Gene: Tgfbrap1 (transforming growth factor, beta receptor associated protein 1) Rattus norvegicus
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Symbol:
Tgfbrap1
Name:
transforming growth factor, beta receptor associated protein 1
RGD ID:
1310772
Description:
Predicted to enable SMAD binding activity and transforming growth factor beta receptor binding activity. Predicted to be involved in several processes, including endosomal vesicle fusion; endosome to lysosome transport; and regulation of DNA-templated transcription. Predicted to be located in early endosome. Predicted to be part of CORVET complex. Predicted to be active in cytoplasm and membrane. Orthologous to human TGFBRAP1 (transforming growth factor beta receptor associated protein 1); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC301373; transforming growth factor-beta receptor-associated protein 1
RGD Orthologs
Alliance Orthologs
More Info
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More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 9 52,813,087 - 52,863,441 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 9 52,813,087 - 52,863,441 (-) Ensembl GRCr8 mRatBN7.2 9 45,320,975 - 45,371,329 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 9 45,320,930 - 45,371,311 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 9 53,815,752 - 53,865,936 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 9 58,938,553 - 58,988,735 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 9 57,218,826 - 57,269,178 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 9 49,852,560 - 49,902,943 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 9 49,852,560 - 49,902,943 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 9 49,523,134 - 49,573,517 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 9 42,251,501 - 42,301,886 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 9 43,038,902 - 43,089,223 (-) NCBI Celera RGSC_v3.1 9 42,255,317 - 42,280,535 (-) NCBI Cytogenetic Map 9 q22 NCBI
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Imported Disease Annotations - ClinVar
Only show annotations with direct experimental evidence (0 objects hidden)
Tgfbrap1 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Tgfbrap1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Tgfbrap1 Rat 1,2-dimethylhydrazine increases expression ISO Tgfbrap1 (Mus musculus) 6480464 1,2-Dimethylhydrazine results in increased expression of TGFBRAP1 mRNA CTD PMID:22206623 Tgfbrap1 Rat 17beta-estradiol affects expression ISO TGFBRAP1 (Homo sapiens) 6480464 Estradiol affects the expression of TGFBRAP1 mRNA CTD PMID:21826169 Tgfbrap1 Rat 17beta-estradiol increases expression ISO Tgfbrap1 (Mus musculus) 6480464 Estradiol results in increased expression of TGFBRAP1 mRNA CTD PMID:39298647 Tgfbrap1 Rat 17beta-estradiol increases expression ISO TGFBRAP1 (Homo sapiens) 6480464 Estradiol results in increased expression of TGFBRAP1 mRNA CTD PMID:23019147 Tgfbrap1 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Tgfbrap1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Tgfbrap1 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Tgfbrap1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Tgfbrap1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO TGFBRAP1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin affects the expression of TGFBRAP1 mRNA CTD PMID:22574217 Tgfbrap1 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of TGFBRAP1 mRNA CTD PMID:33387578 Tgfbrap1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of TGFBRAP1 mRNA CTD PMID:22298810 Tgfbrap1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Tgfbrap1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of TGFBRAP1 mRNA CTD PMID:21570461 Tgfbrap1 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Tgfbrap1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Tgfbrap1 Rat aflatoxin B1 increases expression ISO TGFBRAP1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of TGFBRAP1 mRNA CTD PMID:22100608 Tgfbrap1 Rat aflatoxin B1 increases methylation ISO TGFBRAP1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of TGFBRAP1 intron CTD PMID:30157460 Tgfbrap1 Rat aflatoxin B1 decreases methylation ISO TGFBRAP1 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of TGFBRAP1 gene CTD PMID:27153756 Tgfbrap1 Rat all-trans-retinoic acid decreases expression ISO TGFBRAP1 (Homo sapiens) 6480464 Tretinoin results in decreased expression of TGFBRAP1 mRNA CTD PMID:33167477 Tgfbrap1 Rat arsenite(3-) multiple interactions ISO TGFBRAP1 (Homo sapiens) 6480464 arsenite inhibits the reaction [G3BP1 protein binds to TGFBRAP1 mRNA] CTD PMID:32406909 Tgfbrap1 Rat atrazine decreases expression ISO TGFBRAP1 (Homo sapiens) 6480464 Atrazine results in decreased expression of TGFBRAP1 mRNA CTD PMID:22378314 Tgfbrap1 Rat atrazine affects methylation EXP 6480464 Atrazine affects the methylation of TGFBRAP1 gene CTD PMID:28931070 Tgfbrap1 Rat benzo[a]pyrene increases expression ISO Tgfbrap1 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of TGFBRAP1 mRNA CTD PMID:22228805 Tgfbrap1 Rat benzo[a]pyrene diol epoxide I decreases expression ISO TGFBRAP1 (Homo sapiens) 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TGFBRAP1 mRNA CTD PMID:20018196 Tgfbrap1 Rat benzo[e]pyrene increases methylation ISO TGFBRAP1 (Homo sapiens) 6480464 benzo(e)pyrene results in increased methylation of TGFBRAP1 intron CTD PMID:30157460 Tgfbrap1 Rat bisphenol A affects expression ISO TGFBRAP1 (Homo sapiens) 6480464 bisphenol A affects the expression of TGFBRAP1 mRNA CTD PMID:21826169 Tgfbrap1 Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of TGFBRAP1 mRNA CTD PMID:25181051 Tgfbrap1 Rat bisphenol A increases expression ISO Tgfbrap1 (Mus musculus) 6480464 bisphenol A results in increased expression of TGFBRAP1 mRNA CTD PMID:26063408 Tgfbrap1 Rat cadmium dichloride decreases expression ISO TGFBRAP1 (Homo sapiens) 6480464 Cadmium Chloride results in decreased expression of TGFBRAP1 mRNA CTD PMID:38174414 Tgfbrap1 Rat carbon nanotube increases expression ISO Tgfbrap1 (Mus musculus) 6480464 Nanotubes, Carbon results in increased expression of TGFBRAP1 mRNA CTD PMID:25554681 Tgfbrap1 Rat chlorpyrifos increases expression ISO Tgfbrap1 (Mus musculus) 6480464 Chlorpyrifos results in increased expression of TGFBRAP1 mRNA CTD PMID:37019170 Tgfbrap1 Rat choline multiple interactions ISO Tgfbrap1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... CTD PMID:20938992 Tgfbrap1 Rat dibutyl phthalate decreases expression ISO Tgfbrap1 (Mus musculus) 6480464 Dibutyl Phthalate results in decreased expression of TGFBRAP1 mRNA CTD PMID:17361019|PMID:21266533 Tgfbrap1 Rat dicrotophos increases expression ISO TGFBRAP1 (Homo sapiens) 6480464 dicrotophos results in increased expression of TGFBRAP1 mRNA CTD PMID:28302478 Tgfbrap1 Rat epoxiconazole decreases expression ISO Tgfbrap1 (Mus musculus) 6480464 epoxiconazole results in decreased expression of TGFBRAP1 mRNA CTD PMID:35436446 Tgfbrap1 Rat fenthion decreases expression ISO Tgfbrap1 (Mus musculus) 6480464 Fenthion results in decreased expression of TGFBRAP1 mRNA CTD PMID:34813904 Tgfbrap1 Rat folic acid multiple interactions ISO Tgfbrap1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... CTD PMID:20938992 Tgfbrap1 Rat folic acid decreases expression ISO Tgfbrap1 (Mus musculus) 6480464 Folic Acid results in decreased expression of TGFBRAP1 mRNA CTD PMID:25629700 Tgfbrap1 Rat hydrogen peroxide increases expression ISO TGFBRAP1 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of TGFBRAP1 mRNA CTD PMID:39709020 Tgfbrap1 Rat inulin multiple interactions ISO Tgfbrap1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of TGFBRAP1 mRNA CTD PMID:36331819 Tgfbrap1 Rat L-methionine multiple interactions ISO Tgfbrap1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... CTD PMID:20938992 Tgfbrap1 Rat methapyrilene increases methylation ISO TGFBRAP1 (Homo sapiens) 6480464 Methapyrilene results in increased methylation of TGFBRAP1 intron CTD PMID:30157460 Tgfbrap1 Rat methidathion decreases expression ISO Tgfbrap1 (Mus musculus) 6480464 methidathion results in decreased expression of TGFBRAP1 mRNA CTD PMID:34813904 Tgfbrap1 Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of TGFBRAP1 gene CTD PMID:35440735 Tgfbrap1 Rat panobinostat multiple interactions ISO TGFBRAP1 (Homo sapiens) 6480464 (+)-JQ1 compound promotes the reaction [panobinostat affects the expression of TGFBRAP1 mRNA]; panobinostat promotes the more ... CTD PMID:26733615 Tgfbrap1 Rat panobinostat affects expression ISO TGFBRAP1 (Homo sapiens) 6480464 panobinostat affects the expression of TGFBRAP1 mRNA CTD PMID:26733615 Tgfbrap1 Rat PCB138 multiple interactions ISO Tgfbrap1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Tgfbrap1 Rat pentachlorophenol increases expression ISO Tgfbrap1 (Mus musculus) 6480464 Pentachlorophenol results in increased expression of TGFBRAP1 mRNA CTD PMID:23892564 Tgfbrap1 Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Tgfbrap1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of TGFBRAP1 mRNA CTD PMID:36331819 Tgfbrap1 Rat sodium arsenite decreases expression ISO TGFBRAP1 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of TGFBRAP1 mRNA CTD PMID:38568856 Tgfbrap1 Rat thiram decreases expression ISO TGFBRAP1 (Homo sapiens) 6480464 Thiram results in decreased expression of TGFBRAP1 mRNA CTD PMID:38568856 Tgfbrap1 Rat titanium dioxide decreases methylation ISO Tgfbrap1 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of TGFBRAP1 gene CTD PMID:35295148 Tgfbrap1 Rat triphenyl phosphate affects expression ISO TGFBRAP1 (Homo sapiens) 6480464 triphenyl phosphate affects the expression of TGFBRAP1 mRNA CTD PMID:37042841 Tgfbrap1 Rat triptonide increases expression ISO Tgfbrap1 (Mus musculus) 6480464 triptonide results in increased expression of TGFBRAP1 mRNA CTD PMID:33045310 Tgfbrap1 Rat tungsten decreases expression ISO Tgfbrap1 (Mus musculus) 6480464 Tungsten results in decreased expression of TGFBRAP1 mRNA CTD PMID:30912803 Tgfbrap1 Rat tunicamycin increases expression ISO Tgfbrap1 (Mus musculus) 6480464 Tunicamycin results in increased expression of TGFBRAP1 mRNA CTD PMID:17127020 Tgfbrap1 Rat valproic acid affects expression ISO TGFBRAP1 (Homo sapiens) 6480464 Valproic Acid affects the expression of TGFBRAP1 mRNA CTD PMID:25979313 Tgfbrap1 Rat zoledronic acid increases expression ISO TGFBRAP1 (Homo sapiens) 6480464 zoledronic acid results in increased expression of TGFBRAP1 protein CTD PMID:28871336