Arhgap26 (Rho GTPase activating protein 26) - Rat Genome Database

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Pathways
Gene: Arhgap26 (Rho GTPase activating protein 26) Rattus norvegicus
Analyze
Symbol: Arhgap26
Name: Rho GTPase activating protein 26
RGD ID: 1310923
Description: Predicted to enable GTPase activator activity; phospholipid binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within mitophagy. Predicted to be located in cytosol and endosome membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia and juvenile myelomonocytic leukemia. Orthologous to human ARHGAP26 (Rho GTPase activating protein 26); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC307459; rho GTPase-activating protein 26
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81830,702,602 - 31,489,047 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1831,089,787 - 31,489,047 (+)EnsemblGRCr8
mRatBN7.21830,835,806 - 31,237,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1830,838,671 - 31,235,194 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1830,942,835 - 31,342,100 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01831,823,102 - 32,109,068 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01831,038,061 - 31,437,340 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01831,807,052 - 32,557,176 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1831,812,109 - 32,207,801 (-)Ensemblrn6Rnor6.0
Rnor_5.01831,484,480 - 31,890,142 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41831,934,753 - 32,327,551 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1830,473,925 - 30,862,447 (+)NCBICelera
RGSC_v3.11831,969,213 - 32,366,772 (+)NCBI
Cytogenetic Map18p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-tribromophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beryllium sulfate  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
L-methionine  (ISO)
maneb  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
endosome membrane  (IEA,ISO)
focal adhesion  (IEA)
mitochondrion  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. Borkhardt A, etal., Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9168-73.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:18954304   PMID:22871113  


Genomics

Comparative Map Data
Arhgap26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81830,702,602 - 31,489,047 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1831,089,787 - 31,489,047 (+)EnsemblGRCr8
mRatBN7.21830,835,806 - 31,237,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1830,838,671 - 31,235,194 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1830,942,835 - 31,342,100 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01831,823,102 - 32,109,068 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01831,038,061 - 31,437,340 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01831,807,052 - 32,557,176 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1831,812,109 - 32,207,801 (-)Ensemblrn6Rnor6.0
Rnor_5.01831,484,480 - 31,890,142 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41831,934,753 - 32,327,551 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1830,473,925 - 30,862,447 (+)NCBICelera
RGSC_v3.11831,969,213 - 32,366,772 (+)NCBI
Cytogenetic Map18p11NCBI
ARHGAP26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385142,770,377 - 143,229,011 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5142,770,377 - 143,229,011 (+)Ensemblhg38GRCh38
GRCh375142,149,942 - 142,608,576 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365142,130,476 - 142,588,765 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345142,130,475 - 142,586,243NCBI
Celera5138,231,606 - 138,689,843 (+)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5137,297,685 - 137,755,859 (+)NCBIHuRef
CHM1_15141,583,958 - 142,042,097 (+)NCBICHM1_1
T2T-CHM13v2.05143,301,685 - 143,760,366 (+)NCBIT2T-CHM13v2.0
Arhgap26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391838,734,531 - 39,509,338 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1838,809,771 - 39,243,587 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl1839,126,198 - 39,509,337 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381838,601,617 - 39,376,285 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1838,676,718 - 39,110,534 (+)Ensemblmm10GRCm38
GRCm38.p6 Ensembl1838,993,145 - 39,376,284 (+)Ensemblmm10GRCm38
MGSCv371839,152,799 - 39,535,939 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361839,119,119 - 39,502,259 (+)NCBIMGSCv36mm8
Celera1840,342,827 - 40,729,629 (+)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1820.51NCBI
Arhgap26
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541510,637,036 - 11,066,942 (-)Ensembl
ChiLan1.0NW_00495541510,635,410 - 11,066,551 (-)NCBIChiLan1.0ChiLan1.0
ARHGAP26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24138,013,059 - 138,473,459 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15136,152,606 - 136,613,010 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05138,125,142 - 138,585,550 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15144,234,924 - 144,692,794 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5144,234,913 - 144,686,252 (+)EnsemblpanPan2panpan1.1
ARHGAP26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,627,448 - 38,045,589 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,626,698 - 38,040,079 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha234,680,038 - 35,098,851 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0238,083,780 - 38,503,041 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,082,980 - 38,503,041 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1235,161,756 - 35,580,842 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0235,974,945 - 36,394,221 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0236,776,768 - 37,196,026 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arhgap26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213149,532,091 - 149,957,881 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650411,108,092 - 11,531,861 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650411,106,030 - 11,531,854 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP26
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2144,301,413 - 144,778,072 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12144,301,234 - 144,778,090 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22150,495,714 - 150,918,740 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP26
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12345,399,159 - 45,860,331 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2345,399,259 - 45,849,040 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603431,987,248 - 32,447,720 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap26
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247741,977,963 - 2,442,410 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247741,978,049 - 2,443,632 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Arhgap26
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1155,561,615 - 5,948,168 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arhgap26
3439 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:26
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000018843
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181564228031610627Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181221668431644508Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181221668431644508Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228031610627Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat

Markers in Region
D18Got32  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21831,222,380 - 31,222,575 (-)MAPPERmRatBN7.2
Rnor_6.01831,822,422 - 31,822,616NCBIRnor6.0
Rnor_5.01831,499,850 - 31,500,044UniSTSRnor5.0
RGSC_v3.41832,321,089 - 32,321,284RGDRGSC3.4
RGSC_v3.41832,321,090 - 32,321,284UniSTSRGSC3.4
Celera1830,856,003 - 30,856,197UniSTS
RGSC_v3.11832,356,356 - 32,356,550RGD
RH 3.4 Map18444.8UniSTS
RH 3.4 Map18444.8RGD
RH 2.0 Map18495.2RGD
Cytogenetic Map18p11UniSTS
D18Chm42  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81831,113,759 - 31,113,915 (+)Marker Load Pipeline
mRatBN7.21830,862,646 - 30,862,802 (-)MAPPERmRatBN7.2
Rnor_6.01832,183,671 - 32,183,828NCBIRnor6.0
Rnor_5.01831,863,090 - 31,863,247UniSTSRnor5.0
RGSC_v3.41831,958,726 - 31,958,883UniSTSRGSC3.4
Celera1830,497,889 - 30,498,046UniSTS
Cytogenetic Map18p11UniSTS
MHAa67b10.seq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21831,154,875 - 31,155,047 (-)MAPPERmRatBN7.2
Rnor_6.01831,889,620 - 31,889,791NCBIRnor6.0
Rnor_5.01831,566,936 - 31,567,107UniSTSRnor5.0
RGSC_v3.41832,252,519 - 32,252,690UniSTSRGSC3.4
Celera1830,788,952 - 30,789,123UniSTS
Cytogenetic Map18p11UniSTS
BF392044  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21831,114,363 - 31,114,506 (-)MAPPERmRatBN7.2
Rnor_6.01831,931,521 - 31,931,663NCBIRnor6.0
Rnor_5.01831,608,027 - 31,608,169UniSTSRnor5.0
RGSC_v3.41832,210,400 - 32,210,542UniSTSRGSC3.4
Celera1830,747,988 - 30,748,130UniSTS
RH 3.4 Map18439.5UniSTS
Cytogenetic Map18p11UniSTS
BE097330  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21830,835,777 - 30,835,943 (-)MAPPERmRatBN7.2
Rnor_6.01832,210,528 - 32,210,693NCBIRnor6.0
Rnor_5.01831,889,947 - 31,890,112UniSTSRnor5.0
RGSC_v3.41831,931,861 - 31,932,026UniSTSRGSC3.4
Celera1830,471,033 - 30,471,198UniSTS
RH 3.4 Map18442.8UniSTS
Cytogenetic Map18p11UniSTS
BE120196  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21831,174,148 - 31,174,314 (-)MAPPERmRatBN7.2
Rnor_6.01831,870,681 - 31,870,846NCBIRnor6.0
Rnor_5.01831,548,109 - 31,548,274UniSTSRnor5.0
RGSC_v3.41832,270,990 - 32,271,155UniSTSRGSC3.4
Celera1830,808,268 - 30,808,433UniSTS
RH 3.4 Map18443.9UniSTS
Cytogenetic Map18p11UniSTS
BM385892  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21830,841,745 - 30,841,959 (-)MAPPERmRatBN7.2
Rnor_6.01832,204,513 - 32,204,726NCBIRnor6.0
Rnor_5.01831,883,932 - 31,884,145UniSTSRnor5.0
RGSC_v3.41831,937,828 - 31,938,041UniSTSRGSC3.4
Celera1830,476,989 - 30,477,202UniSTS
RH 3.4 Map18445.2UniSTS
Cytogenetic Map18p11UniSTS
Tuba2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01831,590,656 - 31,590,810NCBIRnor5.0
RGSC_v3.41832,227,767 - 32,227,920UniSTSRGSC3.4
Celera1830,765,355 - 30,765,508UniSTS
Cytogenetic Map18p11UniSTS
ECD04098  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21830,839,016 - 30,839,749 (-)MAPPERmRatBN7.2
Rnor_6.01832,206,723 - 32,207,455NCBIRnor6.0
Rnor_5.01831,886,142 - 31,886,874UniSTSRnor5.0
Cytogenetic Map18p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018843   ⟹   ENSRNOP00000018843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1831,089,787 - 31,489,047 (+)Ensembl
mRatBN7.2 Ensembl1830,838,671 - 31,228,842 (+)Ensembl
Rnor_6.0 Ensembl1831,816,155 - 32,207,801 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090882   ⟹   ENSRNOP00000073385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1830,838,671 - 31,186,667 (+)Ensembl
Rnor_6.0 Ensembl1831,812,109 - 32,207,749 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101992   ⟹   ENSRNOP00000096429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1831,089,787 - 31,489,047 (+)Ensembl
mRatBN7.2 Ensembl1830,838,671 - 31,235,194 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102830   ⟹   ENSRNOP00000098009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1831,089,787 - 31,476,749 (+)Ensembl
mRatBN7.2 Ensembl1830,838,671 - 31,225,647 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106545   ⟹   ENSRNOP00000094639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1831,089,787 - 31,489,047 (+)Ensembl
mRatBN7.2 Ensembl1830,838,671 - 31,235,194 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111290   ⟹   ENSRNOP00000078827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1831,089,787 - 31,489,047 (+)Ensembl
mRatBN7.2 Ensembl1830,838,671 - 31,235,194 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115900   ⟹   ENSRNOP00000090557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1831,089,789 - 31,485,260 (+)Ensembl
mRatBN7.2 Ensembl1830,838,671 - 31,235,194 (+)Ensembl
RefSeq Acc Id: NM_001395140   ⟹   NP_001382069
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,089,787 - 31,489,047 (+)NCBI
mRatBN7.21830,838,671 - 31,237,945 (+)NCBI
RefSeq Acc Id: XM_006254660   ⟹   XP_006254722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,086,895 - 31,489,047 (+)NCBI
mRatBN7.21830,835,806 - 31,232,689 (+)NCBI
Rnor_6.01831,812,308 - 32,207,856 (-)NCBI
Rnor_5.01831,484,480 - 31,890,142 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006254663   ⟹   XP_006254725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81831,086,895 - 31,489,047 (+)NCBI
mRatBN7.21830,838,991 - 31,232,689 (+)NCBI
Rnor_6.01831,812,308 - 32,207,481 (-)NCBI
Rnor_5.01831,484,480 - 31,890,142 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063277362   ⟹   XP_063133432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81830,702,602 - 31,489,047 (+)NCBI
RefSeq Acc Id: XP_006254722   ⟸   XM_006254660
- Peptide Label: isoform X1
- UniProtKB: A0A8I6APL5 (UniProtKB/TrEMBL),   A0A8I6AL79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254725   ⟸   XM_006254663
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AAB3 (UniProtKB/TrEMBL),   A0A8I5ZLR1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018843   ⟸   ENSRNOT00000018843
Ensembl Acc Id: ENSRNOP00000073385   ⟸   ENSRNOT00000090882
Ensembl Acc Id: ENSRNOP00000096429   ⟸   ENSRNOT00000101992
Ensembl Acc Id: ENSRNOP00000098009   ⟸   ENSRNOT00000102830
Ensembl Acc Id: ENSRNOP00000094639   ⟸   ENSRNOT00000106545
Ensembl Acc Id: ENSRNOP00000078827   ⟸   ENSRNOT00000111290
Ensembl Acc Id: ENSRNOP00000090557   ⟸   ENSRNOT00000115900
RefSeq Acc Id: NP_001382069   ⟸   NM_001395140
- UniProtKB: A0A8I6AL79 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133432   ⟸   XM_063277362
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZLR1 (UniProtKB/TrEMBL)
Protein Domains
PH   Rho-GAP   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMS4-F1-model_v2 AlphaFold D3ZMS4 1-761 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700748
Promoter ID:EPDNEW_R11265
Type:multiple initiation site
Name:Arhgap26_1
Description:Rho GTPase activating protein 26
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01832,207,787 - 32,207,847EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310923 AgrOrtholog
BioCyc Gene G2FUF-7748 BioCyc
Ensembl Genes ENSRNOG00000013920 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018843.7 UniProtKB/TrEMBL
  ENSRNOT00000101992 ENTREZGENE
  ENSRNOT00000101992.2 UniProtKB/TrEMBL
  ENSRNOT00000102830.2 UniProtKB/TrEMBL
  ENSRNOT00000106545 ENTREZGENE
  ENSRNOT00000106545.2 UniProtKB/TrEMBL
  ENSRNOT00000111290.2 UniProtKB/TrEMBL
  ENSRNOT00000115900 ENTREZGENE
  ENSRNOT00000115900.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro AH/BAR-dom UniProtKB/TrEMBL
  BAR_dom UniProtKB/TrEMBL
  GRAF_BAR UniProtKB/TrEMBL
  GRAF_fam UniProtKB/TrEMBL
  GRAF_SH3 UniProtKB/TrEMBL
  PH_GRAF UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene 307459 ENTREZGENE
PANTHER OLIGOPHRENIN 1 UniProtKB/TrEMBL
  PTHR12552:SF4 UniProtKB/TrEMBL
Pfam BAR_3 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH3_9 UniProtKB/TrEMBL
PhenoGen Arhgap26 PhenoGen
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013920 RatGTEx
SMART RhoGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  Rho_GAP UniProtKB/TrEMBL
  SSF103657 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A8I5ZLR1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AAB3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AL79 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APL5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GMS4_RAT UniProtKB/TrEMBL
  A6J3H9_RAT UniProtKB/TrEMBL
  D3ZMS4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Arhgap26  Rho GTPase activating protein 26   Arhgap26_predicted  Rho GTPase activating protein 26 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Arhgap26_predicted  Rho GTPase activating protein 26 (predicted)      Symbol and Name status set to approved 70820 APPROVED