAGGAG
ATATTCAAGAAATGAAGAAATAGCAGGTCTTGTTCAAATGCTGTTATCATGGACTTTGATTTTC
ATGAGTTTTTTAAAAGCCTGTGTTTCCCAAAGGCAGTGATAATAAAAACTAAATATCTTTGCTC
TTAAAAGGAGAGTAACATTGTAGATGCTTGTCTTAAATAACTTGGTATGTACTAGAAAATTTAA
ATGGACCATAAATTTAGATGAAGCAATGTTTCCGAGGTATTATGTCAAGATATAAAGTTCTTCC
ATGTAATGTAAGTTTAGTGTGTCATAGTCCTAAGCGTAAATATAAAACACGTTGCAATTGTTAC
ATTTTAAAGAGATTGTTTAGTATATAAAAATTCTAATCATTGTGTTTAGAACACTTTTCTCTTT
TGTTGTAAGCATGACACATGAAGTAGAAGCAGTAAACTGTCTTTAGAGGTAGTGATTTGTAGAA
TTGATGTGATTTTTAAGACATTAAAATTAAGCTGCAAATGTTATTTCTGCATTTTTTCATGTAT
GATTTCTTGTCATAGCTTGAAAAATTGGATGAATCAGTTTCATTTTTATAATCTTTACTTTAAA
AATAAAAATGTATCTTGTGATTTGTAAATGTACCAGGAGTGGGGATAAAGTCTGTTTATAATGT
AAAGCTCTTTTGTATATTTTAATTTCTGGACCACACTGTAGCTAGTTATTCCATTTAATCTTAA
GGTAATTTAAATCTATAAAATAAATATCTCAATTATATTATCAAAAAAAAAAAAAAAAAAAAAA
AAAA

hide sequence

RefSeq Acc Id:

XM_039098864 ⟹ XP_038954792

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	25,690,161 - 25,717,080 (-)	NCBI
mRatBN7.2	20	25,691,474 - 25,717,558 (-)	NCBI

RefSeq Acc Id:

XM_063279286 ⟹ XP_063135356

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	25,659,847 - 25,692,308 (-)	NCBI

RefSeq Acc Id:

XM_063279287 ⟹ XP_063135357

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	25,662,114 - 25,692,308 (-)	NCBI

RefSeq Acc Id:

XM_063279288 ⟹ XP_063135358

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	25,659,847 - 25,680,366 (-)	NCBI

RefSeq Acc Id:

XM_063279289 ⟹ XP_063135359

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	25,659,847 - 25,681,068 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001094330	(Get FASTA)	NCBI Sequence Viewer
	NP_001416221	(Get FASTA)	NCBI Sequence Viewer
	XP_038954792	(Get FASTA)	NCBI Sequence Viewer
	XP_063135356	(Get FASTA)	NCBI Sequence Viewer
	XP_063135357	(Get FASTA)	NCBI Sequence Viewer
	XP_063135358	(Get FASTA)	NCBI Sequence Viewer
	XP_063135359	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41639	(Get FASTA)	NCBI Sequence Viewer
	AAI66494	(Get FASTA)	NCBI Sequence Viewer
	EDL97370	(Get FASTA)	NCBI Sequence Viewer
	EDL97371	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000052899
	ENSRNOP00000083522
GenBank Protein	P16261	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001094330 ⟸ NM_001100860

- UniProtKB:

P16261 (UniProtKB/Swiss-Prot), B2GV20 (UniProtKB/TrEMBL), F1MA22 (UniProtKB/TrEMBL), A0A9K3Y7D2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAALVAAAALAAAEPPPAVPQAAGSGGPTSRRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLL
QAHNHHYKHLGVLSALRAVPQKEGYLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTFITTKLGVS
GHVHRLMAGSMAGMTAVICTYPLDVVRVRLAFQVKGEHTYSGIIHAFKTIYAKEGGFLGFYRGL
MPTILGMAPYAGVSFFTFGTLKSVGLSYAPTLLGRPSSDNPNVLVLKTHINLLCGGVAGAIAQT
ISYPFDVTRRRMQLGAVLPEFEKCLTMRETMKYVYGHHGIRRGLYRGLSLNYIRCIPSQAVAFT
TYELMKQFFHLN

hide sequence

Ensembl Acc Id:

ENSRNOP00000000438 ⟸ ENSRNOT00000000438

Ensembl Acc Id:

ENSRNOP00000052899 ⟸ ENSRNOT00000056047

RefSeq Acc Id:	XP_038954792 ⟸ XM_039098864
- Peptide Label:	isoform X5
- UniProtKB:	P16261 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSRNOP00000077473 ⟸ ENSRNOT00000102171

Ensembl Acc Id:

ENSRNOP00000083522 ⟸ ENSRNOT00000103093

RefSeq Acc Id:	XP_063135356 ⟸ XM_063279286
- Peptide Label:	isoform X1
- UniProtKB:	D3ZG52 (UniProtKB/Swiss-Prot), A0A8I5ZZI9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063135359 ⟸ XM_063279289
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063135358 ⟸ XM_063279288
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063135357 ⟸ XM_063279287
- Peptide Label:	isoform X2
- UniProtKB:	D3ZG52 (UniProtKB/Swiss-Prot)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P16261-F1-model_v2	AlphaFold	P16261	1-322	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701572

Promoter ID:

EPDNEW_R12096

Type:

initiation region

Name:

Slc25a16_1

Description:

solute carrier family 25 member 16

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	27,308,078 - 27,308,138	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311311	AgrOrtholog
BioCyc Gene	G2FUF-3808	BioCyc
Ensembl Genes	ENSRNOG00000000387	Ensembl, ENTREZGENE
	ENSRNOG00000071263	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000056047	ENTREZGENE
	ENSRNOT00000103093	ENTREZGENE
Gene3D-CATH	1.50.40.10	UniProtKB/Swiss-Prot
	3.90.320.10	UniProtKB/Swiss-Prot
	P-loop containing nucleotide triphosphate hydrolases	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7110872	IMAGE-MGC_LOAD
InterPro	Dna2/JHS1_DEXXQ-box	UniProtKB/Swiss-Prot
	DNA2/NAM7-like	UniProtKB/Swiss-Prot
	DNA2/NAM7-like_C	UniProtKB/Swiss-Prot
	DNA2/NAM7_AAA_11	UniProtKB/Swiss-Prot
	DNA2_Rift	UniProtKB/Swiss-Prot
	DNA_replication_fac_Dna2_N	UniProtKB/Swiss-Prot
	Graves_DC	UniProtKB/Swiss-Prot
	Mit_carrier	UniProtKB/Swiss-Prot
	Mitochondrial_sb/sol_carrier	UniProtKB/Swiss-Prot
	Mt_carrier_dom_sf	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
	PDDEXK-like_dom_sf	UniProtKB/Swiss-Prot
	SF1_C_Upf1	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:188021	IMAGE-MGC_LOAD
NCBI Gene	361836	ENTREZGENE
PANTHER	DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2	UniProtKB/Swiss-Prot
	DNA2/NAM7 HELICASE FAMILY	UniProtKB/Swiss-Prot
	SOLUTE CARRIER FAMILY 25	UniProtKB/Swiss-Prot
Pfam	AAA_11	UniProtKB/Swiss-Prot
	AAA_12	UniProtKB/Swiss-Prot
	Dna2	UniProtKB/Swiss-Prot
	Dna2_Rift	UniProtKB/Swiss-Prot
	Mito_carr	UniProtKB/Swiss-Prot
PhenoGen	Slc25a16	PhenoGen
PRINTS	GRAVESDC	UniProtKB/Swiss-Prot
	MITOCARRIER	UniProtKB/Swiss-Prot
PROSITE	SOLCAR	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000000387	RatGTEx
	ENSRNOG00000071263	RatGTEx
Superfamily-SCOP	P-loop containing nucleoside triphosphate hydrolases	UniProtKB/Swiss-Prot
	SSF103506	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZZI9	ENTREZGENE
	A0A9K3Y7D2	ENTREZGENE, UniProtKB/TrEMBL
	A6JL05	ENTREZGENE, UniProtKB/TrEMBL
	B2GV20	ENTREZGENE, UniProtKB/TrEMBL
	D3ZG52	ENTREZGENE, UniProtKB/Swiss-Prot
	F1MA22	ENTREZGENE
	GDC_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-15	Slc25a16	solute carrier family 25 member 16	Slc25a16	solute carrier family 25 (mitochondrial carrier), member 16	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-06-25	Slc25a16	solute carrier family 25 (mitochondrial carrier), member 16	Slc25a16	solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Slc25a16	solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16	Slc25a16_predicted	solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Slc25a16_predicted	solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar