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Gene: Creld2 (CRELD disulfide isomerase 2) Rattus norvegicus

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Symbol:

Creld2

Name:

CRELD disulfide isomerase 2 (Ensembl:cysteine-rich with EGF-like domains 2)

RGD ID:

1310614

Description:

Predicted to enable calcium ion binding activity and protein disulfide isomerase activity. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and extracellular space. Orthologous to human CRELD2 (cysteine rich with EGF like domains 2); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cysteine-rich with EGF-like domain protein 2; cysteine-rich with EGF-like domains 2; LOC362978; MGC112714; RGD1310614; similar to RIKEN cDNA 5730592L21

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CRELD2 (CRELD disulfide isomerase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):	Creld2 (cysteine-rich with EGF-like domains 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Creld2 (CRELD disulfide isomerase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CRELD2 (CRELD disulfide isomerase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CRELD2 (cysteine rich with EGF like domains 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Creld2 (CRELD disulfide isomerase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CRELD2 (cysteine rich with EGF like domains 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CRELD2 (CRELD disulfide isomerase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Creld2 (CRELD disulfide isomerase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Creld2 (CRELD disulfide isomerase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FFAR2 (free fatty acid receptor 2)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Creld2 (cysteine-rich with EGF-like domains 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CRELD2 (CRELD disulfide isomerase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	creld2 (cysteine-rich with EGF-like domains 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	creld2 (cysteine-rich with EGF-like domains 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11377	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11377	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	crld-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	creld2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	creld2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	121,788,754 - 121,796,230 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	121,788,745 - 121,796,228 (+)	Ensembl				GRCr8
mRatBN7.2	7	119,909,626 - 119,916,556 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	119,909,633 - 119,916,543 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	121,660,746 - 121,667,601 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	123,886,926 - 123,893,781 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	123,850,170 - 123,857,025 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	129,812,746 - 129,819,641 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	129,812,789 - 129,819,634 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	129,501,469 - 129,508,353 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	127,123,883 - 127,130,729 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	116,383,403 - 116,390,251 (+)	NCBI		Celera
RGSC_v3.1	7	127,158,110 - 127,164,955 (+)	NCBI
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrotoluene (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

2-palmitoylglycerol (ISO)

3H-1,2-dithiole-3-thione (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

acrolein (ISO)

alpha-pinene (ISO)

Aroclor 1254 (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

captan (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

clobetasol (ISO)

clofibric acid (EXP)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

coumarin (EXP)

cyclosporin A (ISO)

dichloroacetic acid (ISO)

dioxygen (EXP)

diquat (ISO)

disulfiram (ISO)

diuron (EXP)

dorsomorphin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

fenpyroximate (ISO)

folic acid (ISO)

folpet (ISO)

FR900359 (ISO)

gentamycin (EXP)

glafenine (EXP)

graphene oxide (ISO)

inulin (ISO)

ivermectin (ISO)

ketamine (EXP)

leflunomide (EXP)

metformin (EXP)

methamphetamine (EXP,ISO)

methimazole (EXP)

monosodium L-glutamate (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

nitrates (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (EXP)

phenylmercury acetate (ISO)

pinostrobin (ISO)

piperonyl butoxide (EXP)

pirinixic acid (ISO)

progesterone (ISO)

propiconazole (ISO)

quercetin (ISO)

resveratrol (EXP,ISO)

rotenone (EXP)

SB 431542 (ISO)

senecionine (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

sodium dodecyl sulfate (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

tacrolimus hydrate (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (EXP,ISO)

thiram (ISO)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

troglitazone (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

endoplasmic reticulum (IEA,ISO)

extracellular matrix (IBA)

extracellular space (IBA,IEA,ISO)

Golgi apparatus (IEA,ISO)

Molecular Function

calcium ion binding (IEA)

isomerase activity (IEA)

protein binding (ISO)

protein disulfide isomerase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:16238698	PMID:19615339	PMID:21729698

Genomics

Comparative Map Data

Creld2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	121,788,754 - 121,796,230 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	121,788,745 - 121,796,228 (+)	Ensembl				GRCr8
mRatBN7.2	7	119,909,626 - 119,916,556 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	119,909,633 - 119,916,543 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	121,660,746 - 121,667,601 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	123,886,926 - 123,893,781 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	123,850,170 - 123,857,025 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	129,812,746 - 129,819,641 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	129,812,789 - 129,819,634 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	129,501,469 - 129,508,353 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	127,123,883 - 127,130,729 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	116,383,403 - 116,390,251 (+)	NCBI		Celera
RGSC_v3.1	7	127,158,110 - 127,164,955 (+)	NCBI
Cytogenetic Map	7	q34	NCBI

CRELD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	49,918,634 - 49,927,537 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	49,917,989 - 49,927,544 (+)	Ensembl			hg38	GRCh38
GRCh37	22	50,312,282 - 50,321,185 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	48,698,348 - 48,707,180 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	22	34,233,563 - 34,242,609 (+)	NCBI		Celera
Cytogenetic Map	22	q13.33	NCBI
HuRef	22	33,259,128 - 33,267,907 (+)	NCBI		HuRef
CHM1_1	22	50,271,043 - 50,279,680 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	50,423,116 - 50,432,198 (+)	NCBI		T2T-CHM13v2.0

Creld2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	88,703,849 - 88,710,884 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	88,703,849 - 88,710,886 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	88,819,646 - 88,826,681 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	88,819,646 - 88,826,683 (+)	Ensembl			mm10	GRCm38
MGSCv37	15	88,650,076 - 88,657,111 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	88,647,412 - 88,654,447 (+)	NCBI		MGSCv36	mm8
Celera	15	90,945,467 - 90,952,501 (+)	NCBI		Celera
Cytogenetic Map	15	E3	NCBI
cM Map	15	44.31	NCBI

Creld2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	33,040,024 - 33,046,390 (+)	Ensembl
ChiLan1.0	NW_004955413	33,039,931 - 33,046,622 (+)	NCBI	ChiLan1.0	ChiLan1.0

CRELD2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	59,818,034 - 59,829,711 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	62,502,741 - 62,515,691 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	30,139,539 - 30,152,462 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	49,141,978 - 49,156,608 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	49,141,973 - 49,156,375 (+)	Ensembl			panPan2	panpan1.1

CRELD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	17,286,141 - 17,293,327 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	17,286,134 - 17,293,740 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	17,265,219 - 17,273,037 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	18,014,613 - 18,022,399 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	18,014,606 - 18,022,384 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	17,737,981 - 17,745,763 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	18,061,023 - 18,068,841 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	18,193,194 - 18,201,016 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Creld2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	835,794 - 844,011 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936629	835,789 - 844,049 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936629	835,802 - 844,009 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CRELD2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	709,045 - 716,771 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	709,042 - 716,766 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	110,965,837 - 110,973,559 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CRELD2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	32,420,315 - 32,430,770 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	32,420,370 - 32,430,904 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	92,963,716 - 92,975,425 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Creld2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	735,230 - 744,912 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624752	738,074 - 744,897 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Creld2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	258,142,512 - 258,149,577 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Creld2
74 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	46
Count of miRNA genes:	37
Interacting mature miRNAs:	43
Transcripts:	ENSRNOT00000006357
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	121393075	137014596	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	119280025	135560836	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	82111245	123048330	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	104186212	135371468	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	93302009	131686183	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	95485047	137014596	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	115313999	136544683	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	46307490	127866166	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	85043242	130043242	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	85497398	130497398	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	92362341	137014596	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	83626689	128626689	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	82111382	132099989	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	98549867	137014596	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	82111245	123048330	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	40540077	123682549	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	110725024	135371468	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	100548246	137014596	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	82111245	134948181	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	77807807	122807807	Rat
1582240	Sffal1	Serum free fatty acids level QTL 1	3.4	0.0021	blood free fatty acid amount (VT:0001553)	serum free fatty acids level (CMO:0000547)	7	118556868	125929417	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	116269196	132020414	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	78682549	123682549	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	71827901	136544683	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001037208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006242216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263946	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098722	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229732	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006357 ⟹ ENSRNOP00000006357

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	121,788,745 - 121,796,228 (+)	Ensembl
mRatBN7.2 Ensembl	7	119,909,639 - 119,916,543 (+)	Ensembl
Rnor_6.0 Ensembl	7	129,812,789 - 129,819,634 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102244 ⟹ ENSRNOP00000081306

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	121,788,745 - 121,795,476 (+)	Ensembl
mRatBN7.2 Ensembl	7	119,909,633 - 119,915,797 (+)	Ensembl

RefSeq Acc Id:

NM_001037208 ⟹ NP_001032285

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	121,789,384 - 121,796,230 (+)	NCBI
mRatBN7.2	7	119,909,705 - 119,916,551 (+)	NCBI
Rnor_6.0	7	129,812,789 - 129,819,636 (+)	NCBI
Rnor_5.0	7	129,501,469 - 129,508,353 (+)	NCBI
RGSC_v3.4	7	127,123,883 - 127,130,729 (+)	RGD
Celera	7	116,383,403 - 116,390,251 (+)	RGD

Sequence:

show sequence

CAGACTCCGCCGCAGTTCTCGGTGGGTCGCCGGGCTGCCCTCCCGCCATGCACCTGCTGCTTGC
AGCCGGGTTCGGGCTGCTACTGCTGCTGCTGCCGCCACCCGCGGCCTCCAAGAAGCCGACACAG
TGCCAGAGGTGCCGGACGCTGGTGGACAAGTTCAACCAGGGGATGGCCAACACGGCCAGGAAGA
ATTTCGGAGGCGGCAACACGGCGTGGGAAGAGAAGACTCTGTCGAAGTATGAATTCAGTGAGAT
CCGGCTTCTGGAGATCATGGAGGGTCTGTGTGACAGCAGTGACTTTGAGTGCAACCAACTCTTG
GAGCAGCAGGAAGAGCAGCTCGAGGCCTGGTGGCAGTCCCTGAAGAAGGATTACCCCAACTTAT
TTGAGTGGTTCTGTGTACGCACACTGAAAGCATGCTGTCTTCCAGGCACCTACGGGCCAGACTG
TAAAGAATGCCAGGGTGGGTCCGAGAGGCCTTGTAGCGGCAACGGCTACTGCAGCGGCGATGGC
AGCAGGCAGGGCGACGGGTCCTGCCAGTGTCACGCGGGCTACAAGGGACCACTGTGTATTGACT
GCATGGATGGCTACTTCAGTTTGCAGAGGAACGAGACCCACAGCATCTGCTTGGCCTGTGATGA
GTCTTGCAAGACATGCTCAGGTCCAAGCAACAAAGACTGTGTCCAGTGTGAAGTGGGCTGGGCA
CGAGTGGAAGACGCCTGCGTGGATGTAGATGAGTGTGCGGCAGAGACACCTCCCTGCAGTGAGG
CACAGTACTGTGAGAATGTCAACGGATCGTACATCTGTGAAGAATGTGATTCTACCTGTGTGGG
CTGTACAGGAAAAGGCCCAGCCAATTGTAAAGAATGCATCGCTGGCTACACCAAGCAGAGTGGA
CAGTGTGCAGACATAGATGAATGCTCACTAGAAGAAAAAGCCTGTAAGAGAAGAAACGAAAACT
GCTACAATGTTCCAGGGAGCTTTGTGTGCGTGTGTCCGGATGGCTTTGAGGAGACAGAAGACGC
TTGTGTGCAGACAGCACAAAGCGAAGTCACAGAGGAAAACCCCACACAGCCACTCTCCCATGAG
GATTTGTGATAGACATCTGGATTCAGAAGCCAGACTCACCCTTTAAGTTATTGAGAGGATATAT
ATAGAAAATGTGGCCCATGGACATCAACCCCATTTCTCCAGGAAGACCTCAGAGGGAGAAGCTG
CCTACTCTGAAAAAGCTGATACTCACTTGGCCCTTTAAAAAGCTGCATTTCTTGGTGGTTCATA
AGCAGATTTGTATATTTTGATACTGTTCTTTATAATAAAATTGATCATTGAAGGTCACCAGGAA
AAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006242216 ⟹ XP_006242278

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	121,789,308 - 121,796,230 (+)	NCBI
mRatBN7.2	7	119,909,626 - 119,916,556 (+)	NCBI
Rnor_6.0	7	129,812,746 - 129,819,641 (+)	NCBI
Rnor_5.0	7	129,501,469 - 129,508,353 (+)	NCBI

Sequence:

show sequence

TAGCCCGGGGAACGGCCGGCGCGCGGGCCGGTGGGCGGAGGCTCAGACTCCGCCGCAGTTCTCG
GTGGGTCGCCGGGCTGCCCTCCCGCCATGCACCTGCTGCTTGCAGCCGGGTTCGGGCTGCTACT
GCTGCTGCTGCCGCCACCCGCGGCCTCCAAGAAGCCGACACAGTGCCAGAGGTGCCGGACGCTG
GTGGACAAGTTCAACCAGGGGATGGCCAACACGGCCAGGAAGAATTTCGGAGGCGGCAACACGG
CGTGGGAAGAGAAGACTCTGTCGAAGTATGAATTCAGTGAGATCCGGCTTCTGGAGATCATGGA
GGGTCTGTGTGACAGCAGTGACTTTGAGTGCAACCAACTCTTGGAGCAGCAGGAAGAGCAGCTC
GAGGCCTGGTGGCAGTCCCTGAAGAAGGATTACCCCAACTTATTTGAGTGGTTCTGTGTACGCA
CACTGAAAGCATGCTGTCTTCCAGGCACCTACGGGCCAGACTGTAAAGCCTGTGATGAGTCTTG
CAAGACATGCTCAGGTCCAAGCAACAAAGACTGTGTCCAGTGTGAAGTGGGCTGGGCACGAGTG
GAAGACGCCTGCGTGGATGTAGATGAGTGTGCGGCAGAGACACCTCCCTGCAGTGAGGCACAGT
ACTGTGAGAATGTCAACGGATCGTACATCTGTGAAGAATGTGATTCTACCTGTGTGGGCTGTAC
AGGAAAAGGCCCAGCCAATTGTAAAGAATGCATCGCTGGCTACACCAAGCAGAGTGGACAGTGT
GCAGACATAGATGAATGCTCACTAGAAGAAAAAGCCTGTAAGAGAAGAAACGAAAACTGCTACA
ATGTTCCAGGGAGCTTTGTGTGCGTGTGTCCGGATGGCTTTGAGGAGACAGAAGACGCTTGTGT
GCAGACAGCACAAAGCGAAGTCACAGAGGAAAACCCCACACAGCCACTCTCCCATGAGGATTTG
TGATAGACATCTGGATTCAGAAGCCAGACTCACCCTTTAAGTTATTGAGAGGATATATATAGAA
AATGTGGCCCATGGACATCAACCCCATTTCTCCAGGAAGACCTCAGAGGGAGAAGCTGCCTACT
CTGAAAAAGCTGATACTCACTTGGCCCTTTAAAAAGCTGCATTTCTTGGTGGTTCATAAGCAGA
TTTGTATATTTTGATACTGTTCTTTATAATAAAATTGATCATTGAAGGTCACCAGGAACAGAA

hide sequence

RefSeq Acc Id:

XM_063263946 ⟹ XP_063120016

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	121,788,754 - 121,796,230 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001032285	(Get FASTA)	NCBI Sequence Viewer
	XP_006242278	(Get FASTA)	NCBI Sequence Viewer
	XP_063120016	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98722	(Get FASTA)	NCBI Sequence Viewer
	EDL76521	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006357
	ENSRNOP00000006357.5
GenBank Protein	Q4G063	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001032285 ⟸ NM_001037208
- Peptide Label:	precursor
- UniProtKB:	Q4G063 (UniProtKB/Swiss-Prot), A6K7H8 (UniProtKB/TrEMBL), A0A8I6G5R7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MHLLLAAGFGLLLLLLPPPAASKKPTQCQRCRTLVDKFNQGMANTARKNFGGGNTAWEEKTLSK YEFSEIRLLEIMEGLCDSSDFECNQLLEQQEEQLEAWWQSLKKDYPNLFEWFCVRTLKACCLPG TYGPDCKECQGGSERPCSGNGYCSGDGSRQGDGSCQCHAGYKGPLCIDCMDGYFSLQRNETHSI CLACDESCKTCSGPSNKDCVQCEVGWARVEDACVDVDECAAETPPCSEAQYCENVNGSYICEEC DSTCVGCTGKGPANCKECIAGYTKQSGQCADIDECSLEEKACKRRNENCYNVPGSFVCVCPDGF EETEDACVQTAQSEVTEENPTQPLSHEDL hide sequence

RefSeq Acc Id:

XP_006242278 ⟸ XM_006242216

- Peptide Label:

isoform X2

- Sequence:

show sequence

MHLLLAAGFGLLLLLLPPPAASKKPTQCQRCRTLVDKFNQGMANTARKNFGGGNTAWEEKTLSK
YEFSEIRLLEIMEGLCDSSDFECNQLLEQQEEQLEAWWQSLKKDYPNLFEWFCVRTLKACCLPG
TYGPDCKACDESCKTCSGPSNKDCVQCEVGWARVEDACVDVDECAAETPPCSEAQYCENVNGSY
ICEECDSTCVGCTGKGPANCKECIAGYTKQSGQCADIDECSLEEKACKRRNENCYNVPGSFVCV
CPDGFEETEDACVQTAQSEVTEENPTQPLSHEDL

hide sequence

Ensembl Acc Id:

ENSRNOP00000006357 ⟸ ENSRNOT00000006357

Ensembl Acc Id:

ENSRNOP00000081306 ⟸ ENSRNOT00000102244

RefSeq Acc Id:	XP_063120016 ⟸ XM_063263946
- Peptide Label:	isoform X1
- UniProtKB:	Q4G063 (UniProtKB/Swiss-Prot), A6K7H8 (UniProtKB/TrEMBL), A0A8I6G5R7 (UniProtKB/TrEMBL)

Protein Domains

EGF-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4G063-F1-model_v2	AlphaFold	Q4G063	1-349	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695574

Promoter ID:

EPDNEW_R6099

Type:

initiation region

Name:

Creld2_1

Description:

cysteine-rich with EGF-like domains 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	129,812,790 - 129,812,850	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310614	AgrOrtholog
BioCyc Gene	G2FUF-32486	BioCyc
Ensembl Genes	ENSRNOG00000004659	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000006357	ENTREZGENE
	ENSRNOT00000006357.6	UniProtKB/Swiss-Prot
Gene3D-CATH	Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2	UniProtKB/Swiss-Prot
	Laminin	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7371287	IMAGE-MGC_LOAD
InterPro	EGF-like_Ca-bd_dom	UniProtKB/Swiss-Prot
	EGF-like_dom	UniProtKB/Swiss-Prot
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/Swiss-Prot
	EGF_Ca-bd_CS	UniProtKB/Swiss-Prot
	Furin_repeat	UniProtKB/Swiss-Prot
	Growth_fac_rcpt_cys_sf	UniProtKB/Swiss-Prot
	Laminin_EGF	UniProtKB/Swiss-Prot
	Nephronectin_domain	UniProtKB/Swiss-Prot
	NOTCH1_EGF-like	UniProtKB/Swiss-Prot
KEGG Report	rno:362978	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112714	IMAGE-MGC_LOAD
NCBI Gene	362978	ENTREZGENE
PANTHER	PA14 DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot
	UROMODULIN-LIKE	UniProtKB/Swiss-Prot
Pfam	EGF_CA	UniProtKB/Swiss-Prot
PhenoGen	Creld2	PhenoGen
PROSITE	ASX_HYDROXYL	UniProtKB/Swiss-Prot
	EGF_1	UniProtKB/Swiss-Prot
	EGF_2	UniProtKB/Swiss-Prot
	EGF_3	UniProtKB/Swiss-Prot
	EGF_CA	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000004659	RatGTEx
SMART	EGF	UniProtKB/Swiss-Prot
	EGF_CA	UniProtKB/Swiss-Prot
	SM00261	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF57184	UniProtKB/Swiss-Prot
UniProt	A0A8I6G5R7	ENTREZGENE, UniProtKB/TrEMBL
	A6K7H8	ENTREZGENE, UniProtKB/TrEMBL
	CREL2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2025-11-13	Creld2	CRELD disulfide isomerase 2	Creld2	cysteine-rich with EGF-like domains 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Creld2	cysteine-rich with EGF-like domains 2	RGD1310614	similar to RIKEN cDNA 5730592L21	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1310614	similar to RIKEN cDNA 5730592L21	RGD1310614_predicted	similar to RIKEN cDNA 5730592L21 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1310614_predicted	similar to RIKEN cDNA 5730592L21 (predicted)	LOC362978_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC362978_predicted	similar to RIKEN cDNA 5730592L21 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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