Zfp641 (zinc finger protein 641) - Rat Genome Database

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Gene: Zfp641 (zinc finger protein 641) Rattus norvegicus
Analyze
Symbol: Zfp641
Name: zinc finger protein 641
RGD ID: 1310412
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleolus. Predicted to be active in nucleoplasm. Orthologous to human ZNF641 (zinc finger protein 641); INTERACTS WITH 1,2-dimethylhydrazine; acrylamide; amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC300197; RGD1310412; similar to hypothetical protein FLJ31295; Znf641
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,313,620 - 131,324,149 (-)NCBIGRCr8
mRatBN7.27129,434,576 - 129,444,847 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,434,576 - 129,444,644 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,239,733 - 131,249,812 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,465,264 - 133,475,342 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,377,758 - 133,387,837 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07139,897,574 - 139,907,624 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,899,775 - 139,907,640 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,041,694 - 139,051,592 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,021,618 - 137,031,750 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17137,100,930 - 137,122,506 (-)NCBI
Celera7125,925,946 - 125,936,042 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IBA,ISO)
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp641
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87131,313,620 - 131,324,149 (-)NCBIGRCr8
mRatBN7.27129,434,576 - 129,444,847 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7129,434,576 - 129,444,644 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7131,239,733 - 131,249,812 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07133,465,264 - 133,475,342 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07133,377,758 - 133,387,837 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07139,897,574 - 139,907,624 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7139,899,775 - 139,907,640 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,041,694 - 139,051,592 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,021,618 - 137,031,750 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17137,100,930 - 137,122,506 (-)NCBI
Celera7125,925,946 - 125,936,042 (-)NCBICelera
Cytogenetic Map7q36NCBI
ZNF641
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,334,587 - 48,351,246 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1248,337,180 - 48,351,414 (-)EnsemblGRCh38hg38GRCh38
GRCh371248,728,370 - 48,745,029 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,022,179 - 47,030,844 (-)NCBINCBI36Build 36hg18NCBI36
Celera1247,529,785 - 47,541,023 (-)NCBICelera
Cytogenetic Map12q13.11NCBI
HuRef1245,767,779 - 45,779,016 (-)NCBIHuRef
CHM1_11248,699,127 - 48,710,365 (-)NCBICHM1_1
T2T-CHM13v2.01248,295,893 - 48,312,553 (-)NCBIT2T-CHM13v2.0
Zfp641
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,183,466 - 98,194,395 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1598,183,466 - 98,194,042 (-)EnsemblGRCm39 Ensembl
GRCm381598,285,585 - 98,296,515 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,285,585 - 98,296,161 (-)EnsemblGRCm38mm10GRCm38
MGSCv371598,116,553 - 98,126,514 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361598,114,156 - 98,124,117 (-)NCBIMGSCv36mm8
Celera15100,417,913 - 100,427,898 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1554.29NCBI
Znf641
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555007,209,119 - 7,217,704 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555007,207,311 - 7,217,704 (-)NCBIChiLan1.0ChiLan1.0
ZNF641
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21045,820,374 - 45,834,274 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11245,817,141 - 45,831,035 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01240,386,114 - 40,402,447 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11241,263,246 - 41,274,118 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1241,263,246 - 41,274,118 (+)Ensemblpanpan1.1panPan2
ZNF641
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,370,859 - 6,382,367 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,372,540 - 6,379,340 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2739,895,583 - 39,906,728 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0276,438,592 - 6,449,766 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl276,439,103 - 6,449,759 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,374,829 - 6,385,963 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0276,410,681 - 6,421,823 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02740,214,643 - 40,225,786 (-)NCBIUU_Cfam_GSD_1.0
Znf641
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,947,202 - 66,961,721 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365126,207,841 - 6,215,158 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365126,203,974 - 6,215,353 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF641
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl578,707,849 - 78,718,269 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1578,707,843 - 78,718,277 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2581,900,564 - 81,911,092 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103238228
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11144,565,771 - 44,577,142 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1144,568,575 - 44,575,916 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037201,591,328 - 201,602,375 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf641
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248163,870,764 - 3,884,329 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248163,870,713 - 3,882,424 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp641
87 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:42
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000045473
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 17
Low 3 43 55 41 19 41 8 9 57 35 40 11 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045473   ⟹   ENSRNOP00000047139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7129,434,576 - 129,444,644 (-)Ensembl
Rnor_6.0 Ensembl7139,899,775 - 139,907,640 (-)Ensembl
RefSeq Acc Id: NM_001106792   ⟹   NP_001100262
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,313,624 - 131,323,691 (-)NCBI
mRatBN7.27129,434,576 - 129,444,644 (-)NCBI
Rnor_6.07139,897,574 - 139,907,624 (-)NCBI
Rnor_5.07139,041,694 - 139,051,592 (-)NCBI
RGSC_v3.47137,021,618 - 137,031,750 (-)RGD
Celera7125,925,946 - 125,936,042 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078914   ⟹   XP_038934842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,313,620 - 131,324,149 (-)NCBI
mRatBN7.27129,435,786 - 129,444,847 (-)NCBI
RefSeq Acc Id: XM_039078915   ⟹   XP_038934843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,313,620 - 131,324,149 (-)NCBI
mRatBN7.27129,435,786 - 129,444,847 (-)NCBI
RefSeq Acc Id: XM_039078916   ⟹   XP_038934844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,313,620 - 131,324,149 (-)NCBI
mRatBN7.27129,435,786 - 129,444,847 (-)NCBI
RefSeq Acc Id: XM_039078917   ⟹   XP_038934845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,313,620 - 131,321,322 (-)NCBI
mRatBN7.27129,435,786 - 129,442,283 (-)NCBI
RefSeq Acc Id: XM_039078918   ⟹   XP_038934846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87131,313,620 - 131,320,460 (-)NCBI
mRatBN7.27129,435,786 - 129,442,312 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001100262   ⟸   NM_001106792
- UniProtKB: D4A704 (UniProtKB/TrEMBL),   A6KC69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000047139   ⟸   ENSRNOT00000045473
RefSeq Acc Id: XP_038934844   ⟸   XM_039078916
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038934843   ⟸   XM_039078915
- Peptide Label: isoform X1
- UniProtKB: D4A704 (UniProtKB/TrEMBL),   A6KC69 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934842   ⟸   XM_039078914
- Peptide Label: isoform X1
- UniProtKB: D4A704 (UniProtKB/TrEMBL),   A6KC69 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934846   ⟸   XM_039078918
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038934845   ⟸   XM_039078917
- Peptide Label: isoform X3
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A704-F1-model_v2 AlphaFold D4A704 1-421 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310412 AgrOrtholog
BioCyc Gene G2FUF-32147 BioCyc
Ensembl Genes ENSRNOG00000032447 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045473 ENTREZGENE
  ENSRNOT00000045473.6 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:300197 UniProtKB/TrEMBL
NCBI Gene 300197 ENTREZGENE
PANTHER KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/TrEMBL
  KRAB DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp641 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032447 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A6KC69 ENTREZGENE, UniProtKB/TrEMBL
  D4A704 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-19 Zfp641  zinc finger protein 641  Znf641  zinc finger protein 641  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Znf641  zinc finger protein 641  Zfp641  zinc finger protein 641   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Zfp641  zinc finger protein 641   Zfp641_predicted  zinc finger protein 641 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Zfp641_predicted  zinc finger protein 641 (predicted)  RGD1310412_predicted  similar to hypothetical protein FLJ31295 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1310412_predicted  similar to hypothetical protein FLJ31295 (predicted)  LOC300197_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC300197_predicted  similar to hypothetical protein FLJ31295 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL