Loxl3 (lysyl oxidase-like 3) - Rat Genome Database

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Gene: Loxl3 (lysyl oxidase-like 3) Rattus norvegicus
Analyze
Symbol: Loxl3
Name: lysyl oxidase-like 3
RGD ID: 1311011
Description: Predicted to enable fibronectin binding activity and protein-lysine 6-oxidase activity. Predicted to be involved in several processes, including collagen fibril organization; fibronectin fibril organization; and negative regulation of T-helper 17 cell lineage commitment. Predicted to be located in cytoplasm; extracellular region; and nucleus. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in myopia. Orthologous to human LOXL3 (lysyl oxidase like 3); INTERACTS WITH acetamide; acrylamide; atrazine.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC312478; lysyl oxidase homolog 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,098,358 - 117,114,673 (+)NCBIGRCr8
mRatBN7.24115,540,640 - 115,556,958 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,540,685 - 115,557,466 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,017,222 - 121,033,539 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,792,423 - 116,808,736 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,406,990 - 115,423,299 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,866,782 - 113,883,713 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,866,804 - 113,883,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,552,500 - 178,568,813 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,245,933 - 117,262,248 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,491,707 - 117,506,378 (+)NCBI
Celera4104,535,320 - 104,551,634 (+)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 10 of 10 rows
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Loxl3Rat3-methylglutaconic aciduria type 8  ISOLOXL3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
Loxl3Ratautistic disorder  ISOLOXL3 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVar 
Loxl3Ratcongenital disorder of glycosylation type IIb  ISOLOXL3 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital disorder of glycosylation type 2BClinVarPMID:24716661 more ...
Loxl3Ratdystonia  ISOLOXL3 (Homo sapiens)8554872ClinVar Annotator: match by term: DystoniaClinVarPMID:16697227 more ...
Loxl3Ratgenetic disease  ISOLOXL3 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
Loxl3RatLeigh disease  ISOLOXL3 (Homo sapiens)8554872ClinVar Annotator: match by term: Leigh syndromeClinVarPMID:25741868
Loxl3RatMethylmalonyl-CoA Epimerase Deficiency  ISOLOXL3 (Homo sapiens)8554872ClinVar Annotator: match by term: METHYLMALONIC ACIDURIA IIIClinVarPMID:16697227 more ...
Loxl3RatMyopia 28  ISOLOXL3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
Loxl3RatParkinson's Disease 13  ISOLOXL3 (Homo sapiens)8554872ClinVar Annotator: match by term: Parkinson disease 13 more ...ClinVarPMID:15961413 more ...
Loxl3RatStickler syndrome  ISOLOXL3 (Homo sapiens)8554872ClinVar Annotator: match by term: Stickler syndromeClinVarPMID:25741868 more ...
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Object Symbol
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Reference
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Source
Original Reference(s)
Loxl3RatDisease Progression  ISOLOXL3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35841383
Loxl3Rathepatocellular carcinoma  ISOLOXL3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35841383
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Loxl3RatMyopia 28  ISOLOXL3 (Homo sapiens)7240710 OMIM 

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Object Symbol
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Reference
Notes
Source
Original Reference(s)
Loxl3Rat17alpha-ethynylestradiol multiple interactionsISOLoxl3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LOXL3 mRNACTDPMID:17942748
Loxl3Rat17beta-estradiol increases expressionISOLOXL3 (Homo sapiens)6480464Estradiol results in increased expression of LOXL3 mRNACTDPMID:31614463
Loxl3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOLoxl3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LOXL3 mRNACTDPMID:17942748
Loxl3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOLoxl3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of LOXL3 mRNACTDPMID:27562557
Loxl3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOLoxl3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of LOXL3 mRNACTDPMID:21570461
Loxl3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOLOXL3 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of LOXL3 mRNACTDPMID:20106945 and PMID:21632981
Loxl3Rat3,4-methylenedioxymethamphetamine increases expressionISOLoxl3 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of LOXL3 mRNACTDPMID:20188158
Loxl3Rat4,4'-sulfonyldiphenol decreases methylationISOLoxl3 (Mus musculus)6480464bisphenol S results in decreased methylation of LOXL3 exonCTDPMID:33297965
Loxl3Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of LOXL3 mRNACTDPMID:31881176
Loxl3Ratacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of LOXL3 mRNACTDPMID:28959563
Loxl3Ratall-trans-retinoic acid increases expressionISOLOXL3 (Homo sapiens)6480464Tretinoin results in increased expression of LOXL3 mRNACTDPMID:33167477
Loxl3Ratarsenite(3-) decreases expressionISOLoxl3 (Mus musculus)6480464arsenite results in decreased expression of LOXL3 mRNACTDPMID:18929588
Loxl3Ratarsenite(3-) affects expressionISOLOXL3 (Homo sapiens)6480464arsenite affects the expression of LOXL3 mRNACTDPMID:22959463
Loxl3Ratarsenite(3-) multiple interactionsISOLoxl3 (Mus musculus)6480464TRP53 protein affects the reaction [arsenite results in decreased expression of LOXL3 mRNA]CTDPMID:18929588
Loxl3Ratatrazine increases expressionISOLOXL3 (Homo sapiens)6480464Atrazine results in increased expression of LOXL3 mRNACTDPMID:22378314
Loxl3Ratatrazine decreases expressionEXP 6480464Atrazine results in decreased expression of LOXL3 mRNACTDPMID:36841081
Loxl3Ratazoxystrobin multiple interactionsEXP 6480464[azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased methylation of LOXL3 geneCTDPMID:33854195
Loxl3Ratbenzo[a]pyrene increases expressionISOLoxl3 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of LOXL3 mRNACTDPMID:32417428
Loxl3Ratbenzo[a]pyrene decreases methylationISOLOXL3 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of LOXL3 5' UTRCTDPMID:27901495
Loxl3Ratbenzo[a]pyrene increases methylationISOLOXL3 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of LOXL3 promoterCTDPMID:27901495

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Biological Process
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Object Symbol
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Original Reference(s)
Loxl3Ratcollagen fibril organization involved_inIBAMGI:96817 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Loxl3Ratepithelial to mesenchymal transition involved_inISOLOXL3 (Homo sapiens)1624291 PMID:16096638RGDPMID:16096638
Loxl3Ratfibronectin fibril organization involved_inISOLoxl3 (Mus musculus)1624291 PMID:26954549RGDPMID:26954549
Loxl3Ratinflammatory response involved_inISOLoxl3 (Mus musculus)1624291 PMID:28065600RGDPMID:28065600
Loxl3Ratlung development involved_inISOLoxl3 (Mus musculus)1624291 PMID:27645581RGDPMID:27645581
Loxl3Ratnegative regulation of DNA-templated transcription involved_inISOLOXL3 (Homo sapiens)1624291 PMID:16096638RGDPMID:16096638
Loxl3Ratnegative regulation of T-helper 17 cell lineage commitment involved_inISOLoxl3 (Mus musculus)1624291 PMID:28065600RGDPMID:28065600
Loxl3Ratnegative regulation of T-helper 17 cell lineage commitment involved_inISOLOXL3 (Homo sapiens)1624291 PMID:28065600RGDPMID:28065600
Loxl3Ratpeptidyl-lysine oxidation involved_inISOLoxl3 (Mus musculus)1624291 PMID:26954549RGDPMID:26954549
Loxl3Ratpeptidyl-lysine oxidation involved_inISOLOXL3 (Homo sapiens)1624291 PMID:28065600RGDPMID:28065600
Loxl3Ratpositive regulation of integrin-mediated signaling pathway involved_inISOLoxl3 (Mus musculus)1624291 PMID:26954549RGDPMID:26954549
Loxl3Ratroof of mouth development involved_inISOLoxl3 (Mus musculus)1624291 PMID:26307084RGDPMID:26307084
Loxl3Ratsomite development involved_inISOLoxl3 (Mus musculus)1624291 PMID:26954549RGDPMID:26954549
Loxl3Ratspinal cord development involved_inISOLoxl3 (Mus musculus)1624291 PMID:26307084RGDPMID:26307084
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Cellular Component
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Object Symbol
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Reference
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Original Reference(s)
Loxl3Ratcollagen-containing extracellular matrix is_active_inIBAPANTHER:PTN008698711 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Loxl3Ratcytoplasm located_inISOLOXL3 (Homo sapiens)1624291 PMID:28065600RGDPMID:28065600
Loxl3Ratextracellular region located_inISOLOXL3 (Homo sapiens)1624291 PMID:11284725RGDPMID:11284725
Loxl3Ratextracellular region located_inIEAUniProtKB-SubCell:SL-01121600115GO_REF:0000044UniProtGO_REF:0000044
Loxl3Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Loxl3Ratextracellular space located_inISOLoxl3 (Mus musculus)1624291 PMID:26954549RGDPMID:26954549
Loxl3Ratextracellular space is_active_inIBAMGI:106096 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Loxl3Ratextracellular space located_inIEAUniRule:UR0013507591600115GO_REF:0000104UniProtGO_REF:0000104
Loxl3Ratmembrane located_inIEAInterPro:IPR001190 and InterPro:IPR0367721600115GO_REF:0000002InterProGO_REF:0000002
Loxl3Ratnucleus located_inISOLOXL3 (Homo sapiens)1624291 PMID:28065600RGDPMID:28065600
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Molecular Function
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Object Symbol
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Original Reference(s)
Loxl3Ratcopper ion binding enablesIEAUniRule:UR0013507591600115GO_REF:0000104UniProtGO_REF:0000104
Loxl3Ratcopper ion binding enablesIEAInterPro:IPR001695 and InterPro:IPR0198281600115GO_REF:0000002InterProGO_REF:0000002
Loxl3Ratcopper ion binding enablesIEAInterPro:IPR0016951600115GO_REF:0000002InterProGO_REF:0000002
Loxl3Ratfibronectin binding enablesISOLoxl3 (Mus musculus)1624291 PMID:26954549RGDPMID:26954549
Loxl3Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Loxl3Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Loxl3Ratoxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor enablesIEAInterPro:IPR001695 and InterPro:IPR0198281600115GO_REF:0000002InterProGO_REF:0000002
Loxl3Ratoxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor enablesIEAInterPro:IPR0016951600115GO_REF:0000002InterProGO_REF:0000002
Loxl3Ratprotein binding enablesISOLOXL3 (Homo sapiens)1624291UniProtKB:O95863 more ...RGDPMID:16096638 more ...
Loxl3Ratprotein-lysine 6-oxidase activity enablesISOLOXL3 (Homo sapiens)1624291 PMID:28065600RGDPMID:28065600
Loxl3Ratprotein-lysine 6-oxidase activity enablesIEAEC:1.4.3.131600115GO_REF:0000003UniProtGO_REF:0000003
Loxl3Ratprotein-lysine 6-oxidase activity enablesIEAUniRule:UR0013507591600115GO_REF:0000104UniProtGO_REF:0000104
Loxl3Ratprotein-lysine 6-oxidase activity enablesISOLoxl3 (Mus musculus)1624291 PMID:26954549RGDPMID:26954549
Loxl3Ratprotein-lysine 6-oxidase activity enablesIBAFB:FBgn0039848 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:11284725   PMID:16096638   PMID:24006456   PMID:26307084   PMID:26954549   PMID:27645581   PMID:28065600   PMID:29966587   PMID:36134856   PMID:38153629  



Loxl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,098,358 - 117,114,673 (+)NCBIGRCr8
mRatBN7.24115,540,640 - 115,556,958 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,540,685 - 115,557,466 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,017,222 - 121,033,539 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,792,423 - 116,808,736 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,406,990 - 115,423,299 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,866,782 - 113,883,713 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,866,804 - 113,883,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,552,500 - 178,568,813 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,245,933 - 117,262,248 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,491,707 - 117,506,378 (+)NCBI
Celera4104,535,320 - 104,551,634 (+)NCBICelera
Cytogenetic Map4q34NCBI
LOXL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,532,258 - 74,555,702 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,532,258 - 74,555,690 (-)EnsemblGRCh38hg38GRCh38
GRCh37274,759,385 - 74,781,069 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,613,454 - 74,634,570 (-)NCBINCBI36Build 36hg18NCBI36
Build 34274,671,600 - 74,692,717NCBI
Celera274,591,054 - 74,612,170 (-)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,496,207 - 74,517,323 (-)NCBIHuRef
CHM1_1274,689,342 - 74,710,457 (-)NCBICHM1_1
T2T-CHM13v2.0274,540,824 - 74,564,305 (-)NCBIT2T-CHM13v2.0
Loxl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,011,186 - 83,029,547 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,011,154 - 83,029,543 (+)EnsemblGRCm39 Ensembl
GRCm38683,034,205 - 83,052,566 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,034,173 - 83,052,562 (+)EnsemblGRCm38mm10GRCm38
MGSCv37682,984,218 - 83,002,558 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36682,999,882 - 83,018,222 (+)NCBIMGSCv36mm8
Celera685,015,734 - 85,035,153 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Loxl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,236,836 - 11,259,570 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,236,415 - 11,255,801 (+)NCBIChiLan1.0ChiLan1.0
LOXL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,833,505 - 51,856,127 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,836,098 - 51,858,879 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,598,870 - 74,622,502 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,105,957 - 76,128,495 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,105,957 - 76,128,495 (-)Ensemblpanpan1.1panPan2
LOXL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,590,996 - 48,610,264 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,591,768 - 48,610,392 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,232,758 - 48,252,169 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,450,304 - 49,469,724 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,450,333 - 49,469,843 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,467,472 - 48,486,874 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,534,207 - 48,553,616 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,091,871 - 49,111,294 (+)NCBIUU_Cfam_GSD_1.0
Loxl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,971,949 - 9,992,107 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556745,798 - 765,918 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936556745,798 - 765,926 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOXL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,498,189 - 68,517,445 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,498,114 - 68,516,829 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,670,347 - 71,688,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOXL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,722,588 - 32,745,480 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,725,112 - 32,745,004 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,425,804 - 79,448,819 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Loxl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474928,960,593 - 28,980,428 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474928,959,682 - 28,980,428 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Loxl3
53 total Variants

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:36
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000010293
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat

1 to 10 of 52 rows
RH124140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21544,766,673 - 44,767,926 (+)MAPPERmRatBN7.2
mRatBN7.24115,555,823 - 115,556,054 (+)MAPPERmRatBN7.2
Rnor_6.04113,882,579 - 113,882,809NCBIRnor6.0
Rnor_6.01551,361,065 - 51,362,317NCBIRnor6.0
Rnor_5.01555,088,807 - 55,090,059UniSTSRnor5.0
Rnor_5.04178,567,679 - 178,567,909UniSTSRnor5.0
RGSC_v3.44117,261,114 - 117,261,344UniSTSRGSC3.4
RGSC_v3.41550,064,728 - 50,065,980UniSTSRGSC3.4
Celera1544,449,013 - 44,450,265UniSTS
Celera4104,550,500 - 104,550,730UniSTS
Cytogenetic Map4q34UniSTS
Cytogenetic Map15p11UniSTS
RH128117  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84117,114,839 - 117,115,159 (+)Marker Load Pipeline
mRatBN7.24115,557,124 - 115,557,444 (+)MAPPERmRatBN7.2
Rnor_6.04113,883,880 - 113,884,199NCBIRnor6.0
Rnor_5.04178,568,980 - 178,569,299UniSTSRnor5.0
RGSC_v3.44117,262,415 - 117,262,734UniSTSRGSC3.4
Celera4104,551,801 - 104,552,120UniSTS
Cytogenetic Map4q34UniSTS
Loxl3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24115,555,575 - 115,556,931 (+)MAPPERmRatBN7.2
Rnor_6.04113,882,331 - 113,883,686NCBIRnor6.0
Rnor_5.04178,567,431 - 178,568,786UniSTSRnor5.0
RGSC_v3.44117,260,866 - 117,262,221UniSTSRGSC3.4
Celera4104,550,252 - 104,551,607UniSTS
Cytogenetic Map4q34UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000081196   ⟹   ENSRNOP00000074073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,540,685 - 115,557,466 (+)Ensembl
Rnor_6.0 Ensembl4113,866,804 - 113,883,477 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105834   ⟹   ENSRNOP00000083226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,540,685 - 115,557,466 (+)Ensembl
RefSeq Acc Id: NM_001107866   ⟹   NP_001101336
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,098,358 - 117,114,673 (+)NCBI
mRatBN7.24115,540,640 - 115,556,958 (+)NCBI
Rnor_6.04113,867,398 - 113,883,713 (+)NCBI
Rnor_5.04178,552,500 - 178,568,813 (+)NCBI
RGSC_v3.44117,245,933 - 117,262,248 (+)RGD
Celera4104,535,320 - 104,551,634 (+)RGD
Sequence:
RefSeq Acc Id: XM_039107586   ⟹   XP_038963514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,105,472 - 117,114,673 (+)NCBI
mRatBN7.24115,551,103 - 115,556,958 (+)NCBI
Protein RefSeqs NP_001101336 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963514 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL91104 (Get FASTA)   NCBI Sequence Viewer  
  EDL91105 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074073.1
  ENSRNOP00000083226.1
  ENSRNOP00000109267
RefSeq Acc Id: NP_001101336   ⟸   NM_001107866
- Peptide Label: precursor
- UniProtKB: D3ZP82 (UniProtKB/TrEMBL),   A6IAI6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074073   ⟸   ENSRNOT00000081196
RefSeq Acc Id: XP_038963514   ⟸   XM_039107586
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000083226   ⟸   ENSRNOT00000105834
SRCR

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZP82-F1-model_v2 AlphaFold D3ZP82 1-754 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693162
Promoter ID:EPDNEW_R3687
Type:initiation region
Name:Loxl3_1
Description:lysyl oxidase-like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04113,867,443 - 113,867,503EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-44035 BioCyc
Ensembl Genes ENSRNOG00000061373 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081196.2 UniProtKB/TrEMBL
  ENSRNOT00000105834.1 UniProtKB/TrEMBL
  ENSRNOT00000148185 ENTREZGENE
Gene3D-CATH 3.10.250.10 UniProtKB/TrEMBL
InterPro LOX-like_protein UniProtKB/TrEMBL
  Lysyl_oxidase UniProtKB/TrEMBL
  Lysyl_oxidase_CS UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/TrEMBL
  Srcr_rcpt UniProtKB/TrEMBL
KEGG Report rno:312478 UniProtKB/TrEMBL
NCBI Gene 312478 ENTREZGENE
PANTHER LYSYL OXIDASE HOMOLOG 3 UniProtKB/TrEMBL
  LYSYL OXIDASE-LIKE-RELATED UniProtKB/TrEMBL
Pfam Lysyl_oxidase UniProtKB/TrEMBL
  SRCR UniProtKB/TrEMBL
PhenoGen Loxl3 PhenoGen
PRINTS LYSYLOXIDASE UniProtKB/TrEMBL
  SPERACTRCPTR UniProtKB/TrEMBL
PROSITE LYSYL_OXIDASE UniProtKB/TrEMBL
  SRCR_1 UniProtKB/TrEMBL
  SRCR_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061373 RatGTEx
SMART SM00202 UniProtKB/TrEMBL
Superfamily-SCOP Srcr_receptor UniProtKB/TrEMBL
UniProt A0A8I5ZWI7_RAT UniProtKB/TrEMBL
  A6IAI6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZP82 ENTREZGENE, UniProtKB/TrEMBL
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Loxl3  lysyl oxidase-like 3   Loxl3_predicted  lysyl oxidase-like 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Loxl3_predicted  lysyl oxidase-like 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED