Advanced Search (OLGA)

Gene: Dyrk3 (dual specificity tyrosine phosphorylation regulated kinase 3) Rattus norvegicus

Analyze

Symbol:

Dyrk3

Name:

dual specificity tyrosine phosphorylation regulated kinase 3

RGD ID:

1310924

Description:

Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including nuclear speck organization; regulation of intracellular signal transduction; and stress granule disassembly. Predicted to be located in cytoplasmic stress granule; nuclear speck; and pericentriolar material. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Orthologous to human DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

dual specificity tyrosine-phosphorylation-regulated kinase 3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3; LOC304775

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	45,146,383 - 45,157,082 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	45,146,384 - 45,157,249 (-)	Ensembl				GRCr8
mRatBN7.2	13	42,594,120 - 42,604,898 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	42,594,121 - 42,604,778 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	45,201,064 - 45,211,516 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	46,489,195 - 46,499,647 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	43,753,320 - 43,763,751 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	47,906,230 - 47,916,877 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	47,906,231 - 47,916,877 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	52,989,584 - 52,998,242 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	44,077,971 - 44,089,140 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	42,940,800 - 42,951,281 (-)	NCBI		Celera
RGSC_v3.1	13	44,092,014 - 44,103,183 (-)	NCBI
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

5-iodotubercidin (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

butyric acid (ISO)

cadmium atom (EXP)

cadmium dichloride (EXP,ISO)

camptothecin (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

deguelin (ISO)

dibenz[a,h]anthracene (ISO)

dioxygen (ISO)

endosulfan (EXP)

ethanol (EXP)

ethylparaben (ISO)

folic acid (ISO)

folpet (ISO)

fulvestrant (ISO)

gentamycin (EXP)

L-methionine (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

methotrexate (ISO)

methoxyacetic acid (EXP)

Moniliformin (ISO)

N-nitrosodiethylamine (ISO)

nitrofen (EXP)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

phenobarbital (ISO)

picoxystrobin (ISO)

resveratrol (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sunitinib (ISO)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP,ISO)

trichostatin A (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell division (IEA)

erythrocyte differentiation (ISO)

negative regulation of apoptotic process (ISO,ISS)

negative regulation of DNA damage response, signal transduction by p53 class mediator (ISO)

nuclear speck organization (ISO,ISS)

organelle disassembly (ISO,ISS)

positive regulation of cell cycle G2/M phase transition (IBA,ISO,ISS)

protein phosphorylation (ISO,ISS)

regulation of cellular response to stress (ISO,ISS)

regulation of TORC1 signaling (ISO,ISS)

stress granule disassembly (IBA,ISO,ISS)

Cellular Component

centrosome (IEA)

cytoplasm (IBA,IEA,ISO,ISS)

cytoplasmic stress granule (ISO,ISS)

cytoskeleton (IBA)

nuclear speck (IEA,ISO,ISS)

nucleoplasm (ISO)

nucleus (IBA,IEA,ISO)

pericentriolar material (ISO,ISS)

Molecular Function

ATP binding (IEA,ISO)

kinase activity (IEA)

magnesium ion binding (ISO)

metal ion binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA,ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IEA,ISO,ISS)

protein serine/threonine/tyrosine kinase activity (IEA)

protein tyrosine kinase activity (IEA)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10779429	PMID:12356771	PMID:12477932	PMID:16524748	PMID:20167603	PMID:23415227	PMID:29634919	PMID:29973724

Genomics

Comparative Map Data

Dyrk3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	45,146,383 - 45,157,082 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	45,146,384 - 45,157,249 (-)	Ensembl				GRCr8
mRatBN7.2	13	42,594,120 - 42,604,898 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	42,594,121 - 42,604,778 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	45,201,064 - 45,211,516 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	46,489,195 - 46,499,647 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	43,753,320 - 43,763,751 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	47,906,230 - 47,916,877 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	47,906,231 - 47,916,877 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	52,989,584 - 52,998,242 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	44,077,971 - 44,089,140 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	42,940,800 - 42,951,281 (-)	NCBI		Celera
RGSC_v3.1	13	44,092,014 - 44,103,183 (-)	NCBI
Cytogenetic Map	13	q13	NCBI

DYRK3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	206,635,536 - 206,655,158 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	206,635,536 - 206,684,419 (+)	Ensembl			hg38	GRCh38
GRCh37	1	206,808,881 - 206,828,503 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	204,875,504 - 204,889,165 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	203,197,275 - 203,210,936	NCBI
Celera	1	180,060,336 - 180,073,977 (+)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	177,507,198 - 177,520,842 (+)	NCBI		HuRef
CHM1_1	1	208,081,070 - 208,094,731 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	205,899,707 - 205,919,328 (+)	NCBI		T2T-CHM13v2.0

Dyrk3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	131,056,178 - 131,065,991 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	131,055,192 - 131,066,077 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	131,128,441 - 131,138,234 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	131,127,455 - 131,138,340 (-)	Ensembl			mm10	GRCm38
MGSCv37	1	133,025,018 - 133,034,811 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	132,955,987 - 132,965,780 (-)	NCBI		MGSCv36	mm8
Celera	1	133,751,422 - 133,761,320 (-)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	56.9	NCBI

Dyrk3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	42,190,043 - 42,199,730 (+)	Ensembl
ChiLan1.0	NW_004955406	42,190,043 - 42,199,323 (+)	NCBI	ChiLan1.0	ChiLan1.0

DYRK3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	42,727,196 - 42,741,856 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	42,692,713 - 42,707,371 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	182,237,556 - 182,255,984 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	186,516,874 - 186,531,191 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	186,517,041 - 186,530,272 (+)	Ensembl			panPan2	panpan1.1

DYRK3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	5,816,839 - 5,826,194 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	5,814,201 - 5,902,220 (+)	NCBI			canFam3	CanFam3.1
ROS_Cfam_1.0	7	5,506,569 - 5,517,349 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	5,506,504 - 5,516,606 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	5,441,218 - 5,451,997 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	5,542,159 - 5,552,933 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	5,581,793 - 5,592,573 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Dyrk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	68,700,263 - 68,718,566 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936557	5,947,157 - 5,956,958 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936557	5,947,157 - 5,956,874 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DYRK3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	67,268,633 - 67,280,111 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	67,268,600 - 67,279,617 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	73,652,010 - 73,653,545 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DYRK3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	22,718,056 - 22,728,143 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	22,718,284 - 22,728,074 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	23,415,330 - 23,428,720 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dyrk3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	4,797,401 - 4,809,444 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624807	4,800,801 - 4,815,779 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dyrk3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	4,666,789 - 4,677,231 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Dyrk3
88 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	117
Count of miRNA genes:	96
Interacting mature miRNAs:	98
Transcripts:	ENSRNOT00000006502
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	11866254	56866254	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	24853925	69853925	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	39968211	83286298	Rat
1300163	Cardf1	Cardiac cell morphology QTL 1	4.18		aorta morphology trait (VT:0000272)	artery lesion measurement (CMO:0000975)	13	12448421	47969993	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	17468282	62468282	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	12384320	57384320	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
2303032	Bp328	Blood pressure QTL 328			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	43736327	47969993	Rat
61339	Bp24	Blood pressure QTL 24		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	6002008	47359539	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	24335432	55601132	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37087983	82087983	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	40983585	85983585	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	12448421	48744906	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	26244808	71244808	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	33794096	78794096	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	39924693	84924693	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	34834947	79834947	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	33794096	60914504	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	3088755	48088755	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	39814726	84814726	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	39968211	84968211	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	26244808	71244808	Rat
11530006	Niddm72	Non-insulin dependent diabetes mellitus QTL 72		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	38286298	83286298	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	17711336	62711336	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	11866254	56866254	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	11	66	160	86	85	54	87	54	6	340	182	11	137	80	92	31	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024767	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001430049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001430050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001430051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001430052	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001430053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769465	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090691	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090693	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC097474	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006502 ⟹ ENSRNOP00000006502

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	45,146,384 - 45,157,039 (-)	Ensembl
mRatBN7.2 Ensembl	13	42,594,121 - 42,604,778 (-)	Ensembl
Rnor_6.0 Ensembl	13	47,906,231 - 47,916,877 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000087793 ⟹ ENSRNOP00000072484

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	47,906,255 - 47,916,185 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000131929 ⟹ ENSRNOP00000105592

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	45,146,384 - 45,157,249 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000143289 ⟹ ENSRNOP00000111596

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	45,146,384 - 45,155,582 (-)	Ensembl

RefSeq Acc Id:

NM_001024767 ⟹ NP_001019938

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	45,146,383 - 45,157,039 (-)	NCBI
mRatBN7.2	13	42,594,120 - 42,604,778 (-)	NCBI
Rnor_6.0	13	47,906,230 - 47,916,877 (-)	NCBI
Rnor_5.0	13	52,989,584 - 52,998,242 (-)	NCBI
RGSC_v3.4	13	44,077,971 - 44,089,140 (-)	RGD
Celera	13	42,940,800 - 42,951,281 (-)	RGD

Sequence:

show sequence

CCTGCGGACCGCGCGAGCCCATCTCAGAGCCGCGGCTTGTAGTGAAGCCTGCAGGTGCGGGGCT
AGAGGCGACCCACCGGGCCAACCGCCGCCTCTGTGCCCGCGGGGCGAGCTCGCGATGGGAGGCG
CAGCCCGCGAGCGCGGGAGGAAGGACGCGGCGCTGCCGGGGGCCGGGCTCCCGCCGCAGCAGCG
GAGGTTGGGGGATGGTGTCTATGATACCTTCATGATGATAGATGAAACCAAGTGCCCACCCTAT
ACAAACACACTTTGCAATCCCTCTGAAGCACCTGTCTCCAGAAGGCTAAATATTACCACTGAGC
CATTCACGAGAGGCCACACTCAGCACTTCGTGAGTGGGGGTGTGATGAAGGTGGAGCAACTGTT
TCAAGAATTTGGCAGCAGAAGAACCAGTACTCTCCAGTCCGATGGCGTCAGCAACTCCGAAAAG
TCCTCTCCTGCTTCTCAGGGGAAGAGTTCAGACAGCCTGGGTACAGTGAAGTGCAGCCTCTCAT
CCAGACCATCTAAGGTGCTCCCGCTGACTCCTGAGCAAGCTCTGAAGCAGTACAAGCACCACCT
CACCGCCTACGAGAAGCTGGAGATCATCAGCTACCCAGAAATCTACTTCGTGGGCCCGAATGCC
AAGAAGCGGCAAGGAGTTATTGGTGGTCCCAATAACGGGGGGTACGACGATGCGGACGGGGCCT
ATATCCACGTGCCTCGAGACCATCTGGCTTACCGCTATGAGGTGCTGAAAATTATTGGCAAGGG
GAGTTTTGGACAGGTAGCCCGGGTCTACGATCACAAACTCCGACAGTACGTGGCCCTGAAAATG
GTGCGCAACGAGAAGCGCTTTCACCGCCAGGCAGCCGAGGAGATCCGGATTCTGGAGCATCTTA
AAAAGCAAGACAAAACTGGGAGCATGAATGTCATCCACATGTTAGAAAGCTTCACCTTCCGGAA
CCACGTGTGCATGGCCTTTGAGTTGCTAAGCATAGACCTGTACGAGCTCATTAAAAAAAACAAG
TTTCAGGGCTTCAGCGTCCAGTTGGTCCGGAAGTTCGCCCAGTCCATCCTGCAGTCCTTGGACG
CCCTTCACAAAAATAAGATCATTCACTGTGATCTGAAGCCTGAGAACATTCTCCTGAAGCATCA
CGGACGGAGCGCGACCAAGGTCATTGACTTCGGGTCCAGCTGTTTTGAGTATCAGAAACTTTAC
ACGTACATCCAGTCCCGTTTCTACAGAGCCCCGGAAATCATCTTGGGGTGCCGCTACAGCACGC
CAATTGACATATGGAGTTTTGGTTGCATCCTCGCAGAACTTTTGACAGGACAGCCCCTGTTCCC
AGGAGAGGATGAAGGAGACCAGTTGGCCTGCATGATGGAGTTGCTAGGAATGCCACCACAGAAA
CTTCTGGAGCAATCCAAACGTGCCAAGTACTTTATTAACTCCAAAGGCTTGCCTCGATACTGCT
CCGTAACTACCCAGACGGACGGGAGGGTTGTGCTTCTCGGGGGCCGCTCACGCAGGGGTAAAAA
GCGAGGCCCACCAGGCAGCAAAGACTGGGCAGCCGCGCTGAAGGGGTGCGATGACTACTTGTTC
ATAGAGTTTCTGAAAAGGTGCCTTCAGTGGGACCCCTCTGCCCGCCTCACCCCAGCTCAAGCAT
TAAGACATCCTTGGATTAGCAAGTCTGCACCCAGGCCCCTCACCACGGACAAGGTGTCAGGGAA
ACGGGTAGTTAATCCTACAAATGCTTTCCAGGGACTGGGCTCCAAGCTGCCTCCAGTCGTTGGA
ATCGCCAGTAAGCTTAAAGCTAACCTAATGTCGGAAACCAGTGGTAGTATACCTCTGTGCAGTG
TATTGCCAAAGCTGATCAGCTAATGGACCACTCAGACTCATACATACGTATTTTTAATTACCTT
ACAGACATGCAAATGGAAAAAAAAATAATTGAAGCCCATTCACCGATGGATATGTTTTTGTTAG
ACTTTTTTTTTTTAACAAGGCAGAACATTTTTATATGACTATAAACAAACGCTTCAAGGGCTAA
TGTCTAACCAGCTTGTATTGGCCATCTGGAGTATACATTAAATGACTTTTTAATAGGTCAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039090691 ⟹ XP_038946619

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	45,146,383 - 45,157,082 (-)	NCBI
mRatBN7.2	13	42,594,120 - 42,604,818 (-)	NCBI

RefSeq Acc Id:

XM_039090693 ⟹ XP_038946621

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	45,146,383 - 45,157,082 (-)	NCBI
mRatBN7.2	13	42,594,120 - 42,604,818 (-)	NCBI

RefSeq Acc Id:

XM_039090694 ⟹ XP_038946622

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	45,146,383 - 45,157,081 (-)	NCBI
mRatBN7.2	13	42,594,120 - 42,604,898 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001019938	(Get FASTA)	NCBI Sequence Viewer
	NP_001416978	(Get FASTA)	NCBI Sequence Viewer
	NP_001416979	(Get FASTA)	NCBI Sequence Viewer
	NP_001416980	(Get FASTA)	NCBI Sequence Viewer
	NP_001416981	(Get FASTA)	NCBI Sequence Viewer
	NP_001416982	(Get FASTA)	NCBI Sequence Viewer
	XP_038946619	(Get FASTA)	NCBI Sequence Viewer
	XP_038946621	(Get FASTA)	NCBI Sequence Viewer
	XP_038946622	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97474	(Get FASTA)	NCBI Sequence Viewer
	EDM09834	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006502
	ENSRNOP00000006502.5
GenBank Protein	Q4V8A3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001019938 ⟸ NM_001024767

- UniProtKB:

Q4V8A3 (UniProtKB/Swiss-Prot), F1LN50 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGGAARERGRKDAALPGAGLPPQQRRLGDGVYDTFMMIDETKCPPYTNTLCNPSEAPVSRRLNI
TTEPFTRGHTQHFVSGGVMKVEQLFQEFGSRRTSTLQSDGVSNSEKSSPASQGKSSDSLGTVKC
SLSSRPSKVLPLTPEQALKQYKHHLTAYEKLEIISYPEIYFVGPNAKKRQGVIGGPNNGGYDDA
DGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL
EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ
SLDALHKNKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGCR
YSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPQKLLEQSKRAKYFINSKGLP
RYCSVTTQTDGRVVLLGGRSRRGKKRGPPGSKDWAAALKGCDDYLFIEFLKRCLQWDPSARLTP
AQALRHPWISKSAPRPLTTDKVSGKRVVNPTNAFQGLGSKLPPVVGIASKLKANLMSETSGSIP
LCSVLPKLIS

hide sequence

Ensembl Acc Id:

ENSRNOP00000006502 ⟸ ENSRNOT00000006502

Ensembl Acc Id:

ENSRNOP00000072484 ⟸ ENSRNOT00000087793

RefSeq Acc Id:	XP_038946622 ⟸ XM_039090694
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038946621 ⟸ XM_039090693
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038946619 ⟸ XM_039090691
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000111596 ⟸ ENSRNOT00000143289

Ensembl Acc Id:

ENSRNOP00000105592 ⟸ ENSRNOT00000131929

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4V8A3-F1-model_v2	AlphaFold	Q4V8A3	1-586	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698792

Promoter ID:

EPDNEW_R9317

Type:

initiation region

Name:

Dyrk3_1

Description:

dual specificity tyrosine phosphorylation regulated kinase 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	47,916,899 - 47,916,959	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310924	AgrOrtholog
BioCyc Gene	G2FUF-18356	BioCyc
Ensembl Genes	ENSRNOG00000004870	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000006502	ENTREZGENE
	ENSRNOT00000006502.6	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.10.30	UniProtKB/Swiss-Prot
	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7457808	IMAGE-MGC_LOAD
InterPro	DYRK	UniProtKB/Swiss-Prot
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
	Ser_Thr_dual-spec_kinase	UniProtKB/Swiss-Prot
KEGG Report	rno:304775	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:114539	IMAGE-MGC_LOAD
NCBI Gene	304775	ENTREZGENE
PANTHER	DUAL SPECIFICITY PROTEIN KINASE	UniProtKB/Swiss-Prot
	DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 3	UniProtKB/Swiss-Prot
Pfam	Pkinase	UniProtKB/Swiss-Prot
PhenoGen	Dyrk3	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000004870	RatGTEx
SMART	S_TKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot
UniProt	A0ABK0LIP8_RAT	UniProtKB/TrEMBL
	A0ABK0M3J2_RAT	UniProtKB/TrEMBL
	A6IC13	ENTREZGENE, UniProtKB/TrEMBL
	DYRK3_RAT	UniProtKB/Swiss-Prot
	F1LN50	ENTREZGENE, UniProtKB/TrEMBL
	Q4V8A3	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Dyrk3	dual specificity tyrosine phosphorylation regulated kinase 3	Dyrk3	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Dyrk3	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	Dyrk3_predicted	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Dyrk3_predicted	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message