Mier3 (MIER family member 3) - Rat Genome Database

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Pathways
Gene: Mier3 (MIER family member 3) Rattus norvegicus
Analyze
Symbol: Mier3
Name: MIER family member 3
RGD ID: 1311241
Description: Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in breast cancer and lung adenocarcinoma. Orthologous to human MIER3 (MIER family member 3); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC310086; mesoderm induction early response 1, family member 3; mesoderm induction early response protein 3; RGD1311241; similar to RIKEN cDNA D130064H19
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8245,021,167 - 45,049,745 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl245,021,283 - 45,049,745 (+)EnsemblGRCr8
mRatBN7.2243,287,546 - 43,316,422 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl243,287,916 - 43,316,136 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx250,408,447 - 50,432,200 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0248,466,902 - 48,490,655 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0243,318,416 - 43,342,169 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0243,266,301 - 43,295,175 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl243,266,739 - 43,294,889 (+)Ensemblrn6Rnor6.0
Rnor_5.0262,313,119 - 62,341,562 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4243,003,828 - 43,027,625 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera239,077,974 - 39,101,738 (+)NCBICelera
RGSC_v3.1242,924,292 - 42,953,309 (+)NCBI
Cytogenetic Map2q14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (IBA,IEA,ISO)
nucleus  (IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene. denDekker AD, etal., Cancer Res. 2012 Nov 15;72(22):6002-12. doi: 10.1158/0008-5472.CAN-12-0748. Epub 2012 Sep 19.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail. Huang W, etal., Exp Cell Res. 2021 Sep 1;406(1):112722. doi: 10.1016/j.yexcr.2021.112722. Epub 2021 Jul 6.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. MIER3 suppresses the progression of non-small cell lung cancer by inhibiting Wnt/β-Catenin pathway and histone acetyltransferase activity. Zhang H, etal., Transl Cancer Res. 2020 Jan;9(1):346-357. doi: 10.21037/tcr.2020.01.07.
Additional References at PubMed
PMID:28046085  


Genomics

Comparative Map Data
Mier3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8245,021,167 - 45,049,745 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl245,021,283 - 45,049,745 (+)EnsemblGRCr8
mRatBN7.2243,287,546 - 43,316,422 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl243,287,916 - 43,316,136 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx250,408,447 - 50,432,200 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0248,466,902 - 48,490,655 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0243,318,416 - 43,342,169 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0243,266,301 - 43,295,175 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl243,266,739 - 43,294,889 (+)Ensemblrn6Rnor6.0
Rnor_5.0262,313,119 - 62,341,562 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4243,003,828 - 43,027,625 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera239,077,974 - 39,101,738 (+)NCBICelera
RGSC_v3.1242,924,292 - 42,953,309 (+)NCBI
Cytogenetic Map2q14NCBI
MIER3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38556,919,603 - 56,952,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl556,919,602 - 56,971,675 (-)Ensemblhg38GRCh38
GRCh37556,215,430 - 56,247,950 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36556,251,186 - 56,283,711 (-)NCBIBuild 36Build 36hg18NCBI36
Celera553,169,638 - 53,202,174 (-)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef553,187,350 - 53,219,884 (-)NCBIHuRef
CHM1_1556,218,436 - 56,250,963 (-)NCBICHM1_1
T2T-CHM13v2.0557,747,855 - 57,780,385 (-)NCBIT2T-CHM13v2.0
Mier3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913111,822,607 - 111,855,130 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13111,817,513 - 111,855,130 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3813111,686,073 - 111,718,596 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13111,680,979 - 111,718,596 (+)Ensemblmm10GRCm38
MGSCv3713112,476,386 - 112,508,802 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3613112,807,229 - 112,838,514 (+)NCBIMGSCv36mm8
Celera13116,010,054 - 116,024,988 (+)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1363.36NCBI
Mier3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544610,961,436 - 10,992,971 (+)Ensembl
ChiLan1.0NW_00495544610,962,336 - 10,992,645 (+)NCBIChiLan1.0ChiLan1.0
MIER3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2456,971,837 - 57,004,495 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1555,125,468 - 55,158,126 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0557,060,314 - 57,092,948 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1558,690,719 - 58,722,146 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl558,689,857 - 58,722,146 (+)EnsemblpanPan2panpan1.1
MIER3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1244,057,161 - 44,135,210 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl244,060,500 - 44,108,034 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha241,118,466 - 41,196,496 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0244,539,169 - 44,617,541 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl244,539,170 - 44,590,675 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1241,615,980 - 41,694,009 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0242,419,426 - 42,497,469 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0243,239,394 - 43,317,194 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mier3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213202,065,171 - 202,095,395 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648011,002,583 - 11,032,329 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648011,001,964 - 11,031,891 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIER3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1635,990,469 - 36,025,436 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11635,990,468 - 36,025,424 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21638,256,410 - 38,291,399 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MIER3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1453,144,256 - 53,177,429 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl453,147,773 - 53,172,089 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660492,036,468 - 2,069,711 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mier3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247592,162,981 - 2,324,008 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247592,060,688 - 2,325,104 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mier3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13185,331,608 - 185,358,278 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mier3
291 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:243
Count of miRNA genes:139
Interacting mature miRNAs:189
Transcripts:ENSRNOT00000017571
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)23561408353462005Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9685065Swd6Spike wave discharge measurement QTL 65.80.01brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge rate (CMO:0001739)24095742350526673Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
stSG625181  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2243,314,859 - 43,316,219 (+)MAPPERmRatBN7.2
Rnor_6.0243,293,613 - 43,294,972NCBIRnor6.0
Rnor_5.0262,340,000 - 62,341,359UniSTSRnor5.0
RGSC_v3.4243,026,349 - 43,027,708UniSTSRGSC3.4
Celera239,100,462 - 39,101,821UniSTS
Cytogenetic Map2q14UniSTS
stSG625182  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2243,313,798 - 43,314,879 (+)MAPPERmRatBN7.2
Rnor_6.0243,292,552 - 43,293,632NCBIRnor6.0
Rnor_5.0262,338,939 - 62,340,019UniSTSRnor5.0
RGSC_v3.4243,025,288 - 43,026,368UniSTSRGSC3.4
Celera239,099,401 - 39,100,481UniSTS
Cytogenetic Map2q14UniSTS
stSG625183  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2243,312,680 - 43,313,818 (+)MAPPERmRatBN7.2
Rnor_6.0243,291,434 - 43,292,571NCBIRnor6.0
Rnor_5.0262,337,821 - 62,338,958UniSTSRnor5.0
RGSC_v3.4243,024,170 - 43,025,307UniSTSRGSC3.4
Celera239,098,282 - 39,099,420UniSTS
Cytogenetic Map2q14UniSTS
MIER3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2243,312,384 - 43,312,609 (+)MAPPERmRatBN7.2
Rnor_6.0243,291,138 - 43,291,362NCBIRnor6.0
Rnor_5.0262,337,525 - 62,337,749UniSTSRnor5.0
RGSC_v3.4243,023,874 - 43,024,098UniSTSRGSC3.4
Celera239,097,986 - 39,098,210UniSTS
Cytogenetic Map2q14UniSTS
REN28465  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2243,316,046 - 43,316,307 (+)MAPPERmRatBN7.2
Rnor_6.0243,294,800 - 43,295,060NCBIRnor6.0
Rnor_5.0262,341,187 - 62,341,447UniSTSRnor5.0
RGSC_v3.4243,027,536 - 43,027,796UniSTSRGSC3.4
Celera239,101,649 - 39,101,909UniSTS
Cytogenetic Map2q14UniSTS
REN28471  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2243,314,861 - 43,315,102 (+)MAPPERmRatBN7.2
Rnor_6.0243,293,615 - 43,293,855NCBIRnor6.0
Rnor_5.0262,340,002 - 62,340,242UniSTSRnor5.0
RGSC_v3.4243,026,351 - 43,026,591UniSTSRGSC3.4
Celera239,100,464 - 39,100,704UniSTS
Cytogenetic Map2q14UniSTS
ECD09476  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2243,315,784 - 43,316,404 (+)MAPPERmRatBN7.2
Rnor_6.0243,294,538 - 43,295,157NCBIRnor6.0
Rnor_5.0262,340,925 - 62,341,544UniSTSRnor5.0
RGSC_v3.4243,027,274 - 43,027,893UniSTSRGSC3.4
Celera239,101,387 - 39,102,006UniSTS
Cytogenetic Map2q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017571   ⟹   ENSRNOP00000017571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl245,021,283 - 45,049,745 (+)Ensembl
mRatBN7.2 Ensembl243,291,881 - 43,316,136 (+)Ensembl
Rnor_6.0 Ensembl243,271,092 - 43,294,889 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087031   ⟹   ENSRNOP00000069147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl245,021,283 - 45,049,745 (+)Ensembl
mRatBN7.2 Ensembl243,287,916 - 43,316,136 (+)Ensembl
Rnor_6.0 Ensembl243,266,739 - 43,291,943 (+)Ensembl
RefSeq Acc Id: NM_001168000   ⟹   NP_001161472
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8245,025,662 - 45,049,459 (+)NCBI
mRatBN7.2243,292,338 - 43,316,136 (+)NCBI
Rnor_6.0243,271,092 - 43,294,889 (+)NCBI
Rnor_5.0262,313,119 - 62,341,562 (+)NCBI
RGSC_v3.4243,003,828 - 43,027,625 (+)RGD
Celera239,077,974 - 39,101,738 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231924   ⟹   XP_006231986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8245,021,233 - 45,049,745 (+)NCBI
mRatBN7.2243,287,913 - 43,316,422 (+)NCBI
Rnor_6.0243,266,737 - 43,295,175 (+)NCBI
Rnor_5.0262,313,119 - 62,341,562 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231925   ⟹   XP_006231987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8245,021,167 - 45,049,745 (+)NCBI
mRatBN7.2243,287,546 - 43,316,422 (+)NCBI
Rnor_6.0243,266,301 - 43,295,175 (+)NCBI
Rnor_5.0262,313,119 - 62,341,562 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102181   ⟹   XP_038958109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8245,021,653 - 45,049,745 (+)NCBI
mRatBN7.2243,288,330 - 43,316,422 (+)NCBI
RefSeq Acc Id: XM_063281723   ⟹   XP_063137793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8245,021,744 - 45,049,745 (+)NCBI
RefSeq Acc Id: XR_010063601
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8245,021,233 - 45,049,745 (+)NCBI
RefSeq Acc Id: NP_001161472   ⟸   NM_001168000
- UniProtKB: A6I5N1 (UniProtKB/TrEMBL),   D3ZE77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231986   ⟸   XM_006231924
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JUL8 (UniProtKB/TrEMBL),   D3ZE77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231987   ⟸   XM_006231925
- Peptide Label: isoform X2
- UniProtKB: A6I5N1 (UniProtKB/TrEMBL),   D3ZE77 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069147   ⟸   ENSRNOT00000087031
Ensembl Acc Id: ENSRNOP00000017571   ⟸   ENSRNOT00000017571
RefSeq Acc Id: XP_038958109   ⟸   XM_039102181
- Peptide Label: isoform X2
- UniProtKB: A6I5N1 (UniProtKB/TrEMBL),   D3ZE77 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137793   ⟸   XM_063281723
- Peptide Label: isoform X2
- UniProtKB: A6I5N1 (UniProtKB/TrEMBL),   D3ZE77 (UniProtKB/TrEMBL)
Protein Domains
ELM2   SANT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JUL8-F1-model_v2 AlphaFold A0A0G2JUL8 1-548 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691140
Promoter ID:EPDNEW_R1659
Type:multiple initiation site
Name:Mier3_1
Description:MIER family member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0243,266,780 - 43,266,840EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311241 AgrOrtholog
BioCyc Gene G2FUF-54420 BioCyc
Ensembl Genes ENSRNOG00000013121 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017571.9 UniProtKB/TrEMBL
  ENSRNOT00000087031 ENTREZGENE
  ENSRNOT00000087031.3 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1240.50 UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
InterPro ELM2 UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  MIER/MTA UniProtKB/TrEMBL
  MIER1/3_C UniProtKB/TrEMBL
  SANT_DNA-bd UniProtKB/TrEMBL
  SANT_eukarya UniProtKB/TrEMBL
KEGG Report rno:310086 UniProtKB/TrEMBL
NCBI Gene 310086 ENTREZGENE
PANTHER PTHR10865 UniProtKB/TrEMBL
  PTHR10865:SF22 UniProtKB/TrEMBL
Pfam ELM2 UniProtKB/TrEMBL
  MIER1_beta_C UniProtKB/TrEMBL
  Myb_DNA-binding UniProtKB/TrEMBL
PhenoGen Mier3 PhenoGen
PROSITE ELM2 UniProtKB/TrEMBL
  SANT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013121 RatGTEx
SMART ELM2 UniProtKB/TrEMBL
  SANT UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A0G2JUL8 ENTREZGENE, UniProtKB/TrEMBL
  A6I5N1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZE77 ENTREZGENE, UniProtKB/TrEMBL
  H9BFG6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-15 Mier3  MIER family member 3  Mier3  mesoderm induction early response 1, family member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-27 Mier3  mesoderm induction early response 1, family member 3  RGD1311241_predicted  similar to RIKEN cDNA D130064H19 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1311241_predicted  similar to RIKEN cDNA D130064H19 (predicted)  LOC310086_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC310086_predicted  similar to RIKEN cDNA D130064H19 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL