Cst9l (cystatin 9-like) - Rat Genome Database

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Gene: Cst9l (cystatin 9-like) Rattus norvegicus
Analyze
Symbol: Cst9l
Name: cystatin 9-like
RGD ID: 1311032
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be involved in antimicrobial humoral response. Predicted to be active in extracellular space. Orthologous to several human genes including CST9L (cystatin 9 like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cst9; cystatin 9; LOC362231
RGD Orthologs
Human
Mouse
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,741,232 - 156,744,045 (+)NCBIGRCr8
mRatBN7.23136,288,093 - 136,290,906 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3136,288,093 - 136,290,906 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3140,240,024 - 140,242,835 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,824,174 - 148,826,985 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,513,723 - 146,516,536 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03143,172,691 - 143,175,504 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3143,172,686 - 143,175,500 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,581,044 - 149,583,857 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,601,785 - 137,604,598 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,507,294 - 137,510,171 (+)NCBI
Celera3135,129,456 - 135,132,269 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cst9lRatfamilial hyperinsulinemic hypoglycemia 1  ISOCST9L (Homo sapiens)8554872ClinVar Annotator: match by term: Hyperinsulinemic hypoglycemia more ...ClinVarPMID:38605124

1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cst9lRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CST9L mRNACTDPMID:32109520
Cst9lRataflatoxin B1 increases mutagenesisEXP 6480464Aflatoxin B1 results in increased mutagenesis of CST9L geneCTDPMID:36908029
Cst9lRatbenzo[a]pyrene increases methylationISOCST9L (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of CST9L 3' UTR more ...CTDPMID:27901495
Cst9lRatbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of CST9L mRNACTDPMID:25181051
Cst9lRatcetrorelix multiple interactionsISOCST9L (Homo sapiens)6480464[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of CST9L mRNA and [cetrorelix co-treated with testosterone enanthate] results in increased expression of CST9L mRNACTDPMID:18160741
Cst9lRatCGP 52608 multiple interactionsISOCST9L (Homo sapiens)6480464CGP 52608 promotes the reaction [RORA protein binds to CST9L gene]CTDPMID:28238834
Cst9lRatdesogestrel multiple interactionsISOCST9L (Homo sapiens)6480464[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of CST9L mRNACTDPMID:18160741
Cst9lRatmethotrexate increases expressionISOCST9L (Homo sapiens)6480464Methotrexate results in increased expression of CST9L mRNACTDPMID:24449571
Cst9lRatorphenadrine affects expressionEXP 6480464Orphenadrine affects the expression of CST9L mRNACTDPMID:23665939
Cst9lRattestosterone enanthate multiple interactionsISOCST9L (Homo sapiens)6480464[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of CST9L mRNA and [cetrorelix co-treated with testosterone enanthate] results in increased expression of CST9L mRNACTDPMID:18160741

1 to 10 of 10 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cst9lRatantimicrobial humoral response involved_inIEAUniProtKB:Q9Z0H6 and ensembl:ENSMUSP000000289351600115GO_REF:0000107EnsemblGO_REF:0000107
Cst9lRatantimicrobial humoral response involved_inIBAMGI:1340053 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cst9lRatantimicrobial humoral response involved_inISOCst9 (Mus musculus)1624291 PMID:23922243RGDPMID:23922243

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cst9lRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Cst9lRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Cst9lRatextracellular space is_active_inIBAPANTHER:PTN000151555 and UniProtKB:Q5W1881600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cst9lRatcysteine-type endopeptidase inhibitor activity enablesIEAUniProtKB-KW:KW-07891600115GO_REF:0000043UniProtGO_REF:0000043
Cst9lRatcysteine-type endopeptidase inhibitor activity enablesIEAInterPro:IPR0000101600115GO_REF:0000002InterProGO_REF:0000002
Cst9lRatpeptidase inhibitor activity enablesIEAUniProtKB-KW:KW-06461600115GO_REF:0000043UniProtGO_REF:0000043
Cst9lRatprotein binding enablesISOCST9L (Homo sapiens)1624291UniProtKB:A8MQ03 more ...RGDPMID:25416956 and PMID:32296183


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:23922243  



Cst9l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,741,232 - 156,744,045 (+)NCBIGRCr8
mRatBN7.23136,288,093 - 136,290,906 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3136,288,093 - 136,290,906 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3140,240,024 - 140,242,835 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,824,174 - 148,826,985 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,513,723 - 146,516,536 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03143,172,691 - 143,175,504 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3143,172,686 - 143,175,500 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,581,044 - 149,583,857 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,601,785 - 137,604,598 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,507,294 - 137,510,171 (+)NCBI
Celera3135,129,456 - 135,132,269 (+)NCBICelera
Cytogenetic Map3q41NCBI
CST9L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382023,564,732 - 23,568,484 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2023,564,732 - 23,568,484 (-)EnsemblGRCh38hg38GRCh38
GRCh372023,545,369 - 23,549,121 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362023,493,369 - 23,497,329 (-)NCBINCBI36Build 36hg18NCBI36
Celera2023,618,635 - 23,622,652 (-)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2023,506,670 - 23,510,688 (-)NCBIHuRef
CHM1_12023,545,153 - 23,549,170 (-)NCBICHM1_1
T2T-CHM13v2.02023,624,266 - 23,628,019 (-)NCBIT2T-CHM13v2.0
Cst9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392148,677,067 - 148,680,657 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2148,677,067 - 148,680,658 (+)EnsemblGRCm39 Ensembl
GRCm382148,835,147 - 148,838,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2148,835,147 - 148,838,738 (+)EnsemblGRCm38mm10GRCm38
MGSCv372148,660,883 - 148,664,473 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362148,526,588 - 148,530,178 (+)NCBIMGSCv36mm8
Celera2150,098,314 - 150,104,986 (+)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.58NCBI
LOC485559
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1231,913 - 5,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2333,977 - 39,594 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.023245,047 - 250,664 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.123103,818 - 109,435 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.023186,015 - 191,632 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.023175,050 - 180,667 (-)NCBIUU_Cfam_GSD_1.0
LOC100516302
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1730,451,597 - 30,454,777 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11730,451,710 - 30,454,724 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21734,540,856 - 34,543,898 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CST9L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1252,972,068 - 52,977,192 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605092,863,399 - 92,866,371 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

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Variants in Cst9l
10 total Variants

Predicted Target Of
Summary Value
Count of predictions:222
Count of miRNA genes:166
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000006869
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat

1 to 10 of 30 rows



appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
3 1 21 10 10 4 7 4 16 9 20 42 6



Ensembl Acc Id: ENSRNOT00000006869   ⟹   ENSRNOP00000006869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3136,288,093 - 136,290,906 (+)Ensembl
Rnor_6.0 Ensembl3143,172,686 - 143,175,500 (+)Ensembl
RefSeq Acc Id: NM_001108597   ⟹   NP_001102067
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83156,741,232 - 156,744,045 (+)NCBI
mRatBN7.23136,288,093 - 136,290,906 (+)NCBI
Rnor_6.03143,172,691 - 143,175,504 (+)NCBI
Rnor_5.03149,581,044 - 149,583,857 (+)NCBI
RGSC_v3.43137,601,785 - 137,604,598 (+)RGD
Celera3135,129,456 - 135,132,269 (+)RGD
Sequence:
Protein RefSeqs NP_001102067 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95082 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006869
  ENSRNOP00000006869.4
RefSeq Acc Id: NP_001102067   ⟸   NM_001108597
- Peptide Label: precursor
- UniProtKB: D3ZMS9 (UniProtKB/TrEMBL),   A6K7D7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006869   ⟸   ENSRNOT00000006869
Cystatin

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMS9-F1-model_v2 AlphaFold D3ZMS9 1-137 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692504
Promoter ID:EPDNEW_R3028
Type:initiation region
Name:Cst9l_1
Description:cystatin 9-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03143,172,722 - 143,172,782EPDNEW


1 to 18 of 18 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-47484 BioCyc
Ensembl Genes ENSRNOG00000005162 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006869 ENTREZGENE
  ENSRNOT00000006869.7 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.10 UniProtKB/TrEMBL
InterPro CST9-like UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/TrEMBL
  Prot_inh_cystat UniProtKB/TrEMBL
KEGG Report rno:362231 UniProtKB/TrEMBL
NCBI Gene 362231 ENTREZGENE
PANTHER CYSTATIN-9-LIKE UniProtKB/TrEMBL
  PTHR46945 UniProtKB/TrEMBL
Pfam Cystatin UniProtKB/TrEMBL
PhenoGen Cst9l PhenoGen
RatGTEx ENSRNOG00000005162 RatGTEx
Superfamily-SCOP SSF54403 UniProtKB/TrEMBL
UniProt A6K7D7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMS9 ENTREZGENE, UniProtKB/TrEMBL
1 to 18 of 18 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Cst9l  cystatin 9-like  Cst9  cystatin 9   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Cst9  cystatin 9   Cst9_predicted  cystatin 9 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cst9_predicted  cystatin 9 (predicted)      Symbol and Name status set to approved 70820 APPROVED