Ppil4 (peptidylprolyl isomerase like 4) - Rat Genome Database

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Gene: Ppil4 (peptidylprolyl isomerase like 4) Rattus norvegicus
Analyze
Symbol: Ppil4
Name: peptidylprolyl isomerase like 4
RGD ID: 1311051
Description: Predicted to enable RNA binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human PPIL4 (peptidylprolyl isomerase like 4); INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361449; peptidyl-prolyl cis-trans isomerase-like 4; peptidylprolyl isomerase (cyclophilin)-like 4; peptidylprolyl isomerase-like 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814,093,956 - 4,126,016 (+)NCBIGRCr8
mRatBN7.212,273,582 - 2,305,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12,273,609 - 2,305,632 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx11,923,442 - 1,955,506 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.017,923,846 - 7,955,911 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.012,205,554 - 2,237,618 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.011,897,316 - 1,930,311 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl11,897,338 - 1,929,763 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013,593,929 - 3,626,926 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.412,466,684 - 2,499,257 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.112,466,655 - 2,497,752 (+)NCBI
Celera1822,354 - 854,938 (+)NCBICelera
Cytogenetic Map1p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22658674   PMID:22681889  


Genomics

Comparative Map Data
Ppil4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814,093,956 - 4,126,016 (+)NCBIGRCr8
mRatBN7.212,273,582 - 2,305,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12,273,609 - 2,305,632 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx11,923,442 - 1,955,506 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.017,923,846 - 7,955,911 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.012,205,554 - 2,237,618 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.011,897,316 - 1,930,311 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl11,897,338 - 1,929,763 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013,593,929 - 3,626,926 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.412,466,684 - 2,499,257 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.112,466,655 - 2,497,752 (+)NCBI
Celera1822,354 - 854,938 (+)NCBICelera
Cytogenetic Map1p13NCBI
PPIL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386149,504,495 - 149,546,043 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6149,504,495 - 149,546,043 (-)EnsemblGRCh38hg38GRCh38
GRCh376149,825,631 - 149,867,179 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366149,867,324 - 149,908,864 (-)NCBINCBI36Build 36hg18NCBI36
Build 346149,867,323 - 149,908,864NCBI
Celera6150,560,719 - 150,602,255 (-)NCBICelera
Cytogenetic Map6q25.1NCBI
HuRef6147,392,338 - 147,433,888 (-)NCBIHuRef
CHM1_16150,090,379 - 150,131,968 (-)NCBICHM1_1
T2T-CHM13v2.06150,704,210 - 150,745,755 (-)NCBIT2T-CHM13v2.0
Ppil4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39107,668,653 - 7,698,329 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl107,668,655 - 7,698,899 (+)EnsemblGRCm39 Ensembl
GRCm38107,792,889 - 7,822,565 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl107,792,891 - 7,823,135 (+)EnsemblGRCm38mm10GRCm38
MGSCv37107,512,692 - 7,542,361 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36107,483,111 - 7,513,325 (+)NCBIMGSCv36mm8
Celera107,671,600 - 7,701,253 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.38NCBI
Ppil4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543911,704,834 - 11,746,548 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543911,705,096 - 11,745,478 (+)NCBIChiLan1.0ChiLan1.0
PPIL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25169,522,937 - 169,572,146 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16167,416,528 - 167,465,731 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06147,323,295 - 147,365,129 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16152,029,650 - 152,071,336 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6152,029,650 - 152,071,336 (-)Ensemblpanpan1.1panPan2
PPIL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1140,296,957 - 40,342,116 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl140,296,957 - 40,342,759 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha141,133,955 - 41,179,115 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0140,476,789 - 40,521,969 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl140,474,474 - 40,522,019 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1140,353,033 - 40,398,188 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0140,217,992 - 40,263,150 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0140,558,603 - 40,604,005 (-)NCBIUU_Cfam_GSD_1.0
Ppil4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946135,249,515 - 135,284,480 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364892,499,320 - 2,536,472 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364892,501,508 - 2,536,472 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPIL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,400,983 - 16,446,854 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1116,400,938 - 16,446,860 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2118,675,426 - 18,763,800 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPIL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11322,094,303 - 22,135,446 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1322,094,326 - 22,134,546 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040198,117,847 - 198,158,508 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppil4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247858,518,595 - 8,565,262 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247858,518,567 - 8,569,933 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppil4
47 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:477
Count of miRNA genes:265
Interacting mature miRNAs:312
Transcripts:ENSRNOT00000021437
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat

Markers in Region
AI603613  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21363,463,041 - 63,463,257 (+)MAPPERmRatBN7.2
Rnor_6.01368,738,812 - 68,739,027NCBIRnor6.0
Rnor_6.011,920,942 - 1,922,537NCBIRnor6.0
Rnor_5.013,617,557 - 3,619,152UniSTSRnor5.0
Rnor_5.01373,701,191 - 73,701,406UniSTSRnor5.0
RGSC_v3.41366,252,892 - 66,253,107UniSTSRGSC3.4
Celera1363,393,937 - 63,394,152UniSTS
RH 3.4 Map13232.1UniSTS
Cytogenetic Map1p13UniSTS
Cytogenetic Map13q21UniSTS
BI297080  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.212,304,500 - 2,304,664 (+)MAPPERmRatBN7.2
Rnor_6.011,928,600 - 1,928,763NCBIRnor6.0
Rnor_5.013,625,215 - 3,625,378UniSTSRnor5.0
RGSC_v3.412,497,546 - 2,497,709UniSTSRGSC3.4
Celera1853,227 - 853,390UniSTS
RH 3.4 Map18.3UniSTS
Cytogenetic Map1p13UniSTS
RH141810  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.212,305,331 - 2,305,526 (+)MAPPERmRatBN7.2
Rnor_6.011,929,431 - 1,929,625NCBIRnor6.0
Rnor_5.013,626,046 - 3,626,240UniSTSRnor5.0
RGSC_v3.412,498,377 - 2,498,571UniSTSRGSC3.4
Celera1854,058 - 854,252UniSTS
RH 3.4 Map122.8UniSTS
Cytogenetic Map1p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000021437   ⟹   ENSRNOP00000021437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl12,273,609 - 2,305,632 (+)Ensembl
Rnor_6.0 Ensembl11,897,338 - 1,929,763 (+)Ensembl
RefSeq Acc Id: NM_001395054   ⟹   NP_001381983
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814,093,977 - 4,126,016 (+)NCBI
mRatBN7.212,273,598 - 2,305,639 (+)NCBI
RefSeq Acc Id: XM_039081052   ⟹   XP_038936980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814,093,956 - 4,126,012 (+)NCBI
mRatBN7.212,273,582 - 2,304,127 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001381983 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936980 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93692 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021437.7
Ensembl Acc Id: ENSRNOP00000021437   ⟸   ENSRNOT00000021437
RefSeq Acc Id: XP_038936980   ⟸   XM_039081052
- Peptide Label: isoform X1
- UniProtKB: A6JP20 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001381983   ⟸   NM_001395054
- UniProtKB: D4AEG3 (UniProtKB/TrEMBL)
Protein Domains
PPIase cyclophilin-type   RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AEG3-F1-model_v2 AlphaFold D4AEG3 1-492 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689482
Promoter ID:EPDNEW_R7
Type:initiation region
Name:Ppil4_1
Description:peptidylprolyl isomerase like 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.011,897,356 - 1,897,416EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311051 AgrOrtholog
BioCyc Gene G2FUF-62445 BioCyc
Ensembl Genes ENSRNOG00000015552 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021437.8 UniProtKB/TrEMBL
Gene3D-CATH 2.40.100.10 UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/TrEMBL
InterPro CRIP UniProtKB/TrEMBL
  Cyclophilin-like_dom UniProtKB/TrEMBL
  cyclophilin_PPIL4 UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  PPIase_cyclophilin UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_RNP1 UniProtKB/TrEMBL
NCBI Gene 361449 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4 UniProtKB/TrEMBL
  PTHR45843 UniProtKB/TrEMBL
Pfam Pro_isomerase UniProtKB/TrEMBL
  RRM_1 UniProtKB/TrEMBL
PhenoGen Ppil4 PhenoGen
PRINTS CSAPPISMRASE UniProtKB/TrEMBL
PROSITE CSA_PPIASE_2 UniProtKB/TrEMBL
  RRM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015552 RatGTEx
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF50891 UniProtKB/TrEMBL
  SSF54928 UniProtKB/TrEMBL
UniProt A6JP20 ENTREZGENE, UniProtKB/TrEMBL
  D4AEG3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Ppil4  peptidylprolyl isomerase like 4  Ppil4  peptidylprolyl isomerase (cyclophilin)-like 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ppil4  peptidylprolyl isomerase (cyclophilin)-like 4   Ppil4_predicted  peptidylprolyl isomerase (cyclophilin)-like 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ppil4_predicted  peptidylprolyl isomerase (cyclophilin)-like 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED