Me3 (malic enzyme 3) - Rat Genome Database

Name: Me3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Me3 (malic enzyme 3) Rattus norvegicus

Analyze

Symbol:

Me3

Name:

malic enzyme 3

RGD ID:

1311070

Description:

Predicted to enable NADP+ binding activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Predicted to be active in mitochondrial matrix. Orthologous to human ME3 (malic enzyme 3); PARTICIPATES IN pyruvate metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC361602; malic enzyme 3, NADP(+)-dependent, mitochondrial; mitochondrial malic enzyme 3; NADP-dependent malic enzyme, mitochondrial

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ME3 (malic enzyme 3)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Me3 (malic enzyme 3, NADP(+)-dependent, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Me3 (malic enzyme 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ME3 (malic enzyme 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ME3 (malic enzyme 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Me3 (malic enzyme 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ME3 (malic enzyme 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ME3 (malic enzyme 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Me3 (malic enzyme 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ME1 (malic enzyme 1)	HGNC	OrthoDB
Homo sapiens (human):	LOC122455342 (testis-specific serine/proline-rich protein)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ME3 (malic enzyme 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Me3 (malic enzyme 3, NADP(+)-dependent, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	me3 (malic enzyme 3, NADP(+)-dependent, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MAE1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG7848	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Men	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Men-b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Menl-1	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Menl-2	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	men-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	me3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	152,946,595 - 153,148,026 (+)	NCBI		GRCr8
mRatBN7.2	1	143,534,024 - 143,735,551 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	143,534,139 - 143,733,132 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	151,479,136 - 151,672,663 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	158,655,512 - 158,849,041 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	151,529,440 - 151,722,961 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	153,861,535 - 154,058,608 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	153,861,569 - 154,056,654 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	160,166,289 - 160,361,740 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	146,220,504 - 146,422,659 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	146,297,071 - 146,500,992 (+)	NCBI
Celera	1	141,786,200 - 141,975,029 (+)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

exudative vitreoretinopathy 1 (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1,1-dichloroethene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

Benzo[ghi]perylene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

cisplatin (EXP,ISO)

clofibric acid (EXP)

cobalt dichloride (ISO)

dexamethasone (ISO)

dibenz[a,h]anthracene (ISO)

dichloroacetic acid (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethanol (ISO)

flutamide (EXP)

fonofos (ISO)

furan (EXP)

genistein (ISO)

GW 4064 (ISO)

iron dichloride (ISO)

kojic acid (ISO)

maneb (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

morphine (ISO)

N-nitrosodiethylamine (EXP)

niclosamide (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

parathion (ISO)

PCB138 (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

rac-lactic acid (ISO)

rotenone (EXP)

SB 431542 (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulforaphane (EXP,ISO)

sunitinib (ISO)

tamoxifen (ISO)

terbufos (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

tributylstannane (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

malate metabolic process (IBA,ISO)

pyruvate metabolic process (IBA,ISO)

Cellular Component

mitochondrial matrix (ISO)

mitochondrion (IBA)

Molecular Function

malate dehydrogenase (decarboxylating) (NADP+) activity (IBA,ISO)

malic enzyme activity (ISO)

metal ion binding (IEA)

NAD binding (IEA)

NADP+ binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

pyruvate metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7818469	PMID:18614015	PMID:25594249

Genomics

Comparative Map Data

Me3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	152,946,595 - 153,148,026 (+)	NCBI		GRCr8
mRatBN7.2	1	143,534,024 - 143,735,551 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	143,534,139 - 143,733,132 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	151,479,136 - 151,672,663 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	158,655,512 - 158,849,041 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	151,529,440 - 151,722,961 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	153,861,535 - 154,058,608 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	153,861,569 - 154,056,654 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	160,166,289 - 160,361,740 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	146,220,504 - 146,422,659 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	146,297,071 - 146,500,992 (+)	NCBI
Celera	1	141,786,200 - 141,975,029 (+)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

ME3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	86,434,930 - 86,672,616 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	86,441,108 - 86,672,636 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	86,145,972 - 86,383,658 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	85,829,798 - 86,061,075 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	85,829,885 - 86,061,004	NCBI
Celera	11	83,462,760 - 83,694,235 (-)	NCBI		Celera
Cytogenetic Map	11	q14.2	NCBI
HuRef	11	82,440,697 - 82,672,413 (-)	NCBI		HuRef
CHM1_1	11	86,037,902 - 86,269,349 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	86,377,442 - 86,612,763 (-)	NCBI		T2T-CHM13v2.0

Me3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	89,281,492 - 89,503,423 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	89,281,600 - 89,503,567 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	89,632,284 - 89,854,359 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	89,632,392 - 89,854,359 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	96,781,328 - 97,002,869 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	89,508,010 - 89,729,551 (+)	NCBI		MGSCv36	mm8
Celera	7	86,981,993 - 87,178,718 (+)	NCBI		Celera
Cytogenetic Map	7	D3	NCBI
cM Map	7	50.27	NCBI

Me3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	6,343,476 - 6,557,058 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	6,335,411 - 6,555,494 (+)	NCBI	ChiLan1.0	ChiLan1.0

ME3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	87,349,049 - 87,595,198 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	88,407,386 - 88,646,956 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	81,490,947 - 81,728,589 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	85,104,477 - 85,336,683 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	85,104,477 - 85,222,822 (-)	Ensembl	panpan1.1		panPan2

ME3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	12,813,052 - 13,105,805 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	12,813,047 - 13,105,804 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	12,678,922 - 12,971,512 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	12,995,770 - 13,288,435 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	13,101,638 - 13,288,430 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	12,781,982 - 13,074,486 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	12,853,629 - 13,146,550 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	12,909,897 - 13,203,162 (+)	NCBI		UU_Cfam_GSD_1.0

Me3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	72,614,105 - 72,823,300 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	14,216,513 - 14,423,031 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936498	14,216,510 - 14,422,936 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ME3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	20,294,908 - 20,583,584 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	20,294,871 - 20,613,225 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	22,589,632 - 22,780,615 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ME3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	77,712,748 - 77,934,263 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	77,712,838 - 77,933,727 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	47,792,396 - 48,016,415 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Me3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624845	3,307,568 - 3,546,631 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624845	3,307,610 - 3,546,539 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Me3
1654 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	51
Count of miRNA genes:	48
Interacting mature miRNAs:	50
Transcripts:	ENSRNOT00000023329
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	48963584	144267916	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	57336763	151090257	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	1	87580395	150700247	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	90508614	173018436	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	90508614	180359386	Rat
724567	Tcas6	Tongue tumor susceptibility QTL 6	6.85		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	92948896	144267916	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94494440	172949803	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	94494440	181830018	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
61346	Rf2	Renal disease susceptibility QTL 2	3.7		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	1	99267916	144267916	Rat
61399	Tcat1	Tongue tumor resistance QTL 1	3.3		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)	1	99267916	144267916	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	100357752	183970443	Rat
2317833	Alcrsp19	Alcohol response QTL 19	12.4	0.001	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	100979852	145979852	Rat
1641897	Alcrsp1	Alcohol response QTL 1			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	100979852	145979852	Rat
2303591	Gluco41	Glucose level QTL 41	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	102168504	147168504	Rat
61370	Mcs3	Mammary carcinoma susceptibility QTL 3	2.15		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	102268556	147268556	Rat
1354623	Rf46	Renal function QTL 46	3.8		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	1	102813953	151162766	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
9590300	Scort16	Serum corticosterone level QTL 16	4.39	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	103111621	148111621	Rat
8694370	Bw154	Body weight QTL 154	8.91	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	1	103111621	148111621	Rat
631496	Bp97	Blood pressure QTL 97	3.08		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	106047847	151047847	Rat
1300158	Bp173	Blood pressure QTL 173	3.48		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	1	115540693	185145286	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
631199	Cm23	Cardiac mass QTL 23	4.6	0.0004	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	115585465	172949803	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
2313060	Bss71	Bone structure and strength QTL 71	2.6	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	1	118944747	163944747	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
1598850	Bp297	Blood pressure QTL 297	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
1598866	Bp287	Blood pressure QTL 287	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
61442	Strs1	Sensitivity to stroke QTL 1	7.4		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	1	121767634	166767634	Rat
2293140	Bp313	Blood pressure QTL 313			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121833674	166833674	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350408	181759564	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	123350408	182418476	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	123350408	182418476	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	123350408	182418476	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
634348	Bp138	Blood pressure QTL 138			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	168883176	Rat
9685799	Bp375	Blood pressure QTL 375			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
631654	Bp107	Blood pressure QTL 107			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
9685802	Bp376	Blood pressure QTL 376			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	126540680	171540680	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
631202	Gluco13	Glucose level QTL 13		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	131763437	159756369	Rat
6893347	Bw98	Body weight QTL 98	0.2	0.53	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
6893361	Bw104	Body weight QTL 104	0.59	0.27	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1558645	Bw55	Body weight QTL 55	3.2	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
631206	Niddm40	Non-insulin dependent diabetes mellitus QTL 40			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	136745990	163747690	Rat
71118	Thym1	Thymus enlargement QTL 1	10.17	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
724550	Thym3	Thymus enlargement QTL 3	7.82	0.001	thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	136829932	181829932	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	136830018	181830018	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat

Markers in Region

BI301980

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	143,568,830 - 143,569,020 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	153,895,885 - 153,896,074	NCBI	Rnor6.0
Rnor_5.0	1	160,200,232 - 160,200,421	UniSTS	Rnor5.0
RGSC_v3.4	1	146,255,789 - 146,255,978	UniSTS	RGSC3.4
Celera	1	141,820,906 - 141,821,095	UniSTS
RH 3.4 Map	1	1116.4	UniSTS
Cytogenetic Map	1	q32	UniSTS

RH129606

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	143,533,885 - 143,534,184 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	153,861,316 - 153,861,614	NCBI	Rnor6.0
Rnor_5.0	1	160,166,036 - 160,166,334	UniSTS	Rnor5.0
RGSC_v3.4	1	146,220,251 - 146,220,549	UniSTS	RGSC3.4
Celera	1	141,785,947 - 141,786,245	UniSTS
RH 3.4 Map	1	1115.9	UniSTS
Cytogenetic Map	1	q32	UniSTS

RH133219

Rat Assembly	Chr	Position (strand)	Source
Celera	1	141,973,432 - 141,974,926	UniSTS
RH 3.4 Map	1	1121.0	UniSTS
Cytogenetic Map	1	q32	UniSTS

BF405328

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	143,535,926 - 143,536,019 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	153,863,357 - 153,863,449	NCBI	Rnor6.0
Rnor_5.0	1	160,168,077 - 160,168,169	UniSTS	Rnor5.0
RGSC_v3.4	1	146,222,292 - 146,222,384	UniSTS	RGSC3.4
Celera	1	141,787,988 - 141,788,080	UniSTS
RH 3.4 Map	1	1116.4	UniSTS
Cytogenetic Map	1	q32	UniSTS

BE118196

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	143,532,538 - 143,532,716 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	153,859,969 - 153,860,146	NCBI	Rnor6.0
Rnor_5.0	1	160,164,689 - 160,164,866	UniSTS	Rnor5.0
RGSC_v3.4	1	146,218,904 - 146,219,081	UniSTS	RGSC3.4
Celera	1	141,784,600 - 141,784,777	UniSTS
RH 3.4 Map	1	1114.6	UniSTS
Cytogenetic Map	1	q32	UniSTS

MARC_13809-13810:1046871162:1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	143,728,048 - 143,728,777 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	154,052,701 - 154,053,429	NCBI	Rnor6.0
Rnor_5.0	1	160,357,081 - 160,357,809	UniSTS	Rnor5.0
RGSC_v3.4	1	146,418,037 - 146,418,543	UniSTS	RGSC3.4
Celera	1	141,971,160 - 141,971,889	UniSTS
Cytogenetic Map	1	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		23	5	2		2	8	11	37	27	5	1	8
Low	2	20	24	15	9	15			37	8	36	10
Below cutoff	1		26	22	10	22

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001415972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006229666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063266979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000023329 ⟹ ENSRNOP00000023329

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	143,534,139 - 143,731,927 (+)	Ensembl
Rnor_6.0 Ensembl	1	153,861,569 - 154,056,587 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000087067 ⟹ ENSRNOP00000072989

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	143,534,139 - 143,733,132 (+)	Ensembl
Rnor_6.0 Ensembl	1	153,861,948 - 154,056,654 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095307 ⟹ ENSRNOP00000089037

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	143,534,139 - 143,733,132 (+)	Ensembl

RefSeq Acc Id:

NM_001415972 ⟹ NP_001402901

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	152,946,628 - 153,148,026 (+)	NCBI
mRatBN7.2	1	143,534,057 - 143,735,466 (+)	NCBI

RefSeq Acc Id:

XM_006229666 ⟹ XP_006229728

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	152,946,595 - 153,144,494 (+)	NCBI
mRatBN7.2	1	143,534,024 - 143,735,551 (+)	NCBI
Rnor_6.0	1	153,861,535 - 154,058,608 (+)	NCBI
Rnor_5.0	1	160,166,289 - 160,361,740 (+)	NCBI

Sequence:

show sequence

TGACAGGGGACAGTAGCGTCTTTCCCTACCTGCCTGCAGTGGGGCTGCACAGACTTGAGCTTCT
CACAGACTTGAGCTTCTCCAGTTAGGCAGGTCTGTGCCAGGACCATGGGCGCCGCGCTGGGCAC
TGGCGCACGGCTAACCTCCCTACCTCGCCTAGCCTGCGGCAGCCTTCGGCGTCAGGCACTCTCC
GCGCCCGCCCAGGGATGCCACTCCAAGTCCGGTCCGCCTCGCCCAGTACCCCTGAAGAAGCGCG
GATACGATGTAACCAGGAACCCCCATCTCAACAAGGGCATGGCCTTTACACTGGAAGAGAGGCT
GCAGCTTGGCATCCACGGCCTGATCCCTCCCTGCTTCCTCAGCCAGGATGTCCAGCTCCTCCGC
ATCATGAGATACTATGAGAATCAGCAGAGCGACCTGGACAAGTACATCATCCTCATGACTCTCC
AAGACCGCAATGAGAAGCTCTTCTACCGAGTGCTGACCTCAGACGTGGAGAAGTTCATGCCCAT
TGTGTACACACCCACTGTGGGGCTGGCCTGTCAGCACTATGGCCTCACCTTCCGCCGACCTCGT
GGGCTGTTTATCACCATCCATGACAAGGGCCACATTGCAACAATGCTGAACTCTTGGCCAGAGG
ACAATATTAAGGCTGTGGTGGTGACTGATGGAGAGCGCATACTGGGCTTGGGAGACCTGGGCTG
CTACGGCATGGGCATCCCTGTGGGCAAGCTGGCCCTGTACACAGCATGCGGAGGGGTGAACCCA
CAGCAGTGCCTTCCTGTCCTGCTAGATGTCGGCACCAACAATGAGGAGCTTCTCAGAGACCCTC
TGTACATCGGCCTGAAACACCAACGTGTTCGTGGGAAGGAGTATGATGACCTGCTGGATGAATT
CATGCAGGCTGTGACAGATAAGTTCGGAATAAATTGCCTCATCCAGTTTGAAGACTTTGCCAAT
GCCAATGCCTTCCGTCTACTCAACAAATACCGCAACAAATACTGCATGTTCAATGATGACATCC
AAGGCACAGCCTCTGTCGCTGTGGCAGGGATCCTGGCTGCACTGAGAATCACCAAGAACAGGCT
GTCCAATCATGTGTTTGTTTTCCAGGGTGCGGGTGAGGCAGCCATGGGCATTGCCCACCTCCTT
GTCATGGCCCTGGAAAAGGAAGGCATACCCAAGACAGAGGCCGTAAGGAAGATCTGGATGGTGG
ACTCCAAGGGTCTGATTGTCAAGGGTAGAAGCCACCTAAACCATGAGAAGGAGATGTTTGCCCA
AGAGCATCCTGAAGTCAACTCCCTGGAGGAGGTAGTAAGGCTGGTGAAGCCCACAGCAATTATA
GGTGTCGCTGCCATCGCAGGAGCCTTCACGGAGCAGATTCTGAGGGACATGGCCTCCTTCCATG
AGCGCCCTATCATCTTTGCCCTGAGCAACCCCACCAGCAAGGCTGAGTGCACAGCTGAGAAGTG
CTACCAGGTCACCGAGGGCCGAGGAATCTTTGCCAGTGGAAGTCCTTTTAAGAGTGTGACTCTG
GAAGATGGCAGGACATTCATTCCTGGTCAGGGAAACAATGCCTATGTGTTTCCCGGGGTAGCAC
TGGGCATCATTGCTGGTGGGATCAGACATGTGCCAGATGAAATTTTCCTCCTGACAGCAGAGGT
CCTCGACTATGCGTACAAACACAACCTGGCCTCCTACTATCCAGAGCCCAAGGACAAGGAGGCT
TTTATAAAATCTCTGATCTACACTCCAGACTATGACTCCTTCTCGCTAGACACCTACACCTGGC
CTAAGGAAGCTATGAGTGTTCAGAAGGTCTGACGCCATCTCCAGAGATTGTTTGGGCTCAATGA
AGAAATACAATATAAACAGGTTCCAAAATGGCCAGTCTTGTCACCATGGTTACGGTTGTCATTT
GTTTTCCTTTGGGTGTTGGGGTAAGATGCTAAGGCATACAGCGGTAACAGCCTTGTTCCTGAAG
GACCTGCAGGCTCACCTTCCTATAACCCTTTTCTGAATTCCTTTCTGGATATTTCTTTTACTAT
TAACTGCTAACTATTAACCAAACCTTGTGGGGAAATTCTGCCTAGAATCCTGCCTTTGTAGAGC
TCAAAGTCTAGATCAGACACAAGTCCCATTTCATAAGAAAGTGTGATGTCCACGAAAAAAAAAA
AAGTTCATGTAGAAGTCAGAGTGCTCGGAGAAGAATGGGCACTTCCTATAAAGACACAAAAGGA
GACCTGGCTTTGTACTTTGCCCAAGAGTGAAGGATGGGTTAAGTCATAAGCACTCAAGAAATGC
ATGCAAAACTACATACGAGAAAATGAGGTCCACCCATCAGGGAACTAATCCCTTTCAGAAGAAT
ACATTAATTTCAAGATTGAGTAGGACATGGGGGCTGAGTGGCTAGAGGCTCACTGCCCTTTGGG
TTGTTGGGTACTGTGCATTCTTTTTGGTCATTACTAAAAGGAAAACTAGAGAATTGGGGGTAGG
AAGGGTCAGCATGCCAAAAACTGAGGAAAACGAGGAGCAATGAGAGCAAACACCGTGGGGAAGG
TGTTTAAGTCTAAGAAAGACTTGATGTAATGTTTCAGGTTCCAGAACACTCTCCTCTCCATCCT
TCACACAGACACAATTGAGCAGTTTGCTTCTAGAGGTGACATCAGTCTGCCTTTGGTGTTTTTA
AGGCCTGTTTAGTGAAAACGTCTACCTCCTCCATGTTCAGGAGTGCACACACTCCAAGACAAAC
AGTAAAGAATGGCTTGGAGCCCCTGCTGTGAGCTGTGTCCTTTTACTGCATAAGTCATTCTTAA
GACCTACCCTGCTGTCTCCTTGGCCAGGATTCCTGCTGCACATAATGAGTAGGTTCTATATGAC
TGTCTCTCAGGTCAAGCCAGGTAAATTACTAAAATCCATGGAGAATATTTTGCACATTCATGAA
TCAACTGCCCCTTGTTTGGGTCTTATTCTTCCAATACCAGCTTCTTGGGTGCTAGTCCTCAACC
AAGGATATCCCCAAAGCATAGACCTAAATGCAGAAAGAAAAACAATGCATTTCTAGAAGAGAAT
AAAGCAGTGAGTCCTTGTGAAGACTCCCCAGTAAACCTCTGATTACAATCTCACATGCAATGCC
TGTGTCCCTGGGGATACAATTCACAAAAGATGGAAAAAACTGGCTAAGGTTTCCAATTTTCTGA
TCTATTGCATCAGCCCCACATGGCTGCCAAGAATCTTGTTGGATTTCTCATCTCCTCAGGAGAA
ACAATCTGTCTGGACCCAACCTAATCCTTTTTATTCCATGTCCAGACTCAGTAAATGCACCCAG
AGAAGAAAATGGCTGCTTATGCCAGAAAGGATCCCTCCATGGAATCCGATACTGCTAGTTAATA
TCTTTTGTCCCAGTGTTATTAGGTGTGTGAGGTTTAGCACTGTTATAATTTATGGTGAACTCAA
AACTGTAAACCTTGGTGATTTACTAAATAATGTATTTGTTTTGTCGTGCCATATCTTAGATATC
ATATCTTGGAAGTCTCTCTTGCAATTCATTATTTATTCAGATGCTTACTTAAGCTTACAGAGTA
CCTAATGTTTGTAAACATTCTCCAGTTATTTCTCCCACAGAACTCAAACGATTTTTTCCCAAAG
TGAAAATATGGCTGTCTTAACATTAAAACATAGAATCATTTCATCAGCTTCACGGTAAAAATGA
TTATCAAGAAACCTAATTTAAATCACATCACTTGAAAAACATAAAACATTACATGTCCAAATTC
TTAGTAGAAACTCTTGTTCAGGTTGAGAACACATGGGAAAATATCAGACTTTAAAGCTAAGTAA
TAGTAATTTCTAATGTTTGACCAAAAAAAAAATAGGAGTTTCAGAAACTGGATAATTAAACACC
GTTTTAGATACAAA

hide sequence

RefSeq Acc Id:

XM_063266979 ⟹ XP_063123049

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	152,946,595 - 153,142,135 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001402901	(Get FASTA)	NCBI Sequence Viewer
	XP_006229728	(Get FASTA)	NCBI Sequence Viewer
	XP_063123049	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM18573	(Get FASTA)	NCBI Sequence Viewer
	EDM18574	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023329.6
	ENSRNOP00000072989
	ENSRNOP00000072989.1
	ENSRNOP00000089037
	ENSRNOP00000089037.1

RefSeq Acc Id:	XP_006229728 ⟸ XM_006229666
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K4C6 (UniProtKB/TrEMBL), F1M5N4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGAALGTGARLTSLPRLACGSLRRQALSAPAQGCHSKSGPPRPVPLKKRGYDVTRNPHLNKGMA FTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYENQQSDLDKYIILMTLQDRNEKLFYRVLTSD VEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHIATMLNSWPEDNIKAVVVTDGERIL GLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVRGKEY DDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAAL RITKNRLSNHVFVFQGAGEAAMGIAHLLVMALEKEGIPKTEAVRKIWMVDSKGLIVKGRSHLNH EKEMFAQEHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKA ECTAEKCYQVTEGRGIFASGSPFKSVTLEDGRTFIPGQGNNAYVFPGVALGIIAGGIRHVPDEI FLLTAEVLDYAYKHNLASYYPEPKDKEAFIKSLIYTPDYDSFSLDTYTWPKEAMSVQKV hide sequence

RefSeq Acc Id:

ENSRNOP00000072989 ⟸ ENSRNOT00000087067

RefSeq Acc Id:

ENSRNOP00000023329 ⟸ ENSRNOT00000023329

RefSeq Acc Id:

ENSRNOP00000089037 ⟸ ENSRNOT00000095307

RefSeq Acc Id:	NP_001402901 ⟸ NM_001415972
- UniProtKB:	A0A8I6AK15 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063123049 ⟸ XM_063266979
- Peptide Label:	isoform X2

Protein Domains

Malic enzyme N-terminal Malic enzyme NAD-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M5N4-F1-model_v2	AlphaFold	F1M5N4	1-605	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690183

Promoter ID:

EPDNEW_R707

Type:

single initiation site

Name:

Me3_1

Description:

malic enzyme 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	153,861,552 - 153,861,612	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311070	AgrOrtholog
BioCyc Gene	G2FUF-58554	BioCyc
Ensembl Genes	ENSRNOG00000017311	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023329.8	UniProtKB/TrEMBL
	ENSRNOT00000087067.2	UniProtKB/TrEMBL
	ENSRNOT00000095307	ENTREZGENE
	ENSRNOT00000095307.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.10380	UniProtKB/TrEMBL
	6.20.310.10	UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	Aminiacid_DH-like_N_sf	UniProtKB/TrEMBL
	Malic_enzyme_CS	UniProtKB/TrEMBL
	Malic_N	UniProtKB/TrEMBL
	Malic_N_dom_sf	UniProtKB/TrEMBL
	Malic_NAD-bd	UniProtKB/TrEMBL
	Malic_OxRdtase	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:361602	UniProtKB/TrEMBL
NCBI Gene	361602	ENTREZGENE
PANTHER	MALIC ENZYME-RELATED	UniProtKB/TrEMBL
	NADP-DEPENDENT MALIC ENZYME, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	malic	UniProtKB/TrEMBL
	Malic_M	UniProtKB/TrEMBL
PhenoGen	Me3	PhenoGen
PIRSF	PIRSF000106	UniProtKB/TrEMBL
PRINTS	MALOXRDTASE	UniProtKB/TrEMBL
PROSITE	MALIC_ENZYMES	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017311	RatGTEx
SMART	malic	UniProtKB/TrEMBL
	Malic_M	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
	SSF53223	UniProtKB/TrEMBL
UniProt	A0A0G2K4C6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AK15	ENTREZGENE, UniProtKB/TrEMBL
	F1M5N4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-05-04	Me3	malic enzyme 3	Me3	malic enzyme 3, NADP(+)-dependent, mitochondrial	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Me3	malic enzyme 3, NADP(+)-dependent, mitochondrial	Me3_predicted	malic enzyme 3, NADP(+)-dependent, mitochondrial (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Me3_predicted	malic enzyme 3, NADP(+)-dependent, mitochondrial (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)