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Gene: C1qtnf4 (C1q and TNF related 4) Rattus norvegicus

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Symbol:

C1qtnf4

Name:

C1q and TNF related 4

RGD ID:

1311006

Description:

Predicted to enable cytokine activity. Predicted to be involved in positive regulation of cytokine production and positive regulation of signal transduction. Predicted to act upstream of or within cell surface receptor signaling pathway via STAT; gene expression; and reduction of food intake in response to dietary excess. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human C1QTNF4 (C1q and TNF related 4); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

C1q and tumor necrosis factor related protein 4; complement C1q tumor necrosis factor-related protein 4; LOC311184

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	C1QTNF4 (C1q and TNF related 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):	C1qtnf4 (C1q and tumor necrosis factor related protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	C1qtnf4 (C1q and TNF related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	C1QTNF4 (C1q and TNF related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	C1QTNF4 (C1q and TNF related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	C1qtnf4 (C1q and TNF related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	C1QTNF4 (C1q and TNF related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	C1QTNF4 (C1q and TNF related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	C1qtnf4 (C1q and TNF related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	C1qtnf4 (C1q and TNF related 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	C1QTNF4 (C1q and TNF related 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	C1QTNF4 (C1q and TNF related 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	C1qtnf4 (C1q and tumor necrosis factor related protein 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	c1qtnf4 (C1q and TNF related 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	c1qtnf4 (C1q and TNF related 4)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	c1qtnf13	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	c1qtnf13	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	c1qtnf4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	c1qtnf4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	97,310,220 - 97,328,818 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	97,327,670 - 97,342,587 (+)	Ensembl				GRCr8
mRatBN7.2	3	76,854,368 - 76,872,991 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	76,857,735 - 76,874,139 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	80,346,243 - 80,350,680 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	88,944,724 - 88,949,161 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	86,796,122 - 86,800,558 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	79,713,580 - 79,718,018 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	79,713,567 - 79,718,025 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	86,422,700 - 86,427,138 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	75,248,277 - 75,252,715 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	76,077,560 - 76,081,999 (+)	NCBI		Celera
RGSC_v3.1	3	75,144,709 - 75,149,087 (+)	NCBI
Cytogenetic Map	3	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(2,4,5-trichlorophenoxy)acetic acid (ISO)

1,1-dichloroethene (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,4'-trichlorobiphenyl (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

arsenous acid (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (EXP)

cadmium dichloride (EXP)

chlorpyrifos (ISO)

choline (ISO)

cocaine (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

dichloroacetic acid (ISO)

dorsomorphin (ISO)

fenvalerate (EXP)

folic acid (ISO)

gentamycin (EXP)

GSK-J4 (ISO)

L-methionine (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

maneb (ISO)

manganese(II) chloride (EXP)

methapyrilene (ISO)

methimazole (EXP)

panobinostat (ISO)

paraquat (ISO)

PCB138 (EXP,ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor signaling pathway via STAT (ISO)

gene expression (ISO)

inflammatory response (ISO)

macrophage activation (ISO)

positive regulation of interleukin-6 production (ISO)

positive regulation of interleukin-6-mediated signaling pathway (ISO)

positive regulation of non-canonical NF-kappaB signal transduction (ISO)

positive regulation of tumor necrosis factor production (ISO)

protein import (ISO)

protein phosphorylation (ISO)

reduction of food intake in response to dietary excess (ISO)

response to lipopolysaccharide (ISO)

response to wounding (ISO)

toll-like receptor 4 signaling pathway (ISO)

Cellular Component

extracellular region (IEA)

extracellular space (IEA,ISO)

Molecular Function

cytokine activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:21658842	PMID:24366864	PMID:27774931

Genomics

Comparative Map Data

C1qtnf4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	97,310,220 - 97,328,818 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	97,327,670 - 97,342,587 (+)	Ensembl				GRCr8
mRatBN7.2	3	76,854,368 - 76,872,991 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	76,857,735 - 76,874,139 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	80,346,243 - 80,350,680 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	88,944,724 - 88,949,161 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	86,796,122 - 86,800,558 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	79,713,580 - 79,718,018 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	79,713,567 - 79,718,025 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	86,422,700 - 86,427,138 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	75,248,277 - 75,252,715 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	76,077,560 - 76,081,999 (+)	NCBI		Celera
RGSC_v3.1	3	75,144,709 - 75,149,087 (+)	NCBI
Cytogenetic Map	3	q24	NCBI

C1QTNF4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	47,589,667 - 47,595,304 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	47,589,666 - 47,595,642 (-)	Ensembl			hg38	GRCh38
GRCh37	11	47,611,219 - 47,615,963 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	47,567,792 - 47,572,537 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	47,567,791 - 47,572,479	NCBI
Celera	11	47,753,979 - 47,758,717 (-)	NCBI		Celera
Cytogenetic Map	11	p11.2	NCBI
HuRef	11	47,312,306 - 47,317,061 (-)	NCBI		HuRef
CHM1_1	11	47,610,457 - 47,615,202 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	47,750,063 - 47,756,732 (-)	NCBI		T2T-CHM13v2.0

C1qtnf4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	90,713,132 - 90,720,870 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	90,716,204 - 90,720,869 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	90,882,788 - 90,890,526 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	90,885,860 - 90,890,525 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	90,725,943 - 90,730,683 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	90,686,697 - 90,691,358 (+)	NCBI		MGSCv36	mm8
Celera	2	92,270,821 - 92,275,561 (+)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	50.43	NCBI

C1qtnf4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	708,161 - 709,167 (+)	Ensembl
ChiLan1.0	NW_004955422	705,165 - 709,261 (+)	NCBI	ChiLan1.0	ChiLan1.0

C1QTNF4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	49,793,994 - 49,799,724 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	49,813,739 - 49,819,474 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	47,539,243 - 47,544,971 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	48,088,983 - 48,090,128 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

C1QTNF4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	42,060,880 - 42,065,411 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	40,792,685 - 40,796,767 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	42,717,222 - 42,721,306 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	42,720,172 - 42,720,919 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	42,204,460 - 42,208,542 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	41,758,785 - 41,762,857 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	42,488,818 - 42,492,902 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

C1qtnf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	19,526,472 - 19,551,511 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936562	1,659,164 - 1,664,183 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936562	1,659,171 - 1,663,154 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

C1QTNF4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	15,021,969 - 15,027,536 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	15,019,751 - 15,026,905 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	16,197,211 - 16,203,456 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

C1QTNF4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	17,723,720 - 17,730,187 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	115,016,268 - 115,022,663 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

C1qtnf4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	1,231,098 - 1,235,341 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624767	1,230,522 - 1,235,341 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

C1qtnf4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	65,060,756 - 65,065,476 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in C1qtnf4
118 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	65
Count of miRNA genes:	60
Interacting mature miRNAs:	63
Transcripts:	ENSRNOT00000012110
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	51490129	111359995	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	73592611	110333156	Rat
1358293	Bw38	Body weight QTL 38	6	0.0000031	body mass (VT:0001259)	body weight (CMO:0000012)	3	74364268	119364268	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	96509147	141509147	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	73592512	136118980	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	53651826	98651826	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	35403199	97383526	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	49872657	138829559	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	85062224	136118980	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	85062224	136118980	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	81425008	141509147	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	70845569	136091483	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	3	93829559	138829559	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	96509147	141509147	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	58925062	103925062	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	70311536	115311536	Rat
631200	Cm25	Cardiac mass QTL 25	4.8	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	3	81541464	126563126	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	90755164	141509147	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	36721849	110333156	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	42158111	124558371	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	42158111	124558371	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat

Markers in Region

D3Arb19

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	3	97,317,425 - 97,317,579 (+)	Marker Load Pipeline
mRatBN7.2	3	76,861,588 - 76,861,742 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	79,706,596 - 79,706,749	NCBI	Rnor6.0
Rnor_5.0	3	86,416,076 - 86,416,229	UniSTS	Rnor5.0
RGSC_v3.4	3	75,241,366 - 75,241,520	RGD	RGSC3.4
RGSC_v3.4	3	75,241,367 - 75,241,520	UniSTS	RGSC3.4
Celera	3	76,070,640 - 76,070,789	UniSTS
RGSC_v3.1	3	75,137,739 - 75,137,892	RGD
SHRSP x BN Map	3	42.7898	RGD
SHRSP x BN Map	3	42.7898	UniSTS
FHH x ACI Map	3	47.0699	RGD
Cytogenetic Map	3	q24	UniSTS

RH144199

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	76,867,767 - 76,867,939 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	79,712,808 - 79,712,979	NCBI	Rnor6.0
Rnor_5.0	3	86,421,928 - 86,422,099	UniSTS	Rnor5.0
Celera	3	76,076,788 - 76,076,959	UniSTS
Cytogenetic Map	3	q24	UniSTS

RH138557

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	76,870,662 - 76,870,886 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	79,715,702 - 79,715,925	NCBI	Rnor6.0
Rnor_5.0	3	86,424,822 - 86,425,045	UniSTS	Rnor5.0
RGSC_v3.4	3	75,250,400 - 75,250,623	UniSTS	RGSC3.4
Celera	3	76,079,684 - 76,079,907	UniSTS
Cytogenetic Map	3	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
14	11	64	154	78	76	50	68	50	6	315	163	8	131	80	92	26	16	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168928	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012110 ⟹ ENSRNOP00000012110

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	79,713,567 - 79,718,025 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099320 ⟹ ENSRNOP00000089610

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	97,327,670 - 97,332,472 (+)	Ensembl
mRatBN7.2 Ensembl	3	76,857,735 - 76,874,139 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000123813 ⟹ ENSRNOP00000108244

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	97,327,670 - 97,339,737 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000128322 ⟹ ENSRNOP00000106088

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	97,327,670 - 97,339,737 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000136641 ⟹ ENSRNOP00000103551

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	97,327,670 - 97,342,587 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000139493 ⟹ ENSRNOP00000103775

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	97,327,670 - 97,339,737 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000142688 ⟹ ENSRNOP00000107186

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	97,327,670 - 97,339,737 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000164791 ⟹ ENSRNOP00000109902

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	97,327,670 - 97,339,737 (+)	Ensembl

RefSeq Acc Id:

NM_001107745 ⟹ NP_001101215

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,324,371 - 97,328,809 (+)	NCBI
mRatBN7.2	3	76,868,540 - 76,872,978 (+)	NCBI
Rnor_6.0	3	79,713,580 - 79,718,018 (+)	NCBI
Rnor_5.0	3	86,422,700 - 86,427,138 (+)	NCBI
RGSC_v3.4	3	75,248,277 - 75,252,715 (+)	RGD
Celera	3	76,077,560 - 76,081,999 (+)	RGD

Sequence:

show sequence

CCCTTGCGCTTCTCCGCTTCAGCTTCTGCTGTCCTTCCCACTCGCTCACGCCTCCCTTGCCGGG
GTCCCCACTCGTCGCCGGCTGAGCCCCCCGCCACCCCCGGAGGCCTGGTCAAGCCGCAGCGTGG
GCGACCAGTGTGCAGCCCGGCGTCCTCACCGAGCAGGATCGCCGGCTGGGACCGAAGCCGACCC
GCCGGCCGCCAGCCAGGTGCCATGCTGCTCCTCCTGCTCGGCTTCCTAGGCCCGGTGGCCTGCT
GGGCACTGGGCCGGGCTGGGCCTGGCTCCTCGGAGCTGCGGTCAGCCTTCTCGGCGGCTCGCAC
CACCCCACTGGAGGGCACGTCGGAGATGGCGGTGACCTTCGACAAGGTATACGTGAACATCGGA
GGTGACTTCGACGCAGCCACCGGGAGGTTCCGCTGTCGCGTGCCCGGCGCCTATTTCTTCTCCT
TCACAGCGGGCAAGGCCCCGCATAAGAGCCTGTCGGTGATGCTGGTGCGCAACCGCGACGAGGT
GCAGGCGCTGGCCTTCGACGAGCAGCGGCGGCCGGGCGCACGGCGCGCCGCCAGCCAGAGTGCC
ATGCTGCAGCTCGACTACGGCGACACGGTGTGGCTGCGGCTGCACGGCGCCCCGCAGTACGCGC
TCGGCGCGCCCGGCGCCACCTTTAGCGGCTACCTGGTGTACGCGGACGCCGATGCTGACGCGCC
TGCGCGCGGCCCCGCAGCCCTGGAGCCGCGCTCGGCCTTCTCCGCGGCGCGCACGCGCAGCCTG
GTGGGCTCGGACGCGGGACCCGGACCGCGCCACCGGCCGCTGGCCTTCGACACCGAGCTGGTAA
ACATAGGCGGCGACTTCGACGCGGCGGCCGGCGTGTTCCGCTGCCGCCTACCGGGAGCCTATTT
CTTCTCCTTCACGCTGGGCAAGCTGCCGCGCAAGACGCTGTCGGTGAAGCTGATGAAGAACCGC
GACGAGGTGCAGGCCATGATTTACGACGATGGCGCTTCGAGGCGCCGTGAGATGCAGAGTCAGA
GCGTGATGCTGCCACTGCAGCGTGGCGATGCCGTCTGGCTGCTTAGCCACGATCATGATGGCTA
TGGCGCCTACAGCAACCACGGCAAGTACATCACTTTCTCTGGCTTCCTGGTGTACCCTGACCTC
ACTGCTGCCTCCCCGCCGGCCCTCAAGCCCCCAGAGCTCTGAGCCTCTGCTTGGAGGAGCCTGG
GAGAGCCGTGGGGCATGCATGCCGAGCCGGGACCGCGGCCCGAACGCCCCACCGGCCGGAGCAT
GACTACCTGCCCAGCACGCCTGGACTCTACCAATAAAGTGGGGCTGCCTGTCAGCCTTATGGTC
CTGC

hide sequence

RefSeq Acc Id:

XM_039104894 ⟹ XP_038960822

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,313,576 - 97,328,818 (+)	NCBI
mRatBN7.2	3	76,857,737 - 76,872,991 (+)	NCBI

RefSeq Acc Id:

XM_039104895 ⟹ XP_038960823

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	97,310,220 - 97,328,818 (+)	NCBI
mRatBN7.2	3	76,854,368 - 76,872,991 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101215	(Get FASTA)	NCBI Sequence Viewer
	XP_038960822	(Get FASTA)	NCBI Sequence Viewer
	XP_038960823	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68928	(Get FASTA)	NCBI Sequence Viewer
	EDL79486	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000089610
	ENSRNOP00000089610.1
	ENSRNOP00000103551.1
	ENSRNOP00000103775.1
	ENSRNOP00000106088.1
	ENSRNOP00000107186.1
	ENSRNOP00000108244.1
	ENSRNOP00000109902.1

RefSeq Acc Id:	NP_001101215 ⟸ NM_001107745
- Peptide Label:	precursor
- UniProtKB:	B5DF52 (UniProtKB/TrEMBL), A6HN85 (UniProtKB/TrEMBL), A0A8I6ACA8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLLLLLGFLGPVACWALGRAGPGSSELRSAFSAARTTPLEGTSEMAVTFDKVYVNIGGDFDAAT GRFRCRVPGAYFFSFTAGKAPHKSLSVMLVRNRDEVQALAFDEQRRPGARRAASQSAMLQLDYG DTVWLRLHGAPQYALGAPGATFSGYLVYADADADAPARGPAALEPRSAFSAARTRSLVGSDAGP GPRHRPLAFDTELVNIGGDFDAAAGVFRCRLPGAYFFSFTLGKLPRKTLSVKLMKNRDEVQAMI YDDGASRRREMQSQSVMLPLQRGDAVWLLSHDHDGYGAYSNHGKYITFSGFLVYPDLTAASPPA LKPPEL hide sequence

Ensembl Acc Id:

ENSRNOP00000012110 ⟸ ENSRNOT00000012110

RefSeq Acc Id:	XP_038960823 ⟸ XM_039104895
- Peptide Label:	isoform X1
- UniProtKB:	B5DF52 (UniProtKB/TrEMBL), A6HN85 (UniProtKB/TrEMBL), A0A8I6ACA8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038960822 ⟸ XM_039104894
- Peptide Label:	isoform X1
- UniProtKB:	B5DF52 (UniProtKB/TrEMBL), A6HN85 (UniProtKB/TrEMBL), A0A8I6ACA8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000089610 ⟸ ENSRNOT00000099320

Ensembl Acc Id:

ENSRNOP00000103775 ⟸ ENSRNOT00000139493

Ensembl Acc Id:

ENSRNOP00000103551 ⟸ ENSRNOT00000136641

Ensembl Acc Id:

ENSRNOP00000108244 ⟸ ENSRNOT00000123813

Ensembl Acc Id:

ENSRNOP00000107186 ⟸ ENSRNOT00000142688

Ensembl Acc Id:

ENSRNOP00000106088 ⟸ ENSRNOT00000128322

Ensembl Acc Id:

ENSRNOP00000109902 ⟸ ENSRNOT00000164791

Protein Domains

C1q

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F7EUJ8-F1-model_v2	AlphaFold	F7EUJ8	1-325	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692199

Promoter ID:

EPDNEW_R2724

Type:

single initiation site

Name:

C1qtnf4_1

Description:

C1q and TNF related 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	79,713,619 - 79,713,679	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311006	AgrOrtholog
BioCyc Gene	G2FUF-48760	BioCyc
Ensembl Genes	ENSRNOG00000009140	Ensembl
	ENSRNOG00000069579	Ensembl
	ENSRNOG00000081381	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000099320	ENTREZGENE
	ENSRNOT00000099320.2	UniProtKB/TrEMBL
	ENSRNOT00000123813.1	UniProtKB/TrEMBL
	ENSRNOT00000128322.1	UniProtKB/TrEMBL
	ENSRNOT00000136641.1	UniProtKB/TrEMBL
	ENSRNOT00000139493.1	UniProtKB/TrEMBL
	ENSRNOT00000142688.1	UniProtKB/TrEMBL
	ENSRNOT00000164791.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.40	UniProtKB/TrEMBL
InterPro	C1q	UniProtKB/TrEMBL
	Cerebellin_Synaptic_Org	UniProtKB/TrEMBL
	Tumour_necrosis_fac-like	UniProtKB/TrEMBL
KEGG Report	rno:311184	UniProtKB/TrEMBL
NCBI Gene	311184	ENTREZGENE
PANTHER	CEREBELLIN-RELATED	UniProtKB/TrEMBL
	COMPLEMENT C1Q TUMOR NECROSIS FACTOR-RELATED PROTEIN 4	UniProtKB/TrEMBL
Pfam	C1q	UniProtKB/TrEMBL
PhenoGen	C1qtnf4	PhenoGen
PRINTS	COMPLEMNTC1Q	UniProtKB/TrEMBL
PROSITE	C1Q	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009140	RatGTEx
	ENSRNOG00000069579	RatGTEx
	ENSRNOG00000081381	RatGTEx
SMART	C1Q	UniProtKB/TrEMBL
Superfamily-SCOP	TNF_like	UniProtKB/TrEMBL
UniProt	A0A8I6ACA8	ENTREZGENE, UniProtKB/TrEMBL
	A6HN85	ENTREZGENE, UniProtKB/TrEMBL
	B5DF52	ENTREZGENE
UniProt Secondary	B5DF52	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-09	C1qtnf4	C1q and TNF related 4	C1qtnf4	C1q and tumor necrosis factor related protein 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	C1qtnf4	C1q and tumor necrosis factor related protein 4	C1qtnf4_predicted	C1q and tumor necrosis factor related protein 4 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	C1qtnf4_predicted	C1q and tumor necrosis factor related protein 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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