Idua (alpha-L-iduronidase) - Rat Genome Database

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Gene: Idua (alpha-L-iduronidase) Rattus norvegicus
Analyze
Symbol: Idua
Name: alpha-L-iduronidase
RGD ID: 1310943
Description: Enables L-iduronidase activity and signaling receptor binding activity. Involved in glycosaminoglycan catabolic process. Predicted to be located in extracellular space. Predicted to be active in lysosomal lumen. Biomarker of gastric ulcer. Human ortholog(s) of this gene implicated in Scheie syndrome; mucopolysaccharidosis I; mucopolysaccharidosis Ih; and mucopolysaccharidosis Ih/s. Orthologous to human IDUA (alpha-L-iduronidase); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Idual; iduronidase, alpha-L-; iduronidase, alpha-L-like; LOC360904
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8141,175,994 - 1,203,913 (-)NCBIGRCr8
mRatBN7.2141,031,588 - 1,059,494 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,032,171 - 1,046,522 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14932,006 - 946,365 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0142,233,783 - 2,248,142 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014930,476 - 944,835 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0142,041,828 - 2,056,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl142,042,411 - 2,056,762 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,037,369 - 2,052,405 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera141,071,517 - 1,085,862 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: implications for non-viral gene therapy of mucopolysaccharidoses. Aronovich EL, etal., J Gene Med. 2007 May;9(5):403-15.
2. Reversal of lysosomal storage in brain of adult MPS-I mice with intravenous Trojan horse-iduronidase fusion protein. Boado RJ, etal., Mol Pharm. 2011 Aug 1;8(4):1342-50. doi: 10.1021/mp200136x. Epub 2011 Jun 17.
3. Cardiac findings after enzyme replacement therapy for mucopolysaccharidosis type I. Braunlin EA, etal., Am J Cardiol. 2006 Aug 1;98(3):416-8. doi: 10.1016/j.amjcard.2006.02.047. Epub 2006 Jun 12.
4. Mucopolysaccharidosis type I: identification of 8 novel mutations and determination of the frequency of the two common alpha-L-iduronidase mutations (W402X and Q70X) among European patients. Bunge S, etal., Hum Mol Genet. 1994 Jun;3(6):861-6.
5. Coated vesicles from rat liver and calf brain contain lysosomal enzymes bound to mannose 6-phosphate receptors. Campbell CH and Rome LH, J Biol Chem. 1983 Nov 10;258(21):13347-52.
6. Murine mucopolysaccharidosis type I: targeted disruption of the murine alpha-L-iduronidase gene. Clarke LA, etal., Hum Mol Genet. 1997 Apr;6(4):503-11.
7. Characterization of an immunodeficient mouse model of mucopolysaccharidosis type I suitable for preclinical testing of human stem cell and gene therapy. Garcia-Rivera MF, etal., Brain Res Bull. 2007 Nov 1;74(6):429-38. Epub 2007 Aug 6.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Cardiac pathology in mucopolysaccharidosis I mice: Losartan modifies ERK1/2 activation during cardiac remodeling. Gonzalez EA, etal., J Inherit Metab Dis. 2021 May;44(3):740-750. doi: 10.1002/jimd.12327. Epub 2020 Nov 10.
11. Correction of metabolic, craniofacial, and neurologic abnormalities in MPS I mice treated at birth with adeno-associated virus vector transducing the human alpha-L-iduronidase gene. Hartung SD, etal., Mol Ther. 2004 Jun;9(6):866-75.
12. Enzyme-replacement therapy in mucopolysaccharidosis I. Kakkis ED, etal., N Engl J Med. 2001 Jan 18;344(3):182-8. doi: 10.1056/NEJM200101183440304.
13. Mucopolysaccharidosis I: Alpha-L-Iduronidase mutations in three Tunisian families. Laradi S, etal., J Inherit Metab Dis. 2005;28(6):1019-26.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Targeting of the CNS in MPS-IH using a nonviral transferrin-alpha-L-iduronidase fusion gene product. Osborn MJ, etal., Mol Ther. 2008 Aug;16(8):1459-66. doi: 10.1038/mt.2008.119. Epub 2008 Jun 3.
17. High-dose enzyme replacement therapy in murine Hurler syndrome. Ou L, etal., Mol Genet Metab. 2014 Feb;111(2):116-22. doi: 10.1016/j.ymgme.2013.09.008. Epub 2013 Sep 19.
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. A common mutation for mucopolysaccharidosis type I associated with a severe Hurler syndrome phenotype. Scott HS, etal., Hum Mutat. 1992;1(2):103-8.
21. alpha-L-iduronidase mutations (Q70X and P533R) associate with a severe Hurler phenotype. Scott HS, etal., Hum Mutat. 1992;1(4):333-9.
22. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
23. Cord-blood transplants from unrelated donors in patients with Hurler's syndrome. Staba SL, etal., N Engl J Med. 2004 May 6;350(19):1960-9.
24. a- L-iduronidase gene-based therapy using the phiC31 system to treat mucopolysaccharidose type I mice. Stilhano RS, etal., J Gene Med. 2015 Jan-Feb;17(1-2):1-13. doi: 10.1002/jgm.2818.
25. Three novel a-L-iduronidase mutations in 10 unrelated Chinese mucopolysaccharidosis type I families. Sun L, etal., Genet Mol Biol. 2011 Apr;34(2):195-200. Epub 2011 Apr 1.
26. Identification and characterization of 20 novel pathogenic variants in 60 unrelated Indian patients with mucopolysaccharidoses type I and type II. Uttarilli A, etal., Clin Genet. 2016 Dec;90(6):496-508. doi: 10.1111/cge.12795. Epub 2016 May 26.
27. Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation. Wang D, etal., Mol Genet Metab. 2010 Jan;99(1):62-71. doi: 10.1016/j.ymgme.2009.08.002.
28. [Changes in the activities of lysosomal enzyme (glycosidase) in experimental acute gastric mucosal lesion]. Watanabe K, Nihon Geka Gakkai Zasshi. 1986 Apr;87(4):395-402.
29. Changes in the catalytic activities of proteoglycan-degrading lysosomal enzymes in parenchymal and non-parenchymal liver cells and in serum during the development of experimental liver fibrosis. Weber W, etal., J Clin Chem Clin Biochem. 1983 May;21(5):287-93.
30. Enzyme replacement therapy for mucopolysaccharidosis I: a randomized, double-blinded, placebo-controlled, multinational study of recombinant human alpha-L-iduronidase (laronidase). Wraith JE, etal., J Pediatr. 2004 May;144(5):581-8.
31. Enzyme replacement therapy in patients who have mucopolysaccharidosis I and are younger than 5 years: results of a multinational study of recombinant human alpha-L-iduronidase (laronidase). Wraith JE, etal., Pediatrics. 2007 Jul;120(1):e37-46. doi: 10.1542/peds.2006-2156. Epub 2007 Jun 4.
32. Mucopolysaccharidosis type I: identification of common mutations that cause Hurler and Scheie syndromes in Japanese populations. Yamagishi A, etal., Hum Mutat. 1996;7(1):23-9.
33. Treatment of the mouse model of mucopolysaccharidosis I with retrovirally transduced bone marrow. Zheng Y, etal., Mol Genet Metab. 2003 Aug;79(4):233-44.
Additional References at PubMed
PMID:12477932   PMID:16979922   PMID:18022143   PMID:19834056   PMID:21873421   PMID:22580166   PMID:23376485   PMID:23533145   PMID:24036510   PMID:25410057  


Genomics

Comparative Map Data
Idua
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8141,175,994 - 1,203,913 (-)NCBIGRCr8
mRatBN7.2141,031,588 - 1,059,494 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,032,171 - 1,046,522 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14932,006 - 946,365 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0142,233,783 - 2,248,142 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014930,476 - 944,835 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0142,041,828 - 2,056,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl142,042,411 - 2,056,762 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,037,369 - 2,052,405 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera141,071,517 - 1,085,862 (-)NCBICelera
Cytogenetic Map14p22NCBI
IDUA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384986,997 - 1,008,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4986,997 - 1,004,564 (+)EnsemblGRCh38hg38GRCh38
GRCh374980,785 - 998,352 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364970,785 - 988,317 (+)NCBINCBI36Build 36hg18NCBI36
Build 344970,614 - 988,146NCBI
Celera4917,731 - 935,177 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef4952,003 - 969,463 (+)NCBIHuRef
CHM1_14980,568 - 998,100 (+)NCBICHM1_1
T2T-CHM13v2.04985,128 - 1,002,611 (+)NCBIT2T-CHM13v2.0
Idua
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395108,808,197 - 108,833,312 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5108,808,197 - 108,832,423 (+)EnsemblGRCm39 Ensembl
GRCm385108,660,331 - 108,685,446 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5108,660,331 - 108,684,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv375109,098,125 - 109,113,577 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365108,909,667 - 108,924,856 (+)NCBIMGSCv36mm8
Celera5105,791,051 - 105,807,497 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.24NCBI
Idua
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955514475,731 - 488,007 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955514474,830 - 488,007 (+)NCBIChiLan1.0ChiLan1.0
IDUA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v231,315,303 - 1,334,024 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan141,282,815 - 1,304,372 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v041,102,288 - 1,120,973 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.141,020,519 - 1,037,990 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl41,020,582 - 1,037,877 (+)Ensemblpanpan1.1panPan2
IDUA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1391,517,225 - 91,534,593 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl391,522,035 - 91,534,593 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha393,988,643 - 94,001,108 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0392,515,340 - 92,532,617 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl392,519,804 - 92,532,813 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1391,693,928 - 91,706,431 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0391,746,826 - 91,759,387 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0392,130,626 - 92,143,201 (-)NCBIUU_Cfam_GSD_1.0
Idua
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528568,493,659 - 68,512,811 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647722,200,474 - 22,215,077 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647722,200,471 - 22,215,473 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDUA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8334,617 - 351,969 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18334,604 - 351,970 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IDUA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12747,778,220 - 47,794,435 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2747,778,335 - 47,794,352 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366680862,223 - 78,429 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Idua
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475526,154,186 - 26,169,365 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475526,151,302 - 26,169,324 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Idua
87 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:300
Count of miRNA genes:207
Interacting mature miRNAs:230
Transcripts:ENSRNOT00000000048
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat

Markers in Region
RH140328  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2141,031,685 - 1,031,882 (+)MAPPERmRatBN7.2
Rnor_6.0142,041,926 - 2,042,122NCBIRnor6.0
Rnor_5.0142,037,467 - 2,037,663UniSTSRnor5.0
RGSC_v3.4141,572,710 - 1,572,906UniSTSRGSC3.4
Celera141,071,032 - 1,071,228UniSTS
Cytogenetic Map14p22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 45 29 19 29 2 72 35 36 11
Low 7 12 12 12 8 9 2 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000048   ⟹   ENSRNOP00000000048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,032,171 - 1,046,522 (-)Ensembl
Rnor_6.0 Ensembl142,042,411 - 2,056,762 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114043   ⟹   ENSRNOP00000078233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,032,171 - 1,046,442 (-)Ensembl
RefSeq Acc Id: NM_001172084   ⟹   NP_001165555
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,176,577 - 1,190,928 (-)NCBI
mRatBN7.2141,032,171 - 1,046,522 (-)NCBI
Rnor_6.0142,042,411 - 2,056,762 (-)NCBI
Rnor_5.0142,037,369 - 2,052,405 (-)NCBI
Celera141,071,517 - 1,085,862 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769938   ⟹   XP_008768160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,175,994 - 1,190,104 (-)NCBI
mRatBN7.2141,031,588 - 1,045,685 (-)NCBI
Rnor_6.0142,041,828 - 2,052,002 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092145   ⟹   XP_038948073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,175,994 - 1,203,913 (-)NCBI
mRatBN7.2141,031,588 - 1,059,494 (-)NCBI
RefSeq Acc Id: XM_039092147   ⟹   XP_038948075
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,175,994 - 1,180,445 (-)NCBI
mRatBN7.2141,031,588 - 1,046,692 (-)NCBI
RefSeq Acc Id: XM_063273312   ⟹   XP_063129382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,175,994 - 1,190,941 (-)NCBI
RefSeq Acc Id: XM_063273313   ⟹   XP_063129383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,175,994 - 1,203,906 (-)NCBI
RefSeq Acc Id: XM_063273315   ⟹   XP_063129385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,175,994 - 1,203,913 (-)NCBI
RefSeq Acc Id: XR_005492984
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,178,436 - 1,190,942 (-)NCBI
mRatBN7.2141,034,027 - 1,046,539 (-)NCBI
RefSeq Acc Id: XR_010057382
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,177,780 - 1,190,942 (-)NCBI
RefSeq Acc Id: XR_010057383
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,177,780 - 1,190,942 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001165555   ⟸   NM_001172084
- Peptide Label: precursor
- UniProtKB: D3ZE16 (UniProtKB/TrEMBL),   A0A8I6G2G6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768160   ⟸   XM_008769938
- Peptide Label: isoform X5
- UniProtKB: A0A8I6G2G6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000048   ⟸   ENSRNOT00000000048
RefSeq Acc Id: XP_038948073   ⟸   XM_039092145
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G2G6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948075   ⟸   XM_039092147
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000078233   ⟸   ENSRNOT00000114043
RefSeq Acc Id: XP_063129385   ⟸   XM_063273315
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063129383   ⟸   XM_063273313
- Peptide Label: isoform X3
- UniProtKB: D3ZE16 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129382   ⟸   XM_063273312
- Peptide Label: isoform X1
Protein Domains
Alpha-L-iduronidase C-terminal   Glycosyl hydrolases family 39 N-terminal catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZE16-F1-model_v2 AlphaFold D3ZE16 1-643 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699144
Promoter ID:EPDNEW_R9668
Type:initiation region
Name:Idua_1
Description:iduronidase, alpha-L-
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0142,056,737 - 2,056,797EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310943 AgrOrtholog
BioCyc Gene G2FUF-16685 BioCyc
Ensembl Genes ENSRNOG00000000043 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000048 ENTREZGENE
  ENSRNOT00000000048.7 UniProtKB/TrEMBL
  ENSRNOT00000114043.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Glycosidases UniProtKB/TrEMBL
InterPro GH39_as UniProtKB/TrEMBL
  GH39_C UniProtKB/TrEMBL
  GH39_cat UniProtKB/TrEMBL
  Glyco_hydro_39 UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
KEGG Report rno:360904 UniProtKB/TrEMBL
NCBI Gene Idua ENTREZGENE
OMIM 252800
PANTHER ALPHA-L-IDURONIDASE UniProtKB/TrEMBL
  ALPHA-L-IDURONIDASE UniProtKB/TrEMBL
Pfam Glyco_hydro_39 UniProtKB/TrEMBL
  Glyco_hydro_39_C UniProtKB/TrEMBL
PhenoGen Idua PhenoGen
PRINTS GLHYDRLASE39 UniProtKB/TrEMBL
PROSITE GLYCOSYL_HYDROL_F39 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000043 RatGTEx
Superfamily-SCOP Glyco_hydro_cat UniProtKB/TrEMBL
  Glycosyl hydrolase domain UniProtKB/TrEMBL
UniProt A0A8I6G2G6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZE16 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-03 Idua  alpha-L-iduronidase  Idua  iduronidase, alpha-L-  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-09-25 Idua  iduronidase, alpha-L-  Idual  iduronidase, alpha-L-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-09 Idual  iduronidase, alpha-L-like  Idua  iduronidase, alpha-L-  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 Idua  iduronidase, alpha-L-  Idua  iduronidase, alpha-L-  Gene reactivated at release of RGSC5.0 assembly 2298974 REACTIVATED
2008-04-30 Idua  iduronidase, alpha-L-   Idua_predicted  iduronidase, alpha-L- (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Idua_predicted  iduronidase, alpha-L- (predicted)      Symbol and Name status set to approved 70820 APPROVED