Tns2 (tensin 2) - Rat Genome Database

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Gene: Tns2 (tensin 2) Rattus norvegicus
Analyze
Symbol: Tns2
Name: tensin 2
RGD ID: 1310917
Description: Predicted to enable identical protein binding activity; kinase binding activity; and protein tyrosine phosphatase activity. Predicted to be involved in negative regulation of cell population proliferation; negative regulation of insulin receptor signaling pathway; and peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within several processes, including collagen metabolic process; multicellular organismal-level homeostasis; and response to muscle activity. Predicted to be active in focal adhesion. Orthologous to human TNS2 (tensin 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC315326; Tenc1; tensin like C1 domain containing phosphatase; tensin like C1 domain containing phosphatase (tensin 2); tensin-2; tensin-like C1 domain-containing phosphatase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,108,401 - 135,126,505 (+)NCBIGRCr8
mRatBN7.27133,229,746 - 133,247,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,206,364 - 133,247,888 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,995,296 - 135,009,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,224,662 - 137,238,607 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,203,480 - 137,217,529 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,702,623 - 143,720,995 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,707,237 - 143,720,595 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,502,878 - 141,517,546 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,842,199 - 140,857,001 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,917,125 - 140,933,434 (+)NCBI
Celera7129,664,892 - 129,683,186 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tns2Ratnephrotic syndrome  ISOTNS2 (Homo sapiens)8554872ClinVar Annotator: match by term: Nephrotic syndromeClinVarPMID:25741868 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tns2RatPierson syndrome  ISSTns2 (Mus musculus)13592920OMIM:609049MouseDO 

1 to 20 of 97 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tns2Rat17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of TNS2 mRNACTDPMID:26865667
Tns2Rat17alpha-ethynylestradiol multiple interactionsISOTns2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of TNS2 mRNACTDPMID:17942748
Tns2Rat17alpha-ethynylestradiol increases expressionISOTns2 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of TNS2 mRNACTDPMID:17942748
Tns2Rat17alpha-ethynylestradiol affects expressionISOTns2 (Mus musculus)6480464Ethinyl Estradiol affects the expression of TNS2 mRNACTDPMID:17555576
Tns2Rat17beta-estradiol affects expressionISOTns2 (Mus musculus)6480464Estradiol affects the expression of TNS2 mRNACTDPMID:39298647
Tns2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOTNS2 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of TNS2 mRNACTDPMID:20106945
Tns2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOTns2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of TNS2 mRNACTDPMID:25975270
Tns2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOTns2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of TNS2 mRNACTDPMID:17942748
Tns2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTns2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TNS2 mRNACTDPMID:18343893 and PMID:21570461
Tns2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of TNS2 mRNACTDPMID:21215274
Tns2Rat2,3,7,8-Tetrachlorodibenzofuran affects expressionISOTns2 (Mus musculus)64804642 more ...CTDPMID:18343893
Tns2Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of TNS2 mRNACTDPMID:21346803
Tns2Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of TNS2 mRNACTDPMID:21346803
Tns2Rat4,4'-sulfonyldiphenol increases expressionISOTns2 (Mus musculus)6480464bisphenol S results in increased expression of TNS2 mRNACTDPMID:30951980
Tns2Rat4,4'-sulfonyldiphenol decreases expressionISOTns2 (Mus musculus)6480464bisphenol S results in decreased expression of TNS2 mRNACTDPMID:39298647
Tns2Ratacrolein multiple interactionsISOTNS2 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in increased expression of TNS2 mRNACTDPMID:32845096
Tns2Ratacrylamide decreases expressionISOTNS2 (Homo sapiens)6480464Acrylamide results in decreased expression of TNS2 mRNACTDPMID:32763439
Tns2Rataflatoxin B1 decreases methylationISOTNS2 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of TNS2 intronCTDPMID:30157460
Tns2RatAflatoxin B2 alpha increases methylationISOTNS2 (Homo sapiens)6480464aflatoxin B2 results in increased methylation of TNS2 exonCTDPMID:30157460
Tns2Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in increased expression of TNS2 mRNACTDPMID:35163327

1 to 20 of 97 rows

Biological Process
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tns2Ratcellular homeostasis acts_upstream_of_or_withinISOTns2 (Mus musculus)1624291MGI:2447990 PMID:10823724RGDPMID:10823724
Tns2Ratcellular homeostasis acts_upstream_of_or_withinIEAUniProtKB:Q8CGB6 and ensembl:ENSMUSP000000410871600115GO_REF:0000107EnsemblGO_REF:0000107
Tns2Ratcollagen metabolic process acts_upstream_of_or_withinISOTns2 (Mus musculus)1624291MGI:2447990 PMID:10823724RGDPMID:10823724
Tns2Ratcollagen metabolic process acts_upstream_of_or_withinIEAUniProtKB:Q8CGB6 and ensembl:ENSMUSP000000410871600115GO_REF:0000107EnsemblGO_REF:0000107
Tns2Ratkidney development acts_upstream_of_or_withinIEAUniProtKB:Q8CGB6 and ensembl:ENSMUSP000000410871600115GO_REF:0000107EnsemblGO_REF:0000107
Tns2Ratkidney development acts_upstream_of_or_withinISOTns2 (Mus musculus)1624291MGI:2447990 PMID:10823724RGDPMID:10823724
Tns2Ratmulticellular organism growth acts_upstream_of_or_withinIEAUniProtKB:Q8CGB6 and ensembl:ENSMUSP000000410871600115GO_REF:0000107EnsemblGO_REF:0000107
Tns2Ratmulticellular organism growth acts_upstream_of_or_withinISOTns2 (Mus musculus)1624291MGI:2447990 PMID:10823724RGDPMID:10823724
Tns2Ratmulticellular organismal-level homeostasis acts_upstream_of_or_withinISOTns2 (Mus musculus)1624291MGI:2447990 PMID:10823724RGDPMID:10823724
Tns2Ratmulticellular organismal-level homeostasis acts_upstream_of_or_withinIEAUniProtKB:Q8CGB6 and ensembl:ENSMUSP000000410871600115GO_REF:0000107EnsemblGO_REF:0000107
Tns2Ratnegative regulation of cell population proliferation involved_inISOTNS2 (Homo sapiens)1624291 PMID:16951145RGDPMID:16951145
Tns2Ratnegative regulation of cell population proliferation involved_inIEAUniProtKB:Q63HR2 and ensembl:ENSP000003196841600115GO_REF:0000107EnsemblGO_REF:0000107
Tns2Ratnegative regulation of insulin receptor signaling pathway involved_inISOTNS2 (Homo sapiens)1624291 PMID:23401856RGDPMID:23401856
Tns2Ratnegative regulation of insulin receptor signaling pathway involved_inIEAUniProtKB:Q63HR2 and ensembl:ENSP000003196841600115GO_REF:0000107EnsemblGO_REF:0000107
Tns2Ratnegative regulation of insulin receptor signaling pathway involved_inIBAPANTHER:PTN002906774 and UniProtKB:Q63HR21600115GO_REF:0000033GO_CentralGO_REF:0000033
Tns2Ratpeptidyl-tyrosine dephosphorylation involved_inISOTNS2 (Homo sapiens)1624291 PMID:23401856RGDPMID:23401856
Tns2Ratresponse to muscle activity acts_upstream_of_or_withinIEAUniProtKB:Q8CGB6 and ensembl:ENSMUSP000000410871600115GO_REF:0000107EnsemblGO_REF:0000107
Tns2Ratresponse to muscle activity acts_upstream_of_or_withinISOTns2 (Mus musculus)1624291MGI:2447990 PMID:10823724RGDPMID:10823724
1 to 18 of 18 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tns2Ratanchoring junction located_inIEAUniProtKB-KW:KW-09651600115GO_REF:0000043UniProtGO_REF:0000043
Tns2Ratfocal adhesion located_inISOTNS2 (Homo sapiens)1624291 PMID:16951145 and PMID:22019427RGDPMID:16951145 and PMID:22019427
Tns2Ratfocal adhesion is_active_inIBAFB:FBgn0000244 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tns2Ratfocal adhesion located_inIEAUniProtKB:Q63HR2 and ensembl:ENSP000003196841600115GO_REF:0000107EnsemblGO_REF:0000107
Tns2Ratfocal adhesion located_inIEAUniProtKB-SubCell:SL-01181600115GO_REF:0000044UniProtGO_REF:0000044

Molecular Function
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tns2Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Tns2Ratidentical protein binding enablesISOTNS2 (Homo sapiens)1624291UniProtKB:Q63HR2 and PMID:32296183RGDPMID:32296183
Tns2Ratidentical protein binding enablesIEAUniProtKB:Q63HR2 and ensembl:ENSP000003196841600115GO_REF:0000107EnsemblGO_REF:0000107
Tns2Ratkinase binding enablesISOTNS2 (Homo sapiens)1624291UniProtKB:P43405 and PMID:22019427RGDPMID:22019427
Tns2Ratkinase binding enablesIEAUniProtKB:Q63HR2 and ensembl:ENSP000003196841600115GO_REF:0000107EnsemblGO_REF:0000107
Tns2Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Tns2Ratphosphoprotein phosphatase activity enablesIEAUniProtKB-KW:KW-09041600115GO_REF:0000043UniProtGO_REF:0000043
Tns2Ratprotein binding enablesISOTNS2 (Homo sapiens)1624291UniProtKB:A0A0S2Z4G9 more ...RGDPMID:16273093 more ...
Tns2Ratprotein tyrosine phosphatase activity enablesISOTNS2 (Homo sapiens)1624291 PMID:23401856RGDPMID:23401856
Tns2Ratprotein tyrosine phosphatase activity enablesIEAUniProtKB:Q63HR2 and ensembl:ENSP000003196841600115GO_REF:0000107EnsemblGO_REF:0000107
Tns2Ratprotein tyrosine phosphatase activity enablesIBAPANTHER:PTN002906774 and UniProtKB:Q63HR21600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 11 of 11 rows


#
Reference Title
Reference Citation
1. Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational control. Eom T, etal., J Cell Biol. 2014 Oct 27;207(2):237-52. doi: 10.1083/jcb.201401005. Epub 2014 Oct 20.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:8889548   PMID:10823724   PMID:16951145   PMID:21423176   PMID:22019427   PMID:23401856  



Tns2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,108,401 - 135,126,505 (+)NCBIGRCr8
mRatBN7.27133,229,746 - 133,247,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,206,364 - 133,247,888 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,995,296 - 135,009,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,224,662 - 137,238,607 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,203,480 - 137,217,529 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,702,623 - 143,720,995 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,707,237 - 143,720,595 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,502,878 - 141,517,546 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,842,199 - 140,857,001 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,917,125 - 140,933,434 (+)NCBI
Celera7129,664,892 - 129,683,186 (+)NCBICelera
Cytogenetic Map7q36NCBI
TNS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,046,991 - 53,064,379 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,046,969 - 53,064,379 (+)EnsemblGRCh38hg38GRCh38
GRCh371253,440,775 - 53,458,163 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,727,077 - 51,744,430 (+)NCBINCBI36Build 36hg18NCBI36
Celera1253,088,528 - 53,106,057 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,483,949 - 50,501,247 (+)NCBIHuRef
CHM1_11253,407,410 - 53,424,570 (+)NCBICHM1_1
T2T-CHM13v2.01253,011,375 - 53,028,746 (+)NCBIT2T-CHM13v2.0
Tns2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,006,910 - 102,024,836 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,008,848 - 102,024,836 (+)EnsemblGRCm39 Ensembl
GRCm3815102,098,475 - 102,116,401 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,100,413 - 102,116,401 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715101,933,419 - 101,946,832 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,930,264 - 101,944,433 (+)NCBIMGSCv36mm8
Celera15104,258,906 - 104,272,318 (+)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.29NCBI
Tns2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458333,985 - 346,927 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955458333,104 - 347,399 (+)NCBIChiLan1.0ChiLan1.0
TNS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,124,742 - 41,144,429 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,121,508 - 41,142,654 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,692,148 - 35,712,685 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,473,106 - 36,488,469 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,473,106 - 36,488,471 (-)Ensemblpanpan1.1panPan2
TNS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,096,287 - 2,112,626 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,096,616 - 2,113,619 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,138,331 - 44,152,954 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,100,795 - 2,115,425 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,100,798 - 2,114,670 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,117,696 - 2,131,151 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,104,036 - 2,117,489 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,536,968 - 44,551,681 (+)NCBIUU_Cfam_GSD_1.0
Tns2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,774,409 - 62,793,289 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,371,684 - 10,393,156 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,376,442 - 10,390,421 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,300,167 - 18,320,781 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,305,488 - 18,320,784 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,901,927 - 18,908,694 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,163,217 - 49,183,110 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1149,169,060 - 49,182,611 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037196,882,676 - 196,900,450 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tns2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249041,115,288 - 1,128,354 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249041,110,149 - 1,128,848 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tns2
66 total Variants

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:67
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000014310, ENSRNOT00000074212
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 15 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat

1 to 10 of 15 rows
D7Rat101  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87135,117,186 - 135,117,323 (+)Marker Load Pipeline
mRatBN7.27133,238,570 - 133,238,707 (+)MAPPERmRatBN7.2
Rnor_6.07143,711,663 - 143,711,799NCBIRnor6.0
Rnor_5.07141,508,246 - 141,508,382UniSTSRnor5.0
RGSC_v3.47140,846,401 - 140,846,882RGDRGSC3.4
RGSC_v3.47140,846,742 - 140,846,878UniSTSRGSC3.4
RGSC_v3.17140,923,179 - 140,923,315RGD
Celera7129,673,895 - 129,674,031UniSTS
RH 3.4 Map71064.8UniSTS
RH 3.4 Map71064.8RGD
RH 2.0 Map7793.9RGD
SHRSP x BN Map788.4599RGD
Cytogenetic Map7q36UniSTS
AA818518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,247,560 - 133,247,706 (+)MAPPERmRatBN7.2
Rnor_6.07143,720,667 - 143,720,812NCBIRnor6.0
Rnor_5.07141,517,218 - 141,517,363UniSTSRnor5.0
RGSC_v3.47140,856,674 - 140,856,819UniSTSRGSC3.4
Celera7129,682,858 - 129,683,003UniSTS
RH 3.4 Map71065.8UniSTS
Cytogenetic Map7q36UniSTS
AA893657  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,247,444 - 133,247,585 (+)MAPPERmRatBN7.2
Rnor_6.07143,720,551 - 143,720,691NCBIRnor6.0
Rnor_5.07141,517,102 - 141,517,242UniSTSRnor5.0
RGSC_v3.47140,856,558 - 140,856,698UniSTSRGSC3.4
Celera7129,682,742 - 129,682,882UniSTS
RH 3.4 Map6516.3UniSTS
Cytogenetic Map7q36UniSTS
RH135385  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87135,113,263 - 135,113,456 (+)Marker Load Pipeline
mRatBN7.27133,234,645 - 133,234,839 (+)MAPPERmRatBN7.2
Rnor_6.07143,707,740 - 143,707,932NCBIRnor6.0
Rnor_5.07141,504,323 - 141,504,515UniSTSRnor5.0
RGSC_v3.47140,842,819 - 140,843,011UniSTSRGSC3.4
Celera7129,669,972 - 129,670,164UniSTS
RH 3.4 Map71064.0UniSTS
Cytogenetic Map7q36UniSTS
MARC_7649-7650:996688053:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2669,600,566 - 69,600,797 (+)MAPPERmRatBN7.2
mRatBN7.27133,244,430 - 133,245,161 (+)MAPPERmRatBN7.2
Rnor_6.07143,717,527 - 143,718,257NCBIRnor6.0
Rnor_6.0672,933,904 - 72,934,134NCBIRnor6.0
Rnor_5.07141,514,111 - 141,514,841UniSTSRnor5.0
Rnor_5.0682,494,665 - 82,494,895UniSTSRnor5.0
RGSC_v3.4672,305,758 - 72,305,988UniSTSRGSC3.4
RGSC_v3.47140,852,606 - 140,853,336UniSTSRGSC3.4
Celera7129,679,761 - 129,680,491UniSTS
Celera668,476,527 - 68,476,757UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map6q23UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 19 of 19 rows
RefSeq Transcripts NM_001108114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008776609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008776611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008776612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008776613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC110347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF419140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENSRNOT00000014033   ⟹   ENSRNOP00000014033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,206,364 - 133,247,888 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000074212   ⟹   ENSRNOP00000064911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,233,941 - 133,247,888 (+)Ensembl
Rnor_6.0 Ensembl7143,707,237 - 143,720,595 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105703   ⟹   ENSRNOP00000094945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,232,288 - 133,247,888 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108446   ⟹   ENSRNOP00000090796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,230,300 - 133,247,888 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118793   ⟹   ENSRNOP00000096207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,233,941 - 133,247,847 (+)Ensembl
RefSeq Acc Id: NM_001108114   ⟹   NP_001101584
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,112,559 - 135,126,505 (+)NCBI
mRatBN7.27133,233,941 - 133,247,889 (+)NCBI
RefSeq Acc Id: XM_008765865   ⟹   XP_008764087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,111,815 - 135,126,503 (+)NCBI
mRatBN7.27133,232,304 - 133,247,889 (+)NCBI
Rnor_6.07143,704,814 - 143,720,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765869   ⟹   XP_008764091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,110,005 - 135,126,503 (+)NCBI
mRatBN7.27133,231,382 - 133,247,889 (+)NCBI
Rnor_6.07143,704,691 - 143,720,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595336   ⟹   XP_017450825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,108,401 - 135,126,503 (+)NCBI
mRatBN7.27133,229,746 - 133,247,889 (+)NCBI
Rnor_6.07143,702,623 - 143,720,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595337   ⟹   XP_017450826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,117,999 - 135,126,503 (+)NCBI
mRatBN7.27133,239,374 - 133,247,889 (+)NCBI
Rnor_6.07143,712,475 - 143,720,995 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017595338   ⟹   XP_017450827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,117,978 - 135,126,503 (+)NCBI
mRatBN7.27133,239,310 - 133,247,889 (+)NCBI
Rnor_6.07143,712,426 - 143,720,995 (+)NCBI
Sequence:
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: XP_008764091   ⟸   XM_008765869
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AEG8 (UniProtKB/TrEMBL),   M0R671 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764087   ⟸   XM_008765865
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AKK0 (UniProtKB/TrEMBL),   M0R671 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450825   ⟸   XM_017595336
- Peptide Label: isoform X1
- UniProtKB: F7FBH3 (UniProtKB/TrEMBL),   M0R671 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450827   ⟸   XM_017595338
- Peptide Label: isoform X4
- UniProtKB: M0R671 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450826   ⟸   XM_017595337
- Peptide Label: isoform X4
- UniProtKB: M0R671 (UniProtKB/TrEMBL)
- Sequence:
C2 tensin-type   Phorbol-ester/DAG-type   Phosphatase tensin-type   SH2

Name Modeler Protein Id AA Range Protein Structure
AF-M0R671-F1-model_v2 AlphaFold M0R671 1-1400 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 57 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-31951 BioCyc
Ensembl Genes ENSRNOG00000010588 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014033.6 UniProtKB/TrEMBL
  ENSRNOT00000074212 ENTREZGENE
  ENSRNOT00000074212.2 UniProtKB/TrEMBL
  ENSRNOT00000105703 ENTREZGENE
  ENSRNOT00000105703.1 UniProtKB/TrEMBL
  ENSRNOT00000108446 ENTREZGENE
  ENSRNOT00000108446.1 UniProtKB/TrEMBL
  ENSRNOT00000118793 ENTREZGENE
  ENSRNOT00000118793.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.60.40.1110 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Prot_Kinase_C-like_PE/DAG-bd UniProtKB/TrEMBL
  PTB UniProtKB/TrEMBL
  PTyr_interaction_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tensin_like_SH2 UniProtKB/TrEMBL
  Tensin_lipid_phosphatase_dom UniProtKB/TrEMBL
  Tensin_phosphatase_C2-dom UniProtKB/TrEMBL
  Tensin_PTB UniProtKB/TrEMBL
  Tensin_PTEN_phosphatase UniProtKB/TrEMBL
NCBI Gene 315326 ENTREZGENE
PANTHER TENSIN UniProtKB/TrEMBL
  TENSIN-2 UniProtKB/TrEMBL
Pfam PTB UniProtKB/TrEMBL
  PTEN_C2 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PhenoGen Tns2 PhenoGen
PROSITE C2_TENSIN UniProtKB/TrEMBL
  PPASE_TENSIN UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
1 to 40 of 57 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-01-26 Tns2  tensin 2  Tenc1  tensin like C1 domain containing phosphatase (tensin 2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Tenc1  tensin like C1 domain containing phosphatase (tensin 2)  Tenc1  tensin like C1 domain containing phosphatase   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tenc1  tensin like C1 domain containing phosphatase   Tenc1_predicted  tensin like C1 domain containing phosphatase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tenc1_predicted  tensin like C1 domain containing phosphatase (predicted)      Symbol and Name status set to approved 70820 APPROVED