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Gene: Pwp1 (PWP1 homolog, endonuclein) Rattus norvegicus

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Symbol:

Pwp1

Name:

PWP1 homolog, endonuclein

RGD ID:

1310705

Description:

Predicted to enable histone H4K20me3 reader activity. Predicted to be involved in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to act upstream of or within negative regulation of DNA-templated transcription and positive regulation of stem cell differentiation. Predicted to be located in nucleolus. Predicted to be active in nucleus. Orthologous to human PWP1 (PWP1 homolog, endonuclein); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 4-amino-2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

INFERRED

Previously known as:

LOC362856; periodic tryptophan protein 1 homolog; periodic tryptophan protein 1 homolog (S. cerevisiae); PWP1 homolog; PWP1 homolog (S. cerevisiae); RGD1310705; similar to periodic tryptophan protein 1 homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PWP1 (PWP1 homolog, endonuclein)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Pwp1 (PWP1 homolog, endonuclein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pwp1 (PWP1 homolog, endonuclein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PWP1 (PWP1 homolog, endonuclein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PWP1 (PWP1 homolog, endonuclein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pwp1 (PWP1 homolog, endonuclein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PWP1 (PWP1 homolog, endonuclein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PWP1 (PWP1 homolog, endonuclein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pwp1 (PWP1 homolog, endonuclein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pwp1 (PWP1 homolog, endonuclein)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RCCD1 (RCC1 domain containing 1)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Pwp1 (PWP1 homolog, endonuclein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PWP1 (PWP1 homolog, endonuclein)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pwp1 (PWP1 homolog, endonuclein)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	JC8.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PWP1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	nclb	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pwp1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	19,870,465 - 19,886,463 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	19,866,927 - 19,886,463 (-)	Ensembl				GRCr8
mRatBN7.2	7	17,982,730 - 17,998,728 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	17,982,235 - 17,998,731 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	19,944,886 - 19,960,878 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	22,107,256 - 22,123,255 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	21,884,528 - 21,900,521 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	23,988,776 - 24,004,774 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	23,988,776 - 24,004,774 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	24,138,856 - 24,154,854 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	20,120,919 - 20,136,917 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	15,214,789 - 15,230,786 (-)	NCBI		Celera
RGSC_v3.1	7	20,134,743 - 20,150,979 (-)	NCBI
Cytogenetic Map	7	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

captan (ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

cyclosporin A (ISO)

DDE (ISO)

dicrotophos (ISO)

diethylstilbestrol (ISO)

dioxygen (ISO)

elemental selenium (ISO)

flutamide (EXP)

folic acid (ISO)

folpet (ISO)

FR900359 (ISO)

geraniol (ISO)

hydrogen peroxide (ISO)

ivermectin (ISO)

methoxychlor (EXP)

nitrates (ISO)

ochratoxin A (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

pentachlorophenol (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

quercetin (ISO)

resveratrol (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

titanium dioxide (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin organization (IEA)

negative regulation of DNA-templated transcription (ISO)

positive regulation of stem cell differentiation (ISO)

positive regulation of transcription of nucleolar large rRNA by RNA polymerase I (IBA,ISO)

regulation of DNA-templated transcription (IEA)

ribosome biogenesis (IEA)

rRNA processing (IEA)

Cellular Component

chromosome (IEA)

nucleolus (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

histone H4K20me3 reader activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:25335925	PMID:29065309

Genomics

Comparative Map Data

Pwp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	19,870,465 - 19,886,463 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	19,866,927 - 19,886,463 (-)	Ensembl				GRCr8
mRatBN7.2	7	17,982,730 - 17,998,728 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	17,982,235 - 17,998,731 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	19,944,886 - 19,960,878 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	22,107,256 - 22,123,255 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	21,884,528 - 21,900,521 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	23,988,776 - 24,004,774 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	23,988,776 - 24,004,774 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	24,138,856 - 24,154,854 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	20,120,919 - 20,136,917 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	15,214,789 - 15,230,786 (-)	NCBI		Celera
RGSC_v3.1	7	20,134,743 - 20,150,979 (-)	NCBI
Cytogenetic Map	7	q13	NCBI

PWP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	107,685,799 - 107,713,162 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	107,685,766 - 107,713,462 (+)	Ensembl			hg38	GRCh38
GRCh37	12	108,079,576 - 108,106,939 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	106,603,720 - 106,630,387 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	12	107,745,148 - 107,771,815 (+)	NCBI		Celera
Cytogenetic Map	12	q23.3	NCBI
HuRef	12	105,139,992 - 105,166,399 (+)	NCBI		HuRef
CHM1_1	12	108,045,562 - 108,072,208 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	107,649,292 - 107,676,654 (+)	NCBI		T2T-CHM13v2.0

Pwp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	85,707,695 - 85,724,967 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	85,665,358 - 85,724,960 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	85,871,831 - 85,889,103 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	85,829,494 - 85,889,096 (+)	Ensembl			mm10	GRCm38
MGSCv37	10	85,334,576 - 85,351,848 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	85,301,664 - 85,318,895 (+)	NCBI		MGSCv36	mm8
Celera	10	87,846,400 - 87,863,672 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	41.73	NCBI

Pwp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	41,314,978 - 41,329,979 (+)	Ensembl
ChiLan1.0	NW_004955405	41,314,978 - 41,329,988 (+)	NCBI	ChiLan1.0	ChiLan1.0

PWP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	115,744,264 - 115,771,046 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	115,740,682 - 115,767,443 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	105,255,755 - 105,282,519 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	108,652,024 - 108,679,503 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	108,652,024 - 108,679,503 (+)	Ensembl			panPan2	panpan1.1

PWP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	31,121,411 - 31,146,791 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	31,117,044 - 31,146,726 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	31,106,725 - 31,131,840 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	31,966,427 - 31,991,573 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	31,963,399 - 31,991,569 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	31,705,879 - 31,730,950 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	31,995,000 - 32,020,274 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	32,181,687 - 32,206,812 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pwp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	14,425,723 - 14,447,295 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	7,431,990 - 7,457,709 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	7,436,137 - 7,457,709 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PWP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	12,701,589 - 12,730,849 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	12,703,067 - 12,730,884 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	12,488,889 - 12,517,518 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PWP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	102,917,553 - 102,943,696 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	102,917,606 - 102,942,481 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	142,129,905 - 142,155,174 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pwp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624750	2,103,469 - 2,119,166 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624750	2,103,530 - 2,119,088 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pwp1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	162,720,223 - 162,735,909 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pwp1
127 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	145
Count of miRNA genes:	117
Interacting mature miRNAs:	122
Transcripts:	ENSRNOT00000007549
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1669658	46669658	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	1	23748937	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	7216097	52216097	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	10517086	62346019	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	10112916	99900612	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	1	31777942	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	1	104117804	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1709527	46709527	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	32612984	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	10112916	60150541	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	9460877	54460877	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	29716167	Rat
1300138	Hrtrt9	Heart rate QTL 9	4.72		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	10498820	55498820	Rat
738033	Anxrr6	Anxiety related response QTL 6	4.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	7	17460447	62460447	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34650782	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	32612984	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191877	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC112739	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC136584	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000007549 ⟹ ENSRNOP00000007549

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	19,866,927 - 19,886,463 (-)	Ensembl
mRatBN7.2 Ensembl	7	17,982,235 - 17,998,731 (-)	Ensembl
Rnor_6.0 Ensembl	7	23,988,776 - 24,004,774 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110565 ⟹ ENSRNOP00000091552

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	19,870,465 - 19,886,463 (-)	Ensembl
mRatBN7.2 Ensembl	7	17,982,235 - 17,998,731 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000144172 ⟹ ENSRNOP00000103719

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	19,866,927 - 19,886,463 (-)	Ensembl

RefSeq Acc Id:

NM_001191877 ⟹ NP_001178806

RefSeq Status:

INFERRED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	19,870,465 - 19,886,463 (-)	NCBI
mRatBN7.2	7	17,982,730 - 17,998,728 (-)	NCBI
Rnor_6.0	7	23,988,776 - 24,004,774 (-)	NCBI
Rnor_5.0	7	24,138,856 - 24,154,854 (-)	NCBI
Celera	7	15,214,789 - 15,230,786 (-)	NCBI

Sequence:

show sequence

GCTCATAGTCTCTCCCAGCGACCAGGTGTCTTGTTCGCGCTGGGTTCAAGCGGAACATCATGAA
CCGCAGCCGCCAAGTGACCTGCGTGGCCTGGGTCCGCCGCGGCGTGGCCAAAGAGACGCCAGAC
AAGGTAGAGCTAAGTAAAGAGGAAGTGAAACGTCTCATTGCTGAAGCAAAAGAAAAGTTACAAG
AGGAGGGTGGGAGTGAGGAAGAGGAGGTAGGCAGTCCTTCAGAAGATGGCATGCAGAGAGCCCG
GGTCCAGGCCCGGCCTACGGAGCCGCTGGAGGATGGGGATCCACAAGACGACCGTACACTGGAC
GACGATGAGCTGGCGGAGTACGACTTAGATAACTATGACCAAGAGGACAACCCAGATGCTGAGA
CCATTGGAGAATCTCTGTTGGGGCTTACGGTCTATGGCAGTAACGATCAGGATCCATACGTCAC
CCTCAAAGACACGGAACAGTACGAGCACGAAGACTTCTTGATTAAGCCGACCGACAACCTCATC
GTCTGTGGCCGTGCAGAACAAGAGCAGTGTAACTTAGAGGTGCACGTGTACAATCAAGAAGAGG
AGTCTTTCTATGTCCACCATGACATACTCCTGTCTGCATATCCTCTAAGTGTGGAATGGCTGAA
TTTTGATCCTAGCCCAGATGCGGCTACTGGAAATTACATTGCTGTGGGAAACATGACCCCTGTC
ATTGAGGTGTGGGACCTGGATATCGTGGACTCTCTAGAACCAGTCTTCACACTGGGAAGCAAGC
TTTCAAAAAAGAAGAAGAAGAAAGGGAAAAAGAGTTCGTCAGCAGAAGGACATACTGATGCTGT
CCTTGACCTTTCCTGGAATAAGACAGTCAGAAACGTGCTGGCGAGTGCATCAGCAGACAGCACT
GTAATCCTGTGGGATCTGTCTGTGGGGAAGCCAGCGGCCAGGCTTACTGCACATACAGACAAGG
TTCAGACTCTGCAGTTTCATCCATTTGAAGCACAGACTCTGATTTCTGGGTCCTATGACAAATC
CGTGGCTCTGTACGACTGCAGAGACCCCAGCCAGAACCACCGTCTGTGGAGGTTTAGTGGGCAG
ATCGAGAGAGTGACCTGGAACCACTTCTCACCGTGCCATTTCTTGGCCAGTACAGATGATGGCT
TTGTATATAATCTGGATGCGCGCTCAGATAAGCCGATTTTTACACTTAATGCACACAACGATGA
AATCTCTGGTCTTGATCTGAGCAGTCAGATCAAAGGCTGCCTTGTGACCGCTTCAGCAGACAAA
TTTGTGAAGATCTGGGACATCTTAGGAGAGAGGCCAAGTCTCATTCATTCTAGAGACATGAAGA
TGGGAGTTCTCTTTTGTTCTTCATGCTGCCCTGATTTGCCGTTTGTTTACGCCTTTGGAGGACA
GAAAGAAGGGCTTCGGGTTTGGGACATAAGCACTGTGTCTTCAGTAAACGAAGCGTTTGGAAGA
CGGGAGAGACTGGCCATTGGCAGCACAAAAGGTTTATCTGTTAGTGACCCCTGTAGGAGCGGGA
GCCCACAGACACCAATGGAGTCCTGACAAAGATCAGTTCCTGGTGTGCTTACCTTAGCTCGGAG
TTTTAAAAACTGGCCTAAAACTGTTCACATGTATCTGCAGCCACAGATGAACAAAACTCCGTTC
CTGTTGCCATTCCTCTCTGCAGCTTTGGTGGCAGTCCACAGCCTTTGGGCTGCCTTCAACTGGA
TACTGTACAGTGTTCTTGCATTTCTTGGAAATAAAAGTTTTTTTTTTTTTTAAATGATTCCTTA
AACAGGCCATCTGAGTAGGAACTGTAGGTTTATAAAATACATGGTAACTGAAGTTTCTGAGATG
GGACTTGCTCTGTTAGCCAGGCTGATGTGGCTGGTGCTTGTCCCAGCGCTAGGGAGGAGAGAGA
TGTGTAGATTTCCTAAGACATGTGGCCAGCCAGCCAGCCTGCTCAGGGACCCACCTGCCTCCAT
CGTCCCAGGCGCTGATTACCCATATGCATGGTAGGTTCTAGAATTGAATTCAGGCCCTCAGTCT
TGCAAGTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001178806	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000007549.5
	ENSRNOP00000091552
	ENSRNOP00000091552.1
	ENSRNOP00000103719.1

RefSeq Acc Id:

NP_001178806 ⟸ NM_001191877

- UniProtKB:

D4A1H8 (UniProtKB/TrEMBL), A0A8I6ACA5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNRSRQVTCVAWVRRGVAKETPDKVELSKEEVKRLIAEAKEKLQEEGGSEEEEVGSPSEDGMQR
ARVQARPTEPLEDGDPQDDRTLDDDELAEYDLDNYDQEDNPDAETIGESLLGLTVYGSNDQDPY
VTLKDTEQYEHEDFLIKPTDNLIVCGRAEQEQCNLEVHVYNQEEESFYVHHDILLSAYPLSVEW
LNFDPSPDAATGNYIAVGNMTPVIEVWDLDIVDSLEPVFTLGSKLSKKKKKKGKKSSSAEGHTD
AVLDLSWNKTVRNVLASASADSTVILWDLSVGKPAARLTAHTDKVQTLQFHPFEAQTLISGSYD
KSVALYDCRDPSQNHRLWRFSGQIERVTWNHFSPCHFLASTDDGFVYNLDARSDKPIFTLNAHN
DEISGLDLSSQIKGCLVTASADKFVKIWDILGERPSLIHSRDMKMGVLFCSSCCPDLPFVYAFG
GQKEGLRVWDISTVSSVNEAFGRRERLAIGSTKGLSVSDPCRSGSPQTPMES

hide sequence

Ensembl Acc Id:

ENSRNOP00000007549 ⟸ ENSRNOT00000007549

Ensembl Acc Id:

ENSRNOP00000091552 ⟸ ENSRNOT00000110565

Ensembl Acc Id:

ENSRNOP00000103719 ⟸ ENSRNOT00000144172

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A1H8-F1-model_v2	AlphaFold	D4A1H8	1-500	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695095

Promoter ID:

EPDNEW_R5620

Type:

multiple initiation site

Name:

Pwp1_1

Description:

PWP1 homolog, endonuclein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	24,004,789 - 24,004,849	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310705	AgrOrtholog
BioCyc Gene	G2FUF-34634	BioCyc
Ensembl Genes	ENSRNOG00000005350	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007549.8	UniProtKB/TrEMBL
	ENSRNOT00000110565	ENTREZGENE
	ENSRNOT00000110565.2	UniProtKB/TrEMBL
	ENSRNOT00000144172.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	G-protein_beta_WD-40_rep	UniProtKB/TrEMBL
	PWP1	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:362856	UniProtKB/TrEMBL
NCBI Gene	362856	ENTREZGENE
PANTHER	PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG	UniProtKB/TrEMBL
	PTHR14091	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PhenoGen	Pwp1	PhenoGen
PRINTS	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000005350	RatGTEx
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	WD40_like	UniProtKB/TrEMBL
UniProt	A0A8I6ACA5	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LFY1_RAT	UniProtKB/TrEMBL
	D4A1H8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-17	Pwp1	PWP1 homolog, endonuclein	Pwp1	PWP1 homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Pwp1	PWP1 homolog (S. cerevisiae)	Pwp1_predicted	PWP1 homolog (S. cerevisiae) (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Pwp1_predicted	PWP1 homolog (S. cerevisiae) (predicted)	RGD1310705_predicted	similar to periodic tryptophan protein 1 homolog; periodic tryptophan protein 1 homolog (S. cerevisiae) (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1310705_predicted	similar to periodic tryptophan protein 1 homolog; periodic tryptophan protein 1 homolog (S. cerevisiae) (predicted)	LOC362856_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC362856_predicted	similar to periodic tryptophan protein 1 homolog; periodic tryptophan protein 1 homolog (S. cerevisiae) (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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