Gas2l1 (growth arrest-specific 2 like 1) - Rat Genome Database

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Gene: Gas2l1 (growth arrest-specific 2 like 1) Rattus norvegicus
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Symbol: Gas2l1
Name: growth arrest-specific 2 like 1
RGD ID: 1311206
Description: Predicted to enable actin filament binding activity; cytoskeletal anchor activity; and microtubule binding activity. Predicted to be involved in several processes, including cytoskeleton organization; negative regulation of microtubule depolymerization; and protein localization to microtubule plus-end. Predicted to be located in actin filament. Predicted to be active in cytoplasm. Predicted to colocalize with microtubule plus-end and stress fiber. Orthologous to human GAS2L1 (growth arrest specific 2 like 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GAS2-like protein 1; LOC360973
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,169,398 - 84,175,514 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1484,169,398 - 84,175,514 (-)EnsemblGRCr8
mRatBN7.21479,955,350 - 79,961,830 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,950,555 - 79,961,438 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1484,357,658 - 84,363,768 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01485,597,740 - 85,603,850 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,047,079 - 82,053,189 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01485,308,443 - 85,318,475 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,308,443 - 85,318,194 (-)Ensemblrn6Rnor6.0
Rnor_5.01485,986,064 - 85,995,860 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41485,716,617 - 85,726,368 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1478,842,658 - 78,852,409 (-)NCBICelera
RGSC_v3.11485,740,654 - 85,745,508 (-)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GAR22: a novel target gene of thyroid hormone receptor causes growth inhibition in human erythroid cells. Gamper I, etal., Exp Hematol. 2009 May;37(5):539-548.e4. doi: 10.1016/j.exphem.2009.02.002.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules. Goriounov D, etal., J Cell Sci. 2003 Mar 15;116(Pt 6):1045-58.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24706950   PMID:31486213  


Genomics

Comparative Map Data
Gas2l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81484,169,398 - 84,175,514 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1484,169,398 - 84,175,514 (-)EnsemblGRCr8
mRatBN7.21479,955,350 - 79,961,830 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,950,555 - 79,961,438 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1484,357,658 - 84,363,768 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01485,597,740 - 85,603,850 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01482,047,079 - 82,053,189 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01485,308,443 - 85,318,475 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,308,443 - 85,318,194 (-)Ensemblrn6Rnor6.0
Rnor_5.01485,986,064 - 85,995,860 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41485,716,617 - 85,726,368 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1478,842,658 - 78,852,409 (-)NCBICelera
RGSC_v3.11485,740,654 - 85,745,508 (-)NCBI
Cytogenetic Map14q21NCBI
GAS2L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382229,306,650 - 29,312,787 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2229,306,394 - 29,312,787 (+)Ensemblhg38GRCh38
GRCh372229,702,640 - 29,708,776 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,032,997 - 28,038,774 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342228,027,550 - 28,033,328NCBI
Celera2213,502,852 - 13,508,630 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2212,667,224 - 12,673,019 (+)NCBIHuRef
CHM1_12229,662,401 - 29,668,196 (+)NCBICHM1_1
T2T-CHM13v2.02229,769,795 - 29,776,198 (+)NCBIT2T-CHM13v2.0
Gas2l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,004,131 - 5,015,351 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl115,004,132 - 5,015,327 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38115,054,131 - 5,065,348 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,054,132 - 5,065,327 (-)Ensemblmm10GRCm38
MGSCv37114,954,134 - 4,965,330 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36114,950,920 - 4,964,854 (-)NCBIMGSCv36mm8
Celera115,551,023 - 5,562,217 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.21NCBI
Gas2l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554553,613,092 - 3,621,306 (+)Ensembl
ChiLan1.0NW_0049554553,613,092 - 3,618,476 (+)NCBIChiLan1.0ChiLan1.0
GAS2L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22339,290,157 - 39,296,331 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12241,990,691 - 41,996,963 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02210,362,391 - 10,368,173 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12228,169,388 - 28,175,278 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2228,169,387 - 28,175,278 (+)EnsemblpanPan2panpan1.1
GAS2L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,615,531 - 22,620,605 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,615,319 - 22,621,311 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2622,486,993 - 22,492,483 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02622,989,305 - 22,994,798 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2622,989,296 - 22,994,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12622,698,503 - 22,703,987 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02622,961,632 - 22,967,113 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,026,621 - 23,032,106 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gas2l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,537,639 - 112,543,342 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366573,327,339 - 3,333,797 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366573,327,363 - 3,333,087 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAS2L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,449,787 - 46,455,276 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11446,449,767 - 46,455,278 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,414,643 - 49,420,160 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GAS2L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11912,175,207 - 12,181,295 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1912,176,015 - 12,183,723 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045113,968,749 - 113,975,139 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gas2l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247475,684,108 - 5,688,124 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247475,683,107 - 5,688,405 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gas2l1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11174,036,890 - 74,043,022 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gas2l1
40 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:183
Count of miRNA genes:122
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000065135
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)1484164970100078267Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat

Markers in Region
AI852688  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81484,170,282 - 84,170,432 (+)Marker Load Pipeline
mRatBN7.21479,956,233 - 79,956,384 (+)MAPPERmRatBN7.2
Rnor_6.01485,312,974 - 85,313,124NCBIRnor6.0
Rnor_5.01485,990,595 - 85,990,745UniSTSRnor5.0
RGSC_v3.41485,721,148 - 85,721,298UniSTSRGSC3.4
Celera1478,847,189 - 78,847,339UniSTS
Cytogenetic Map14q21UniSTS
RH17231  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21479,956,606 - 79,956,715 (+)MAPPERmRatBN7.2
Rnor_6.01485,313,347 - 85,313,455NCBIRnor6.0
Rnor_5.01485,990,968 - 85,991,076UniSTSRnor5.0
RGSC_v3.41485,721,521 - 85,721,629UniSTSRGSC3.4
Celera1478,847,562 - 78,847,670UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000065135   ⟹   ENSRNOP00000063743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1479,950,555 - 79,961,252 (-)Ensembl
Rnor_6.0 Ensembl1485,308,443 - 85,318,194 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080541   ⟹   ENSRNOP00000075569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1484,169,398 - 84,175,514 (-)Ensembl
mRatBN7.2 Ensembl1479,956,511 - 79,961,438 (-)Ensembl
RefSeq Acc Id: NM_001401406   ⟹   NP_001388335
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,169,398 - 84,175,514 (-)NCBI
mRatBN7.21479,955,350 - 79,961,466 (-)NCBI
RefSeq Acc Id: XM_039092216   ⟹   XP_038948144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,169,398 - 84,172,840 (-)NCBI
mRatBN7.21479,955,350 - 79,958,730 (-)NCBI
RefSeq Acc Id: XM_039092217   ⟹   XP_038948145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,172,295 - 84,174,669 (-)NCBI
mRatBN7.21479,958,247 - 79,961,830 (-)NCBI
RefSeq Acc Id: XM_063273391   ⟹   XP_063129461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81484,170,519 - 84,174,669 (-)NCBI
Ensembl Acc Id: ENSRNOP00000063743   ⟸   ENSRNOT00000065135
RefSeq Acc Id: XP_038948144   ⟸   XM_039092216
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948145   ⟸   XM_039092217
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000075569   ⟸   ENSRNOT00000080541
RefSeq Acc Id: NP_001388335   ⟸   NM_001401406
- UniProtKB: D3ZR69 (UniProtKB/TrEMBL),   A6IKK5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129461   ⟸   XM_063273391
- Peptide Label: isoform X3
Protein Domains
Calponin-homology (CH)   GAR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZR69-F1-model_v2 AlphaFold D3ZR69 1-428 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699453
Promoter ID:EPDNEW_R9977
Type:multiple initiation site
Name:Gas2l1_1
Description:growth arrest-specific 2 like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01485,318,194 - 85,318,254EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311206 AgrOrtholog
BioCyc Gene G2FUF-15151 BioCyc
Ensembl Genes ENSRNOG00000009040 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080541 ENTREZGENE
  ENSRNOT00000080541.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  3.30.920.20 UniProtKB/TrEMBL
InterPro Calponin-like_dom_sf UniProtKB/TrEMBL
  Calponin_act-bd UniProtKB/TrEMBL
  GAR_dom_sf UniProtKB/TrEMBL
  GAS2 UniProtKB/TrEMBL
NCBI Gene 360973 ENTREZGENE
PANTHER PTHR46756:SF16 UniProtKB/TrEMBL
  TRANSGELIN UniProtKB/TrEMBL
Pfam GAS2 UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
PhenoGen Gas2l1 PhenoGen
PROSITE GAR UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009040 RatGTEx
SMART GAS2 UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
Superfamily-SCOP Calponin-homology UniProtKB/TrEMBL
  SSF143575 UniProtKB/TrEMBL
UniProt A0A0G2KAY0_RAT UniProtKB/TrEMBL
  A6IKK5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZR69 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Gas2l1  growth arrest-specific 2 like 1   Gas2l1_predicted  growth arrest-specific 2 like 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Gas2l1_predicted  growth arrest-specific 2 like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED