Afap1l2 (actin filament associated protein 1-like 2) - Rat Genome Database

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Gene: Afap1l2 (actin filament associated protein 1-like 2) Rattus norvegicus
Analyze
Symbol: Afap1l2
Name: actin filament associated protein 1-like 2
RGD ID: 1310668
Description: Predicted to enable SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Predicted to be involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; regulation of gene expression; and regulation of mitotic cell cycle. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human AFAP1L2 (actin filament associated protein 1 like 2); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: actin filament-associated protein 1-like 2; LOC292130; phosphatidylinositol 3-kinase-associated protein; RGD1310668; similar to expressed sequence AU041783
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81265,969,368 - 266,065,951 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1265,969,368 - 266,065,943 (-)EnsemblGRCr8
mRatBN7.21255,964,238 - 256,060,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1255,964,238 - 256,060,820 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1264,173,321 - 264,271,064 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01270,879,366 - 270,977,112 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01263,525,174 - 263,622,184 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01277,730,760 - 277,827,299 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1277,730,760 - 277,827,269 (-)Ensemblrn6Rnor6.0
Rnor_5.01285,110,704 - 285,206,347 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41263,220,056 - 263,256,132 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1251,661,305 - 251,756,440 (-)NCBICelera
RGSC_v3.11263,431,340 - 263,470,406 (-)NCBI
Cytogenetic Map1q55NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boron nitride  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
cytarabine  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
p-tert-Amylphenol  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17412687   PMID:21084565   PMID:22496359   PMID:29330129  


Genomics

Comparative Map Data
Afap1l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81265,969,368 - 266,065,951 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1265,969,368 - 266,065,943 (-)EnsemblGRCr8
mRatBN7.21255,964,238 - 256,060,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1255,964,238 - 256,060,820 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1264,173,321 - 264,271,064 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01270,879,366 - 270,977,112 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01263,525,174 - 263,622,184 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01277,730,760 - 277,827,299 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1277,730,760 - 277,827,269 (-)Ensemblrn6Rnor6.0
Rnor_5.01285,110,704 - 285,206,347 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41263,220,056 - 263,256,132 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1251,661,305 - 251,756,440 (-)NCBICelera
RGSC_v3.11263,431,340 - 263,470,406 (-)NCBI
Cytogenetic Map1q55NCBI
AFAP1L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810114,280,725 - 114,405,175 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10114,293,604 - 114,404,775 (-)Ensemblhg38GRCh38
GRCh3710116,054,583 - 116,164,261 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610116,044,573 - 116,154,505 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410116,044,573 - 116,154,505NCBI
Celera10109,783,766 - 109,893,772 (-)NCBICelera
Cytogenetic Map10q25.3NCBI
HuRef10109,682,148 - 109,791,263 (-)NCBIHuRef
CHM1_110116,338,430 - 116,448,310 (-)NCBICHM1_1
T2T-CHM13v2.010115,174,841 - 115,299,200 (-)NCBIT2T-CHM13v2.0
Afap1l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391956,900,786 - 57,017,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1956,900,793 - 56,996,660 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381956,912,354 - 57,028,589 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1956,912,361 - 57,008,228 (-)Ensemblmm10GRCm38
MGSCv371956,986,844 - 57,083,065 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361956,965,609 - 57,061,427 (-)NCBIMGSCv36mm8
Celera1959,103,348 - 59,201,420 (-)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1952.04NCBI
Afap1l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543119,276,412 - 19,315,446 (-)Ensembl
ChiLan1.0NW_00495543119,275,257 - 19,378,507 (-)NCBIChiLan1.0ChiLan1.0
AFAP1L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28126,179,723 - 126,289,322 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110126,185,060 - 126,294,630 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010110,894,774 - 111,004,373 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110114,324,736 - 114,434,148 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10114,324,736 - 114,434,148 (-)EnsemblpanPan2panpan1.1
AFAP1L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12825,137,235 - 25,228,454 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2825,133,296 - 25,194,431 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2825,288,383 - 25,385,034 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02825,670,683 - 25,767,385 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2825,660,531 - 25,767,342 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12825,226,033 - 25,322,680 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02825,241,116 - 25,337,719 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02825,434,826 - 25,491,955 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Afap1l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721320,863,716 - 20,954,780 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364864,606,521 - 4,697,690 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364864,606,529 - 4,697,481 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AFAP1L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14124,630,799 - 124,672,813 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114124,630,797 - 124,737,350 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214135,751,428 - 135,862,187 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AFAP1L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19107,164,687 - 107,274,433 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9107,162,963 - 107,273,307 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604868,397,100 - 68,508,000 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Afap1l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473732,195,126 - 32,326,607 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473732,189,377 - 32,297,110 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Afap1l2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1259,158,672 - 59,248,656 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:57
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000023113, ENSRNOT00000073346
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1263946994269633915Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat

Markers in Region
RH143842  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21256,060,567 - 256,060,708 (+)MAPPERmRatBN7.2
Rnor_6.01277,827,017 - 277,827,157NCBIRnor6.0
Rnor_5.01285,206,100 - 285,206,240UniSTSRnor5.0
Celera1251,756,188 - 251,756,328UniSTS
RH 3.4 Map11680.3UniSTS
Cytogenetic Map1q55UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 159 91 90 59 34 59 6 298 134 11 138 81 92 31 14 14

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001305184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB568258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023113   ⟹   ENSRNOP00000023113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,969,368 - 266,006,881 (-)Ensembl
mRatBN7.2 Ensembl1255,964,238 - 256,001,759 (-)Ensembl
Rnor_6.0 Ensembl1277,731,799 - 277,768,368 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000073346   ⟹   ENSRNOP00000064164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,969,368 - 266,065,943 (-)Ensembl
mRatBN7.2 Ensembl1255,964,238 - 256,060,820 (-)Ensembl
Rnor_6.0 Ensembl1277,730,760 - 277,827,269 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084915   ⟹   ENSRNOP00000073158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1277,821,122 - 277,827,178 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105824   ⟹   ENSRNOP00000081810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,969,368 - 266,010,110 (-)Ensembl
mRatBN7.2 Ensembl1255,964,238 - 256,060,466 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109408   ⟹   ENSRNOP00000081451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,969,368 - 266,006,467 (-)Ensembl
mRatBN7.2 Ensembl1255,964,238 - 256,001,345 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110011   ⟹   ENSRNOP00000097019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1265,969,368 - 266,065,734 (-)Ensembl
mRatBN7.2 Ensembl1255,964,238 - 256,060,820 (-)Ensembl
RefSeq Acc Id: NM_001305184   ⟹   NP_001292113
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81265,969,368 - 266,065,943 (-)NCBI
mRatBN7.21255,964,238 - 256,060,820 (-)NCBI
Rnor_6.01277,730,760 - 277,827,269 (-)NCBI
Celera1251,661,305 - 251,756,440 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760580   ⟹   XP_008758802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81265,969,368 - 266,065,951 (-)NCBI
mRatBN7.21255,964,238 - 256,060,827 (-)NCBI
Rnor_6.01277,730,760 - 277,827,299 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588861   ⟹   XP_017444350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81265,969,368 - 266,065,950 (-)NCBI
mRatBN7.21255,964,238 - 256,060,825 (-)NCBI
Rnor_6.01277,730,760 - 277,827,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063282799   ⟹   XP_063138869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81265,969,368 - 266,065,951 (-)NCBI
RefSeq Acc Id: XM_063282800   ⟹   XP_063138870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81265,969,368 - 266,065,950 (-)NCBI
RefSeq Acc Id: XM_063282801   ⟹   XP_063138871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81265,969,368 - 266,065,949 (-)NCBI
RefSeq Acc Id: XM_063282802   ⟹   XP_063138872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81265,969,368 - 266,065,950 (-)NCBI
RefSeq Acc Id: XM_063282803   ⟹   XP_063138873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81265,969,368 - 266,065,950 (-)NCBI
RefSeq Acc Id: XM_063282804   ⟹   XP_063138874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81265,969,368 - 266,065,950 (-)NCBI
RefSeq Acc Id: XM_063282805   ⟹   XP_063138875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81265,969,368 - 266,065,948 (-)NCBI
RefSeq Acc Id: XP_008758802   ⟸   XM_008760580
- Peptide Label: isoform X1
- UniProtKB: F1M5W8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001292113   ⟸   NM_001305184
- UniProtKB: M0R484 (UniProtKB/TrEMBL),   F1M5W8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444350   ⟸   XM_017588861
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ARV2 (UniProtKB/TrEMBL),   F1M5W8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073158   ⟸   ENSRNOT00000084915
Ensembl Acc Id: ENSRNOP00000064164   ⟸   ENSRNOT00000073346
Ensembl Acc Id: ENSRNOP00000023113   ⟸   ENSRNOT00000023113
Ensembl Acc Id: ENSRNOP00000081810   ⟸   ENSRNOT00000105824
Ensembl Acc Id: ENSRNOP00000097019   ⟸   ENSRNOT00000110011
Ensembl Acc Id: ENSRNOP00000081451   ⟸   ENSRNOT00000109408
RefSeq Acc Id: XP_063138869   ⟸   XM_063282799
- Peptide Label: isoform X2
- UniProtKB: F1M5W8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138874   ⟸   XM_063282804
- Peptide Label: isoform X8
- UniProtKB: F1M5W8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138870   ⟸   XM_063282800
- Peptide Label: isoform X4
- UniProtKB: F1M5W8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138873   ⟸   XM_063282803
- Peptide Label: isoform X7
- UniProtKB: F1M5W8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138872   ⟸   XM_063282802
- Peptide Label: isoform X6
- UniProtKB: F1M5W8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138871   ⟸   XM_063282801
- Peptide Label: isoform X5
- UniProtKB: F1M5W8 (UniProtKB/TrEMBL),   A0A8I5ZTP6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138875   ⟸   XM_063282805
- Peptide Label: isoform X9
- UniProtKB: F1M5W8 (UniProtKB/TrEMBL)
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R484-F1-model_v2 AlphaFold M0R484 1-832 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691006
Promoter ID:EPDNEW_R1529
Type:multiple initiation site
Name:Afap1l2_2
Description:actin filament associated protein 1-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1530  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01277,826,917 - 277,826,977EPDNEW
RGD ID:13691011
Promoter ID:EPDNEW_R1530
Type:single initiation site
Name:Afap1l2_1
Description:actin filament associated protein 1-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1529  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01277,827,263 - 277,827,323EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310668 AgrOrtholog
BioCyc Gene G2FUF-55303 BioCyc
Ensembl Genes ENSRNOG00000017164 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023113 ENTREZGENE
  ENSRNOT00000023113.9 UniProtKB/TrEMBL
  ENSRNOT00000073346 ENTREZGENE
  ENSRNOT00000073346.5 UniProtKB/TrEMBL
  ENSRNOT00000105824.2 UniProtKB/TrEMBL
  ENSRNOT00000109408.2 UniProtKB/TrEMBL
  ENSRNOT00000110011 ENTREZGENE
  ENSRNOT00000110011.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro AFAP UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
KEGG Report rno:292130 UniProtKB/TrEMBL
NCBI Gene 292130 ENTREZGENE
PANTHER PTHR14338 UniProtKB/TrEMBL
  PTHR14338:SF4 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
PhenoGen Afap1l2 PhenoGen
PROSITE PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017164 RatGTEx
SMART SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0A8I5ZSJ9_RAT UniProtKB/TrEMBL
  A0A8I5ZTP6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ARV2 ENTREZGENE, UniProtKB/TrEMBL
  F1M5W8 ENTREZGENE, UniProtKB/TrEMBL
  M0R484 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-27 Afap1l2  actin filament associated protein 1-like 2  RGD1310668_predicted  similar to expressed sequence AU041783 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1310668_predicted  similar to expressed sequence AU041783 (predicted)  LOC292130_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC292130_predicted  similar to expressed sequence AU041783 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL