Dynlt2 (dynein light chain Tctex-type 2) - Rat Genome Database

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Gene: Dynlt2 (dynein light chain Tctex-type 2) Rattus norvegicus
Analyze
Symbol: Dynlt2
Name: dynein light chain Tctex-type 2
RGD ID: 1310947
Description: Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in cytosol; membrane; and sperm flagellum. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. Orthologous to human DYNLT2 (dynein light chain Tctex-type 2); INTERACTS WITH bisphenol A; trichloroethene; vinclozolin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dynein light chain Tctex-type protein 2; LOC365153; t-complex-associated testis expressed 3; Tcte3; tctex1 domain-containing protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8164,644,404 - 64,656,368 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl164,644,404 - 64,656,368 (-)EnsemblGRCr8
mRatBN7.2155,971,285 - 55,983,249 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl155,971,283 - 55,983,307 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx160,831,780 - 60,843,594 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,488,923 - 69,500,750 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0162,741,735 - 62,753,549 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0156,970,673 - 56,982,657 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl156,970,654 - 56,982,642 (-)Ensemblrn6Rnor6.0
Rnor_5.0158,153,750 - 58,165,762 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4153,893,851 - 53,905,680 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera152,183,615 - 52,195,445 (-)NCBICelera
RGSC_v3.1153,896,795 - 53,908,625 (-)NCBI
Cytogenetic Map1q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7601308   PMID:11278908  


Genomics

Comparative Map Data
Dynlt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8164,644,404 - 64,656,368 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl164,644,404 - 64,656,368 (-)EnsemblGRCr8
mRatBN7.2155,971,285 - 55,983,249 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl155,971,283 - 55,983,307 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx160,831,780 - 60,843,594 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,488,923 - 69,500,750 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0162,741,735 - 62,753,549 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0156,970,673 - 56,982,657 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl156,970,654 - 56,982,642 (-)Ensemblrn6Rnor6.0
Rnor_5.0158,153,750 - 58,165,762 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4153,893,851 - 53,905,680 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera152,183,615 - 52,195,445 (-)NCBICelera
RGSC_v3.1153,896,795 - 53,908,625 (-)NCBI
Cytogenetic Map1q12NCBI
DYNLT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386169,725,091 - 169,751,572 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6169,740,106 - 169,751,587 (-)Ensemblhg38GRCh38
GRCh376170,140,205 - 170,151,668 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366169,882,140 - 169,893,563 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346169,957,846 - 169,969,270NCBI
Celera6170,850,390 - 170,861,813 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6167,559,988 - 167,571,405 (-)NCBIHuRef
CHM1_16170,402,437 - 170,413,860 (-)NCBICHM1_1
T2T-CHM13v2.06171,079,012 - 171,105,502 (-)NCBIT2T-CHM13v2.0
Dynlt2a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391715,233,025 - 15,261,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1715,247,414 - 15,261,750 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381715,027,154 - 15,041,559 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1715,027,152 - 15,041,488 (-)Ensemblmm10GRCm38
MGSCv371715,164,118 - 15,178,523 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361714,119,490 - 14,133,892 (-)NCBIMGSCv36mm8
MGSCv361714,732,117 - 14,746,522 (-)NCBIMGSCv36mm8
Cytogenetic Map17A2NCBI
cM Map178.95NCBI
Dynlt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554113,866,312 - 3,903,862 (+)NCBIChiLan1.0ChiLan1.0
DYNLT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25189,989,865 - 190,002,300 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16187,865,672 - 187,885,655 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06167,809,672 - 167,823,713 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16172,850,077 - 172,861,575 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6172,850,077 - 172,861,575 (-)EnsemblpanPan2panpan1.1
Dynlt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946150,928,619 - 150,949,692 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648918,180,622 - 18,201,669 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648918,180,621 - 18,201,739 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYNLT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1540,929 - 552,882 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11541,010 - 552,018 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.211,232,787 - 1,235,594 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DYNLT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604069,546,450 - 69,547,922 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dynlt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248505,661,414 - 5,683,082 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248505,661,488 - 5,683,244 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dynlt2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v114959,785 - 972,117 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dynlt2
220 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:90
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000047157
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 10 43 129 86 85 54 36 54 6 241 106 9 104 62 64 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000047157   ⟹   ENSRNOP00000046026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl164,644,404 - 64,656,368 (-)Ensembl
mRatBN7.2 Ensembl155,971,335 - 55,983,307 (-)Ensembl
Rnor_6.0 Ensembl156,970,725 - 56,982,554 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078312   ⟹   ENSRNOP00000073517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl164,644,404 - 64,656,368 (-)Ensembl
mRatBN7.2 Ensembl155,971,283 - 55,983,307 (-)Ensembl
Rnor_6.0 Ensembl156,970,654 - 56,982,642 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109584   ⟹   ENSRNOP00000090535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl164,644,512 - 64,656,368 (-)Ensembl
mRatBN7.2 Ensembl155,971,393 - 55,983,307 (-)Ensembl
RefSeq Acc Id: NM_001191559   ⟹   NP_001178488
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8164,644,404 - 64,656,368 (-)NCBI
mRatBN7.2155,971,285 - 55,983,249 (-)NCBI
Rnor_6.0156,970,725 - 56,982,554 (-)NCBI
Rnor_5.0158,153,750 - 58,165,762 (-)NCBI
Celera152,183,615 - 52,195,445 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001412559   ⟹   NP_001399488
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8164,644,404 - 64,656,368 (-)NCBI
mRatBN7.2155,971,285 - 55,983,249 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001178488 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399488 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99836 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046026
  ENSRNOP00000046026.1
  ENSRNOP00000073517
  ENSRNOP00000073517.1
  ENSRNOP00000090535.1
RefSeq Acc Id: NP_001178488   ⟸   NM_001191559
- Peptide Label: isoform 2
- UniProtKB: D3ZNC4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073517   ⟸   ENSRNOT00000078312
Ensembl Acc Id: ENSRNOP00000046026   ⟸   ENSRNOT00000047157
Ensembl Acc Id: ENSRNOP00000090535   ⟸   ENSRNOT00000109584
RefSeq Acc Id: NP_001399488   ⟸   NM_001412559
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K5Q6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K5Q6-F1-model_v2 AlphaFold A0A0G2K5Q6 1-193 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689640
Promoter ID:EPDNEW_R165
Type:multiple initiation site
Name:Tcte3_1
Description:t-complex-associated testis expressed 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0156,982,639 - 56,982,699EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310947 AgrOrtholog
BioCyc Gene G2FUF-61325 BioCyc
Ensembl Genes ENSRNOG00000015293 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047157 ENTREZGENE
  ENSRNOT00000047157.3 UniProtKB/TrEMBL
  ENSRNOT00000078312 ENTREZGENE
  ENSRNOT00000078312.3 UniProtKB/TrEMBL
  ENSRNOT00000109584.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1140.40 UniProtKB/TrEMBL
InterPro Tctex UniProtKB/TrEMBL
  Tctex-1-like_sf UniProtKB/TrEMBL
KEGG Report rno:365153 UniProtKB/TrEMBL
NCBI Gene 365153 ENTREZGENE
PANTHER DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2 UniProtKB/TrEMBL
  Tctex UniProtKB/TrEMBL
Pfam Tctex-1 UniProtKB/TrEMBL
PhenoGen Dynlt2 PhenoGen
RatGTEx ENSRNOG00000015293 RatGTEx
UniProt A0A0G2K5Q6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANG5_RAT UniProtKB/TrEMBL
  D3ZNC4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-09-08 Dynlt2  dynein light chain Tctex-type 2  Tcte3  t-complex-associated testis expressed 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tcte3  t-complex-associated testis expressed 3   Tcte3_predicted  t-complex-associated testis expressed 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tcte3_predicted  t-complex-associated testis expressed 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED