Abo2 (histo-blood group ABO system transferase 2) - Rat Genome Database

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Gene: Abo2 (histo-blood group ABO system transferase 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Abo2
Name: histo-blood group ABO system transferase 2
RGD ID: 1311152
Description: Predicted to enable glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and vesicle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; graft-versus-host disease; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase); PARTICIPATES IN lacto-series glycosphingolipid metabolic pathway; INTERACTS WITH bisphenol A; methamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a transferase; Abo; ABO blood group (alpha 1-3-N-acetylgalactosaminyltransferase, alpha 1-3-galactosyltransferase); ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase); b blood group galactosyltransferase; b transferase; blood group A glycosyltransferase 2; cis-AB transferase 2; fucosylglycoprotein 3-alpha-galactosyltransferase; fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; glycoprotein-fucosylgalactoside alpha-galactosyltransferase; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; histo-blood group A transferase; histo-blood group ABO system transferase; histo-blood group ABO system transferase 2-like; histo-blood group B transferase; LOC100911704; NAGAT 2; putative blood group A transferase T2; transferase B, alpha 1-3-galactosyltransferase)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,409,553 - 30,426,477 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl330,409,553 - 30,426,477 (+)EnsemblGRCr8
mRatBN7.2310,011,475 - 10,028,397 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,002,834 - 10,028,396 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx313,073,279 - 13,089,583 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0321,658,678 - 21,674,982 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0319,913,976 - 19,930,283 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,386,434 - 5,402,666 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,386,434 - 5,402,666 (-)Ensemblrn6Rnor6.0
Rnor_5.0310,737,036 - 10,753,429 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.435,589,306 - 5,596,367 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera34,828,494 - 4,829,181 (+)NCBICelera
RGSC_v3.135,309,990 - 5,597,149 (+)NCBI
Cytogenetic Map3p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Golgi apparatus  (IBA)
membrane  (IEA)
vesicle  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease. Banales JM, etal., Am J Pathol. 2008 Dec;173(6):1637-46. Epub 2008 Nov 6.
2. Lack of association between asthma and ABO blood group. Bijanzadeh M, etal., Lung. 2009 Nov-Dec;187(6):389-92. Epub 2009 Sep 22.
3. ABO/secretor genetic complex is associated with the susceptibility of childhood asthma in Taiwan. Chen YL, etal., Clin Exp Allergy. 2005 Jul;35(7):926-32.
4. ABO blood group and susceptibility to severe acute respiratory syndrome. Cheng Y, etal., JAMA. 2005 Mar 23;293(12):1450-1.
5. [The distribution of ABO system blood groups in patients with unilocular echinococcosis]. Chobanov RE and Salekhov AA, Med Parazitol (Mosk). 1990 Mar-Apr;(2):18-20.
6. [Correlations of the antigenic specificity of human blood with the levels of antihemagglutinins to influenza viruses]. Fedorova GI, etal., Vopr Virusol. 1983 Jan-Feb;28(1):54-7.
7. Microarray analysis of retinoid-dependent gene activity during rat embryogenesis: increased collagen fibril production in a model of retinoid insufficiency. Flentke GR, etal., Dev Dyn. 2004 Apr;229(4):886-98.
8. Enzymes that synthesize the IB4 epitope are not sufficient to impart IB4 binding in dorsal root ganglia of rat. Fullmer JM, etal., J Comp Neurol. 2007 Mar 1;501(1):70-82.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Expression of histo-blood group A antigen increases resistance to apoptosis and facilitates escape from immune control of rat colon carcinoma cells. Marionneau S, etal., Glycobiology. 2002 Dec;12(12):851-6.
12. Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during a Nippostrongylus brasiliensis parasite infection. Olson FJ, etal., J Biol Chem 2002 Apr 26;277(17):15044-52.
13. ABO and Rh blood groups in patients with cholelithiasis and carcinoma of the gall bladder. Pandey M, etal., BMJ. 1995 Jun 24;310(6995):1639.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. ABO Blood Group, Helicobacter pylori Seropositivity, and Risk of Pancreatic Cancer: A Case-Control Study. Risch HA, etal., J Natl Cancer Inst. 2010 Feb 24.
18. Characterization of the rat alpha(1,3)galactosyltransferase: evidence for two independent genes encoding glycosyltransferases that synthesize Galalpha(1,3)Gal by two separate glycosylation pathways. Taylor SG, etal., Glycobiology 2003 May;13(5):327-37.
19. Cloning of a rat gene encoding the histo-blood group B enzyme: rats have more than one Abo gene. Turcot AL, etal., Glycobiology. 2003 Dec;13(12):919-28. Epub 2003 Jun 10.
20. [Genetic markers of the ABO blood system in pulmonary sarcoidosis patients of different ethnic origin]. Volkova KI and Godes IE, Klin Med (Mosk). 1996;74(8):44-6.
21. Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium. Wolpin BM, etal., Cancer Res. 2010 Feb 1;70(3):1015-23. Epub 2010 Jan 26.

Genomics

Variants

.
Variants in Abo2
147 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:56
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000061276
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH132268  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,162,172 - 10,162,384 (+)MAPPERmRatBN7.2
mRatBN7.2310,028,107 - 10,028,319 (-)MAPPERmRatBN7.2
Rnor_6.035,386,026 - 5,386,237NCBIRnor6.0
Rnor_6.034,374,754 - 4,374,965NCBIRnor6.0
Rnor_5.039,729,996 - 9,730,207UniSTSRnor5.0
Rnor_5.0310,737,095 - 10,737,306UniSTSRnor5.0
RGSC_v3.435,596,564 - 5,596,775UniSTSRGSC3.4
RGSC_v3.435,730,628 - 5,730,839UniSTSRGSC3.4
Celera34,960,705 - 4,960,916UniSTS
Celera34,829,378 - 4,829,589UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 7 24 19 15 3 6 3 3 38 22 16 4 21 12 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000061276   ⟹   ENSRNOP00000057988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl330,409,553 - 30,426,477 (+)Ensembl
mRatBN7.2 Ensembl310,011,475 - 10,028,393 (+)Ensembl
Rnor_6.0 Ensembl35,386,434 - 5,402,666 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099183   ⟹   ENSRNOP00000091204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,002,834 - 10,028,396 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106649   ⟹   ENSRNOP00000079782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl330,419,652 - 30,426,477 (+)Ensembl
mRatBN7.2 Ensembl310,021,572 - 10,028,396 (+)Ensembl
RefSeq Acc Id: NM_001271298   ⟹   NP_001258227
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,409,553 - 30,426,477 (+)NCBI
mRatBN7.2310,011,475 - 10,028,397 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001258227 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057988
  ENSRNOP00000057988.3
  ENSRNOP00000079782.1
Ensembl Acc Id: ENSRNOP00000057988   ⟸   ENSRNOT00000061276
Ensembl Acc Id: ENSRNOP00000079782   ⟸   ENSRNOT00000106649
Ensembl Acc Id: ENSRNOP00000091204   ⟸   ENSRNOT00000099183
RefSeq Acc Id: NP_001258227   ⟸   NM_001271298
- UniProtKB: D4A7T1 (UniProtKB/TrEMBL),   A6JTH9 (UniProtKB/TrEMBL)
- Sequence:

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RE11-F1-model_v2 AlphaFold M0RE11 1-327 view protein structure
AF-D4A7T1-F1-model_v2 AlphaFold D4A7T1 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311152 AgrOrtholog
BioCyc Gene G2FUF-50337 BioCyc
Ensembl Genes ENSRNOG00000045801 Ensembl
  ENSRNOG00000077667 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061276 ENTREZGENE
  ENSRNOT00000061276.6 UniProtKB/TrEMBL
  ENSRNOT00000106649.2 UniProtKB/TrEMBL
Gene3D-CATH Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A UniProtKB/TrEMBL
InterPro Glyco_trans_6 UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/TrEMBL
NCBI Gene 296504 ENTREZGENE
PANTHER Glyco_trans_6 UniProtKB/TrEMBL
  HISTO-BLOOD GROUP ABO SYSTEM TRANSFERASE UniProtKB/TrEMBL
Pfam Glyco_transf_6 UniProtKB/TrEMBL
PhenoGen Abo2 PhenoGen
RatGTEx ENSRNOG00000045801 RatGTEx
  ENSRNOG00000077667 RatGTEx
Superfamily-SCOP SSF53448 UniProtKB/TrEMBL
UniProt A0A8I5ZPA3_RAT UniProtKB/TrEMBL
  A6JTH9 ENTREZGENE, UniProtKB/TrEMBL
  D4A7T1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Abo2  histo-blood group ABO system transferase 2  LOC100911704  histo-blood group ABO system transferase 2-like  Data merged from RGD:6491244 737654 PROVISIONAL
2012-07-05 LOC100911704  histo-blood group ABO system transferase 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-04-21 Abo  ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)  Abo_predicted  ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 Abo_predicted  ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) (predicted)  LOC687450  similar to N-acetylgalactosaminyltransferase A blood group-like enzyme  Data merged from RGD:1585355 1643240 APPROVED
2006-11-19 LOC687450  similar to N-acetylgalactosaminyltransferase A blood group-like enzyme      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Abo_predicted  ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) (predicted)      Symbol and Name status set to approved 70820 APPROVED