Thbs2 (thrombospondin 2) - Rat Genome Database

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Gene: Thbs2 (thrombospondin 2) Rattus norvegicus
Analyze
Symbol: Thbs2
Name: thrombospondin 2
RGD ID: 1310979
Description: Predicted to enable calcium ion binding activity and heparin binding activity. Involved in negative regulation of angiogenesis and positive regulation of synapse assembly. Predicted to be located in basement membrane and platelet alpha granule. Predicted to be active in extracellular matrix. Orthologous to human THBS2 (thrombospondin 2); PARTICIPATES IN cell-extracellular matrix signaling pathway; malaria pathway; phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: thrombospondin-2; TSP-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8164,343,523 - 64,372,918 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl164,343,523 - 64,372,918 (-)EnsemblGRCr8
mRatBN7.2155,670,394 - 55,699,789 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl155,670,394 - 55,699,789 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx160,536,594 - 60,566,100 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,193,840 - 69,223,143 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0162,446,539 - 62,476,051 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0156,653,929 - 56,683,571 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl156,653,938 - 56,683,731 (-)Ensemblrn6Rnor6.0
Rnor_5.0157,842,346 - 57,871,988 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4153,584,406 - 53,613,652 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera151,888,359 - 51,917,750 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
arsenic acid  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
barium sulfate  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
Didecyldimethylammonium  (ISO)
diethyl malate  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ferric oxide  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
hexaconazole  (ISO)
ifosfamide  (ISO)
irinotecan  (EXP)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
panobinostat  (ISO)
paracetamol  (EXP)
pentane-2,3-dione  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
streptozocin  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction. Boekholdt SM, etal., Arterioscler Thromb Vasc Biol. 2002 Dec 1;22(12):e24-7.
2. Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Christopherson KS, etal., Cell. 2005 Feb 11;120(3):421-33.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Differential regulation of thrombospondin-1 and thrombospondin-2 after focal cerebral ischemia/reperfusion. Lin TN, etal., Stroke. 2003 Jan;34(1):177-86.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Control of in vivo microvessel ingrowth by modulation of biomaterial local architecture and chemistry. Sanders JE, etal., J Biomed Mater Res. 2002 Apr;60(1):36-43.
13. Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy. Schroen B, etal., Circ Res. 2004 Sep 3;95(5):515-22. Epub 2004 Jul 29.
14. Alteration of thrombospondin-1 and -2 in rat brains following experimental intracerebral hemorrhage. Zhou HJ, etal., J Neurosurg. 2010 Feb 5.
Additional References at PubMed
PMID:1737102   PMID:8889548   PMID:10669089   PMID:15748999   PMID:19189070   PMID:19571575   PMID:20714802   PMID:21124846   PMID:23043906   PMID:23541831   PMID:24006456   PMID:27068509  
PMID:28953973   PMID:31904090   PMID:37219820  


Genomics

Comparative Map Data
Thbs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8164,343,523 - 64,372,918 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl164,343,523 - 64,372,918 (-)EnsemblGRCr8
mRatBN7.2155,670,394 - 55,699,789 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl155,670,394 - 55,699,789 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx160,536,594 - 60,566,100 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,193,840 - 69,223,143 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0162,446,539 - 62,476,051 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0156,653,929 - 56,683,571 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl156,653,938 - 56,683,731 (-)Ensemblrn6Rnor6.0
Rnor_5.0157,842,346 - 57,871,988 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4153,584,406 - 53,613,652 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera151,888,359 - 51,917,750 (-)NCBICelera
Cytogenetic Map1q12NCBI
THBS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386169,215,785 - 169,253,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6169,215,780 - 169,254,060 (-)Ensemblhg38GRCh38
GRCh376169,615,880 - 169,653,941 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366169,357,800 - 169,396,062 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346169,433,507 - 169,471,769NCBI
Celera6170,328,643 - 170,365,927 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6167,041,671 - 167,078,465 (-)NCBIHuRef
CHM1_16169,878,047 - 169,916,199 (-)NCBICHM1_1
T2T-CHM13v2.06170,567,396 - 170,606,903 (-)NCBIT2T-CHM13v2.0
Thbs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391714,885,762 - 14,914,524 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1714,885,762 - 14,914,497 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381714,665,500 - 14,694,262 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1714,665,500 - 14,694,235 (-)Ensemblmm10GRCm38
MGSCv371714,802,507 - 14,831,269 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361714,403,747 - 14,430,687 (-)NCBIMGSCv36mm8
Celera1715,465,975 - 15,494,741 (-)NCBICelera
Cytogenetic Map17A2NCBI
cM Map178.95NCBI
Thbs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554114,314,984 - 4,347,383 (+)Ensembl
ChiLan1.0NW_0049554114,315,055 - 4,347,044 (+)NCBIChiLan1.0ChiLan1.0
THBS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25189,471,526 - 189,511,065 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16187,355,812 - 187,395,128 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06167,290,482 - 167,329,319 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16172,131,476 - 172,169,026 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6172,130,727 - 172,169,028 (-)EnsemblpanPan2panpan1.1
THBS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1156,402,519 - 56,429,975 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl156,402,524 - 56,451,892 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha157,194,281 - 57,221,451 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0156,586,312 - 56,613,645 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl156,584,696 - 56,613,622 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1156,481,253 - 56,508,431 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0156,328,999 - 56,356,324 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0156,956,445 - 56,983,636 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Thbs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946150,622,058 - 150,655,464 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648917,874,052 - 17,907,393 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648917,874,064 - 17,907,255 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THBS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1855,389 - 882,473 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11854,473 - 882,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.211,590,783 - 1,617,082 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THBS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11397,033,791 - 97,066,274 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604068,988,667 - 69,052,256 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thbs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248505,071,512 - 5,105,074 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248505,072,070 - 5,104,865 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Thbs2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1141,222,301 - 1,246,617 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Thbs2
235 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:179
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000014552
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 153 91 90 59 28 59 6 292 128 11 132 81 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000014552   ⟹   ENSRNOP00000014552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl164,343,523 - 64,372,918 (-)Ensembl
mRatBN7.2 Ensembl155,670,394 - 55,699,789 (-)Ensembl
Rnor_6.0 Ensembl156,653,938 - 56,683,731 (-)Ensembl
RefSeq Acc Id: NM_001169138   ⟹   NP_001162609
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8164,343,523 - 64,372,918 (-)NCBI
mRatBN7.2155,670,394 - 55,699,789 (-)NCBI
Rnor_6.0156,653,929 - 56,683,571 (-)NCBI
Rnor_5.0157,842,346 - 57,871,988 (-)NCBI
RGSC_v3.4153,584,406 - 53,613,652 (-)RGD
Celera151,888,359 - 51,917,750 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001162609 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014552
  ENSRNOP00000014552.6
RefSeq Acc Id: NP_001162609   ⟸   NM_001169138
- Peptide Label: precursor
- UniProtKB: D4A2G6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014552   ⟸   ENSRNOT00000014552
Protein Domains
EGF-like   TSP C-terminal   VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2G6-F1-model_v2 AlphaFold D4A2G6 1-1172 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689637
Promoter ID:EPDNEW_R162
Type:single initiation site
Name:Thbs2_1
Description:thrombospondin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0156,683,567 - 56,683,627EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310979 AgrOrtholog
BioCyc Gene G2FUF-61335 BioCyc
Ensembl Genes ENSRNOG00000010529 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014552 ENTREZGENE
  ENSRNOT00000014552.9 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  2.60.120.200 UniProtKB/TrEMBL
  4.10.1080.10 UniProtKB/TrEMBL
  6.20.200.20 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro ConA-like_subgrp UniProtKB/TrEMBL
  EGF-like_Ca-bd UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_dom_MSP1-like UniProtKB/TrEMBL
  Thrombospondin_1_rpt UniProtKB/TrEMBL
  Thrombospondin_3-like_rpt UniProtKB/TrEMBL
  Thrombospondin_3_rpt UniProtKB/TrEMBL
  Thrombospondin_C UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
  TSP_type-3_rpt UniProtKB/TrEMBL
  TSPN-like_N UniProtKB/TrEMBL
  VWF_C UniProtKB/TrEMBL
KEGG Report rno:292406 UniProtKB/TrEMBL
NCBI Gene 292406 ENTREZGENE
PANTHER PTHR10199:SF10 UniProtKB/TrEMBL
  THROMBOSPONDIN UniProtKB/TrEMBL
Pfam EGF_3 UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
  TSP_3 UniProtKB/TrEMBL
  TSP_C UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
PhenoGen Thbs2 PhenoGen
PRINTS TSP1REPEAT UniProtKB/TrEMBL
PROSITE EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
  TSP3 UniProtKB/TrEMBL
  TSP_CTER UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
  VWFC_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010529 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
  TSPN UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  EGF/Laminin UniProtKB/TrEMBL
  FnI-like domain UniProtKB/TrEMBL
  SSF103647 UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
UniProt D4A2G6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Thbs2  thrombospondin 2  Thbs2_predicted  thrombospondin 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Thbs2_predicted  thrombospondin 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED