Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-alpha-phellandrene | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | alpha phellandrene results in increased expression of SMIM14 mRNA | CTD | PMID:25075043 | 1,2-dimethylhydrazine | multiple interactions | ISO | Smim14 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SMIM14 mRNA | CTD | PMID:22206623 | 17beta-estradiol | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of SMIM14 mRNA | CTD | PMID:23019147 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of SMIM14 mRNA | CTD | PMID:29581250 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of SMIM14 mRNA] | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SMIM14 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SMIM14 mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SMIM14 mRNA | CTD | PMID:21215274 | 2-deoxy-D-glucose | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Deoxyglucose results in decreased expression of SMIM14 mRNA | CTD | PMID:33770205 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | SMIM14 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SMIM14 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | SMIM14 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of SMIM14 gene | CTD | PMID:31601247 | 4-hydroxyphenyl retinamide | increases expression | ISO | Smim14 (Mus musculus) | 6480464 | Fenretinide results in increased expression of SMIM14 mRNA | CTD | PMID:28973697 | 5-aza-2'-deoxycytidine | affects expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Decitabine affects the expression of SMIM14 mRNA | CTD | PMID:23300844 | 5-fluorouracil | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Fluorouracil results in increased expression of SMIM14 mRNA | CTD | PMID:16510598 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of SMIM14 mRNA | CTD | PMID:31881176 | aflatoxin B1 | affects expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of SMIM14 protein | CTD | PMID:20106945 | aflatoxin B1 | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of SMIM14 mRNA | CTD | PMID:27153756 | aflatoxin B1 | decreases methylation | ISO | SMIM14 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of SMIM14 gene | CTD | PMID:27153756 | alpha-phellandrene | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | alpha phellandrene results in increased expression of SMIM14 mRNA | CTD | PMID:25075043 | ampicillin | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Ampicillin results in decreased expression of SMIM14 mRNA | CTD | PMID:21632981 | antirheumatic drug | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of SMIM14 mRNA | CTD | PMID:24449571 | aristolochic acid A | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of SMIM14 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of SMIM14 mRNA | CTD | PMID:20106945 more ... | benzo[a]pyrene | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SMIM14 mRNA | CTD | PMID:32234424 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20018196 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SMIM14 mRNA | CTD | PMID:25181051 more ... | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SMIM14 mRNA | CTD | PMID:30903817 | bisphenol A | multiple interactions | ISO | SMIM14 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SMIM14 mRNA | CTD | PMID:28628672 | bleomycin A2 | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Bleomycin results in decreased expression of SMIM14 mRNA | CTD | PMID:33770205 | calcitriol | multiple interactions | ISO | SMIM14 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of SMIM14 mRNA | CTD | PMID:21592394 | calcitriol | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of SMIM14 mRNA | CTD | PMID:21592394 | carbamazepine | affects expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of SMIM14 mRNA | CTD | PMID:25979313 | cisplatin | affects expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Cisplatin affects the expression of SMIM14 mRNA | CTD | PMID:23300844 | cisplatin | multiple interactions | ISO | SMIM14 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of SMIM14 mRNA | CTD | PMID:27392435 | clofibrate | decreases expression | ISO | Smim14 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of SMIM14 mRNA | CTD | PMID:23811191 | coumestrol | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of SMIM14 mRNA | CTD | PMID:19167446 | crocidolite asbestos | decreases expression | ISO | Smim14 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of SMIM14 mRNA | CTD | PMID:29279043 | cyclosporin A | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of SMIM14 mRNA | CTD | PMID:20106945 more ... | dexamethasone | multiple interactions | ISO | SMIM14 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SMIM14 mRNA | CTD | PMID:28628672 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of SMIM14 mRNA | CTD | PMID:21266533 | dicrotophos | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of SMIM14 mRNA | CTD | PMID:28302478 | dinophysistoxin 1 | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | dinophysistoxin 1 results in decreased expression of SMIM14 mRNA | CTD | PMID:28939011 | dioxygen | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Oxygen deficiency results in increased expression of SMIM14 mRNA | CTD | PMID:17175027 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of SMIM14 mRNA | CTD | PMID:21551480 | dorsomorphin | multiple interactions | ISO | SMIM14 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SMIM14 mRNA | CTD | PMID:29803840 | ethanol | multiple interactions | ISO | Smim14 (Mus musculus) | 6480464 | Ethanol affects the expression of and affects the splicing of SMIM14 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | ISO | Smim14 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SMIM14 mRNA | CTD | PMID:22206623 | genistein | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Genistein results in decreased expression of SMIM14 mRNA | CTD | PMID:23019147 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of SMIM14 mRNA | CTD | PMID:33387578 | hydroxyurea | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Hydroxyurea results in decreased expression of SMIM14 mRNA | CTD | PMID:33770205 | indometacin | multiple interactions | ISO | SMIM14 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SMIM14 mRNA | CTD | PMID:28628672 | inulin | multiple interactions | ISO | Smim14 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of SMIM14 mRNA | CTD | PMID:36331819 | manganese atom | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Manganese results in increased expression of SMIM14 mRNA | CTD | PMID:17175027 | manganese(0) | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Manganese results in increased expression of SMIM14 mRNA | CTD | PMID:17175027 | manganese(II) chloride | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | manganese chloride results in increased expression of SMIM14 mRNA | CTD | PMID:17175027 | mercury atom | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Mercury results in increased expression of SMIM14 mRNA | CTD | PMID:16823088 | mercury(0) | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Mercury results in increased expression of SMIM14 mRNA | CTD | PMID:16823088 | methyl methanesulfonate | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of SMIM14 mRNA | CTD | PMID:23649840 | niclosamide | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Niclosamide results in increased expression of SMIM14 mRNA | CTD | PMID:36318118 | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of SMIM14 mRNA | CTD | PMID:24136188 | p-chloromercuribenzoic acid | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in decreased expression of SMIM14 mRNA | CTD | PMID:26272509 | p-chloromercuribenzoic acid | multiple interactions | ISO | SMIM14 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMIM14 mRNA | CTD | PMID:27188386 | panobinostat | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Panobinostat results in increased expression of SMIM14 mRNA | CTD | PMID:33770205 | paracetamol | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of SMIM14 mRNA | CTD | PMID:22230336 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SMIM14 mRNA | CTD | PMID:33387578 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Smim14 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of SMIM14 mRNA | CTD | PMID:36331819 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of SMIM14 mRNA | CTD | PMID:28374803 | SB 431542 | multiple interactions | ISO | SMIM14 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of SMIM14 mRNA | CTD | PMID:25895662 | sirolimus | multiple interactions | ISO | SMIM14 (Homo sapiens) | 6480464 | Sirolimus inhibits the reaction [TP73 protein results in increased expression of SMIM14 mRNA] | CTD | PMID:21245298 | sodium arsenite | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SMIM14 mRNA | CTD | PMID:34032870 | sunitinib | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of SMIM14 mRNA | CTD | PMID:31533062 | tacrolimus hydrate | increases expression | ISO | Smim14 (Mus musculus) | 6480464 | Tacrolimus results in increased expression of SMIM14 mRNA | CTD | PMID:25270620 | temozolomide | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of SMIM14 mRNA | CTD | PMID:31758290 | testosterone | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Testosterone results in increased expression of SMIM14 mRNA | CTD | PMID:21592394 | testosterone | multiple interactions | ISO | SMIM14 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of SMIM14 mRNA | CTD | PMID:21592394 | tetrachloromethane | increases expression | ISO | Smim14 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of SMIM14 mRNA | CTD | PMID:27339419 and PMID:31919559 | thapsigargin | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Thapsigargin results in increased expression of SMIM14 mRNA | CTD | PMID:22378314 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of SMIM14 mRNA | CTD | PMID:23411599 and PMID:34492290 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of SMIM14 mRNA | CTD | PMID:33387578 | trichostatin A | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of SMIM14 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | SMIM14 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMIM14 mRNA | CTD | PMID:27188386 | trovafloxacin | decreases expression | ISO | Smim14 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of SMIM14 mRNA | CTD | PMID:35537566 | tunicamycin | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of SMIM14 mRNA | CTD | PMID:22378314 and PMID:29453283 | urethane | increases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Urethane results in increased expression of SMIM14 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SMIM14 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | SMIM14 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SMIM14 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | SMIM14 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SMIM14 mRNA | CTD | PMID:27188386 | vinclozolin | decreases methylation | EXP | | 6480464 | vinclozolin results in decreased methylation of SMIM14 gene | CTD | PMID:31682807 | |