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Gene: Tmem176a (transmembrane protein 176A) Rattus norvegicus

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Symbol:

Tmem176a

Name:

transmembrane protein 176A

RGD ID:

1310725

Description:

Predicted to act upstream of or within negative regulation of dendritic cell differentiation. Predicted to be located in membrane. Orthologous to human TMEM176A (transmembrane protein 176A); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

0610011i04rik; hepatocellular carcinoma-associated antigen 112; hypothetical LOC297077; LOC297077; MGC112703; RGD1310725

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	79,101,946 - 79,109,499 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	79,101,857 - 79,111,175 (+)	Ensembl				GRCr8
mRatBN7.2	4	77,774,940 - 77,778,620 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	77,774,843 - 77,778,620 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	82,982,347 - 82,986,027 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	78,757,819 - 78,761,499 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	77,198,109 - 77,201,789 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	78,458,735 - 78,462,415 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	78,458,625 - 78,462,423 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	143,146,378 - 143,150,058 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	76,919,918 - 76,923,598 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	72,712,007 - 72,715,688 (+)	NCBI		Celera
RGSC_v3.1	4	77,195,665 - 77,200,002 (+)	NCBI
Cytogenetic Map	4	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

long QT syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

atrazine (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

clofibrate (ISO)

cobalt dichloride (EXP)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

cyproconazole (ISO)

dibutyl phthalate (EXP,ISO)

diclofenac (ISO)

diuron (EXP)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

ferric oxide (ISO)

flutamide (EXP)

folic acid (ISO)

fonofos (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

inulin (ISO)

isoprenaline (ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

methapyrilene (EXP)

methidathion (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-methyl-4-phenylpyridinium (ISO)

nefazodone (EXP)

nickel atom (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

paclitaxel (EXP)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (EXP)

propiconazole (ISO)

pyrazinecarboxamide (EXP)

rotenone (EXP,ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

senecionine (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

terbufos (ISO)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

thalidomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (ISO)

triclosan (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of dendritic cell differentiation (IBA,ISO)

Cellular Component

membrane (IEA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:20501748

Genomics

Comparative Map Data

Tmem176a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	79,101,946 - 79,109,499 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	79,101,857 - 79,111,175 (+)	Ensembl				GRCr8
mRatBN7.2	4	77,774,940 - 77,778,620 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	77,774,843 - 77,778,620 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	82,982,347 - 82,986,027 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	78,757,819 - 78,761,499 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	77,198,109 - 77,201,789 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	78,458,735 - 78,462,415 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	78,458,625 - 78,462,423 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	4	143,146,378 - 143,150,058 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	76,919,918 - 76,923,598 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	72,712,007 - 72,715,688 (+)	NCBI		Celera
RGSC_v3.1	4	77,195,665 - 77,200,002 (+)	NCBI
Cytogenetic Map	4	q24	NCBI

TMEM176A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	150,800,769 - 150,805,118 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	150,799,598 - 150,805,122 (+)	Ensembl			hg38	GRCh38
GRCh37	7	150,497,857 - 150,502,206 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	150,128,787 - 150,133,141 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	7	145,054,882 - 145,059,236 (+)	NCBI		Celera
Cytogenetic Map	7	q36.1	NCBI
HuRef	7	144,309,934 - 144,314,288 (+)	NCBI		HuRef
CHM1_1	7	150,506,066 - 150,510,420 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	151,973,144 - 151,977,889 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	149,827,144 - 149,831,498 (+)	NCBI

Tmem176a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	48,818,417 - 48,822,298 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	48,817,853 - 48,824,005 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	48,841,483 - 48,845,364 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	48,840,919 - 48,847,071 (+)	Ensembl			mm10	GRCm38
MGSCv37	6	48,791,482 - 48,795,363 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	48,771,108 - 48,776,634 (+)	NCBI		MGSCv36	mm8
Celera	6	49,351,236 - 49,355,117 (+)	NCBI		Celera
Cytogenetic Map	6	B2.3	NCBI
cM Map	6	23.75	NCBI

Tmem176a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955491	5,209,923 - 5,213,251 (+)	Ensembl
ChiLan1.0	NW_004955491	5,209,426 - 5,213,194 (+)	NCBI	ChiLan1.0	ChiLan1.0

TMEM176A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	187,216,094 - 187,220,502 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	39,226,358 - 39,230,767 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	142,383,001 - 142,387,407 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	154,535,019 - 154,539,613 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	154,535,019 - 154,539,613 (+)	Ensembl			panPan2	panpan1.1

TMEM176A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	14,927,031 - 14,931,350 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	14,926,805 - 14,931,238 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	15,535,289 - 15,539,607 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	16,642,520 - 16,646,838 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	16,642,293 - 16,647,499 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	15,021,512 - 15,025,830 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	15,603,025 - 15,607,343 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	15,653,561 - 15,657,879 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tmem176a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	6,632,165 - 6,636,335 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	6,267,877 - 6,271,290 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936527	6,267,135 - 6,271,275 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM176A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	6,337,837 - 6,342,555 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	18	6,337,835 - 6,342,603 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	6,647,757 - 6,650,861 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMEM176A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	118,992,217 - 118,996,469 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	118,991,363 - 118,996,471 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666072	14,964,082 - 14,968,398 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem176a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624800	5,821,826 - 5,833,217 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624800	5,822,702 - 5,833,752 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tmem176a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	92,148,064 - 92,151,832 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tmem176a
86 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	46
Count of miRNA genes:	46
Interacting mature miRNAs:	46
Transcripts:	ENSRNOT00000049891
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	39431983	123203361	Rat
1549843	Bw53	Body weight QTL 53		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	59753119	104753119	Rat
61445	Strs3	Sensitivity to stroke QTL 3	3		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	4	41400577	86400577	Rat
6893678	Bw108	Body weight QTL 108	2.6	0.006	body mass (VT:0001259)	body weight (CMO:0000012)	4	44425024	89425024	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	27730518	170099664	Rat
1357342	Bw40	Body weight QTL 40		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	4	74233320	119233320	Rat
1358363	Sradr3	Stress Responsive Adrenal Weight QTL 3	6.19		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	4	58817672	103817672	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	26234499	134199155	Rat
70167	Bw22	Body weight QTL 22	3.1		body mass (VT:0001259)	body weight (CMO:0000012)	4	74233320	119233320	Rat
61336	Bp21	Blood pressure QTL 21	4.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	58080146	80212111	Rat
1549839	Bw52	Body weight QTL 52		0.0001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	71647492	116647492	Rat
6909128	Pancm4	Pancreatic morphology QTL 4	11.35		pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	4	27862204	126119996	Rat
8694439	Bw168	Body weight QTL 168	9.57	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	41400603	86400603	Rat
61476	Aia3	Adjuvant induced arthritis QTL 3	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	75939858	140508796	Rat
8655906	Rf60	Renal function QTL 60	3.8		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	4	30448961	82336920	Rat
1641919	Alc22	Alcohol consumption QTL 22		0.0005	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	65060960	127749483	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	45429897	149763204	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	51085655	113588029	Rat
2317588	Eae27	Experimental allergic encephalomyelitis QTL 27			nervous system integrity trait (VT:0010566)	percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)	4	69036742	114036742	Rat
1300139	Hrtrt6	Heart rate QTL 6	2.85		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	40490442	117737312	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	57613339	151163960	Rat
4889969	Bss96	Bone structure and strength QTL 96	4.9		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	4	57613242	102613242	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	12212457	182430611	Rat
4889972	Bss97	Bone structure and strength QTL 97	5.6		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	4	57613242	102613242	Rat
6478684	Anxrr30	Anxiety related response QTL 30		0.00087	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	64084079	109084079	Rat
5685012	Bmd87	Bone mineral density QTL 87	5.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	4	35113290	80113290	Rat
5685009	Bmd86	Bone mineral density QTL 86	3.7		tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	4	57613242	102613242	Rat
634311	Sach7	Saccharin preference QTL 7			taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	58079875	82597589	Rat
2306547	Iddm38	Insulin dependent diabetes mellitus QTL 38			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	68353567	113353567	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	60916264	184426481	Rat
2306545	Iddm39	Insulin dependent diabetes mellitus QTL 39			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	78687630	123687630	Rat
631261	Tcas3	Tongue tumor susceptibility QTL 3	6.88		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	4	11706604	92690519	Rat
6478772	Anxrr49	Anxiety related response QTL 49		0.15488	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	64084079	109084079	Rat
631646	Stl4	Serum triglyceride level QTL 4	6.5	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	4	74169813	134199155	Rat
2312569	Pur19	Proteinuria QTL 19	3.4	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	4	59836842	104836842	Rat
8655961	Kidm43	Kidney mass QTL 43	18		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	37269577	82269577	Rat
61406	Scwia1	Streptococcal cell wall induced arthritis QTL 1	2.3		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	4	75939858	140508796	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	45429897	149763204	Rat
634344	Hcar7	Hepatocarcinoma resistance QTL 7	7.8		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	4	61041057	94638356	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5889999	148002343	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	174095838	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	45429709	157555683	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	63245026	129846354	Rat
631651	Bp124	Blood pressure QTL 124	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	64209744	109209744	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	60916264	184426481	Rat
1558651	Swd3	Spike wave discharge measurement QTL 3	4.62	0.000024	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	4	41400577	86400577	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	57664252	127749483	Rat
631546	Bp86	Blood pressure QTL 86	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	58079875	92690793	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	65495851	159259805	Rat
6478743	Anxrr40	Anxiety related response QTL 40		0.83076	defecation behavior trait (VT:0010462)	defecation rate (CMO:0000998)	4	64084079	109084079	Rat
61434	Cia3	Collagen induced arthritis QTL 3	4.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	63224393	108224393	Rat
7394826	Bw126	Body weight QTL 126		0.002	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	63900458	88813920	Rat
12798520	Anxrr55	Anxiety related response QTL 55	4.45	0.01	locomotor behavior trait (VT:0001392)	number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)	4	33538597	116185060	Rat
631671	Iddm11	Insulin dependent diabetes mellitus QTL 11	3.6	0.0012	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	59603319	80216952	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	91	59	6	355	191	11	141	81	92	31	14	14

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001039008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285768	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285769	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC127409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098714	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209602	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219180	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231468	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000049891 ⟹ ENSRNOP00000048649

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	4	79,101,857 - 79,111,175 (+)	Ensembl
mRatBN7.2 Ensembl	4	77,774,843 - 77,778,620 (+)	Ensembl
Rnor_6.0 Ensembl	4	78,458,625 - 78,462,423 (+)	Ensembl

RefSeq Acc Id:

NM_001039008 ⟹ NP_001034097

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	79,105,819 - 79,109,499 (+)	NCBI
mRatBN7.2	4	77,774,940 - 77,778,620 (+)	NCBI
Rnor_6.0	4	78,458,735 - 78,462,415 (+)	NCBI
Rnor_5.0	4	143,146,378 - 143,150,058 (+)	NCBI
RGSC_v3.4	4	76,919,918 - 76,923,598 (+)	RGD
Celera	4	72,712,007 - 72,715,688 (+)	RGD

Sequence:

show sequence

AGGAACCAGACAATGTCCACAGACATGGGGACTGCAGATGTCGGCGAGGTGGACCCTGAAGCCC
CACAACCCACCAACATTGAAGTGCACATCCATCAGGAGTCTGTCCTGGCCAAACTCCTGCTGGC
TGGATGCTCGTTTCTAAGGGTCCCAGCATCTGCCTCCACCCAGAGCCAGGGCAGCAGCAGAGTG
CTGGTGGCCTCCTGGGTGGTGCAGATCGTGCTGGGGATCCTGAGTGTGGTTCTGGGCGGAATTC
TCTACATCTGCCACTATTTAGCCATGAATACCCAGGGTGCCCCATTCTGGACCGGGATCGTGGC
TATGCTGGCTGGAGCTGTCGCCTTTCTTCAAAAGAAACGGGGTGGTACCTGCTGGGCCCTGATG
AGGATCCTTCTTGTGCTGGCGAGTTTCTGCACAGCTGTGGCCGCCATTGTTATTGGGTCCAGGG
AGTTCAATAATTACTGGTACTATCTCAGAGATGATGTCTGTAAAAGCGACACTTCATATCGCTG
GTCCACCATGCCCAGCATCACCCCAGTTCCCGAAGAAGCTAATAGGATAGGACTGTGCAAATAC
TACACAAGCATGCTAAAGACCCTGCTCATAAGCCTCCAGGCAATGCTCTTGGGTGTCTGGGTGC
TGCTGCTCCTGGCTTCTCTCATCCCTGTATGTGTCTACCTCTGGAAAAGATTCTTCACAAAGGC
GGAAACAGAGAAGAAACTGCTGGGTGCAGCTGTGATCTAGCCCCAACTTTCCTCTTGCTCTGGG
AGTCCCCCTTCTGAAGCCTGAAAGAAGCGTCAGGCAGGAAGAAGACCCTACCCCACTACCAGGG
CCATCGCTGTGGCCTGGCCCCACCCAACACCACAGCAGCTCACAAGAGCACTTGCTCAGTTCTC
CTCTGCCTTCACCACCCTGCATCCCTTCTCAGGCAGCAACTTGATAATAAACTCCCGTGCTACC
GCAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063285768 ⟹ XP_063141838

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	79,101,946 - 79,109,496 (+)	NCBI

RefSeq Acc Id:

XM_063285769 ⟹ XP_063141839

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	79,102,061 - 79,109,496 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001034097	(Get FASTA)	NCBI Sequence Viewer
	XP_063141838	(Get FASTA)	NCBI Sequence Viewer
	XP_063141839	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98714	(Get FASTA)	NCBI Sequence Viewer
	EDL88227	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000048649
	ENSRNOP00000048649.2
GenBank Protein	Q4G068	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001034097 ⟸ NM_001039008

- UniProtKB:

Q4G068 (UniProtKB/Swiss-Prot), A6K0J1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSTDMGTADVGEVDPEAPQPTNIEVHIHQESVLAKLLLAGCSFLRVPASASTQSQGSSRVLVAS
WVVQIVLGILSVVLGGILYICHYLAMNTQGAPFWTGIVAMLAGAVAFLQKKRGGTCWALMRILL
VLASFCTAVAAIVIGSREFNNYWYYLRDDVCKSDTSYRWSTMPSITPVPEEANRIGLCKYYTSM
LKTLLISLQAMLLGVWVLLLLASLIPVCVYLWKRFFTKAETEKKLLGAAVI

hide sequence

Ensembl Acc Id:

ENSRNOP00000048649 ⟸ ENSRNOT00000049891

RefSeq Acc Id:	XP_063141838 ⟸ XM_063285768
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063141839 ⟸ XM_063285769
- Peptide Label:	isoform X2
- UniProtKB:	Q4G068 (UniProtKB/Swiss-Prot), A6K0J1 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4G068-F1-model_v2	AlphaFold	Q4G068	1-243	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693034

Promoter ID:

EPDNEW_R3557

Type:

initiation region

Name:

Tmem176a_1

Description:

transmembrane protein 176A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	78,458,684 - 78,458,744	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310725	AgrOrtholog
BioCyc Gene	G2FUF-44937	BioCyc
Ensembl Genes	ENSRNOG00000023708	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000049891	ENTREZGENE
	ENSRNOT00000049891.5	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7323021	IMAGE-MGC_LOAD
InterPro	CD20-like	UniProtKB/Swiss-Prot
	TMEM176A/TMEM176B	UniProtKB/Swiss-Prot
KEGG Report	rno:297077	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112703	IMAGE-MGC_LOAD
NCBI Gene	297077	ENTREZGENE
PANTHER	PTHR15756	UniProtKB/Swiss-Prot
	TRANSMEMBRANE PROTEIN 176A	UniProtKB/Swiss-Prot
Pfam	CD20	UniProtKB/Swiss-Prot
PhenoGen	Tmem176a	PhenoGen
RatGTEx	ENSRNOG00000023708	RatGTEx
UniProt	A6K0J1	ENTREZGENE, UniProtKB/TrEMBL
	Q4G068	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-27	Tmem176a	transmembrane protein 176A	RGD1310725	hypothetical LOC297077	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1310725	hypothetical LOC297077	RGD1310725_predicted	hypothetical LOC297077 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1310725_predicted	hypothetical LOC297077 (predicted)	LOC297077_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC297077_predicted	hypothetical LOC297077 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar