Diablo (diablo, IAP-binding mitochondrial protein) - Rat Genome Database

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Gene: Diablo (diablo, IAP-binding mitochondrial protein) Rattus norvegicus
Analyze
Symbol: Diablo
Name: diablo, IAP-binding mitochondrial protein
RGD ID: 1310885
Description: Predicted to be involved in intrinsic apoptotic signaling pathway in response to oxidative stress; neuron apoptotic process; and positive regulation of apoptotic process. Predicted to be located in cytoplasmic side of plasma membrane and cytosol. Predicted to be part of CD40 receptor complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 64. Orthologous to human DIABLO (diablo IAP-binding mitochondrial protein); INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: diablo homolog (Drosophila); diablo homolog, mitochondrial; LOC288753; MGC105680; Smac
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81238,716,668 - 38,731,285 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1238,716,668 - 38,731,265 (+)EnsemblGRCr8
mRatBN7.21233,055,784 - 33,070,401 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,055,263 - 33,070,387 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1234,234,556 - 34,249,178 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01234,845,907 - 34,860,529 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,213,188 - 146,214,531 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,490,230 - 38,503,344 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,490,230 - 38,503,330 (+)Ensemblrn6Rnor6.0
Rnor_5.01240,372,113 - 40,385,227 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41234,196,347 - 34,209,633 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1234,742,122 - 34,755,405 (+)NCBICelera
RGSC_v3.11234,059,734 - 34,073,021 (+)NCBI
Cytogenetic Map12q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-fluorouracil  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
acetylsalicylic acid  (ISO)
adenosine  (ISO)
afatinib  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alvocidib  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
cerivastatin  (ISO)
chromium(6+)  (ISO)
chrysazin  (ISO)
cinchocaine  (EXP)
cisplatin  (ISO)
cladribine  (ISO)
clobetasol  (ISO)
clofibric acid  (EXP)
corosolic acid  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP)
cylindrospermopsin  (ISO)
cyproconazole  (EXP)
D-glucose  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenziodolium  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Echinocystic acid  (ISO)
entinostat  (ISO)
epichlorohydrin  (ISO)
epoxiconazole  (EXP)
fenthion  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
fomepizole  (ISO)
fumonisin B1  (ISO)
furfural  (ISO)
glucose  (ISO)
glutathione  (ISO)
hydrogen peroxide  (EXP,ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
kainic acid  (EXP)
lamivudine  (ISO)
LGK974  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
metformin  (ISO)
minocycline  (EXP,ISO)
MitoTEMPO  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (ISO)
morin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nitric oxide  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
propylparaben  (ISO)
pterostilbene  (ISO)
pyrroloquinoline quinone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sorafenib  (ISO)
spermine  (ISO)
streptozocin  (ISO)
T-2 toxin  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
Vernodalol  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats. Hu XL, etal., Eur J Neurosci. 2004 Sep;20(5):1177-88.
3. Expression of apoptosome pathway-related transcripts in non-small cell lung cancer. Krepela E, etal., J Cancer Res Clin Oncol. 2006 Jan;132(1):57-68. Epub 2005 Oct 18.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Nuclear translocation of X-linked inhibitor of apoptosis (XIAP) determines cell fate after hypoxia ischemia in neonatal brain. Russell JC, etal., J Neurochem. 2008 Aug;106(3):1357-70. Epub 2008 May 13.
Additional References at PubMed
PMID:11604410   PMID:12011074   PMID:12477932   PMID:12967350   PMID:14623868   PMID:14651853   PMID:15567514   PMID:15689551   PMID:15814844   PMID:15882989   PMID:16085184   PMID:18338251  
PMID:18614015   PMID:19107361   PMID:20552279   PMID:20614026   PMID:21155217   PMID:22535253   PMID:24305822   PMID:33310074  


Genomics

Comparative Map Data
Diablo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81238,716,668 - 38,731,285 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1238,716,668 - 38,731,265 (+)EnsemblGRCr8
mRatBN7.21233,055,784 - 33,070,401 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,055,263 - 33,070,387 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1234,234,556 - 34,249,178 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01234,845,907 - 34,860,529 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05146,213,188 - 146,214,531 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01238,490,230 - 38,503,344 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1238,490,230 - 38,503,330 (+)Ensemblrn6Rnor6.0
Rnor_5.01240,372,113 - 40,385,227 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41234,196,347 - 34,209,633 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1234,742,122 - 34,755,405 (+)NCBICelera
RGSC_v3.11234,059,734 - 34,073,021 (+)NCBI
Cytogenetic Map12q16NCBI
DIABLO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812122,207,662 - 122,227,456 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12122,207,394 - 122,226,062 (-)Ensemblhg38GRCh38
GRCh3712122,692,209 - 122,712,003 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612121,258,162 - 121,276,552 (-)NCBIBuild 36Build 36hg18NCBI36
Celera12122,281,555 - 122,301,434 (-)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12119,653,145 - 119,672,846 (-)NCBIHuRef
CHM1_112122,660,505 - 122,680,373 (-)NCBICHM1_1
T2T-CHM13v2.012122,203,450 - 122,223,242 (-)NCBIT2T-CHM13v2.0
Diablo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395123,649,393 - 123,664,825 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5123,647,828 - 123,662,239 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385123,511,330 - 123,524,164 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5123,509,765 - 123,524,176 (-)Ensemblmm10GRCm38
MGSCv375123,961,339 - 123,974,173 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365123,771,948 - 123,784,782 (-)NCBIMGSCv36mm8
Celera5120,598,178 - 120,610,967 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map563.02NCBI
Diablo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554826,354,146 - 6,365,344 (+)Ensembl
ChiLan1.0NW_0049554826,354,502 - 6,364,424 (+)NCBIChiLan1.0ChiLan1.0
DIABLO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210130,298,108 - 130,317,695 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112130,294,484 - 130,314,070 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012119,808,718 - 119,829,378 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112123,176,411 - 123,196,359 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12123,176,405 - 123,196,359 (-)EnsemblpanPan2panpan1.1
DIABLO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1267,125,320 - 7,144,884 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl267,125,405 - 7,144,308 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha267,285,592 - 7,304,497 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0267,376,808 - 7,396,382 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl267,375,359 - 7,396,458 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1267,309,065 - 7,327,956 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0267,400,008 - 7,418,867 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0267,355,700 - 7,374,608 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Diablo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118157,210,485 - 157,217,683 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365582,260,359 - 2,268,941 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365582,260,459 - 2,268,941 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIABLO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1430,498,900 - 30,520,070 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11430,498,885 - 30,519,846 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21432,338,122 - 32,359,079 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DIABLO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111117,555,328 - 117,580,419 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11117,552,145 - 117,579,553 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037127,751,294 - 127,771,548 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Diablo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474722,441,541 - 22,457,075 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474722,441,533 - 22,457,056 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Diablo
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11630,322,806 - 30,335,560 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Diablo
168 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:76
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000047861
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
BF397544  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,065,764 - 33,065,968 (+)MAPPERmRatBN7.2
Rnor_6.01238,498,714 - 38,498,917NCBIRnor6.0
Rnor_5.01240,380,597 - 40,380,800UniSTSRnor5.0
RGSC_v3.41234,205,002 - 34,205,205UniSTSRGSC3.4
Celera1234,750,775 - 34,750,978UniSTS
RH 3.4 Map12580.8UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000047861   ⟹   ENSRNOP00000046476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1238,716,668 - 38,731,265 (+)Ensembl
mRatBN7.2 Ensembl1233,055,263 - 33,070,387 (+)Ensembl
Rnor_6.0 Ensembl1238,490,230 - 38,503,330 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102277   ⟹   ENSRNOP00000079537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1238,716,668 - 38,726,557 (+)Ensembl
mRatBN7.2 Ensembl1233,057,084 - 33,065,673 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115798   ⟹   ENSRNOP00000089260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,057,084 - 33,063,895 (+)Ensembl
RefSeq Acc Id: NM_001008292   ⟹   NP_001008293
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81238,716,668 - 38,731,285 (+)NCBI
mRatBN7.21233,055,784 - 33,070,401 (+)NCBI
Rnor_6.01238,490,230 - 38,503,344 (+)NCBI
Rnor_5.01240,372,113 - 40,385,227 (+)NCBI
RGSC_v3.41234,196,347 - 34,209,633 (+)RGD
Celera1234,742,122 - 34,755,405 (+)RGD
Sequence:
RefSeq Acc Id: XM_063271227   ⟹   XP_063127297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81238,717,808 - 38,730,849 (+)NCBI
RefSeq Acc Id: NP_001008293   ⟸   NM_001008292
- UniProtKB: Q5RK17 (UniProtKB/TrEMBL),   D4A7Z5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046476   ⟸   ENSRNOT00000047861
Ensembl Acc Id: ENSRNOP00000089260   ⟸   ENSRNOT00000115798
Ensembl Acc Id: ENSRNOP00000079537   ⟸   ENSRNOT00000102277
RefSeq Acc Id: XP_063127297   ⟸   XM_063271227
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RK17-F1-model_v2 AlphaFold Q5RK17 1-237 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698631
Promoter ID:EPDNEW_R9155
Type:multiple initiation site
Name:Diablo_1
Description:diablo, IAP-binding mitochondrial protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01238,490,224 - 38,490,284EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310885 AgrOrtholog
BioCyc Gene G2FUF-19315 BioCyc
Ensembl Genes ENSRNOG00000029197 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047861 ENTREZGENE
  ENSRNOT00000047861.6 UniProtKB/TrEMBL
  ENSRNOT00000102277.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.70 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7305418 IMAGE-MGC_LOAD
InterPro Smac_DIABLO UniProtKB/TrEMBL
  Smac_DIABLO-like UniProtKB/TrEMBL
KEGG Report rno:288753 UniProtKB/TrEMBL
MGC_CLONE MGC:105680 IMAGE-MGC_LOAD
NCBI Gene 288753 ENTREZGENE
PANTHER DIABLO HOMOLOG, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR32247 UniProtKB/TrEMBL
Pfam Smac_DIABLO UniProtKB/TrEMBL
PhenoGen Diablo PhenoGen
RatGTEx ENSRNOG00000029197 RatGTEx
Superfamily-SCOP Smac_Diablo UniProtKB/TrEMBL
UniProt A0A8I5ZR69_RAT UniProtKB/TrEMBL
  A6J143_RAT UniProtKB/TrEMBL
  A6J145_RAT UniProtKB/TrEMBL
  D4A7Z5 ENTREZGENE
  F7F5S4_RAT UniProtKB/TrEMBL
  Q5RK17 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Diablo  diablo, IAP-binding mitochondrial protein  Diablo  diablo homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Diablo  diablo homolog (Drosophila)  Diablo_predicted  diablo homolog (Drosophila) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Diablo_predicted  diablo homolog (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED