Miga2 (mitoguardin 2) - Rat Genome Database

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Pathways
Gene: Miga2 (mitoguardin 2) Rattus norvegicus
Analyze
Symbol: Miga2
Name: mitoguardin 2
RGD ID: 1310887
Description: Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in mitochondrial fusion. Predicted to act upstream of or within bone development. Predicted to be located in plasma membrane. Orthologous to human MIGA2 (mitoguardin 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam73b; family with sequence similarity 73, member B; hypothetical protein LOC296623; LOC296623; mitoguardin-2; RGD1310887; similar to CG12125-PA; uncharacterized protein LOC296623
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8334,034,018 - 34,056,703 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl334,034,044 - 34,056,703 (+)EnsemblGRCr8
mRatBN7.2313,636,235 - 13,658,895 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,636,238 - 13,658,896 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx316,707,761 - 16,730,411 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0325,292,727 - 25,315,377 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0323,538,481 - 23,561,132 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,928,484 - 8,951,189 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,928,534 - 8,951,189 (+)Ensemblrn6Rnor6.0
Rnor_5.0314,281,269 - 14,303,963 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.439,408,140 - 9,430,785 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera38,402,799 - 8,425,429 (+)NCBICelera
RGSC_v3.139,408,013 - 9,429,645 (+)NCBI
Cytogenetic Map3p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22876197   PMID:26711011   PMID:34800366  


Genomics

Comparative Map Data
Miga2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8334,034,018 - 34,056,703 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl334,034,044 - 34,056,703 (+)EnsemblGRCr8
mRatBN7.2313,636,235 - 13,658,895 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,636,238 - 13,658,896 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx316,707,761 - 16,730,411 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0325,292,727 - 25,315,377 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0323,538,481 - 23,561,132 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,928,484 - 8,951,189 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,928,534 - 8,951,189 (+)Ensemblrn6Rnor6.0
Rnor_5.0314,281,269 - 14,303,963 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.439,408,140 - 9,430,785 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera38,402,799 - 8,425,429 (+)NCBICelera
RGSC_v3.139,408,013 - 9,429,645 (+)NCBI
Cytogenetic Map3p12NCBI
MIGA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389129,036,626 - 129,072,082 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9129,036,614 - 129,072,087 (+)Ensemblhg38GRCh38
GRCh379131,798,905 - 131,834,361 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,839,074 - 130,874,172 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349128,878,806 - 128,913,904NCBI
Celera9102,451,566 - 102,486,648 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9101,406,579 - 101,441,661 (+)NCBIHuRef
CHM1_19131,950,093 - 131,985,185 (+)NCBICHM1_1
T2T-CHM13v2.09141,240,095 - 141,275,546 (+)NCBIT2T-CHM13v2.0
Miga2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39230,254,232 - 30,275,532 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl230,254,245 - 30,275,533 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38230,364,233 - 30,385,520 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl230,364,233 - 30,385,521 (+)Ensemblmm10GRCm38
MGSCv37230,219,855 - 30,241,039 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36230,186,344 - 30,207,528 (+)NCBIMGSCv36mm8
Celera230,069,368 - 30,090,426 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.63NCBI
Miga2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555701,387,013 - 1,402,996 (+)Ensembl
ChiLan1.0NW_0049555701,387,006 - 1,402,996 (+)NCBIChiLan1.0ChiLan1.0
MIGA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21110,279,682 - 10,316,702 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1910,282,029 - 10,319,049 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09100,160,068 - 100,197,095 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19128,820,773 - 128,856,977 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9128,820,773 - 128,856,977 (+)EnsemblpanPan2panpan1.1
MIGA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1954,602,363 - 54,631,287 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl954,604,086 - 54,631,228 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha953,797,951 - 53,826,918 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0955,498,346 - 55,524,165 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl955,498,109 - 55,552,212 (-)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.0954,596,516 - 54,625,519 (-)NCBIUNSW_CanFamBas_1.0
Miga2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947196,713,508 - 196,739,991 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648716,482,049 - 16,509,997 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648716,482,070 - 16,506,890 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIGA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1269,334,838 - 269,363,936 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11269,334,938 - 269,363,938 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21303,351,067 - 303,380,133 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MIGA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,092,712 - 9,126,679 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666096432,196 - 467,610 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Miga2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247606,028,404 - 6,045,137 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247606,028,403 - 6,045,158 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Miga2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v155,245,478 - 5,268,283 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Miga2
291 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:693
Count of miRNA genes:274
Interacting mature miRNAs:351
Transcripts:ENSRNOT00000065300
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH125103  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,655,197 - 13,656,373 (+)MAPPERmRatBN7.2
Rnor_6.038,947,491 - 8,948,666NCBIRnor6.0
Rnor_5.0314,300,265 - 14,301,440UniSTSRnor5.0
RGSC_v3.439,427,087 - 9,428,262UniSTSRGSC3.4
Celera38,421,731 - 8,422,906UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
22 12 71 185 91 90 59 122 59 6 412 226 12 165 97 99 31 28 28

Sequence


Ensembl Acc Id: ENSRNOT00000065300   ⟹   ENSRNOP00000062428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl334,034,044 - 34,056,703 (+)Ensembl
mRatBN7.2 Ensembl313,636,250 - 13,658,896 (+)Ensembl
Rnor_6.0 Ensembl38,928,544 - 8,951,189 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088509   ⟹   ENSRNOP00000075370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl334,034,095 - 34,056,701 (+)Ensembl
mRatBN7.2 Ensembl313,636,238 - 13,658,893 (+)Ensembl
Rnor_6.0 Ensembl38,928,534 - 8,949,947 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000165778   ⟹   ENSRNOP00000106111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl334,034,095 - 34,056,701 (+)Ensembl
RefSeq Acc Id: NM_001106566   ⟹   NP_001100036
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,034,044 - 34,056,703 (+)NCBI
mRatBN7.2313,636,235 - 13,658,895 (+)NCBI
Rnor_6.038,928,544 - 8,951,189 (+)NCBI
Rnor_5.0314,281,269 - 14,303,963 (+)NCBI
RGSC_v3.439,408,140 - 9,430,785 (+)RGD
Celera38,402,799 - 8,425,429 (+)RGD
Sequence:
RefSeq Acc Id: NM_001399326   ⟹   NP_001386255
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,034,044 - 34,056,703 (+)NCBI
mRatBN7.2313,636,235 - 13,658,895 (+)NCBI
RefSeq Acc Id: XM_006233782   ⟹   XP_006233844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,034,102 - 34,056,702 (+)NCBI
mRatBN7.2313,636,284 - 13,658,797 (+)NCBI
Rnor_6.038,928,598 - 8,951,188 (+)NCBI
Rnor_5.0314,281,269 - 14,303,963 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063283490   ⟹   XP_063139560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,034,018 - 34,051,789 (+)NCBI
RefSeq Acc Id: XR_010064604
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,034,018 - 34,052,727 (+)NCBI
RefSeq Acc Id: NP_001100036   ⟸   NM_001106566
- Peptide Label: isoform 2
- UniProtKB: D3Z899 (UniProtKB/TrEMBL),   A6JTY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233844   ⟸   XM_006233782
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KAE6 (UniProtKB/TrEMBL),   A6JTY1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062428   ⟸   ENSRNOT00000065300
Ensembl Acc Id: ENSRNOP00000075370   ⟸   ENSRNOT00000088509
RefSeq Acc Id: NP_001386255   ⟸   NM_001399326
- Peptide Label: isoform 1
- UniProtKB: A0A0G2KAE6 (UniProtKB/TrEMBL),   A6JTY1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139560   ⟸   XM_063283490
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000106111   ⟸   ENSRNOT00000165778

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KAE6-F1-model_v2 AlphaFold A0A0G2KAE6 1-593 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691971
Promoter ID:EPDNEW_R2482
Type:multiple initiation site
Name:Miga2_1
Description:mitoguardin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.038,928,536 - 8,928,596EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310887 AgrOrtholog
BioCyc Gene G2FUF-50219 BioCyc
Ensembl Genes ENSRNOG00000017513 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065300 ENTREZGENE
  ENSRNOT00000065300.5 UniProtKB/TrEMBL
  ENSRNOT00000088509 ENTREZGENE
  ENSRNOT00000088509.3 UniProtKB/TrEMBL
  ENSRNOT00000165778.1 UniProtKB/TrEMBL
InterPro DUF2217 UniProtKB/TrEMBL
KEGG Report rno:296623 UniProtKB/TrEMBL
NCBI Gene 296623 ENTREZGENE
PANTHER MITOGUARDIN 2 UniProtKB/TrEMBL
  PTHR21508 UniProtKB/TrEMBL
Pfam DUF2217 UniProtKB/TrEMBL
PhenoGen Miga2 PhenoGen
RatGTEx ENSRNOG00000017513 RatGTEx
UniProt A0A0G2KAE6 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L7H1_RAT UniProtKB/TrEMBL
  A6JTY1 ENTREZGENE, UniProtKB/TrEMBL
  A6JTY2 ENTREZGENE, UniProtKB/TrEMBL
  D3Z899 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Miga2  mitoguardin 2  Fam73b  family with sequence similarity 73, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Fam73b  family with sequence similarity 73, member B  RGD1310887_predicted  similar to CG12125-PA (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1310887_predicted  similar to CG12125-PA (predicted)  LOC296623_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC296623_predicted  similar to CG12125-PA (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL