Mmgt2 (membrane magnesium transporter 2) - Rat Genome Database

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Gene: Mmgt2 (membrane magnesium transporter 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mmgt2
Name: membrane magnesium transporter 2
RGD ID: 1311260
Description: Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be located in Golgi membrane and early endosome membrane. Predicted to be part of EMC complex. Predicted to be active in Golgi apparatus; early endosome; and plasma membrane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical LOC303211; LOC303211; RGD1311260
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81047,842,722 - 47,859,787 (+)NCBIGRCr8
mRatBN7.21047,343,446 - 47,362,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1047,342,922 - 47,365,757 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1052,046,525 - 52,063,659 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01051,537,075 - 51,554,208 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01047,040,487 - 47,057,618 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01048,986,163 - 48,989,596 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01048,769,803 - 48,773,236 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41048,850,544 - 48,853,976 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11048,864,164 - 48,867,598 (+)NCBI
Celera1046,603,272 - 46,606,704 (+)NCBICelera
Cytogenetic Map10q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Variants

.
Variants in Mmgt2
98 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat

Markers in Region
RH135328  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map10546.1UniSTS
Cytogenetic Map10q23UniSTS
BM388273  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01048,771,794 - 48,772,011NCBIRnor5.0
RGSC_v3.41048,852,536 - 48,852,751UniSTSRGSC3.4
Celera1046,605,264 - 46,605,479UniSTS
RH 3.4 Map10545.6UniSTS
Cytogenetic Map10q23UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000102374   ⟹   ENSRNOP00000085801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1047,350,019 - 47,359,686 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107468   ⟹   ENSRNOP00000081126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1047,343,800 - 47,365,757 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114290   ⟹   ENSRNOP00000078496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1047,355,039 - 47,365,757 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116354   ⟹   ENSRNOP00000079403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1047,342,922 - 47,365,757 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118425   ⟹   ENSRNOP00000092726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1047,355,089 - 47,365,757 (+)Ensembl
RefSeq Acc Id: NM_001013967   ⟹   NP_001013989
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81047,842,722 - 47,859,787 (+)NCBI
mRatBN7.21047,343,446 - 47,360,517 (+)NCBI
Rnor_6.01048,986,163 - 48,989,596 (+)NCBI
Rnor_5.01048,769,803 - 48,773,236 (+)NCBI
RGSC_v3.41048,850,544 - 48,853,976 (+)RGD
Celera1046,603,272 - 46,606,704 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085969   ⟹   XP_038941897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81047,842,894 - 47,859,787 (+)NCBI
mRatBN7.21047,343,628 - 47,362,889 (+)NCBI
RefSeq Acc Id: XM_039085971   ⟹   XP_038941899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81047,842,894 - 47,859,787 (+)NCBI
mRatBN7.21047,343,628 - 47,362,889 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001013989   ⟸   NM_001013967
- UniProtKB: Q6P719 (UniProtKB/Swiss-Prot),   A0A8I6A4V9 (UniProtKB/TrEMBL),   A6HFB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038941897   ⟸   XM_039085969
- Peptide Label: isoform X1
- UniProtKB: Q6P719 (UniProtKB/Swiss-Prot),   A0A8I6A4V9 (UniProtKB/TrEMBL),   A6HFB7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941899   ⟸   XM_039085971
- Peptide Label: isoform X1
- UniProtKB: Q6P719 (UniProtKB/Swiss-Prot),   A0A8I6A4V9 (UniProtKB/TrEMBL),   A6HFB7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000085801   ⟸   ENSRNOT00000102374
RefSeq Acc Id: ENSRNOP00000081126   ⟸   ENSRNOT00000107468
RefSeq Acc Id: ENSRNOP00000092726   ⟸   ENSRNOT00000118425
RefSeq Acc Id: ENSRNOP00000078496   ⟸   ENSRNOT00000114290
RefSeq Acc Id: ENSRNOP00000079403   ⟸   ENSRNOT00000116354

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P719-F1-model_v2 AlphaFold Q6P719 1-124 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311260 AgrOrtholog
BioCyc Gene G2FUF-24758 BioCyc
Ensembl Genes ENSRNOG00000069117 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055030159 UniProtKB/Swiss-Prot
  ENSRNOG00060020306 UniProtKB/Swiss-Prot
  ENSRNOG00065008049 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000102374 ENTREZGENE
  ENSRNOT00000102374.1 UniProtKB/TrEMBL
  ENSRNOT00000107468.1 UniProtKB/TrEMBL
  ENSRNOT00000114290.1 UniProtKB/TrEMBL
  ENSRNOT00000116354.1 UniProtKB/TrEMBL
  ENSRNOT00000118425.1 UniProtKB/TrEMBL
  ENSRNOT00055052338 UniProtKB/Swiss-Prot
  ENSRNOT00055052345 UniProtKB/Swiss-Prot
  ENSRNOT00055052347 UniProtKB/Swiss-Prot
  ENSRNOT00055052359 UniProtKB/Swiss-Prot
  ENSRNOT00055052364 UniProtKB/Swiss-Prot
  ENSRNOT00055052368 UniProtKB/Swiss-Prot
  ENSRNOT00060035154 UniProtKB/Swiss-Prot
  ENSRNOT00060035168 UniProtKB/Swiss-Prot
  ENSRNOT00060035169 UniProtKB/Swiss-Prot
  ENSRNOT00060035192 UniProtKB/Swiss-Prot
  ENSRNOT00060035208 UniProtKB/Swiss-Prot
  ENSRNOT00060035215 UniProtKB/Swiss-Prot
  ENSRNOT00065012721 UniProtKB/Swiss-Prot
  ENSRNOT00065012724 UniProtKB/Swiss-Prot
  ENSRNOT00065012731 UniProtKB/Swiss-Prot
  ENSRNOT00065012733 UniProtKB/Swiss-Prot
  ENSRNOT00065012738 UniProtKB/Swiss-Prot
  ENSRNOT00065012740 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599256 IMAGE-MGC_LOAD
InterPro Magnesium_transport UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:303211 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72604 IMAGE-MGC_LOAD
NCBI Gene 303211 ENTREZGENE
PANTHER MEMBRANE MAGNESIUM TRANSPORTER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR21181 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MMgT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mmgt2 PhenoGen
RatGTEx ENSRNOG00000069117 RatGTEx
  ENSRNOG00055030159 RatGTEx
  ENSRNOG00060020306 RatGTEx
  ENSRNOG00065008049 RatGTEx
UniProt A0A8I6A4V9 ENTREZGENE, UniProtKB/TrEMBL
  A6HFB7 ENTREZGENE, UniProtKB/TrEMBL
  MMGT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-06-12 Mmgt2  membrane magnesium transporter 2  RGD1311260  hypothetical LOC303211  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1311260  hypothetical LOC303211  RGD1311260_predicted  hypothetical LOC303211 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1311260_predicted  hypothetical LOC303211 (predicted)  LOC303211_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303211_predicted  hypothetical LOC303211 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL