Sh3pxd2a (SH3 and PX domains 2A) - Rat Genome Database

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Gene: Sh3pxd2a (SH3 and PX domains 2A) Rattus norvegicus
Analyze
Symbol: Sh3pxd2a
Name: SH3 and PX domains 2A
RGD ID: 1311185
Description: Predicted to enable several functions, including phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in osteoclast fusion and superoxide anion generation. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in podosome. Predicted to be active in cytoplasm. Orthologous to human SH3PXD2A (SH3 and PX domains 2A); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC309460; SH3 and PX domain-containing protein 2A; SH3 multiple domains 1; Sh3md1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81256,094,991 - 256,301,120 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1256,094,991 - 256,300,967 (-)EnsemblGRCr8
mRatBN7.21246,153,660 - 246,359,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,160,502 - 246,360,166 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1254,286,899 - 254,444,343 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01260,980,787 - 261,138,068 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01253,629,151 - 253,786,369 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01267,039,654 - 267,245,868 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1267,046,361 - 267,245,636 (-)Ensemblrn6Rnor6.0
Rnor_5.01274,470,628 - 274,678,690 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41252,601,140 - 252,796,776 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1241,931,038 - 242,085,237 (-)NCBICelera
RGSC_v3.11252,865,756 - 253,103,796 (-)NCBI
Cytogenetic Map1q54NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
dimethyl sulfoxide  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-Nitrosopyrrolidine  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
podosome  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12615925   PMID:18417249   PMID:19755709   PMID:19755710   PMID:20609497   PMID:22584907   PMID:25931508   PMID:27996060  


Genomics

Comparative Map Data
Sh3pxd2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81256,094,991 - 256,301,120 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1256,094,991 - 256,300,967 (-)EnsemblGRCr8
mRatBN7.21246,153,660 - 246,359,806 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,160,502 - 246,360,166 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1254,286,899 - 254,444,343 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01260,980,787 - 261,138,068 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01253,629,151 - 253,786,369 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01267,039,654 - 267,245,868 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1267,046,361 - 267,245,636 (-)Ensemblrn6Rnor6.0
Rnor_5.01274,470,628 - 274,678,690 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41252,601,140 - 252,796,776 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1241,931,038 - 242,085,237 (-)NCBICelera
RGSC_v3.11252,865,756 - 253,103,796 (-)NCBI
Cytogenetic Map1q54NCBI
SH3PXD2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810103,594,027 - 103,855,576 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10103,594,027 - 103,855,584 (-)Ensemblhg38GRCh38
GRCh3710105,353,784 - 105,615,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610105,343,774 - 105,605,154 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410105,343,773 - 105,605,154NCBI
Celera1099,093,721 - 99,355,050 (-)NCBICelera
Cytogenetic Map10q24.33NCBI
HuRef1098,984,423 - 99,246,081 (-)NCBIHuRef
CHM1_110105,637,905 - 105,898,918 (-)NCBICHM1_1
T2T-CHM13v2.010104,481,342 - 104,742,826 (-)NCBIT2T-CHM13v2.0
Sh3pxd2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391947,248,613 - 47,453,053 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1947,248,613 - 47,452,840 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381947,260,174 - 47,464,612 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1947,260,174 - 47,464,401 (-)Ensemblmm10GRCm38
MGSCv371947,334,664 - 47,538,901 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361947,320,224 - 47,517,722 (-)NCBIMGSCv36mm8
Celera1948,016,878 - 48,203,451 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1939.45NCBI
Sh3pxd2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554856,811,844 - 7,009,432 (+)Ensembl
ChiLan1.0NW_0049554856,811,857 - 7,008,011 (+)NCBIChiLan1.0ChiLan1.0
SH3PXD2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28115,480,543 - 115,742,157 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110115,477,065 - 115,747,464 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010100,193,961 - 100,455,200 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110103,655,409 - 103,729,572 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10103,663,163 - 103,861,437 (-)EnsemblpanPan2panpan1.1
SH3PXD2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12815,936,927 - 16,165,537 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2815,943,097 - 16,117,710 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2816,108,640 - 16,342,907 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02816,413,263 - 16,648,091 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2816,417,811 - 16,648,071 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12815,961,861 - 16,196,960 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02815,989,976 - 16,225,123 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02816,128,444 - 16,363,617 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sh3pxd2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721330,740,484 - 30,911,584 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366002,343,658 - 2,509,612 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366002,343,709 - 2,513,497 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH3PXD2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14114,519,928 - 114,777,238 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114114,515,459 - 114,777,251 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214124,396,943 - 124,484,440 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SH3PXD2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1996,645,955 - 96,898,749 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604857,760,430 - 58,016,287 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh3pxd2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248312,786,950 - 2,973,702 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248312,779,899 - 2,973,576 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sh3pxd2a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1246,799,863 - 46,998,731 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sh3pxd2a
2254 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:67
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000027574
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat

Markers in Region
D1Rat454  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81256,131,672 - 256,131,900 (+)Marker Load Pipeline
mRatBN7.21246,190,345 - 246,190,573 (+)MAPPERmRatBN7.2
Rnor_6.01267,076,330 - 267,076,557NCBIRnor6.0
Rnor_5.01274,507,310 - 274,507,537UniSTSRnor5.0
RGSC_v3.41252,630,980 - 252,631,208RGDRGSC3.4
RGSC_v3.41252,630,981 - 252,631,208UniSTSRGSC3.4
Celera1241,960,889 - 241,961,116UniSTS
RGSC_v3.11252,895,553 - 252,895,781RGD
SHRSP x BN Map1139.09UniSTS
SHRSP x BN Map1139.09RGD
Cytogenetic Map1q54UniSTS
D1Got239  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21246,354,238 - 246,354,356 (+)MAPPERmRatBN7.2
Rnor_6.01267,240,424 - 267,240,541NCBIRnor6.0
Rnor_5.01274,673,222 - 274,673,339UniSTSRnor5.0
RGSC_v3.41252,834,114 - 252,834,232RGDRGSC3.4
RGSC_v3.41252,834,115 - 252,834,232UniSTSRGSC3.4
Celera1242,121,646 - 242,121,763UniSTS
RGSC_v3.11253,098,688 - 253,098,805RGD
RH 3.4 Map11635.1UniSTS
RH 3.4 Map11635.1RGD
RH 2.0 Map11244.4RGD
Cytogenetic Map1q54UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027574   ⟹   ENSRNOP00000027574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,160,502 - 246,319,316 (-)Ensembl
Rnor_6.0 Ensembl1267,046,490 - 267,203,986 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082799   ⟹   ENSRNOP00000070182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,160,502 - 246,289,101 (-)Ensembl
Rnor_6.0 Ensembl1267,046,361 - 267,245,636 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099914   ⟹   ENSRNOP00000078462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,160,502 - 246,360,166 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100437   ⟹   ENSRNOP00000090159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,160,502 - 246,360,166 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103789   ⟹   ENSRNOP00000095118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,160,502 - 246,309,813 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118210   ⟹   ENSRNOP00000095611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1246,160,502 - 246,360,166 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123173   ⟹   ENSRNOP00000102627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1256,094,991 - 256,300,967 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138085   ⟹   ENSRNOP00000101895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1256,094,991 - 256,260,609 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000139157   ⟹   ENSRNOP00000109997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1256,094,991 - 256,300,967 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000149640   ⟹   ENSRNOP00000102896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1256,094,991 - 256,300,967 (-)Ensembl
RefSeq Acc Id: NM_001107606   ⟹   NP_001101076
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81256,094,991 - 256,300,967 (-)NCBI
mRatBN7.21246,153,660 - 246,359,655 (-)NCBI
Rnor_6.01267,046,490 - 267,203,986 (-)NCBI
Rnor_5.01274,470,628 - 274,678,690 (-)NCBI
RGSC_v3.41252,601,140 - 252,796,776 (-)RGD
Celera1241,931,038 - 242,085,237 (-)RGD
Sequence:
RefSeq Acc Id: NM_001415946   ⟹   NP_001402875
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81256,094,991 - 256,300,967 (-)NCBI
mRatBN7.21246,153,660 - 246,359,655 (-)NCBI
RefSeq Acc Id: XM_006231514   ⟹   XP_006231576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81256,094,996 - 256,301,120 (-)NCBI
mRatBN7.21246,153,660 - 246,359,806 (-)NCBI
Rnor_6.01267,039,654 - 267,245,868 (-)NCBI
Rnor_5.01274,470,628 - 274,678,690 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080588   ⟹   XP_038936516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81256,094,996 - 256,292,139 (-)NCBI
mRatBN7.21246,153,660 - 246,350,895 (-)NCBI
RefSeq Acc Id: NP_001101076   ⟸   NM_001107606
- Peptide Label: isoform 1
- UniProtKB: A0A8I6G2U9 (UniProtKB/TrEMBL),   D3ZMW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231576   ⟸   XM_006231514
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AP29 (UniProtKB/TrEMBL),   D3ZMW5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070182   ⟸   ENSRNOT00000082799
Ensembl Acc Id: ENSRNOP00000027574   ⟸   ENSRNOT00000027574
RefSeq Acc Id: XP_038936516   ⟸   XM_039080588
- Peptide Label: isoform X2
- UniProtKB: A6JHQ5 (UniProtKB/TrEMBL),   A0A0G2JX92 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095118   ⟸   ENSRNOT00000103789
Ensembl Acc Id: ENSRNOP00000095611   ⟸   ENSRNOT00000118210
Ensembl Acc Id: ENSRNOP00000090159   ⟸   ENSRNOT00000100437
Ensembl Acc Id: ENSRNOP00000078462   ⟸   ENSRNOT00000099914
RefSeq Acc Id: NP_001402875   ⟸   NM_001415946
- Peptide Label: isoform 2
- UniProtKB: A0A8I6AD93 (UniProtKB/TrEMBL),   D3ZMW5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101895   ⟸   ENSRNOT00000138085
Ensembl Acc Id: ENSRNOP00000102627   ⟸   ENSRNOT00000123173
Ensembl Acc Id: ENSRNOP00000109997   ⟸   ENSRNOT00000139157
Ensembl Acc Id: ENSRNOP00000102896   ⟸   ENSRNOT00000149640
Protein Domains
PX   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JX92-F1-model_v2 AlphaFold A0A0G2JX92 1-1109 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311185 AgrOrtholog
BioCyc Gene G2FUF-55485 BioCyc
Ensembl Genes ENSRNOG00000020353 Ensembl
  ENSRNOG00000089802 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000123173 ENTREZGENE
  ENSRNOT00000123173.1 UniProtKB/TrEMBL
  ENSRNOT00000138085.1 UniProtKB/TrEMBL
  ENSRNOT00000139157 ENTREZGENE
  ENSRNOT00000139157.1 UniProtKB/TrEMBL
  ENSRNOT00000149640 ENTREZGENE
  ENSRNOT00000149640.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1520.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro IPR001683 UniProtKB/TrEMBL
  NADPH_Oxidase/PX-Domain UniProtKB/TrEMBL
  PX_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  SH3PXD2A_SH3_1 UniProtKB/TrEMBL
  SH3PXD2A_SH3_2 UniProtKB/TrEMBL
  SH3PXD2A_SH3_3 UniProtKB/TrEMBL
  SH3PXD2A_SH3_4 UniProtKB/TrEMBL
  SH3PXD2A_SH3_5 UniProtKB/TrEMBL
KEGG Report rno:309460 UniProtKB/TrEMBL
NCBI Gene 309460 ENTREZGENE
PANTHER SH3 AND PX DOMAIN-CONTAINING PROTEIN 2B UniProtKB/TrEMBL
  SH3 MULTIPLE DOMAIN UniProtKB/TrEMBL
Pfam PF00787 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PhenoGen Sh3pxd2a PhenoGen
PROSITE PS50195 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020353 RatGTEx
  ENSRNOG00000089802 RatGTEx
SMART SH3 UniProtKB/TrEMBL
Superfamily-SCOP 64268 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
UniProt A0A0G2JX92 ENTREZGENE
  A0A8I6AD93 ENTREZGENE
  A0A8I6AP29 ENTREZGENE
  A0A8I6G2U9 ENTREZGENE
  A0ABK0L9R3_RAT UniProtKB/TrEMBL
  A0ABK0LGP0_RAT UniProtKB/TrEMBL
  A0ABK0LH48_RAT UniProtKB/TrEMBL
  A0ABK0LP68_RAT UniProtKB/TrEMBL
  A6JHQ5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMW5 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Sh3pxd2a  SH3 and PX domains 2A   Sh3pxd2a_predicted  SH3 and PX domains 2A (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Sh3pxd2a_predicted  SH3 and PX domains 2A (predicted)  Sh3md1_predicted  SH3 multiple domains 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Sh3md1_predicted  SH3 multiple domains 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED