Asb18 (ankyrin repeat and SOCS box-containing 18) - Rat Genome Database

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Gene: Asb18 (ankyrin repeat and SOCS box-containing 18) Rattus norvegicus
Analyze
Symbol: Asb18
Name: ankyrin repeat and SOCS box-containing 18
RGD ID: 1310850
Description: Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB18 (ankyrin repeat and SOCS box containing 18); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ankyrin repeat and SOCS box protein 18; LOC316614
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8997,979,018 - 98,043,609 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl997,979,264 - 98,043,540 (-)EnsemblGRCr8
mRatBN7.2990,531,350 - 90,595,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl990,531,596 - 90,595,848 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx998,958,247 - 99,022,459 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09104,094,143 - 104,158,359 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09102,459,678 - 102,523,891 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0997,085,234 - 97,151,832 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl997,085,234 - 97,151,832 (-)Ensemblrn6Rnor6.0
Rnor_5.0996,775,960 - 96,842,558 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4989,056,520 - 89,122,413 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera988,080,107 - 88,144,297 (-)NCBICelera
RGSC_v3.1989,261,408 - 89,327,182 (-)NCBI
Cytogenetic Map9q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Asb18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8997,979,018 - 98,043,609 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl997,979,264 - 98,043,540 (-)EnsemblGRCr8
mRatBN7.2990,531,350 - 90,595,953 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl990,531,596 - 90,595,848 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx998,958,247 - 99,022,459 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09104,094,143 - 104,158,359 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09102,459,678 - 102,523,891 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0997,085,234 - 97,151,832 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl997,085,234 - 97,151,832 (-)Ensemblrn6Rnor6.0
Rnor_5.0996,775,960 - 96,842,558 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4989,056,520 - 89,122,413 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera988,080,107 - 88,144,297 (-)NCBICelera
RGSC_v3.1989,261,408 - 89,327,182 (-)NCBI
Cytogenetic Map9q36NCBI
ASB18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382236,193,459 - 236,264,406 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2236,193,459 - 236,264,409 (-)Ensemblhg38GRCh38
GRCh372237,102,102 - 237,173,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,768,254 - 236,837,727 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2230,816,647 - 230,886,004 (-)NCBICelera
Cytogenetic Map2q37.2NCBI
HuRef2228,898,088 - 228,967,278 (-)NCBIHuRef
CHM1_12237,109,320 - 237,178,797 (-)NCBICHM1_1
T2T-CHM13v2.02236,683,187 - 236,754,065 (-)NCBIT2T-CHM13v2.0
Asb18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39189,880,313 - 89,942,388 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl189,877,942 - 89,942,388 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38189,952,591 - 90,014,666 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl189,950,220 - 90,014,666 (-)Ensemblmm10GRCm38
MGSCv37191,849,253 - 91,911,152 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36191,783,849 - 91,845,748 (-)NCBIMGSCv36mm8
Celera192,893,880 - 92,956,226 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map145.06NCBI
Asb18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955453460,564 - 519,969 (+)Ensembl
ChiLan1.0NW_004955453460,284 - 521,131 (+)NCBIChiLan1.0ChiLan1.0
ASB18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213138,810,556 - 138,894,288 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B138,825,524 - 138,909,254 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B123,423,849 - 123,495,441 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B242,287,056 - 242,356,574 (-)NCBIPanPan1.1PanPan1.1panPan2
ASB18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12547,026,112 - 47,087,245 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2547,027,309 - 47,087,217 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2547,528,818 - 47,589,926 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02547,380,144 - 47,441,308 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2547,380,144 - 47,441,293 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12547,288,307 - 47,349,367 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02547,081,676 - 47,142,602 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02547,311,336 - 47,372,658 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Asb18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303189,081,367 - 189,149,118 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365251,790,901 - 1,853,508 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365251,790,901 - 1,854,724 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASB18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15136,049,740 - 136,116,017 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115136,049,744 - 136,116,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215150,484,534 - 150,550,339 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASB18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110122,211,227 - 122,284,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10122,211,597 - 122,283,388 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604077,120,800 - 77,192,716 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asb18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248471,898,167 - 1,934,040 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248471,896,955 - 1,934,129 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Asb18
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14161,952,341 - 162,014,914 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Asb18
435 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:37
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000040169
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 12 64 83 27 31 11 8 11 6 128 97 10 62 4 34 20 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000040169   ⟹   ENSRNOP00000044574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl997,979,264 - 98,043,470 (-)Ensembl
mRatBN7.2 Ensembl990,531,596 - 90,595,806 (-)Ensembl
Rnor_6.0 Ensembl997,085,234 - 97,151,832 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107326   ⟹   ENSRNOP00000091848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl997,979,264 - 98,043,540 (-)Ensembl
mRatBN7.2 Ensembl990,531,596 - 90,595,848 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113364   ⟹   ENSRNOP00000086930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl997,979,264 - 98,022,879 (-)Ensembl
mRatBN7.2 Ensembl990,531,596 - 90,575,175 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000131821   ⟹   ENSRNOP00000104186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl997,979,264 - 98,043,540 (-)Ensembl
RefSeq Acc Id: NM_001108231   ⟹   NP_001101701
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8997,979,264 - 98,043,470 (-)NCBI
mRatBN7.2990,531,596 - 90,595,806 (-)NCBI
Rnor_6.0997,085,234 - 97,151,832 (-)NCBI
Rnor_5.0996,775,960 - 96,842,558 (-)NCBI
RGSC_v3.4989,056,520 - 89,122,413 (-)RGD
Celera988,080,107 - 88,144,297 (-)RGD
Sequence:
RefSeq Acc Id: XM_039083755   ⟹   XP_038939683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8997,979,018 - 98,043,609 (-)NCBI
mRatBN7.2990,531,350 - 90,595,953 (-)NCBI
RefSeq Acc Id: XM_039083756   ⟹   XP_038939684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8997,995,670 - 98,023,454 (-)NCBI
mRatBN7.2990,547,444 - 90,575,795 (-)NCBI
RefSeq Acc Id: XM_039083757   ⟹   XP_038939685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8997,979,018 - 98,027,317 (-)NCBI
mRatBN7.2990,531,350 - 90,579,677 (-)NCBI
RefSeq Acc Id: XM_063267314   ⟹   XP_063123384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8997,995,670 - 98,027,325 (-)NCBI
RefSeq Acc Id: NP_001101701   ⟸   NM_001108231
- UniProtKB: D3ZU92 (UniProtKB/TrEMBL),   A6JQK8 (UniProtKB/TrEMBL),   A0A8I6A7E9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044574   ⟸   ENSRNOT00000040169
RefSeq Acc Id: XP_038939683   ⟸   XM_039083755
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A7E9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939685   ⟸   XM_039083757
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A7E9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939684   ⟸   XM_039083756
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000091848   ⟸   ENSRNOT00000107326
Ensembl Acc Id: ENSRNOP00000086930   ⟸   ENSRNOT00000113364
RefSeq Acc Id: XP_063123384   ⟸   XM_063267314
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000104186   ⟸   ENSRNOT00000131821
Protein Domains
SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZU92-F1-model_v2 AlphaFold D3ZU92 1-466 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310850 AgrOrtholog
BioCyc Gene G2FUF-26765 BioCyc
Ensembl Genes ENSRNOG00000019557 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040169 ENTREZGENE
  ENSRNOT00000040169.6 UniProtKB/TrEMBL
  ENSRNOT00000107326.2 UniProtKB/TrEMBL
  ENSRNOT00000113364.2 UniProtKB/TrEMBL
  ENSRNOT00000131821 ENTREZGENE
  ENSRNOT00000131821.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  SOCS box UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Multifunctional_ANK_Repeat UniProtKB/TrEMBL
  SOCS_box_dom_like UniProtKB/TrEMBL
  SOCS_C UniProtKB/TrEMBL
KEGG Report rno:316614 UniProtKB/TrEMBL
NCBI Gene 316614 ENTREZGENE
PANTHER ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  ANKYRIN REPEAT AND SOCS BOX PROTEIN 10-RELATED UniProtKB/TrEMBL
  ANKYRIN REPEAT-CONTAINING UniProtKB/TrEMBL
  PROTEIN HOS4 UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Ank_3 UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
PhenoGen Asb18 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019557 RatGTEx
SMART ANK UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  SSF158235 UniProtKB/TrEMBL
UniProt A0A8I6A7E9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AGK3_RAT UniProtKB/TrEMBL
  A0ABK0LS94_RAT UniProtKB/TrEMBL
  A6JQK8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZU92 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Asb18  ankyrin repeat and SOCS box-containing 18   Asb18_predicted  ankyrin repeat and SOCS box-containing 18 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Asb18_predicted  ankyrin repeat and SOCS box-containing 18 (predicted)      Symbol and Name status set to approved 70820 APPROVED