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Gene: Aire (autoimmune regulator) Rattus norvegicus

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Symbol:

Aire

Name:

autoimmune regulator

RGD ID:

1311139

Description:

Predicted to enable several functions, including histone binding activity; identical protein binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including immune system development; negative thymic T cell selection; and positive regulation of macromolecule biosynthetic process. Predicted to be located in cytoplasm; germ cell nucleus; and nuclear body. Predicted to be active in nucleus. Used to study autoimmune polyendocrine syndrome. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator); PARTICIPATES IN primary immunodeficiency pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH acrylamide; bisphenol A; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); LOC294328

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AIRE (autoimmune regulator)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Aire (autoimmune regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Aire (autoimmune regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AIRE (autoimmune regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AIRE (autoimmune regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Aire (autoimmune regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AIRE (autoimmune regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AIRE (autoimmune regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Aire (autoimmune regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Aire (autoimmune regulator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	AIRE (autoimmune regulator)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AIRE (autoimmune regulator)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Aire (autoimmune regulator)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	aire (autoimmune regulator)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	aire (autoimmune regulator)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RCO1	Alliance	DIOPT (OrthoFinder\|OrthoInspector)
Xenopus tropicalis (tropical clawed frog):	aire	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Aire^em1Ang

Genetic Models:

BN-Aire^em1Ang-/- ; SD.BN-Aire^em1Ang-/-

Candidate Gene For:

Iddm23

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	10,635,775 - 10,650,709 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	10,635,775 - 10,650,709 (+)	Ensembl				GRCr8
mRatBN7.2	20	10,636,058 - 10,651,060 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	10,636,123 - 10,651,060 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	11,335,440 - 11,350,201 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	10,696,343 - 10,711,104 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	11,168,390 - 11,183,326 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	11,365,630 - 11,380,636 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	11,365,697 - 11,380,631 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	13,535,776 - 13,550,486 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	10,980,031 - 10,996,102 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	12,141,888 - 12,156,863 (+)	NCBI		Celera
RGSC_v3.1	20	10,980,315 - 10,996,140 (+)	NCBI
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune polyendocrine syndrome (IMP,ISO)

autoimmune polyendocrine syndrome type 1 (ISO,ISS)

candidiasis (ISO)

Experimental Diabetes Mellitus (ISO)

genetic disease (ISO)

Guillain-Barre syndrome (ISS)

primary immunodeficiency disease (ISO)

Sjogren's syndrome (ISS)

Skin Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

Aflatoxin B2 alpha (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP)

butanal (ISO)

cadmium dichloride (EXP)

chloropicrin (ISO)

crocidolite asbestos (ISO)

D-mannitol (ISO)

dimethylarsinic acid (ISO)

heptanal (ISO)

hexanal (ISO)

hydrogen peroxide (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

menadione (ISO)

methapyrilene (ISO)

nonanal (ISO)

octanal (ISO)

paracetamol (ISO)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

propanal (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trimellitic anhydride (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

central tolerance induction to self antigen (IBA,IEA,ISO)

humoral immune response (IBA,IEA,ISO)

immune response (IEA)

negative thymic T cell selection (IBA,ISO)

peripheral T cell tolerance induction (IBA,IEA,ISO)

positive regulation of chemokine production (IEA,ISO)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IBA,IEA,ISO)

regulation of DNA-templated transcription (IEA,ISO)

regulation of thymocyte migration (IBA,IEA,ISO)

regulation of translation (IEA)

thymus epithelium morphogenesis (IBA,IEA,ISO)

tolerance induction (IEA)

Cellular Component

cytoplasm (IEA,ISO)

nuclear body (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

chromatin binding (IBA,IEA,ISO)

DNA binding (IEA)

histone binding (IBA,IEA,ISO)

identical protein binding (IEA,ISO)

metal ion binding (IEA)

protein binding (ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IBA,IEA,ISO)

translation regulator activity (IEA)

zinc ion binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

primary immunodeficiency pathway (IEA)

ubiquitin/proteasome degradation pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal NK cell number (IMP)

abnormal thymus morphology (IMP)

alopecia (IMP)

decreased circulating creatinine level (IMP)

decreased skin pigmentation (IMP)

increased autoantibody level (IMP)

increased autopod size (IMP)

nail dystrophy (IMP)

variable depigmentation (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Aire deficiency causes increased susceptibility to streptozotocin-induced murine type 1 diabetes.	Hassler S, etal., Scand J Immunol. 2008 Jun;67(6):569-80. Epub 2008 Apr 8.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-like Autoimmune Disease.	Ossart J, etal., J Immunol. 2018 Aug 1;201(3):874-887. doi: 10.4049/jimmunol.1701318. Epub 2018 Jun 29.
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Characterization of mutations in patients with autoimmune polyglandular syndrome type 1 (APS1).	Wang CY, etal., Hum Genet. 1998 Dec;103(6):681-5.

Additional References at PubMed

PMID:11156688	PMID:11274163	PMID:11533054	PMID:11854172	PMID:15712268	PMID:17599412	PMID:18292755	PMID:19015306	PMID:19446523	PMID:19923453	PMID:20185822	PMID:23382543
PMID:23993652	PMID:26084028	PMID:28540407

Genomics

Comparative Map Data

Aire
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	10,635,775 - 10,650,709 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	10,635,775 - 10,650,709 (+)	Ensembl				GRCr8
mRatBN7.2	20	10,636,058 - 10,651,060 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	10,636,123 - 10,651,060 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	11,335,440 - 11,350,201 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	10,696,343 - 10,711,104 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	11,168,390 - 11,183,326 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	11,365,630 - 11,380,636 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	11,365,697 - 11,380,631 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	13,535,776 - 13,550,486 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	10,980,031 - 10,996,102 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	12,141,888 - 12,156,863 (+)	NCBI		Celera
RGSC_v3.1	20	10,980,315 - 10,996,140 (+)	NCBI
Cytogenetic Map	20	p12	NCBI

AIRE
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	44,285,876 - 44,298,648 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	44,285,838 - 44,298,648 (+)	Ensembl			hg38	GRCh38
GRCh37	21	45,705,759 - 45,718,531 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	44,530,191 - 44,542,530 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	21	44,534,575 - 44,542,300	NCBI
Celera	21	30,811,017 - 30,823,364 (+)	NCBI		Celera
Cytogenetic Map	21	q22.3	NCBI
HuRef	21	31,076,211 - 31,088,675 (+)	NCBI		HuRef
CHM1_1	21	45,266,544 - 45,278,925 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	42,639,932 - 42,652,704 (+)	NCBI		T2T-CHM13v2.0

Aire
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	77,865,856 - 77,879,444 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	77,865,856 - 77,879,444 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	78,030,022 - 78,043,610 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	78,030,022 - 78,043,610 (-)	Ensembl			mm10	GRCm38
MGSCv37	10	77,492,776 - 77,506,325 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	77,433,160 - 77,446,709 (-)	NCBI		MGSCv36	mm8
Celera	10	79,069,034 - 79,082,580 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Aire
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	41,157,484 - 41,165,014 (-)	Ensembl
ChiLan1.0	NW_004955407	41,157,503 - 41,165,032 (-)	NCBI	ChiLan1.0	ChiLan1.0

AIRE
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	40,293,363 - 40,306,567 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	35,143,474 - 35,157,937 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	30,543,018 - 30,556,225 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	43,837,170 - 43,849,830 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	43,837,340 - 43,848,974 (+)	Ensembl			panPan2	panpan1.1

AIRE
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	38,139,513 - 38,149,294 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	38,139,099 - 38,149,296 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	37,296,701 - 37,307,469 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	37,686,832 - 37,697,601 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	37,686,636 - 37,696,584 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	37,553,994 - 37,564,750 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	37,534,760 - 37,545,522 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	38,032,729 - 38,043,507 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Aire
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	37,330,752 - 37,342,258 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	125,795 - 137,056 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	125,589 - 137,071 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AIRE
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	207,148,401 - 207,158,346 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	207,148,401 - 207,158,355 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	217,028,220 - 217,038,176 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AIRE
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	88,019,122 - 88,031,998 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	88,019,522 - 88,031,801 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	16,133,673 - 16,147,350 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aire
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	29,850,560 - 29,857,029 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624745	29,850,410 - 29,857,351 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Aire
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	18	1,315,187 - 1,330,228 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Aire
204 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	42
Count of miRNA genes:	39
Interacting mature miRNAs:	41
Transcripts:	ENSRNOT00000001611
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	4189476	49189476	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	1	26925056	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1	33724594	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26128279	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8043920	29865039	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600300	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24164241	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	1	34066551	Rat
631265	Iresp1	Immunoglobin response QTL1	8.3		blood anti-double stranded DNA antibody amount (VT:0004762)	serum anti-DNA antibody level (CMO:0001533)	20	9041099	11115921	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29193376	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	1	27341128	Rat
1598870	Bp289	Blood pressure QTL 289	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	8216359	53216359	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29193376	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29193376	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29193376	Rat
1581577	Pur15	Proteinuria QTL 15	4.38	0.0002	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	20	8043920	15089182	Rat
1598858	Cm61	Cardiac mass QTL 61	3.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	20	8216359	53216359	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29193376	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1	14100378	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578510	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600300	Rat

Markers in Region

D20Rat67

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	20	10,650,045 - 10,650,277 (+)	Marker Load Pipeline
mRatBN7.2	20	10,650,396 - 10,650,628 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	11,379,968 - 11,380,199	NCBI	Rnor6.0
Rnor_5.0	20	13,549,818 - 13,550,049	UniSTS	Rnor5.0
RGSC_v3.4	20	10,995,438 - 10,995,671	RGD	RGSC3.4
RGSC_v3.4	20	10,995,439 - 10,995,670	UniSTS	RGSC3.4
Celera	20	12,156,219 - 12,156,431	UniSTS
RGSC_v3.1	20	10,995,412 - 10,995,904	RGD
RH 3.4 Map	20	150.8	UniSTS
RH 3.4 Map	20	150.8	RGD
RH 2.0 Map	20	154.8	RGD
SHRSP x BN Map	20	11.54	RGD
Cytogenetic Map	20	p12	UniSTS

D20Got10

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	10,650,144 - 10,650,325 (+)	MAPPER	mRatBN7.2
mRatBN7.2	13	93,930,095 - 93,931,328 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	11,379,716 - 11,379,896	NCBI	Rnor6.0
Rnor_6.0	13	100,649,193 - 100,650,424	NCBI	Rnor6.0
Rnor_5.0	13	105,583,034 - 105,584,265	UniSTS	Rnor5.0
Rnor_5.0	20	13,549,566 - 13,549,746	UniSTS	Rnor5.0
RGSC_v3.4	20	10,995,189 - 10,995,367	RGD	RGSC3.4
RGSC_v3.4	20	10,995,190 - 10,995,367	UniSTS	RGSC3.4
RGSC_v3.4	13	98,225,241 - 98,226,472	UniSTS	RGSC3.4
Celera	20	12,155,967 - 12,156,147	UniSTS
Celera	13	93,463,578 - 93,464,809	UniSTS
RGSC_v3.1	20	10,995,417 - 10,995,594	RGD
RH 3.4 Map	20	144.9	RGD
RH 3.4 Map	20	144.9	UniSTS
RH 2.0 Map	20	155.9	RGD
Cytogenetic Map	20	p12	UniSTS

D20Ztm3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	10,952,740 - 10,953,040 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	11,669,099 - 11,669,398	NCBI	Rnor6.0
Rnor_5.0	20	13,834,856 - 13,835,155	UniSTS	Rnor5.0
RGSC_v3.4	20	11,336,555 - 11,336,854	UniSTS	RGSC3.4
Celera	20	12,456,436 - 12,456,748	UniSTS
Cytogenetic Map	20	p12	UniSTS

Genetic Models

This gene Aire is modified in the following models/strains:

BN-Aire^em1Ang-/- SD.BN-Aire^em1Ang-/-

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
7	12	31	28	32	17	21	17	2	76	33	29	19	31	15	2	2

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106379	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001434617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256247	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601601	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601602	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC109383	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001611 ⟹ ENSRNOP00000001611

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	10,635,775 - 10,650,709 (+)	Ensembl
mRatBN7.2 Ensembl	20	10,636,123 - 10,651,060 (+)	Ensembl
Rnor_6.0 Ensembl	20	11,365,697 - 11,380,631 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106293 ⟹ ENSRNOP00000082176

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	10,635,775 - 10,650,709 (+)	Ensembl
mRatBN7.2 Ensembl	20	10,636,123 - 10,651,060 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113259 ⟹ ENSRNOP00000094625

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	10,635,775 - 10,650,709 (+)	Ensembl
mRatBN7.2 Ensembl	20	10,636,123 - 10,651,060 (+)	Ensembl

RefSeq Acc Id:

NM_001106379 ⟹ NP_001099849

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	10,635,775 - 10,650,709 (+)	NCBI
mRatBN7.2	20	10,636,123 - 10,651,060 (+)	NCBI
Rnor_6.0	20	11,365,697 - 11,380,631 (+)	NCBI
Rnor_5.0	20	13,535,776 - 13,550,486 (+)	NCBI
RGSC_v3.4	20	10,980,031 - 10,996,102 (+)	RGD
Celera	20	12,141,888 - 12,156,863 (+)	RGD

Sequence:

show sequence

GAACGCAAGCGCGCGGGGGGCCAGCAGGGGGCGCCGAAGCGCAGACCCTGTCTGGAGGATGGCT
GGTGGGGATGGGATGCTGCGCCGCCTGCTGAGGCTGCACCGCACCGAGATCGCAGTGGCCATAG
ACAGCGCCTTTCCGCTGCTGCATGCTCTGGCCGACCACGACGTGGTCCCTGAGGACAAGTTCCA
GGAGACACTCCGGCTGAAAGAGAAGGAAGGCTGCCCCCAGGCCTTCCACGCCCTGCTGTCCTGG
CTCCTGACTCGGGACAGTGGGGCCATCCTGGATTTCTGGAGGGTTCTCTTTAAGGACTACAATC
TGGAGCGGTACAGCCGCCTGCATACCATCCTGGACGGCTTTCCAAAAGATGTGGACCTTAGCCA
GCCTCGGAAAGGGAGGAAGCCCCTTGCTGGTCCCAAGGCTTCAGTAGTGCCACCCAGACCCCCC
ACAAAGAGAAGAGCCCTGGAAGAGCCTCGAGCCACCCCACCAGCAACTCTGGCCTCAAAGAGCA
TCTCTAGCCCAGGTTCCCACTCAAAGGCCAAACCCCCTAAGAAGCCAGAGGGCAACTTGGAGTC
ACAGCGCCTCCCACTGGGAAACGGAATCCAGACCATGGCAGCTTCTGTCCAGAGAGCTGTGACT
GTGTCCTCCGGGGATGTCCCAGGATCCCGAGGGGCTGTGGAAGGGATCCTTATCCAGCAAGTAT
TCGAGTCAGGAGGATCCAAGAAGTGCATCCAGGTTGGAGGGGAGTTTTATAAACCCAGCAAGTT
CGAAGACCCCAGTGGCAATTTGAAGAACAAGACCCGAGGTGGTAGCAGCCTAAAGCCAGTGATC
CGAGGAAAGGGAACCCAGGGTAGAGATGAGCAGAAAGTGAGCCAGCAGTGTGGGGTCCCTCCCC
TTCCACCTCTTCCCAATGAGCCCCAAGTTCACCAGAAGAACGAGGATGAATGCGCTGTGTGCCA
TGACGGAGGCGAGCTCATCTGCTGTGACGGCTGTCCCCGCGCCTTCCACCTGGCTTGCCTGTCC
CCACCTCTGCAGGAGATCCCCAGTGGCCTTTGGAGATGTTCGTGCTGCCTCCAGGGCAGAATCC
AGCAGAACCTGTCCCAGCCTGAGGAGTCCAGGCCCCTGGAGCCATCTGCAGAGACCCCGATTCT
CCTGGGACTGAGGTCAGCTTCCGAGAAAACCAGGGTCCTGTCCAGGGAGCTGCCAGCCGGCTCA
GATGCTGCAGTCACATATGCGAACCTGCTGGCCCCACCTTCCACAGCCCCTGTTCTGGAGCCTT
CAGCACTCTGCCCTCTACCGAGTGCTGGGGCGGAAGGGCAGCCGGGTCCGACACTGAGCGCGCG
ATGCGGTGTGTGCGGCGACTCCACCGACGTGCTGCGGTGCGCACACTGTGCCGCTGCCTTTCAC
TGGCGCTGCCACTTCCCGATGGCTGCTGTCCGGCCAGGGACCAATCTCCGCTGCAAGTCCTGCT
CGGCAGAACCGACTCCCACGCCAGGCGTGCCAGGCGAGGCTGTGCCCACCGCTGTGCGTCCCAC
ACCTGGGCTTGCCAAGGTAGGGGACGACTCTGCTAGTCATGACCCTGTTCTGCATAGGGATGAC
CTGGAGTCCCTCCTGAATGAGCACTCCTTTGACGGCATCCTGCAGTGGGCCATCCAGAGCATGT
CACGCCCGCTGGCCGAGACACCACCCTTTTCTTCCTGACTCCAGGCAGCATAGCACCAGCCCCC
ACCCCACCCCATCAGATGACGCCTTATACCTGCAGCCCCTCCGTTCTGAGAGGACTAGGCTAGT
TAGGGCCAAGAGCTGCAGGACTCAGCTGGCAGACGGCCCTGGTCTTTGTGGAGATGCAAGGCCA
CTCTGTGTCTTGAAATTAAAGTCACTTCTGTGTGC

hide sequence

RefSeq Acc Id:

XM_006256247 ⟹ XP_006256309

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	10,635,781 - 10,650,709 (+)	NCBI
mRatBN7.2	20	10,636,058 - 10,651,051 (+)	NCBI
Rnor_6.0	20	11,365,630 - 11,380,636 (+)	NCBI
Rnor_5.0	20	13,535,776 - 13,550,486 (+)	NCBI

Sequence:

show sequence

GGAGTAAGTATAAACGCTCACAGGTGCCTGCCTCTCCCGATAGCACCTAGACACCCAAGGGAGA
AGGGAACGCAAGCGCGCGGGGGGCCAGCAGGGGGCGCCGAAGCGCAGACCCTGTCTGGAGGATG
GCTGGTGGGGATGGGATGCTGCGCCGCCTGCTGAGGCTGCACCGCACCGAGATCGCAGTGGCCA
TAGACAGCGCCTTTCCGCTGCTGCATGCTCTGGCCGACCACGACGTGGTCCCTGAGGACAAGTT
CCAGGAGACACTCCGGCTGAAAGAGAAGGAAGGCTGCCCCCAGGCCTTCCACGCCCTGCTGTCC
TGGCTCCTGACTCGGGACAGTGGGGCCATCCTGGATTTCTGGAGGGTTCTCTTTAAGGACTACA
ATCTGGAGCGGTACAGCCGCCTGCATACCATCCTGGACGGCTTTCCAAAAGATGTGGACCTTAG
CCAGCCTCGGAAAGGGAGGAAGCCCCTTGCTGGTCCCAAGGCTTCAGTAGTGCCACCCAGACCC
CCCACAAAGAGAAGAGCCCTGGAAGAGCCTCGAGCCACCCCACCAGCAACTCTGGCCTCAAAGA
GCATCTCTAGCCCAGGTTCCCACTCAAAGGCCAAACCCCCTAAGAAGCCAGAGGGCAACTTGGA
GTCACAGCGCCTCCCACTGGGAAACGGAATCCAGACCATGGCAGCTTCTGTCCAGAGAGCTGTG
ACTGTGTCCTCCGGGGATGTCCCAGGATCCCGAGGGGCTGTGGAAGGGATCCTTATCCAGCAAG
TATTCGAGTCAGGAGGATCCAAGAAGTGCATCCAGGTTGGAGGGGAGTTTTATAAACCCAGCAA
GTTCGAAGACCCCAGTGGCAATTTGAAGAACAAGACCCGAGGTGGTAGCAGCCTAAAGCCAGTG
ATCCGAGGAAAGGGAACCCAGGTCACTATACCTGGTAGAGATGAGCAGAAAGTGAGCCAGCAGT
GTGGGGTCCCTCCCCTTCCACCTCTTCCCAATGAGCCCCAAGTTCACCAGAAGAACGAGGATGA
ATGCGCTGTGTGCCATGACGGAGGCGAGCTCATCTGCTGTGACGGCTGTCCCCGCGCCTTCCAC
CTGGCTTGCCTGTCCCCACCTCTGCAGGAGATCCCCAGTGGCCTTTGGAGATGTTCGTGCTGCC
TCCAGGGCAGAATCCAGCAGAACCTGTCCCAGCCTGAGGAGTCCAGGCCCCTGGAGCCATCTGC
AGAGACCCCGATTCTCCTGGGACTGAGGTCAGCTTCCGAGAAAACCAGGGTCCTGTCCAGGGAG
CTGCCAGCCGGCTCAGATGCTGCAGTCACATATGCGAACCTGCTGGCCCCACCTTCCACAGCCC
CTGTTCTGGAGCCTTCAGCACTCTGCCCTCTACCGAGTGCTGGGGCGGAAGGGCAGCCGGGTCC
GACACTGAGCGCGCGATGCGGTGTGTGCGGCGACTCCACCGACGTGCTGCGGTGCGCACACTGT
GCCGCTGCCTTTCACTGGCGCTGCCACTTCCCGATGGCTGCTGTCCGGCCAGGGACCAATCTCC
GCTGCAAGTCCTGCTCGGCAGAACCGACTCCCACGCCAGGCGTGCCAGGCGAGGCTGTGCCCAC
CGCTGTGCGTCCCACACCTGGGCTTGCCAAGGTAGGGGACGACTCTGCTAGTCATGACCCTGTT
CTGCATAGGGATGACCTGGAGTCCCTCCTGAATGAGCACTCCTTTGACGGCATCCTGCAGTGGG
CCATCCAGAGCATGTCACGCCCGCTGGCCGAGACACCACCCTTTTCTTCCTGACTCCAGGCAGC
ATAGCACCAGCCCCCACCCCACCCCATCAGATGACGCCTTATACCTGCAGCCCCTCCGTTCTGA
GAGGACTAGGCTAGTTAGGGCCAAGAGCTGCAGGACTCAGCTGGCAGACGGCCCTGGTCTTTGT
GGAGATGCAAGGCCACTCTGTGTCTTGAAATTAAAGTCACTTCTGTGTGCTTTGA

hide sequence

RefSeq Acc Id:

XM_017601599 ⟹ XP_017457088

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	10,635,833 - 10,648,631 (+)	NCBI
mRatBN7.2	20	10,636,058 - 10,649,758 (+)	NCBI
Rnor_6.0	20	11,365,630 - 11,378,553 (+)	NCBI

Sequence:

show sequence

GGAGTAAGTATAAACGCTCACAGGTGCCTGCCTCTCCCGATAGCACCTAGACACCCAAGGGAGA
AGGGAACGCAAGCGCGCGGGGGGCCAGCAGGGGGCGCCGAAGCGCAGACCCTGTCTGGAGGATG
GCTGGTGGGGATGGGATGCTGCGCCGCCTGCTGAGGCTGCACCGCACCGAGATCGCAGTGGCCA
TAGACAGCGCCTTTCCGCTGCTGCATGCTCTGGCCGACCACGACGTGGTCCCTGAGGACAAGTT
CCAGGAGACACTCCGGCTGAAAGAGAAGGAAGGCTGCCCCCAGGCCTTCCACGCCCTGCTGTCC
TGGCTCCTGACTCGGGACAGTGGGGCCATCCTGGATTTCTGGAGGGTTCTCTTTAAGGACTACA
ATCTGGAGCGGTACAGCCGCCTGCATACCATCCTGGACGGCTTTCCAAAAGATGTGGACCTTAG
CCAGCCTCGGAAAGGGAGGAAGCCCCTTGCTGGTCCCAAGGCTTCAGTAGTGCCACCCAGACCC
CCCACAAAGAGAAGAGCCCTGGAAGAGCCTCGAGCCACCCCACCAGCAACTCTGGCCTCAAAGA
GCATCTCTAGCCCAGGTTCCCACTCAAAGGCCAAACCCCCTAAGAAGCCAGAGGGCAACTTGGA
GTCACAGCGCCTCCCACTGGGAAACGGAATCCAGACCATGGCAGCTTCTGTCCAGAGAGCTGTG
ACTGTGTCCTCCGGGGATGTCCCAGGATCCCGAGGGGCTGTGGAAGGGATCCTTATCCAGCAAG
TATTCGAGTCAGGAGGATCCAAGAAGTGCATCCAGGTTGGAGGGGAGTTTTATAAACCCAGCAA
GTTCGAAGACCCCAGTGGCAATTTGAAGAACAAGACCCGAGGTGGTAGCAGCCTAAAGCCAGTG
ATCCGAGGAAAGGGAACCCAGGTCACTATACCTGGTAGAGATGAGCAGAAAGTGAGCCAGCAGT
GTGGGGTCCCTCCCCTTCCACCTCTTCCCAATGAGCCCCAAGTTCACCAGAAGAACGAGGATGA
ATGCGCTGTGTGCCATGACGGAGGCGAGCTCATCTGCTGTGACGGCTGTCCCCGCGCCTTCCAC
CTGGCTTGCCTGTCCCCACCTCTGCAGGAGATCCCCAGTGGCCTTTGGAGATGTTCGTGCTGCC
TCCAGGGCAGAATCCAGCAGAACCTGTCCCAGCCTGAGGAGTCCAGGCCCCTGGAGCCATCTGC
AGAGACCCCGGACCAATCTCCGCTGCAAGTCCTGCTCGGCAGAACCGACTCCCACGCCAGGCGT
GCCAGGCGAGGCTGTGCCCACCGCTGTGCGTCCCACACCTGGGCTTGCCAAGGTAGGGGACGAC
TCTGCTAG

hide sequence

RefSeq Acc Id:

XM_017601601 ⟹ XP_017457090

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	10,635,833 - 10,648,631 (+)	NCBI
mRatBN7.2	20	10,636,058 - 10,649,758 (+)	NCBI
Rnor_6.0	20	11,365,630 - 11,378,553 (+)	NCBI

Sequence:

show sequence

GGAGTAAGTATAAACGCTCACAGGTGCCTGCCTCTCCCGATAGCACCTAGACACCCAAGGGAGA
AGGGAACGCAAGCGCGCGGGGGGCCAGCAGGGGGCGCCGAAGCGCAGACCCTGTCTGGAGGATG
GCTGGTGGGGATGGGATGCTGCGCCGCCTGCTGAGGCTGCACCGCACCGAGATCGCAGTGGCCA
TAGACAGCGCCTTTCCGCTGCTGCATGCTCTGGCCGACCACGACGTGGTCCCTGAGGACAAGTT
CCAGGAGACACTCCGGCTGAAAGAGAAGGAAGGCTGCCCCCAGGCCTTCCACGCCCTGCTGTCC
TGGCTCCTGACTCGGGACAGTGGGGCCATCCTGGATTTCTGGAGGGTTCTCTTTAAGGACTACA
ATCTGGAGCGGTACAGCCGCCTGCATACCATCCTGGACGGCTTTCCAAAAGATGTGGACCTTAG
CCAGCCTCGGAAAGGGAGGAAGCCCCTTGCTGGTCCCAAGGCTTCAGTAGTGCCACCCAGACCC
CCCACAAAGAGAAGAGCCCTGGAAGAGCCTCGAGCCACCCCACCAGCAACTCTGGCCTCAAAGA
GCATCTCTAGCCCAGGTTCCCACTCAAAGGCCAAACCCCCTAAGAAGCCAGAGGGCAACTTGGA
GTCACAGCGCCTCCCACTGGGAAACGGAATCCAGACCATGGCAGCTTCTGTCCAGAGAGCTGTG
ACTGTGTCCTCCGGGGATGTCCCAGGATCCCGAGGGGCTGTGGAAGGGATCCTTATCCAGCAAG
TATTCGAGTCAGGAGGATCCAAGAAGTGCATCCAGGTTGGAGGGGAGTTTTATAAACCCAGCAA
GTTCGAAGACCCCAGTGGCAATTTGAAGAACAAGACCCGAGGTGGTAGCAGCCTAAAGCCAGTG
ATCCGAGGAAAGGGAACCCAGGGTAGAGATGAGCAGAAAGTGAGCCAGCAGTGTGGGGTCCCTC
CCCTTCCACCTCTTCCCAATGAGCCCCAAGTTCACCAGAAGAACGAGGATGAATGCGCTGTGTG
CCATGACGGAGGCGAGCTCATCTGCTGTGACGGCTGTCCCCGCGCCTTCCACCTGGCTTGCCTG
TCCCCACCTCTGCAGGAGATCCCCAGTGGCCTTTGGAGATGTTCGTGCTGCCTCCAGGGCAGAA
TCCAGCAGAACCTGTCCCAGCCTGAGGAGTCCAGGCCCCTGGAGCCATCTGCAGAGACCCCGGA
CCAATCTCCGCTGCAAGTCCTGCTCGGCAGAACCGACTCCCACGCCAGGCGTGCCAGGCGAGGC
TGTGCCCACCGCTGTGCGTCCCACACCTGGGCTTGCCAAGGTAGGGGACGACTCTGCTAG

hide sequence

RefSeq Acc Id:

XM_063279042 ⟹ XP_063135112

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	10,635,833 - 10,650,614 (+)	NCBI

RefSeq Acc Id:

XM_063279043 ⟹ XP_063135113

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	10,635,833 - 10,650,614 (+)	NCBI

RefSeq Acc Id:

XM_063279044 ⟹ XP_063135114

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	10,635,833 - 10,650,614 (+)	NCBI

RefSeq Acc Id:

XM_063279045 ⟹ XP_063135115

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	10,635,833 - 10,650,614 (+)	NCBI

RefSeq Acc Id:

XM_063279046 ⟹ XP_063135116

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	10,635,833 - 10,650,614 (+)	NCBI

RefSeq Acc Id:

XM_063279047 ⟹ XP_063135117

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	10,635,833 - 10,650,614 (+)	NCBI

RefSeq Acc Id:

XM_063279048 ⟹ XP_063135118

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	10,635,833 - 10,648,631 (+)	NCBI

RefSeq Acc Id:

XM_063279049 ⟹ XP_063135119

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	10,635,833 - 10,648,631 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099849	(Get FASTA)	NCBI Sequence Viewer
	NP_001421546	(Get FASTA)	NCBI Sequence Viewer
	XP_006256309	(Get FASTA)	NCBI Sequence Viewer
	XP_017457088	(Get FASTA)	NCBI Sequence Viewer
	XP_017457090	(Get FASTA)	NCBI Sequence Viewer
	XP_063135112	(Get FASTA)	NCBI Sequence Viewer
	XP_063135113	(Get FASTA)	NCBI Sequence Viewer
	XP_063135114	(Get FASTA)	NCBI Sequence Viewer
	XP_063135115	(Get FASTA)	NCBI Sequence Viewer
	XP_063135116	(Get FASTA)	NCBI Sequence Viewer
	XP_063135117	(Get FASTA)	NCBI Sequence Viewer
	XP_063135118	(Get FASTA)	NCBI Sequence Viewer
	XP_063135119	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL97063	(Get FASTA)	NCBI Sequence Viewer
	EDL97064	(Get FASTA)	NCBI Sequence Viewer
	EDL97065	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001611
	ENSRNOP00000001611.4
	ENSRNOP00000082176
	ENSRNOP00000082176.1
	ENSRNOP00000094625
	ENSRNOP00000094625.1

RefSeq Acc Id:

NP_001099849 ⟸ NM_001106379

- UniProtKB:

A6JK47 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGGDGMLRRLLRLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQETLRLKEKEGCPQAFHALL
SWLLTRDSGAILDFWRVLFKDYNLERYSRLHTILDGFPKDVDLSQPRKGRKPLAGPKASVVPPR
PPTKRRALEEPRATPPATLASKSISSPGSHSKAKPPKKPEGNLESQRLPLGNGIQTMAASVQRA
VTVSSGDVPGSRGAVEGILIQQVFESGGSKKCIQVGGEFYKPSKFEDPSGNLKNKTRGGSSLKP
VIRGKGTQGRDEQKVSQQCGVPPLPPLPNEPQVHQKNEDECAVCHDGGELICCDGCPRAFHLAC
LSPPLQEIPSGLWRCSCCLQGRIQQNLSQPEESRPLEPSAETPILLGLRSASEKTRVLSRELPA
GSDAAVTYANLLAPPSTAPVLEPSALCPLPSAGAEGQPGPTLSARCGVCGDSTDVLRCAHCAAA
FHWRCHFPMAAVRPGTNLRCKSCSAEPTPTPGVPGEAVPTAVRPTPGLAKVGDDSASHDPVLHR
DDLESLLNEHSFDGILQWAIQSMSRPLAETPPFSS

hide sequence

RefSeq Acc Id:

XP_006256309 ⟸ XM_006256247

- Peptide Label:

isoform X1

- Sequence:

show sequence

MAGGDGMLRRLLRLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQETLRLKEKEGCPQAFHALL
SWLLTRDSGAILDFWRVLFKDYNLERYSRLHTILDGFPKDVDLSQPRKGRKPLAGPKASVVPPR
PPTKRRALEEPRATPPATLASKSISSPGSHSKAKPPKKPEGNLESQRLPLGNGIQTMAASVQRA
VTVSSGDVPGSRGAVEGILIQQVFESGGSKKCIQVGGEFYKPSKFEDPSGNLKNKTRGGSSLKP
VIRGKGTQVTIPGRDEQKVSQQCGVPPLPPLPNEPQVHQKNEDECAVCHDGGELICCDGCPRAF
HLACLSPPLQEIPSGLWRCSCCLQGRIQQNLSQPEESRPLEPSAETPILLGLRSASEKTRVLSR
ELPAGSDAAVTYANLLAPPSTAPVLEPSALCPLPSAGAEGQPGPTLSARCGVCGDSTDVLRCAH
CAAAFHWRCHFPMAAVRPGTNLRCKSCSAEPTPTPGVPGEAVPTAVRPTPGLAKVGDDSASHDP
VLHRDDLESLLNEHSFDGILQWAIQSMSRPLAETPPFSS

hide sequence

RefSeq Acc Id:	XP_017457088 ⟸ XM_017601599
- Peptide Label:	isoform X8
- UniProtKB:	A0A8I6AL71 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGGDGMLRRLLRLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQETLRLKEKEGCPQAFHALL SWLLTRDSGAILDFWRVLFKDYNLERYSRLHTILDGFPKDVDLSQPRKGRKPLAGPKASVVPPR PPTKRRALEEPRATPPATLASKSISSPGSHSKAKPPKKPEGNLESQRLPLGNGIQTMAASVQRA VTVSSGDVPGSRGAVEGILIQQVFESGGSKKCIQVGGEFYKPSKFEDPSGNLKNKTRGGSSLKP VIRGKGTQVTIPGRDEQKVSQQCGVPPLPPLPNEPQVHQKNEDECAVCHDGGELICCDGCPRAF HLACLSPPLQEIPSGLWRCSCCLQGRIQQNLSQPEESRPLEPSAETPDQSPLQVLLGRTDSHAR RARRGCAHRCASHTWACQGRGRLC hide sequence

RefSeq Acc Id:	XP_017457090 ⟸ XM_017601601
- Peptide Label:	isoform X10
- UniProtKB:	A6JK49 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGGDGMLRRLLRLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQETLRLKEKEGCPQAFHALL SWLLTRDSGAILDFWRVLFKDYNLERYSRLHTILDGFPKDVDLSQPRKGRKPLAGPKASVVPPR PPTKRRALEEPRATPPATLASKSISSPGSHSKAKPPKKPEGNLESQRLPLGNGIQTMAASVQRA VTVSSGDVPGSRGAVEGILIQQVFESGGSKKCIQVGGEFYKPSKFEDPSGNLKNKTRGGSSLKP VIRGKGTQGRDEQKVSQQCGVPPLPPLPNEPQVHQKNEDECAVCHDGGELICCDGCPRAFHLAC LSPPLQEIPSGLWRCSCCLQGRIQQNLSQPEESRPLEPSAETPDQSPLQVLLGRTDSHARRARR GCAHRCASHTWACQGRGRLC hide sequence

Ensembl Acc Id:

ENSRNOP00000001611 ⟸ ENSRNOT00000001611

Ensembl Acc Id:

ENSRNOP00000082176 ⟸ ENSRNOT00000106293

Ensembl Acc Id:

ENSRNOP00000094625 ⟸ ENSRNOT00000113259

RefSeq Acc Id:	XP_063135114 ⟸ XM_063279044
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I5ZTP2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063135112 ⟸ XM_063279042
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063135115 ⟸ XM_063279045
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_063135116 ⟸ XM_063279046
- Peptide Label:	isoform X6
- UniProtKB:	A6JK48 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063135113 ⟸ XM_063279043
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063135117 ⟸ XM_063279047
- Peptide Label:	isoform X7

RefSeq Acc Id:	XP_063135118 ⟸ XM_063279048
- Peptide Label:	isoform X9

RefSeq Acc Id:	XP_063135119 ⟸ XM_063279049
- Peptide Label:	isoform X11

Protein Domains

HSR PHD-type SAND

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZV49-F1-model_v2	AlphaFold	D3ZV49	1-547	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311139	AgrOrtholog
BioCyc Gene	G2FUF-4274	BioCyc
Ensembl Genes	ENSRNOG00000001213	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001611	ENTREZGENE
	ENSRNOT00000001611.6	UniProtKB/TrEMBL
	ENSRNOT00000106293	ENTREZGENE
	ENSRNOT00000106293.2	UniProtKB/TrEMBL
	ENSRNOT00000113259	ENTREZGENE
	ENSRNOT00000113259.2	UniProtKB/TrEMBL
Gene3D-CATH	3.10.390.10	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
InterPro	AIRE	UniProtKB/TrEMBL
	AIRE_PHD2	UniProtKB/TrEMBL
	SAND_dom	UniProtKB/TrEMBL
	SAND_dom-like	UniProtKB/TrEMBL
	Sp100	UniProtKB/TrEMBL
	Sp110/Sp140/Sp140L-like	UniProtKB/TrEMBL
	Zinc_finger_PHD-type_CS	UniProtKB/TrEMBL
	Znf_FYVE_PHD	UniProtKB/TrEMBL
	Znf_PHD	UniProtKB/TrEMBL
	Znf_PHD-finger	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	rno:294328	UniProtKB/TrEMBL
NCBI Gene	294328	ENTREZGENE
PANTHER	AUTOIMMUNE REGULATOR	UniProtKB/TrEMBL
	NUCLEAR BODY PROTEIN SP140	UniProtKB/TrEMBL
	RIKEN CDNA A630001G21 GENE	UniProtKB/TrEMBL
Pfam	PHD	UniProtKB/TrEMBL
	SAND	UniProtKB/TrEMBL
	Sp100	UniProtKB/TrEMBL
PhenoGen	Aire	PhenoGen
PRINTS	AIREGULATOR	UniProtKB/TrEMBL
PROSITE	HSR	UniProtKB/TrEMBL
	SAND	UniProtKB/TrEMBL
	ZF_PHD_1	UniProtKB/TrEMBL
	ZF_PHD_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001213	RatGTEx
SMART	PHD	UniProtKB/TrEMBL
	SAND	UniProtKB/TrEMBL
Superfamily-SCOP	FYVE_PHD_ZnF	UniProtKB/TrEMBL
	SAND_like	UniProtKB/TrEMBL
UniProt	A0A8I5ZTP2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AL71	ENTREZGENE, UniProtKB/TrEMBL
	A6JK47	ENTREZGENE, UniProtKB/TrEMBL
	A6JK48	ENTREZGENE, UniProtKB/TrEMBL
	A6JK49	ENTREZGENE, UniProtKB/TrEMBL
	D3ZV49	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-26	Aire	autoimmune regulator	Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	Aire_predicted	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Aire_predicted	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Mammalian Phenotype