Calhm5 (calcium homeostasis modulator family member 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Calhm5 (calcium homeostasis modulator family member 5) Rattus norvegicus
Analyze
Symbol: Calhm5
Name: calcium homeostasis modulator family member 5
RGD ID: 1310405
Description: Predicted to enable monoatomic cation channel activity. Predicted to be involved in ATP export and monoatomic cation transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human CALHM5 (calcium homeostasis modulator family member 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium homeostasis modulator protein 5; Fam26e; family with sequence similarity 26, member E; hypothetical protein LOC294431; LOC294431; RGD1310405; similar to chromosome 6 open reading frame 188
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82026,609,400 - 26,615,478 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2026,609,400 - 26,615,478 (-)EnsemblGRCr8
mRatBN7.22026,066,270 - 26,072,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2026,066,242 - 26,072,272 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2027,068,471 - 27,074,549 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02026,454,816 - 26,460,894 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02027,203,055 - 27,209,133 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02027,651,817 - 27,673,817 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2027,651,312 - 27,657,983 (-)Ensemblrn6Rnor6.0
Rnor_5.02029,476,316 - 29,497,695 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42037,693,422 - 37,699,449 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2027,519,947 - 27,526,025 (-)NCBICelera
RGSC_v3.12037,716,432 - 37,722,467 (+)NCBI
Cytogenetic Map20q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:23376485  


Genomics

Comparative Map Data
Calhm5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82026,609,400 - 26,615,478 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2026,609,400 - 26,615,478 (-)EnsemblGRCr8
mRatBN7.22026,066,270 - 26,072,348 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2026,066,242 - 26,072,272 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2027,068,471 - 27,074,549 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02026,454,816 - 26,460,894 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02027,203,055 - 27,209,133 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02027,651,817 - 27,673,817 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2027,651,312 - 27,657,983 (-)Ensemblrn6Rnor6.0
Rnor_5.02029,476,316 - 29,497,695 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42037,693,422 - 37,699,449 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2027,519,947 - 27,526,025 (-)NCBICelera
RGSC_v3.12037,716,432 - 37,722,467 (+)NCBI
Cytogenetic Map20q11NCBI
CALHM5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386116,511,639 - 116,524,788 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6116,511,639 - 116,524,788 (+)Ensemblhg38GRCh38
GRCh376116,832,802 - 116,845,951 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366116,939,501 - 116,946,402 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346116,939,500 - 116,944,630NCBI
Celera6117,575,879 - 117,582,776 (+)NCBICelera
Cytogenetic Map6q22.1NCBI
HuRef6114,412,412 - 114,419,285 (+)NCBIHuRef
CHM1_16117,096,424 - 117,103,339 (+)NCBICHM1_1
T2T-CHM13v2.06117,695,374 - 117,708,525 (+)NCBIT2T-CHM13v2.0
Calhm5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391033,967,348 - 33,972,515 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1033,963,811 - 33,972,515 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381034,091,352 - 34,096,519 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1034,087,815 - 34,096,519 (-)Ensemblmm10GRCm38
MGSCv371033,811,158 - 33,816,325 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361033,780,768 - 33,785,935 (-)NCBIMGSCv36mm8
Celera1035,001,152 - 35,006,319 (-)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1018.85NCBI
Calhm5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955526203,971 - 213,328 (-)Ensembl
ChiLan1.0NW_004955526203,971 - 213,328 (-)NCBIChiLan1.0ChiLan1.0
CALHM5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25136,525,202 - 136,531,031 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16134,418,155 - 134,424,692 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06114,319,599 - 114,325,898 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16118,464,517 - 118,471,411 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6118,464,517 - 118,471,411 (+)EnsemblpanPan2panpan1.1
CALHM5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1156,928,836 - 56,934,196 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl156,928,864 - 56,933,455 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha157,723,791 - 57,729,997 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0157,110,486 - 57,116,699 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl157,110,685 - 57,115,282 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1157,004,939 - 57,011,144 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0156,853,134 - 56,859,286 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0157,482,079 - 57,488,240 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Calhm5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946107,331,091 - 107,336,385 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368241,056,098 - 1,062,157 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049368241,056,082 - 1,061,368 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALHM5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl182,108,977 - 82,119,476 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1182,109,042 - 82,119,480 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2192,219,733 - 92,220,970 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CALHM5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11357,294,969 - 57,300,539 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1357,294,951 - 57,300,068 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604029,622,343 - 29,630,429 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Calhm5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248561,931,511 - 1,935,794 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248561,929,416 - 1,936,196 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Calhm5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11824,126,590 - 24,132,104 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Calhm5
80 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:428
Count of miRNA genes:239
Interacting mature miRNAs:284
Transcripts:ENSRNOT00000057313
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 12 55 126 48 47 16 88 16 6 282 176 11 105 70 88 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000057313   ⟹   ENSRNOP00000054130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2026,609,400 - 26,615,478 (-)Ensembl
mRatBN7.2 Ensembl2026,066,242 - 26,072,272 (-)Ensembl
Rnor_6.0 Ensembl2027,651,312 - 27,657,983 (-)Ensembl
RefSeq Acc Id: NM_001024977   ⟹   NP_001020148
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82026,609,400 - 26,615,478 (-)NCBI
mRatBN7.22026,066,270 - 26,072,348 (-)NCBI
Rnor_6.02027,651,817 - 27,657,895 (-)NCBI
Rnor_5.02029,476,316 - 29,497,695 (-)NCBI
RGSC_v3.42037,693,422 - 37,699,449 (+)RGD
Celera2027,519,947 - 27,526,025 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020148 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89225 (Get FASTA)   NCBI Sequence Viewer  
  EDL93097 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054130
  ENSRNOP00000054130.2
GenBank Protein Q5FWS4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020148   ⟸   NM_001024977
- UniProtKB: Q5FWS4 (UniProtKB/Swiss-Prot),   A6K3S5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054130   ⟸   ENSRNOT00000057313

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FWS4-F1-model_v2 AlphaFold Q5FWS4 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701576
Promoter ID:EPDNEW_R12099
Type:initiation region
Name:Calhm5_1
Description:calcium homeostasis modulator family member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02027,657,819 - 27,657,879EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310405 AgrOrtholog
BioCyc Gene G2FUF-3793 BioCyc
Ensembl Genes ENSRNOG00000000825 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000057313 ENTREZGENE
  ENSRNOT00000057313.5 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7309006 IMAGE-MGC_LOAD
InterPro CALHM UniProtKB/Swiss-Prot
KEGG Report rno:294431 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105561 IMAGE-MGC_LOAD
NCBI Gene 294431 ENTREZGENE
PANTHER PTHR32261 UniProtKB/Swiss-Prot
  PTHR32261:SF8 UniProtKB/Swiss-Prot
Pfam Ca_hom_mod UniProtKB/Swiss-Prot
PhenoGen Calhm5 PhenoGen
RatGTEx ENSRNOG00000000825 RatGTEx
UniProt A6K3S5 ENTREZGENE, UniProtKB/TrEMBL
  CAHM5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-31 Calhm5  calcium homeostasis modulator family member 5  Fam26e  family with sequence similarity 26, member E  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Fam26e  family with sequence similarity 26, member E  RGD1310405  similar to chromosome 6 open reading frame 188  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1310405  similar to chromosome 6 open reading frame 188  RGD1310405_predicted  similar to chromosome 6 open reading frame 188 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310405_predicted  similar to chromosome 6 open reading frame 188 (predicted)  LOC294431_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC294431_predicted  similar to chromosome 6 open reading frame 188 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL