Cst9l (cystatin 9-like) - Rat Genome Database

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Gene: Cst9l (cystatin 9-like) Rattus norvegicus
Analyze
Symbol: Cst9l
Name: cystatin 9-like
RGD ID: 1311032
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be involved in antimicrobial humoral response. Predicted to be active in extracellular space. Orthologous to several human genes including CST9L (cystatin 9 like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cst9; cystatin 9; LOC362231
RGD Orthologs
Human
Mouse
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,741,232 - 156,744,045 (+)NCBIGRCr8
mRatBN7.23136,288,093 - 136,290,906 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3136,288,093 - 136,290,906 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3140,240,024 - 140,242,835 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,824,174 - 148,826,985 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,513,723 - 146,516,536 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03143,172,691 - 143,175,504 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3143,172,686 - 143,175,500 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,581,044 - 149,583,857 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,601,785 - 137,604,598 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,507,294 - 137,510,171 (+)NCBI
Celera3135,129,456 - 135,132,269 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23922243  


Genomics

Comparative Map Data
Cst9l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,741,232 - 156,744,045 (+)NCBIGRCr8
mRatBN7.23136,288,093 - 136,290,906 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3136,288,093 - 136,290,906 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3140,240,024 - 140,242,835 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,824,174 - 148,826,985 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,513,723 - 146,516,536 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03143,172,691 - 143,175,504 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3143,172,686 - 143,175,500 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03149,581,044 - 149,583,857 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43137,601,785 - 137,604,598 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,507,294 - 137,510,171 (+)NCBI
Celera3135,129,456 - 135,132,269 (+)NCBICelera
Cytogenetic Map3q41NCBI
CST9L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382023,564,732 - 23,568,484 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2023,564,732 - 23,568,484 (-)EnsemblGRCh38hg38GRCh38
GRCh372023,545,369 - 23,549,121 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362023,493,369 - 23,497,329 (-)NCBINCBI36Build 36hg18NCBI36
Celera2023,618,635 - 23,622,652 (-)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2023,506,670 - 23,510,688 (-)NCBIHuRef
CHM1_12023,545,153 - 23,549,170 (-)NCBICHM1_1
T2T-CHM13v2.02023,624,266 - 23,628,019 (-)NCBIT2T-CHM13v2.0
Cst9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392148,677,067 - 148,680,657 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2148,677,067 - 148,680,658 (+)EnsemblGRCm39 Ensembl
GRCm382148,835,147 - 148,838,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2148,835,147 - 148,838,738 (+)EnsemblGRCm38mm10GRCm38
MGSCv372148,660,883 - 148,664,473 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362148,526,588 - 148,530,178 (+)NCBIMGSCv36mm8
Celera2150,098,314 - 150,104,986 (+)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.58NCBI
LOC485559
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1231,913 - 5,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2333,977 - 39,594 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.023245,047 - 250,664 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.123103,818 - 109,435 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.023186,015 - 191,632 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.023175,050 - 180,667 (-)NCBIUU_Cfam_GSD_1.0
LOC100516302
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1730,451,597 - 30,454,777 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11730,451,710 - 30,454,724 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21734,540,856 - 34,543,898 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CST9L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1252,972,068 - 52,977,192 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605092,863,399 - 92,866,371 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cst9l
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:222
Count of miRNA genes:166
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000006869
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
3 1 21 10 10 4 7 4 16 9 20 42 6

Sequence


Ensembl Acc Id: ENSRNOT00000006869   ⟹   ENSRNOP00000006869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3136,288,093 - 136,290,906 (+)Ensembl
Rnor_6.0 Ensembl3143,172,686 - 143,175,500 (+)Ensembl
RefSeq Acc Id: NM_001108597   ⟹   NP_001102067
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83156,741,232 - 156,744,045 (+)NCBI
mRatBN7.23136,288,093 - 136,290,906 (+)NCBI
Rnor_6.03143,172,691 - 143,175,504 (+)NCBI
Rnor_5.03149,581,044 - 149,583,857 (+)NCBI
RGSC_v3.43137,601,785 - 137,604,598 (+)RGD
Celera3135,129,456 - 135,132,269 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102067 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95082 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006869.4
RefSeq Acc Id: NP_001102067   ⟸   NM_001108597
- Peptide Label: precursor
- UniProtKB: D3ZMS9 (UniProtKB/TrEMBL),   A6K7D7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006869   ⟸   ENSRNOT00000006869
Protein Domains
Cystatin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMS9-F1-model_v2 AlphaFold D3ZMS9 1-137 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692504
Promoter ID:EPDNEW_R3028
Type:initiation region
Name:Cst9l_1
Description:cystatin 9-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03143,172,722 - 143,172,782EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311032 AgrOrtholog
BioCyc Gene G2FUF-47484 BioCyc
Ensembl Genes ENSRNOG00000005162 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006869.7 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.10 UniProtKB/TrEMBL
InterPro CST9-like UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/TrEMBL
  Prot_inh_cystat UniProtKB/TrEMBL
KEGG Report rno:362231 UniProtKB/TrEMBL
NCBI Gene 362231 ENTREZGENE
PANTHER CYSTATIN-9-LIKE UniProtKB/TrEMBL
  PTHR46945 UniProtKB/TrEMBL
Pfam Cystatin UniProtKB/TrEMBL
PhenoGen Cst9l PhenoGen
RatGTEx ENSRNOG00000005162 RatGTEx
Superfamily-SCOP SSF54403 UniProtKB/TrEMBL
UniProt A6K7D7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMS9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Cst9l  cystatin 9-like  Cst9  cystatin 9   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Cst9  cystatin 9   Cst9_predicted  cystatin 9 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cst9_predicted  cystatin 9 (predicted)      Symbol and Name status set to approved 70820 APPROVED