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Gene: Lgi2 (leucine-rich repeat LGI family, member 2) Rattus norvegicus

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Symbol:

Lgi2

Name:

leucine-rich repeat LGI family, member 2

RGD ID:

1310391

Description:

Predicted to be involved in inhibitory synapse assembly. Predicted to be located in extracellular region. Orthologous to human LGI2 (leucine rich repeat LGI family member 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

leucine-rich repeat LGI family member 2; LOC305417; MGC189141

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	62,628,746 - 62,656,231 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	62,596,150 - 62,656,188 (+)	Ensembl				GRCr8
mRatBN7.2	14	58,415,965 - 58,443,450 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	58,415,965 - 58,443,407 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	62,821,564 - 62,849,027 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	64,135,138 - 64,162,652 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	60,531,888 - 60,559,402 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	60,764,325 - 60,791,809 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	60,764,409 - 60,796,116 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	60,876,468 - 60,903,952 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	63,184,650 - 63,212,134 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	57,514,048 - 57,541,516 (+)	NCBI		Celera
RGSC_v3.1	14	63,158,817 - 63,214,421 (+)	NCBI
Cytogenetic Map	14	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4-hydroxyphenyl retinamide (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

alpha-Zearalanol (EXP)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP)

bromobenzene (EXP)

cadmium dichloride (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

DDT (EXP)

dibenz[a,h]anthracene (ISO)

dimethylarsinic acid (EXP)

diquat (ISO)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

genistein (ISO)

gentamycin (EXP)

GW 4064 (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

methapyrilene (ISO)

Moniliformin (ISO)

paracetamol (EXP)

paraquat (EXP)

potassium dichromate (ISO)

pravastatin (EXP,ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sunitinib (ISO)

testosterone (EXP)

titanium dioxide (ISO)

triclosan (ISO)

trimellitic anhydride (ISO)

zaragozic acid A (EXP,ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

inhibitory synapse assembly (IBA,IEA,ISO)

Cellular Component

extracellular region (IEA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:24006456	PMID:30679375

Genomics

Comparative Map Data

Lgi2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	62,628,746 - 62,656,231 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	62,596,150 - 62,656,188 (+)	Ensembl				GRCr8
mRatBN7.2	14	58,415,965 - 58,443,450 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	58,415,965 - 58,443,407 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	62,821,564 - 62,849,027 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	64,135,138 - 64,162,652 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	60,531,888 - 60,559,402 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	60,764,325 - 60,791,809 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	60,764,409 - 60,796,116 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	60,876,468 - 60,903,952 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	63,184,650 - 63,212,134 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	57,514,048 - 57,541,516 (+)	NCBI		Celera
RGSC_v3.1	14	63,158,817 - 63,214,421 (+)	NCBI
Cytogenetic Map	14	q11	NCBI

LGI2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	24,992,081 - 25,030,946 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	24,998,847 - 25,030,965 (-)	Ensembl			hg38	GRCh38
GRCh37	4	25,000,469 - 25,032,568 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	24,612,488 - 24,641,413 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	4	24,679,658 - 24,708,584	NCBI
Celera	4	25,449,352 - 25,481,288 (-)	NCBI		Celera
Cytogenetic Map	4	p15.2	NCBI
HuRef	4	24,341,380 - 24,373,316 (-)	NCBI		HuRef
CHM1_1	4	24,999,825 - 25,031,778 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	24,973,998 - 25,012,867 (-)	NCBI		T2T-CHM13v2.0

Lgi2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	52,690,859 - 52,723,689 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	52,690,859 - 52,723,804 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	52,533,517 - 52,566,306 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	52,533,517 - 52,566,462 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	52,929,103 - 52,957,519 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	52,826,112 - 52,854,528 (-)	NCBI		MGSCv36	mm8
Celera	5	49,911,427 - 49,940,116 (-)	NCBI		Celera
Cytogenetic Map	5	C1	NCBI
cM Map	5	28.25	NCBI

Lgi2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955480	58,661 - 89,920 (+)	Ensembl
ChiLan1.0	NW_004955480	58,661 - 89,906 (+)	NCBI	ChiLan1.0	ChiLan1.0

LGI2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	25,249,838 - 25,279,005 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	25,443,540 - 25,472,696 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	19,397,279 - 19,429,349 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	24,684,991 - 24,713,880 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	24,684,991 - 24,714,035 (-)	Ensembl			panPan2	panpan1.1

LGI2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	85,114,356 - 85,215,063 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	85,182,657 - 85,211,357 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	87,694,029 - 87,726,513 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	86,155,381 - 86,187,875 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	86,155,137 - 86,183,648 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	85,288,432 - 85,320,930 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	85,393,580 - 85,426,122 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	85,779,270 - 85,811,791 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lgi2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	50,716,260 - 50,776,470 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	4,450,786 - 4,480,108 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	4,417,926 - 4,478,136 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LGI2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	18,986,046 - 19,017,431 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	18,986,549 - 19,017,238 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LGI2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	25,334,139 - 25,363,889 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	25,334,457 - 25,366,819 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666047	71,852,317 - 71,883,674 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lgi2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	7,317,445 - 7,348,236 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624755	7,317,471 - 7,344,003 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lgi2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	53,568,697 - 53,596,249 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lgi2
172 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	30
Count of miRNA genes:	30
Interacting mature miRNAs:	30
Transcripts:	ENSRNOT00000005168
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313089	Bss81	Bone structure and strength QTL 81	3.4	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	14	38023710	83023710	Rat
9590294	Uminl4	Urine mineral level QTL 4	5.66	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	14	59848686	104848686	Rat
70214	Niddm28	Non-insulin dependent diabetes mellitus QTL 28	4.06		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	39009444	84009444	Rat
1300154	Bp189	Blood pressure QTL 189	3.04		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	14	31238080	72970315	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30674469	85041098	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	33424686	102238540	Rat
2313100	Bss82	Bone structure and strength QTL 82	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	14	38023710	83023710	Rat
634328	Hc5	Hypercalciuria QTL 5	2.3		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	14	62398852	107398852	Rat
7387267	Uae42	Urinary albumin excretion QTL 42		0.61	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	14	22521517	67521517	Rat
2317879	Alcrsp27	Alcohol response QTL 27	3.3	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	14	60854936	105854936	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	100078267	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	18895192	63895192	Rat
9589034	Epfw11	Epididymal fat weight QTL 11	6	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	14	59848686	104848686	Rat
2313048	Bss84	Bone structure and strength QTL 84	3.1	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	14	38023710	83023710	Rat
1300136	Rf22	Renal function QTL 22	3.9		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	14	42616258	99224555	Rat
738037	Hcas6	Hepatocarcinoma susceptibility QTL 6	2.93		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	14	39411170	87582095	Rat
2313084	Bss83	Bone structure and strength QTL 83	2.9	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	14	38023710	83023710	Rat

Markers in Region

D14Got151

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	58,440,194 - 58,440,386 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	60,788,554 - 60,788,745	NCBI	Rnor6.0
Rnor_5.0	14	60,900,697 - 60,900,888	UniSTS	Rnor5.0
RGSC_v3.4	14	63,208,879 - 63,209,070	UniSTS	RGSC3.4
Celera	14	57,538,261 - 57,538,452	UniSTS
Cytogenetic Map	14	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
13	12	64	144	78	77	48	25	48	6	256	122	11	122	65	89	29	12	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168885	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005168 ⟹ ENSRNOP00000005168

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	14	60,764,409 - 60,796,116 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097229 ⟹ ENSRNOP00000094580

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	62,628,746 - 62,656,188 (+)	Ensembl
mRatBN7.2 Ensembl	14	58,415,965 - 58,443,407 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000130670 ⟹ ENSRNOP00000110971

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	62,596,150 - 62,656,188 (+)	Ensembl

RefSeq Acc Id:

NM_001107219 ⟹ NP_001100689

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	62,628,746 - 62,656,231 (+)	NCBI
mRatBN7.2	14	58,415,965 - 58,443,450 (+)	NCBI
Rnor_6.0	14	60,764,325 - 60,791,809 (+)	NCBI
Rnor_5.0	14	60,876,468 - 60,903,952 (+)	NCBI
RGSC_v3.4	14	63,184,650 - 63,212,134 (+)	RGD
Celera	14	57,514,048 - 57,541,516 (+)	RGD

Sequence:

show sequence

GTCCGGGCGGGGACCGGGGGACCCGGCATGGCGCTACGGAGAGGCGGCGGGGCGCTGGGGCTGC
TGCTGCTGAGCGCCGCGTGCCTCATCCCGCCGAGCGCGCAGGTGAGGCGGTTGGCGCGCTGCCC
CGCCACTTGCAGCTGTACCAAGGAGTCCATCATCTGCGTGGGCTCCTCTTGGGTGCCTAGGATC
GTGCCTGGCGACATCAGCTCCCTGAGCCTAGTAAATGGAACATTTCTGGAAATCAAGGACCGAA
TGTTTTCCCATCTGCCTTCCCTACAGCTGCTATTGCTGAATTCTAACTCCTTCACGGTGATCCG
GGATGATGCCTTTGCTGGCCTTTTTCATCTTGAATACCTGTTCATTGAAGGGAACAAAATAGAA
ACCATTTCAAGAAATGCCTTTCGGGGCCTCCGTGACCTGACTCACCTTTCTTTGGCCAACAACC
ACATTAAAGCACTTCCAAGGGACGTGTTCAGCGATCTGGATTCCCTGATTGAACTAGACTTAAG
GGGTAATAAATTTGAATGTGACTGCAAAGCCAAATGGCTGTATCTGTGGCTGAAGATGACAAAT
TCCACGGTGTCTGATGTGCTGTGTATCGGTCCACCAGAATACCAGGAGAAGAAACTCAACGACG
TGACCAGCTTTGACTATGAGTGCACCACCACAGATTTTGTCGTTCATCAGACTCTGCCATACCA
GTCGGTGTCAGTAGACACGTTCAACTCCAAGAATGACGTGTACGTGGCCATCGCACAGCCTAGC
ATGGAGAACTGTATGGTGTTGGAGTGGGACCACATAGAAATGAATTTCCGGAGTTATGACAATA
TCACAGGTCAGTCCATCGTGGGCTGCAAGGCCATCCTCATTGATGACCAGGTCTTCGTGGTGGT
AGCCCAACTCTTTGGTGGCTCCCACATTTACAAATACGACGAGAGCTGGACAAAGTTTGTCAAG
TTCCAAGACATAGAGGTATCTCGAATTTCCAAGCCCAATGACATCGAGCTGTTTGAGATCGACG
ATGAGACGTTCTTCATCATCGCTGACAGCTCGAAAGCGGGGCTGTCCACAGTATACAAATGGAG
CAGCAAAGGGTTTTACTCCTACCAGTCACTACATGAGTGGTTCAGGGACACGGATGCAGAGTTT
GTTGACATTGATGGGAAGTCACACCTCATCCTGTCTAGCCGCTCCCAGGTTCCCATCATCTTGC
AGTGGAATAAAAGTTCCAAGAAGTTTGTCCCTCATGGCGACATCCCCAACATGGAGGATGTGCT
GGCTGTGAAGAGCTTCCGAATGCAGAACACCCTGTACCTTTCCCTCACGCGGTTCATCGGGGAC
TCTCGGGTCATGCGGTGGAACAGTAAGCAGTTCGTGGAGGTCCAGGCTCTTCCGTCCCGGGGGG
CCATGACCTTGCAACCCTTCTCCTTCAAAGAGAACCACTACCTGGCCCTGGGGAGTGACTACAC
GTTCTCACAGATATACCAGTGGGATAAAGAGAAACAGCAGTTTAAAAAGTTTAAAGAAATCTAT
GTGCAGGCGCCCCGCTCCTTCACAGCTGTCTCCACCGACAGGAGAGATTTCTTTTTTGCGTCCA
GTTTCAAAGGGAAGACAAAGATTTTTGAACATATCATTGTTGATTTAAGTTTGTGAAGGTGTAA
TCGGAGGGATTTCAAAGACGCATAGTGTTAGCTCTCACAAGAGAGGCAGGACCAAGAAGAAATA
AAAATAATAATAATAAAAAAATCATAAAATAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100689	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68885	(Get FASTA)	NCBI Sequence Viewer
	EDL99888	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000094580
	ENSRNOP00000094580.1
	ENSRNOP00000110971.1

RefSeq Acc Id:	NP_001100689 ⟸ NM_001107219
- Peptide Label:	precursor
- UniProtKB:	B5DF14 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALRRGGGALGLLLLSAACLIPPSAQVRRLARCPATCSCTKESIICVGSSWVPRIVPGDISSLS LVNGTFLEIKDRMFSHLPSLQLLLLNSNSFTVIRDDAFAGLFHLEYLFIEGNKIETISRNAFRG LRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTVSDVLCI GPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKNDVYVAIAQPSMENCMVLEW DHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKYDESWTKFVKFQDIEVSRI SKPNDIELFEIDDETFFIIADSSKAGLSTVYKWSSKGFYSYQSLHEWFRDTDAEFVDIDGKSHL ILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRWNSK QFVEVQALPSRGAMTLQPFSFKENHYLALGSDYTFSQIYQWDKEKQQFKKFKEIYVQAPRSFTA VSTDRRDFFFASSFKGKTKIFEHIIVDLSL hide sequence

Ensembl Acc Id:

ENSRNOP00000005168 ⟸ ENSRNOT00000005168

Ensembl Acc Id:

ENSRNOP00000094580 ⟸ ENSRNOT00000097229

Ensembl Acc Id:

ENSRNOP00000110971 ⟸ ENSRNOT00000130670

Protein Domains

LRRCT

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F7ESR8-F1-model_v2	AlphaFold	F7ESR8	1-466	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699336

Promoter ID:

EPDNEW_R9860

Type:

single initiation site

Name:

Lgi2_1

Description:

leucine-rich repeat LGI family, member 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	60,764,492 - 60,764,552	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310391	AgrOrtholog
BioCyc Gene	G2FUF-15593	BioCyc
Ensembl Genes	ENSRNOG00000003887	Ensembl
	ENSRNOG00000066201	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000097229	ENTREZGENE
	ENSRNOT00000097229.2	UniProtKB/TrEMBL
	ENSRNOT00000130670.1	UniProtKB/TrEMBL
Gene3D-CATH	3.80.10.10	UniProtKB/TrEMBL
InterPro	Cys-rich_flank_reg_C	UniProtKB/TrEMBL
	EAR	UniProtKB/TrEMBL
	EPTP	UniProtKB/TrEMBL
	L_dom-like	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	LGI_related	UniProtKB/TrEMBL
KEGG Report	rno:305417	UniProtKB/TrEMBL
NCBI Gene	305417	ENTREZGENE
PANTHER	LEUCINE-RICH REPEAT LGI FAMILY MEMBER 2	UniProtKB/TrEMBL
	LEUCINE-RICH REPEAT-CONTAINING PROTEIN	UniProtKB/TrEMBL
Pfam	EPTP	UniProtKB/TrEMBL
	LRR_8	UniProtKB/TrEMBL
PhenoGen	Lgi2	PhenoGen
PROSITE	EAR	UniProtKB/TrEMBL
	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003887	RatGTEx
	ENSRNOG00000066201	RatGTEx
SMART	LRR_TYP	UniProtKB/TrEMBL
	LRRCT	UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/TrEMBL
	Putative isomerase YbhE	UniProtKB/TrEMBL
UniProt	A0ABK0M6N5_RAT	UniProtKB/TrEMBL
	B5DF14	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Lgi2	leucine-rich repeat LGI family, member 2	Lgi2_predicted	leucine-rich repeat LGI family, member 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Lgi2_predicted	leucine-rich repeat LGI family, member 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIA