Xkr6 (XK related 6) - Rat Genome Database

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Pathways
Gene: Xkr6 (XK related 6) Rattus norvegicus
Analyze
Symbol: Xkr6
Name: XK related 6
RGD ID: 1310719
Description: Predicted to be involved in apoptotic process involved in development; engulfment of apoptotic cell; and phosphatidylserine exposure on apoptotic cell surface. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human XKR6 (XK related 6); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical LOC305960; LOC305960; RGD1310719; X Kell blood group precursor related family member 6 homolog; X-linked Kx blood group related 6; XK, Kell blood group complex subunit-related family, member 6; XK-related protein 6; XRG6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81542,032,411 - 42,269,300 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1542,033,028 - 42,235,591 (+)EnsemblGRCr8
mRatBN7.21537,857,096 - 38,059,699 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,857,096 - 38,059,682 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1539,714,684 - 39,917,161 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01540,865,345 - 41,067,856 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01539,317,699 - 39,520,289 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01546,784,963 - 47,173,352 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,784,963 - 47,173,335 (+)Ensemblrn6Rnor6.0
Rnor_5.01550,706,269 - 50,932,577 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41542,876,143 - 43,086,249 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1537,718,631 - 37,741,631 (+)NCBICelera
RGSC_v3.11542,891,537 - 43,101,934 (+)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Xkr6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81542,032,411 - 42,269,300 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1542,033,028 - 42,235,591 (+)EnsemblGRCr8
mRatBN7.21537,857,096 - 38,059,699 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,857,096 - 38,059,682 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1539,714,684 - 39,917,161 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01540,865,345 - 41,067,856 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01539,317,699 - 39,520,289 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01546,784,963 - 47,173,352 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,784,963 - 47,173,335 (+)Ensemblrn6Rnor6.0
Rnor_5.01550,706,269 - 50,932,577 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41542,876,143 - 43,086,249 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1537,718,631 - 37,741,631 (+)NCBICelera
RGSC_v3.11542,891,537 - 43,101,934 (+)NCBI
Cytogenetic Map15p12NCBI
XKR6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38810,896,045 - 11,201,833 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl810,896,045 - 11,201,833 (-)Ensemblhg38GRCh38
GRCh37810,753,555 - 11,059,342 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36810,791,064 - 11,096,285 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34810,791,065 - 10,897,401NCBI
Celera89,881,570 - 10,186,826 (-)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef89,683,585 - 9,989,001 (-)NCBIHuRef
CHM1_1810,818,743 - 11,124,140 (-)NCBICHM1_1
T2T-CHM13v2.088,537,206 - 8,882,964 (+)NCBIT2T-CHM13v2.0
Xkr6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391463,841,608 - 64,084,451 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1463,843,952 - 64,058,258 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381463,606,530 - 63,845,706 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1463,606,503 - 63,820,809 (+)Ensemblmm10GRCm38
MGSCv371464,225,367 - 64,439,248 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361462,749,129 - 62,774,129 (+)NCBIMGSCv36mm8
Celera1461,383,611 - 61,597,620 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.34NCBI
Xkr6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540352,410,317 - 52,636,228 (-)Ensembl
ChiLan1.0NW_00495540352,410,318 - 52,636,952 (-)NCBIChiLan1.0ChiLan1.0
XKR6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2727,313,666 - 27,673,253 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan183,345,922 - 3,699,595 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v088,000,361 - 8,310,459 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC486082
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12526,984,638 - 27,022,933 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2527,647,344 - 27,680,612 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02527,145,367 - 27,178,638 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.12527,099,804 - 27,133,067 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02526,993,854 - 27,027,675 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02527,147,903 - 27,181,181 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Xkr6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049435,816,640 - 5,835,750 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366752,751,400 - 2,983,960 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366752,750,401 - 2,768,457 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XKR6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1414,086,418 - 14,381,402 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11414,087,419 - 14,381,402 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21415,526,785 - 15,555,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
XKR6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.187,908,454 - 8,203,995 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605234,208,730 - 34,522,122 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Xkr6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475824,714,482 - 24,931,452 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475824,713,288 - 24,931,452 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Xkr6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11260,582,294 - 60,785,575 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Xkr6
709 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:71
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000015540
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
BF416622  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01547,150,450 - 47,150,616NCBIRnor6.0
Celera1537,725,856 - 37,726,019UniSTS
RH 3.4 Map15282.5UniSTS
Cytogenetic Map15p12UniSTS
AW493804  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01550,674,288 - 50,674,409NCBIRnor5.0
Rnor_5.06118,032,861 - 118,032,980NCBIRnor5.0
Rnor_5.01550,837,030 - 50,837,151NCBIRnor5.0
RGSC_v3.41543,009,198 - 43,009,318UniSTSRGSC3.4
RGSC_v3.46108,069,064 - 108,069,182UniSTSRGSC3.4
Celera1537,665,718 - 37,665,838UniSTS
Celera6101,492,263 - 101,492,381UniSTS
Cytogenetic Map15p12UniSTS
BE114422  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,880,336 - 37,880,492 (+)MAPPERmRatBN7.2
Rnor_6.01546,968,822 - 46,968,977NCBIRnor6.0
Rnor_6.01546,808,229 - 46,808,384NCBIRnor6.0
Rnor_5.01550,729,200 - 50,729,355UniSTSRnor5.0
Rnor_5.01550,569,755 - 50,569,910UniSTSRnor5.0
RGSC_v3.41542,899,274 - 42,899,429UniSTSRGSC3.4
Celera1537,563,297 - 37,563,452UniSTS
RH 3.4 Map15278.0UniSTS
Cytogenetic Map15p12UniSTS
RH137775  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,863,320 - 37,863,464 (+)MAPPERmRatBN7.2
Rnor_6.01546,951,809 - 46,951,952NCBIRnor6.0
Rnor_6.01546,791,216 - 46,791,359NCBIRnor6.0
Rnor_5.01550,712,187 - 50,712,330UniSTSRnor5.0
Rnor_5.01550,552,742 - 50,552,885UniSTSRnor5.0
RGSC_v3.41542,882,061 - 42,882,204UniSTSRGSC3.4
Celera1537,546,200 - 37,546,343UniSTS
RH 3.4 Map15282.3UniSTS
Cytogenetic Map15p12UniSTS
AA891921  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,901,646 - 37,901,760 (+)MAPPERmRatBN7.2
Rnor_6.01546,989,324 - 46,989,437NCBIRnor6.0
Rnor_6.01546,830,595 - 46,830,708NCBIRnor6.0
Rnor_5.01550,749,702 - 50,749,815UniSTSRnor5.0
Rnor_5.01550,592,121 - 50,592,234UniSTSRnor5.0
RGSC_v3.41542,921,782 - 42,921,895UniSTSRGSC3.4
Celera1537,584,548 - 37,584,661UniSTS
RH 3.4 Map15279.3UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 13 68 173 91 90 59 40 59 6 321 136 5 166 102 113 31 31 31

Sequence


Ensembl Acc Id: ENSRNOT00000015540   ⟹   ENSRNOP00000015540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,033,028 - 42,235,591 (+)Ensembl
mRatBN7.2 Ensembl1537,857,096 - 38,059,682 (+)Ensembl
Rnor_6.0 Ensembl1546,784,963 - 47,173,335 (+)Ensembl
RefSeq Acc Id: NM_001012042   ⟹   NP_001012042
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,033,028 - 42,235,608 (+)NCBI
mRatBN7.21537,857,096 - 38,059,699 (+)NCBI
Rnor_6.01546,784,963 - 47,173,352 (+)NCBI
Rnor_5.01550,706,269 - 50,932,577 (+)NCBI
RGSC_v3.41542,876,143 - 43,086,249 (+)RGD
Celera1537,718,631 - 37,741,631 (+)RGD
Sequence:
RefSeq Acc Id: XR_010057819
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,032,411 - 42,269,300 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001012042 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT07109 (Get FASTA)   NCBI Sequence Viewer  
  EDL85325 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015540
  ENSRNOP00000015540.7
GenBank Protein Q5GH57 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012042   ⟸   NM_001012042
- UniProtKB: Q5GH57 (UniProtKB/Swiss-Prot),   F1LPR0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015540   ⟸   ENSRNOT00000015540

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5GH57-F1-model_v2 AlphaFold Q5GH57 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310719 AgrOrtholog
BioCyc Gene G2FUF-13418 BioCyc
Ensembl Genes ENSRNOG00000011634 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015540 ENTREZGENE
  ENSRNOT00000015540.8 UniProtKB/Swiss-Prot
InterPro XK-rel UniProtKB/Swiss-Prot
  XK-related_scramblase UniProtKB/Swiss-Prot
KEGG Report rno:305960 UniProtKB/Swiss-Prot
NCBI Gene 305960 ENTREZGENE
PANTHER XK-RELATED PROTEIN UniProtKB/Swiss-Prot
  XK-RELATED PROTEIN 6 UniProtKB/Swiss-Prot
Pfam XK-related UniProtKB/Swiss-Prot
PhenoGen Xkr6 PhenoGen
RatGTEx ENSRNOG00000011634 RatGTEx
UniProt F1LPR0 ENTREZGENE, UniProtKB/TrEMBL
  Q5GH57 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Xkr6  XK related 6  Xkr6  X-linked Kx blood group related 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-09 Xkr6  X-linked Kx blood group related 6  Xkr6  XK, Kell blood group complex subunit-related family, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Xkr6  XK, Kell blood group complex subunit-related family, member 6  Xkr6  X Kell blood group precursor related family member 6 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Xkr6  X Kell blood group precursor related family member 6 homolog  RGD1310719  hypothetical LOC305960  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1310719  hypothetical LOC305960  RGD1310719_predicted  hypothetical LOC305960 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310719_predicted  hypothetical LOC305960 (predicted)  LOC305960_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC305960_predicted  hypothetical LOC305960 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL