Pate4 (prostate and testis expressed 4) - Rat Genome Database

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Gene: Pate4 (prostate and testis expressed 4) Rattus norvegicus
Analyze
Symbol: Pate4 (Ensembl: Pate4b)
Name: prostate and testis expressed 4 (Ensembl:prostate and testis expressed 4B)
RGD ID: 1311172
Description: Predicted to enable acetylcholine receptor regulator activity. Predicted to act upstream of or within modulation of chemical synaptic transmission and response to wounding. Predicted to be located in acrosomal vesicle and extracellular space. Orthologous to human PATE4 (prostate and testis expressed 4); INTERACTS WITH bisphenol A; thioacetamide; tributylstannane.
Type: protein-coding
Previously known as: LOC363041; Pate4a; Pate4b; prostate and testis expressed 4A; prostate and testis expressed 4B; prostate and testis expressed protein 4; seminal vesicle protein, secretion 7; seminal vesicle secretory protein 7; Svs7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8842,246,492 - 42,249,233 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl842,246,978 - 42,249,234 (-)EnsemblGRCr8
mRatBN7.2833,988,812 - 33,991,552 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl833,966,928 - 33,969,666 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl833,988,812 - 33,991,552 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx838,057,309 - 38,060,047 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0836,340,370 - 36,343,108 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0834,203,199 - 34,205,937 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0836,815,007 - 36,817,747 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0836,832,267 - 36,835,007 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4835,407,990 - 35,410,730 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera835,384,872 - 35,387,612 (-)NCBICelera
RGSC_v3.1835,417,185 - 35,419,485 (-)NCBI
Cytogenetic Map8q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18387948  


Genomics

Comparative Map Data
Pate4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8842,246,492 - 42,249,233 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl842,246,978 - 42,249,234 (-)EnsemblGRCr8
mRatBN7.2833,988,812 - 33,991,552 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl833,966,928 - 33,969,666 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl833,988,812 - 33,991,552 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx838,057,309 - 38,060,047 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0836,340,370 - 36,343,108 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0834,203,199 - 34,205,937 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0836,815,007 - 36,817,747 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0836,832,267 - 36,835,007 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4835,407,990 - 35,410,730 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera835,384,872 - 35,387,612 (-)NCBICelera
RGSC_v3.1835,417,185 - 35,419,485 (-)NCBI
Cytogenetic Map8q21NCBI
PATE4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811125,833,316 - 125,840,072 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11125,833,316 - 125,840,072 (+)Ensemblhg38GRCh38
GRCh3711125,703,211 - 125,709,967 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611125,208,427 - 125,215,177 (+)NCBIBuild 36Build 36hg18NCBI36
Celera11122,863,433 - 122,870,194 (+)NCBICelera
Cytogenetic Map11q24.2NCBI
HuRef11121,645,568 - 121,652,329 (+)NCBIHuRef
CHM1_111125,589,306 - 125,596,066 (+)NCBICHM1_1
T2T-CHM13v2.011125,861,917 - 125,868,678 (+)NCBIT2T-CHM13v2.0
Pate4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39935,518,387 - 35,523,164 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl935,518,389 - 35,523,237 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38935,607,093 - 35,611,885 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl935,607,093 - 35,611,941 (-)Ensemblmm10GRCm38
MGSCv37935,414,678 - 35,419,470 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36935,357,244 - 35,361,517 (-)NCBIMGSCv36mm8
Celera932,844,612 - 32,849,404 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map920.34NCBI
Pate4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541226,912,925 - 26,914,668 (+)NCBIChiLan1.0ChiLan1.0
PATE4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29126,521,171 - 126,527,977 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111127,628,591 - 127,635,528 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011120,651,794 - 120,659,020 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111124,565,341 - 124,572,090 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11124,565,341 - 124,572,090 (+)EnsemblpanPan2panpan1.1
PATE4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11116,996,163 - 117,003,586 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1116,996,723 - 117,001,796 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660439,069,416 - 9,074,968 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pate4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1831,152,219 - 31,154,388 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pate4
7 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:51
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000060454
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625851589833Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
70206Alc20Alcohol consumption QTL 202drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)83910625849610361Rat

Markers in Region
BI280571  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2833,967,079 - 33,967,249 (+)MAPPERmRatBN7.2
mRatBN7.2833,988,963 - 33,989,133 (+)MAPPERmRatBN7.2
Rnor_6.0836,815,159 - 36,815,328NCBIRnor6.0
Rnor_5.0836,832,419 - 36,832,588UniSTSRnor5.0
RGSC_v3.4835,408,142 - 35,408,311UniSTSRGSC3.4
Celera835,385,024 - 35,385,193UniSTS
RH 3.4 Map8297.4UniSTS
Cytogenetic Map8q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 1 8 37 43 42 13 15 13 2 77 40 3 21 18 26 29 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000060454   ⟹   ENSRNOP00000057199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl836,815,007 - 36,817,747 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112259   ⟹   ENSRNOP00000093200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl842,246,978 - 42,249,234 (-)Ensembl
mRatBN7.2 Ensembl833,966,928 - 33,969,666 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117448   ⟹   ENSRNOP00000076608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl833,988,812 - 33,991,552 (-)Ensembl
RefSeq Acc Id: NM_001108757   ⟹   NP_001102227
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2833,988,812 - 33,991,552 (-)NCBI
Rnor_6.0836,815,007 - 36,817,747 (-)NCBI
Rnor_5.0836,832,267 - 36,835,007 (-)NCBI
RGSC_v3.4835,407,990 - 35,410,730 (-)RGD
Celera835,384,872 - 35,387,612 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102227 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83264 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000076608.2
  ENSRNOP00000093200.1
RefSeq Acc Id: NP_001102227   ⟸   NM_001108757
- Peptide Label: precursor
- Sequence:
Ensembl Acc Id: ENSRNOP00000057199   ⟸   ENSRNOT00000060454
Ensembl Acc Id: ENSRNOP00000076608   ⟸   ENSRNOT00000117448
Ensembl Acc Id: ENSRNOP00000093200   ⟸   ENSRNOT00000112259
Protein Domains
UPAR/Ly6

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AE27-F1-model_v2 AlphaFold D4AE27 1-102 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695840
Promoter ID:EPDNEW_R6365
Type:single initiation site
Name:Pate4_1
Description:prostate and testis expressed 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0836,817,746 - 36,817,806EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311172 AgrOrtholog
BioCyc Gene G2FUF-31163 BioCyc
Ensembl Genes ENSRNOG00000039447 Ensembl
  ENSRNOG00000065914 Ensembl
  ENSRNOG00000070114 Ensembl
  ENSRNOG00000080692 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000086195 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000112259.2 UniProtKB/TrEMBL
  ENSRNOT00000117448.2 UniProtKB/TrEMBL
Gene3D-CATH 2.10.60.10 UniProtKB/TrEMBL
InterPro LY6_UPA_recep-like UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/TrEMBL
NCBI Gene 363041 ENTREZGENE
Pfam UPAR_LY6 UniProtKB/TrEMBL
PhenoGen Pate4 PhenoGen
RatGTEx ENSRNOG00000039447 RatGTEx
  ENSRNOG00000065914 RatGTEx
  ENSRNOG00000070114 RatGTEx
  ENSRNOG00000080692 RatGTEx
  ENSRNOG00000086195 RatGTEx
Superfamily-SCOP SSF57302 UniProtKB/TrEMBL
UniProt A0A8I5Y6V7_RAT UniProtKB/TrEMBL
  A6JYL1_RAT UniProtKB/TrEMBL
  D4AE27_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-07-29 Pate4  prostate and testis expressed 4  Pate4b  prostate and testis expressed 4B  Data Merged 737654 PROVISIONAL
2022-03-07 Pate4b  prostate and testis expressed 4B  LOC120094107  prostate and testis expressed 4  Name and Symbol changed 629549 APPROVED
2021-01-27 LOC120094107  prostate and testis expressed 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-05 Pate4  prostate and testis expressed 4  Svs7  seminal vesicle secretory protein 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Svs7  seminal vesicle secretory protein 7  Svs7_predicted  seminal vesicle protein, secretion 7 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Svs7_predicted  seminal vesicle protein, secretion 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED