Lao1 (L-amino acid oxidase 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lao1 (L-amino acid oxidase 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Lao1
Name: L-amino acid oxidase 1
RGD ID: 1310787
Description: Predicted to enable L-amino-acid oxidase activity. Predicted to be involved in amino acid catabolic process. Predicted to be located in extracellular region; PARTICIPATES IN alanine, aspartate and glutamate metabolic pathway; cysteine and methionine metabolic pathway; phenylalanine metabolic pathway; INTERACTS WITH bisphenol A; fenvalerate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC298483
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85137,859,033 - 137,868,926 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5137,859,033 - 137,868,917 (+)EnsemblGRCr8
mRatBN7.25132,573,698 - 132,583,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5132,573,698 - 132,583,582 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5135,303,684 - 135,313,572 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,060,150 - 137,070,038 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,080,744 - 137,090,632 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,011,760 - 138,021,653 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,011,760 - 138,021,644 (+)Ensemblrn6Rnor6.0
Rnor_5.05141,822,023 - 141,831,916 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45139,547,731 - 139,557,624 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5131,103,988 - 131,113,748 (+)NCBICelera
RGSC_v3.15139,552,958 - 139,562,840 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)
fenvalerate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Lao1
50 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:22
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000009520
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133308734140009902Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 2 17 10 7 1 8 1 6 15 13 10 1 16 6

Sequence


Ensembl Acc Id: ENSRNOT00000009520   ⟹   ENSRNOP00000009520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5137,859,033 - 137,868,917 (+)Ensembl
mRatBN7.2 Ensembl5132,573,698 - 132,583,582 (+)Ensembl
Rnor_6.0 Ensembl5138,011,760 - 138,021,644 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102865   ⟹   ENSRNOP00000085434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5132,575,171 - 132,583,582 (+)Ensembl
RefSeq Acc Id: NM_001106682   ⟹   NP_001100152
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85137,859,033 - 137,868,926 (+)NCBI
mRatBN7.25132,573,698 - 132,583,591 (+)NCBI
Rnor_6.05138,011,760 - 138,021,653 (+)NCBI
Rnor_5.05141,822,023 - 141,831,916 (+)NCBI
RGSC_v3.45139,547,731 - 139,557,624 (+)RGD
Celera5131,103,988 - 131,113,748 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100152 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68679 (Get FASTA)   NCBI Sequence Viewer  
  EDL90146 (Get FASTA)   NCBI Sequence Viewer  
  EDL90147 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009520
  ENSRNOP00000009520.5
RefSeq Acc Id: NP_001100152   ⟸   NM_001106682
- Peptide Label: precursor
- UniProtKB: B5DEI2 (UniProtKB/TrEMBL),   A6JZK6 (UniProtKB/TrEMBL),   A0A8I5ZZ75 (UniProtKB/TrEMBL),   F7FCK8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009520   ⟸   ENSRNOT00000009520
Ensembl Acc Id: ENSRNOP00000085434   ⟸   ENSRNOT00000102865
Protein Domains
Amine oxidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DEI2-F1-model_v2 AlphaFold B5DEI2 1-519 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693971
Promoter ID:EPDNEW_R4496
Type:initiation region
Name:Lao1_1
Description:L-amino acid oxidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05138,011,773 - 138,011,833EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310787 AgrOrtholog
BioCyc Gene G2FUF-40110 BioCyc
Ensembl Genes ENSRNOG00000007232 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009520 ENTREZGENE
  ENSRNOT00000009520.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1620 UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/TrEMBL
  3.90.660.10 UniProtKB/TrEMBL
  Guanine Nucleotide Dissociation Inhibitor, domain 1 UniProtKB/TrEMBL
InterPro Amineoxid_fl UniProtKB/TrEMBL
  Amino_oxidase UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/TrEMBL
  Flavin_monoamine_oxidase UniProtKB/TrEMBL
KEGG Report rno:298483 UniProtKB/TrEMBL
NCBI Gene 298483 ENTREZGENE
PANTHER AMINE OXIDASE UniProtKB/TrEMBL
  FLAVIN MONOAMINE OXIDASE UniProtKB/TrEMBL
Pfam Amino_oxidase UniProtKB/TrEMBL
PhenoGen Lao1 PhenoGen
PRINTS AMINEOXDASEF UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007232 RatGTEx
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/TrEMBL
  SSF51905 UniProtKB/TrEMBL
UniProt A0A8I5ZZ75 ENTREZGENE
  A6JZK6 ENTREZGENE, UniProtKB/TrEMBL
  B5DEI2 ENTREZGENE
  F7FCK8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B5DEI2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Lao1  L-amino acid oxidase 1   Lao1_predicted  L-amino acid oxidase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lao1_predicted  L-amino acid oxidase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED