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Gene: Gramd1a (GRAM domain containing 1A) Rattus norvegicus

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Symbol:

Gramd1a

Name:

GRAM domain containing 1A

RGD ID:

1311022

Description:

Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol and intracellular sterol transport. Predicted to be located in organelle membrane contact site. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Orthologous to human GRAMD1A (GRAM domain containing 1A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Eg1rvc; GRAM domain-containing protein 1A; LOC361550; MGC124896; RGD1311022; similar to RIKEN cDNA 1300003M23

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GRAMD1A (GRAM domain containing 1A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gramd1a (GRAM domain containing 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gramd1a (GRAM domain containing 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GRAMD1A (GRAM domain containing 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GRAMD1A (GRAM domain containing 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gramd1a (GRAM domain containing 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GRAMD1A (GRAM domain containing 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GRAMD1A (GRAM domain containing 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gramd1a (GRAM domain containing 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gramd1a (GRAM domain containing 1A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GRAMD1A (GRAM domain containing 1A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gramd1a (GRAM domain containing 1A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gramd1a (GRAM domain containing 1A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG30284	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG30284	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	LAM4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	LAM4	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	LAM6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	YSP2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	YSP2	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	ZC328.3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	GramD1B	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	LAM5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	LAM5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	gramd1a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	95,494,378 - 95,520,730 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	95,494,378 - 95,520,716 (-)	Ensembl				GRCr8
mRatBN7.2	1	86,367,001 - 86,393,348 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	86,367,001 - 86,393,336 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	91,787,463 - 91,813,809 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	100,253,622 - 100,279,972 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	93,545,756 - 93,572,102 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	89,563,982 - 89,590,406 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	89,563,976 - 89,590,490 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	90,718,529 - 90,744,916 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	86,175,392 - 86,189,585 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	80,735,883 - 80,750,076 (-)	NCBI		Celera
RGSC_v3.1	1	86,253,502 - 86,267,696 (-)	NCBI
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

amphetamine (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

azoxystrobin (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

Butylbenzyl phthalate (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chlorpyrifos (EXP,ISO)

clotrimazole (EXP)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

coumarin (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

disulfiram (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

folic acid (ISO)

FR900359 (ISO)

glyphosate (EXP)

imidacloprid (EXP)

leflunomide (ISO)

lipopolysaccharide (ISO)

methimazole (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

phenobarbital (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

temozolomide (ISO)

tetraphene (ISO)

thiabendazole (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

tungsten (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagy (IEA)

cellular response to cholesterol (IEA,ISO,ISS)

intracellular sterol transport (IBA)

lipid transport (IEA)

sterol transport (IEA)

Cellular Component

autophagosome (IEA)

cytoplasmic vesicle (IEA)

endoplasmic reticulum membrane (IBA,IEA,ISO,ISS)

endoplasmic reticulum-plasma membrane contact site (IBA,IEA,ISO,ISS)

organelle membrane contact site (IEA,ISO,ISS)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

cholesterol binding (IBA,IEA,ISO,ISS)

cholesterol transfer activity (IBA,IEA,ISO,ISS)

lipid binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15033532	PMID:29469807	PMID:30220461

Genomics

Comparative Map Data

Gramd1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	95,494,378 - 95,520,730 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	95,494,378 - 95,520,716 (-)	Ensembl				GRCr8
mRatBN7.2	1	86,367,001 - 86,393,348 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	86,367,001 - 86,393,336 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	91,787,463 - 91,813,809 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	100,253,622 - 100,279,972 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	93,545,756 - 93,572,102 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	89,563,982 - 89,590,406 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	89,563,976 - 89,590,490 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	90,718,529 - 90,744,916 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	86,175,392 - 86,189,585 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	80,735,883 - 80,750,076 (-)	NCBI		Celera
RGSC_v3.1	1	86,253,502 - 86,267,696 (-)	NCBI
Cytogenetic Map	1	q21	NCBI

GRAMD1A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	34,994,727 - 35,026,469 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	34,994,784 - 35,026,471 (+)	Ensembl			hg38	GRCh38
GRCh37	19	35,485,631 - 35,517,373 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	40,183,086 - 40,209,213 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	40,183,085 - 40,209,213	NCBI
Celera	19	32,204,615 - 32,230,747 (+)	NCBI		Celera
Cytogenetic Map	19	q13.11	NCBI
HuRef	19	31,999,593 - 32,025,729 (+)	NCBI		HuRef
CHM1_1	19	35,493,184 - 35,519,317 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	37,539,338 - 37,571,085 (+)	NCBI		T2T-CHM13v2.0

Gramd1a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	30,829,552 - 30,855,374 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	30,829,552 - 30,855,321 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	31,130,127 - 31,155,935 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	31,130,127 - 31,155,896 (-)	Ensembl			mm10	GRCm38
MGSCv37	7	31,915,146 - 31,936,069 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	30,838,887 - 30,852,547 (-)	NCBI		MGSCv36	mm8
Celera	7	25,699,357 - 25,720,265 (-)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	19.3	NCBI

Gramd1a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	4,346,610 - 4,372,030 (+)	Ensembl
ChiLan1.0	NW_004955468	4,347,387 - 4,371,096 (+)	NCBI	ChiLan1.0	ChiLan1.0

GRAMD1A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	41,007,216 - 41,037,685 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	42,989,662 - 43,020,091 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	31,940,102 - 31,970,532 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	40,680,367 - 40,711,002 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	40,680,355 - 40,711,002 (+)	Ensembl			panPan2	panpan1.1

GRAMD1A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	117,515,381 - 117,537,906 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	117,515,393 - 117,537,943 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	116,915,913 - 116,938,376 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	118,112,810 - 118,135,256 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	118,112,811 - 118,136,186 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	117,675,392 - 117,697,805 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	117,300,815 - 117,323,259 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	118,357,392 - 118,379,848 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gramd1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	10,423,529 - 10,446,590 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936570	1,199,095 - 1,222,162 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936570	1,199,292 - 1,222,323 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GRAMD1A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	44,573,937 - 44,594,166 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	44,573,889 - 44,594,168 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	39,995,813 - 40,019,491 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GRAMD1A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	29,928,068 - 29,958,839 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	29,937,053 - 29,961,093 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666073	7,701,724 - 7,728,410 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gramd1a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	8,451,889 - 8,474,440 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624794	8,452,064 - 8,474,426 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gramd1a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	164,876,500 - 164,897,858 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gramd1a
63 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	69
Count of miRNA genes:	62
Interacting mature miRNAs:	66
Transcripts:	ENSRNOT00000028660
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
2300324	Fetw1	Fetal weight QTL 1	12.1	0.005	fetal growth trait (VT:0004201)	fetal body weight (CMO:0002080)	1	92963855	109494029	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	81269860	99645535	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	93903998	191260518	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)	1	92683681	137683681	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	92683681	137683681	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat

Markers in Region

RH143594

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	86,377,979 - 86,378,112 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	89,575,110 - 89,575,242	NCBI	Rnor6.0
Rnor_5.0	1	90,729,657 - 90,729,789	UniSTS	Rnor5.0
RGSC_v3.4	1	86,186,369 - 86,186,501	UniSTS	RGSC3.4
Celera	1	80,746,860 - 80,746,992	UniSTS
RH 3.4 Map	1	843.3	UniSTS
Cytogenetic Map	1	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001014160	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001399636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005487912	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY171575	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC105896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000028660 ⟹ ENSRNOP00000028660

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	95,494,378 - 95,520,716 (-)	Ensembl
mRatBN7.2 Ensembl	1	86,367,001 - 86,393,336 (-)	Ensembl
Rnor_6.0 Ensembl	1	89,563,976 - 89,590,490 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094763 ⟹ ENSRNOP00000088720

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	95,494,378 - 95,509,096 (-)	Ensembl
mRatBN7.2 Ensembl	1	86,367,001 - 86,381,719 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097520 ⟹ ENSRNOP00000091102

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	95,494,378 - 95,515,918 (-)	Ensembl
mRatBN7.2 Ensembl	1	86,367,003 - 86,388,553 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116007 ⟹ ENSRNOP00000082331

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	95,494,378 - 95,515,918 (-)	Ensembl
mRatBN7.2 Ensembl	1	86,367,001 - 86,381,145 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000141359 ⟹ ENSRNOP00000112265

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	95,494,378 - 95,520,716 (-)	Ensembl

RefSeq Acc Id:

NM_001014160 ⟹ NP_001014182

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	95,494,378 - 95,515,918 (-)	NCBI
mRatBN7.2	1	86,367,001 - 86,388,541 (-)	NCBI
Rnor_6.0	1	89,563,984 - 89,578,326 (-)	NCBI
Rnor_5.0	1	90,718,529 - 90,744,916 (-)	NCBI
RGSC_v3.4	1	86,175,392 - 86,189,585 (-)	RGD
Celera	1	80,735,883 - 80,750,076 (-)	RGD

Sequence:

show sequence

GGCCGGAGCTCACCGAGCAGCTCCCCGTCTCTTCGGAAGCGGCTTCAGCTCTTGCCCCCAAGCC
GGCCGCCTTCGGCTCCTGAGCCAGAGCCAGGCACCATGGTGGAGAAGGGGTCTGACAGTTCCTC
TGAGAAGAGCGGAGTGTCCGGGACACTCAGCACCCAGAGTCTGGGCAGCCGGAACTTCATCCGC
AACAGTAAGAAGATGCAGAGCTGGTACAGTATGCTGTGTCCCACATACAAACAACGTAACGAGG
ACTTCCGGAAACTCTTTAGCAAACTTCCAGAAGCAGAACGCCTCATTGTGGATTACTCCTGCGC
CCTGCAGCGGGAGATCCTCCTCCAGGGCCGCCTCTACCTCTCTGAGAACTGGATCTGTTTCTAC
AGCAACATCTTCCGCTGGGAGACCACGATTTCCATCCAGTTGAAGGAAGTGACCTGTCTGAAGA
AGGAGAAGACGGCTAAGCTCATCCCCAATGCCATTCAGATCTGTACCGAGAGTGAGAAGCATTT
CTTCACTTCCTTCGGGGCCCGAGACCGTTGCTTCCTCCTCATCTTCCGTCTCTGGCAGAACGCG
CTGCTCGAGAAGACACTGAGTCCTCGAGAGCTTTGGCACCTGGTCCATCAGTGTTATGGCTCGG
AGCTGGGCCTCACCAGTGAAGACGAAGACTATGTCTGCCCCTTGCAACTGAATGGACTCGGGAG
TCCCAAAGAGGTGGGAGATGTGATTGCACTCAGCGACATTAGCCCCTCAGGGGCAGCCGACCGC
AGCCAGGAGCCAAGCCCCGTGGGTTCAAGGTGTGGCCGGGTCACTCCAAACCTCTCTCGAGCCA
GCGGTGATGCAGACCATGGGGCCGAGGAGGACAAAGAAGATCAGACGGACAGTCAGCTGGATGC
CTCCTCCAGCCAGACAGTGACCCCAGTAGCAGAACCTCTGAGTGCTGAGCCGGCCCCGCCAGAT
GGGCCCACGTCCAACCTGGGTCCCCTGGATCTGCTGTCCAGAGAGGAACTGTTGACAGACACGA
GTAACTCCTCCTCATCCACTGGGGAAGAAGGTGACCTGGCTGCATTGCTGCCTGACCTCTCCGG
CCGGCTCCTCATCAACTCCGTCTTCCACGTGGGTGCTGAACGTCTACAGCAGATGCTCTTCTCG
GACTCTCCATTCCTGCAAGGCTTCCTGCAGCAGCGCAAGTTCACAGATGTGACCTTGAGCCCTT
GGAGCAGTGACAGCAAGTGCCACCAGCGCAGAGTCCTGACCTACACCATCCCCATTAGCAACCA
GCTAGGCCCCAAGAGCGCCTCTGTGGTGGAGACACAGACGCTGTTCCGACGTGGCCCACAGGCG
GGCGGGTGCGTGGTGGACTCTGAGGTGCTCACCCAGGGCATCCCGTACCAGGACTACTTCTACA
CTGCCCACCGATACTGTATCCTGGGTCTGGCCCGGAACAAGGCCCGGCTTCGTGTATCCTCAGA
GATCCGCTACCGAAAGCAACCGTGGAGCCTTGTGAAGTCTCTCATTGAGAAGAGCTCGTGGACT
GGCATCGAAGATTATTTCCACCACCTGGATCGAGAACTGGCCAAGGCAGGGAAGGTGTCCCTGG
AGGAAGGGGGGAAAGATGCTCGTGGGCTACTGTCAGGCCTGCGGAGGAGGAAGCGACCCCTGAG
CTGGAGGGGGCACAGAGATGGACCTCAGCACCCAGACCCAGACCCCTGCACCCAGACCAGCATG
CACACCTCAGGTTCCCTCAGCTCTCGCTTCTCGGAACCATCTGTGGATCAGGGCCCCGGGGCAG
GCATCCCCAGTGCCCTGGTTCTCATCAGCATTGTCCTCATTGTTCTCACCGCCCTCAATGCCCT
CCTCTTCTACCGTCTCTGGTCTCTGGAGAGAACAGCCCATACCTTTGAGTCCTGGCACAGCCTG
GCACTGGCCAAGGGCAAGTTCCCCCAGACAGCCACGGAGTGGGCCGAGATCTTGGCTCTGCAGA
AGCATTTCCACAGCGTTGAGGTGCACAAGTGGAGGCAGATCCTTCGCGCATCCGTGGAGCTCCT
GGATGAGATGAAGTTCTCCTTGGAGAAGCTACATCAAGGAATCACTGTCCCAGATCCTCCGCTG
GACACTCAGCCACATCCCGATGACAGTTTTCCCTGAGGACTCCTGATTGAAAAGCCACCATCCC
CTGAACGGACAGAAGGACACACGGAACCCTGGCAGCCACTGCTGGCACGGTGTAAACGCCGCCG
GGAGGTTCCTGCCTGCCCCTCACAGTGGCCCCGCCAAGAGCCACACAGACCTGGGGACCATAGA
ACCAAGATGCACTTTAGATCTGTGTGTGCCTGTGCCGGTCCAGCTGCCACTGCCTGCTCAGCCA
GGGAGCTGGCCTGGTCTTTGGCAGGCTCCCCCTCCAACTAACTTATTTTGCCCAGCTGGGGTTG
TGGGGGGCACCTTTTGGGGTGCACGAGACCCTCTGGGTTTAATGTATTATATTTATTTGGGAAT
AGCAACCCCAATAAAGGGTTGGAAATGACAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001399636 ⟹ NP_001386565

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	95,494,378 - 95,520,716 (-)	NCBI
mRatBN7.2	1	86,367,001 - 86,393,339 (-)	NCBI

RefSeq Acc Id:

XR_005487912

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	95,499,256 - 95,520,730 (-)	NCBI
mRatBN7.2	1	86,371,778 - 86,393,348 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001014182	(Get FASTA)	NCBI Sequence Viewer
	NP_001386565	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI05897	(Get FASTA)	NCBI Sequence Viewer
	AAO45419	(Get FASTA)	NCBI Sequence Viewer
	EDM07656	(Get FASTA)	NCBI Sequence Viewer
	EDM07657	(Get FASTA)	NCBI Sequence Viewer
	EDM07658	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028660
	ENSRNOP00000082331
GenBank Protein	Q3KR56	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001014182 ⟸ NM_001014160
- Peptide Label:	isoform 2
- UniProtKB:	Q3KR56 (UniProtKB/Swiss-Prot), Q6Y8E7 (UniProtKB/Swiss-Prot), A6JA76 (UniProtKB/TrEMBL), A0A8I6GIR6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVEKGSDSSSEKSGVSGTLSTQSLGSRNFIRNSKKMQSWYSMLCPTYKQRNEDFRKLFSKLPEA ERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAI QICTESEKHFFTSFGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYV CPLQLNGLGSPKEVGDVIALSDISPSGAADRSQEPSPVGSRCGRVTPNLSRASGDADHGAEEDK EDQTDSQLDASSSQTVTPVAEPLSAEPAPPDGPTSNLGPLDLLSREELLTDTSNSSSSTGEEGD LAALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQRKFTDVTLSPWSSDSKCHQRRV LTYTIPISNQLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLAR NKARLRVSSEIRYRKQPWSLVKSLIEKSSWTGIEDYFHHLDRELAKAGKVSLEEGGKDARGLLS GLRRRKRPLSWRGHRDGPQHPDPDPCTQTSMHTSGSLSSRFSEPSVDQGPGAGIPSALVLISIV LIVLTALNALLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQKHFHSVEVHKWR QILRASVELLDEMKFSLEKLHQGITVPDPPLDTQPHPDDSFP hide sequence

Ensembl Acc Id:

ENSRNOP00000028660 ⟸ ENSRNOT00000028660

Ensembl Acc Id:

ENSRNOP00000082331 ⟸ ENSRNOT00000116007

Ensembl Acc Id:

ENSRNOP00000091102 ⟸ ENSRNOT00000097520

Ensembl Acc Id:

ENSRNOP00000088720 ⟸ ENSRNOT00000094763

RefSeq Acc Id:	NP_001386565 ⟸ NM_001399636
- Peptide Label:	isoform 1
- UniProtKB:	A0A0H2UHS9 (UniProtKB/TrEMBL), A6JA75 (UniProtKB/TrEMBL), A0A8I6GIR6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000112265 ⟸ ENSRNOT00000141359

Protein Domains

GRAM VASt

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q3KR56-F1-model_v2	AlphaFold	Q3KR56	1-723	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311022	AgrOrtholog
BioCyc Gene	G2FUF-60044	BioCyc
Ensembl Genes	ENSRNOG00000021106	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000028660	ENTREZGENE
	ENSRNOT00000116007	ENTREZGENE
Gene3D-CATH	2.30.29.30	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7380410	IMAGE-MGC_LOAD
InterPro	Cholesterol_transport	UniProtKB/Swiss-Prot
	GRAM	UniProtKB/Swiss-Prot
	PH-like_dom_sf	UniProtKB/Swiss-Prot
	VASt	UniProtKB/Swiss-Prot
KEGG Report	rno:361550	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:124896	IMAGE-MGC_LOAD
NCBI Gene	361550	ENTREZGENE
PANTHER	PROTEIN ASTER-A	UniProtKB/Swiss-Prot
	UNCHARACTERIZED	UniProtKB/Swiss-Prot
Pfam	GRAM	UniProtKB/Swiss-Prot
	VASt	UniProtKB/Swiss-Prot
PhenoGen	Gramd1a	PhenoGen
PROSITE	VAST	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000021106	RatGTEx
SMART	GRAM	UniProtKB/Swiss-Prot
UniProt	A0A0H2UHS9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZUS0_RAT	UniProtKB/TrEMBL
	A0A8I6AJF2_RAT	UniProtKB/TrEMBL
	A0A8I6GIR6	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0M4G4_RAT	UniProtKB/TrEMBL
	A6JA75	ENTREZGENE, UniProtKB/TrEMBL
	A6JA76	ENTREZGENE, UniProtKB/TrEMBL
	A6JA77_RAT	UniProtKB/TrEMBL
	ASTRA_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q6Y8E7	ENTREZGENE
UniProt Secondary	Q6Y8E7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Gramd1a	GRAM domain containing 1A	RGD1311022	similar to RIKEN cDNA 1300003M23	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1311022	similar to RIKEN cDNA 1300003M23	RGD1311022_predicted	similar to RIKEN cDNA 1300003M23 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1311022_predicted	similar to RIKEN cDNA 1300003M23 (predicted)	LOC361550_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC361550_predicted	similar to RIKEN cDNA 1300003M23 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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