Cip2a (cellular inhibitor of PP2A) - Rat Genome Database

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Gene: Cip2a (cellular inhibitor of PP2A) Rattus norvegicus
Analyze
Symbol: Cip2a
Name: cellular inhibitor of PP2A
RGD ID: 1310335
Description: Predicted to enable protein homodimerization activity and protein phosphatase inhibitor activity. Predicted to be involved in broken chromosome clustering. Predicted to act upstream of or within positive regulation of neuroblast proliferation and spermatogenesis. Predicted to be active in chromosome. Orthologous to human CIP2A (cellular inhibitor of PP2A); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell proliferation regulating inhibitor of protein phosphatase 2A; LOC360711; RGD1310335; similar to RIKEN cDNA C330027C09
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,255,123 - 65,285,914 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1165,255,123 - 65,285,914 (-)EnsemblGRCr8
mRatBN7.21151,792,143 - 51,823,016 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,795,024 - 51,822,938 (-)EnsemblmRatBN7.2
Rnor_6.01154,373,794 - 54,404,704 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,377,374 - 54,404,612 (-)Ensemblrn6Rnor6.0
Rnor_5.01157,535,086 - 57,565,999 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41153,036,752 - 53,065,176 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1151,399,119 - 51,429,954 (-)NCBICelera
RGSC_v3.11153,094,980 - 53,123,481 (-)NCBI
Cytogenetic Map11q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20447748   PMID:22461891   PMID:25468996   PMID:28174209  


Genomics

Comparative Map Data
Cip2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,255,123 - 65,285,914 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1165,255,123 - 65,285,914 (-)EnsemblGRCr8
mRatBN7.21151,792,143 - 51,823,016 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,795,024 - 51,822,938 (-)EnsemblmRatBN7.2
Rnor_6.01154,373,794 - 54,404,704 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,377,374 - 54,404,612 (-)Ensemblrn6Rnor6.0
Rnor_5.01157,535,086 - 57,565,999 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41153,036,752 - 53,065,176 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1151,399,119 - 51,429,954 (-)NCBICelera
RGSC_v3.11153,094,980 - 53,123,481 (-)NCBI
Cytogenetic Map11q21NCBI
CIP2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383108,549,864 - 108,589,438 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3108,549,864 - 108,589,644 (-)Ensemblhg38GRCh38
GRCh373108,268,711 - 108,308,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363109,752,094 - 109,790,980 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343109,752,094 - 109,790,980NCBI
Celera3106,665,331 - 106,705,415 (-)NCBICelera
Cytogenetic Map3q13.13NCBI
HuRef3105,641,938 - 105,682,017 (-)NCBIHuRef
CHM1_13108,232,834 - 108,272,603 (-)NCBICHM1_1
T2T-CHM13v2.03111,258,902 - 111,309,711 (-)NCBIT2T-CHM13v2.0
Cip2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391648,814,524 - 48,840,079 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1648,814,548 - 48,840,072 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381648,994,157 - 49,019,716 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1648,994,185 - 49,019,709 (+)Ensemblmm10GRCm38
MGSCv371648,994,301 - 49,019,818 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361648,913,814 - 48,939,328 (+)NCBIMGSCv36mm8
Celera1649,344,570 - 49,370,085 (+)NCBICelera
Cytogenetic Map16B5NCBI
cM Map1630.75NCBI
Cip2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554279,448,102 - 9,480,729 (-)Ensembl
ChiLan1.0NW_0049554279,448,102 - 9,480,729 (-)NCBIChiLan1.0ChiLan1.0
CIP2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22106,510,500 - 106,565,273 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13106,519,913 - 106,570,052 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03105,668,385 - 105,714,487 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13112,606,927 - 112,646,345 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3112,606,933 - 112,646,345 (-)EnsemblpanPan2panpan1.1
CIP2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13313,807,985 - 13,843,296 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3313,808,738 - 13,843,195 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3313,914,424 - 13,949,183 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03313,974,460 - 14,009,049 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3313,974,469 - 14,008,815 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13313,843,821 - 13,878,326 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03313,909,984 - 13,944,741 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03314,322,610 - 14,357,176 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cip2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602140,583,645 - 140,621,079 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366452,224,587 - 2,261,881 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366452,224,034 - 2,261,970 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIP2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13150,934,106 - 150,966,424 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113150,934,065 - 150,966,326 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CIP2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12272,192,788 - 72,234,020 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2272,193,060 - 72,231,673 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604194,238,791 - 94,281,856 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cip2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473140,541,869 - 40,572,565 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cip2a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1433,492,499 - 33,520,007 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cip2a
254 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:85
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000033837
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 165 91 90 59 89 59 6 349 188 11 144 78 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000033837   ⟹   ENSRNOP00000031394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1165,255,123 - 65,285,914 (-)Ensembl
mRatBN7.2 Ensembl1151,795,024 - 51,822,938 (-)Ensembl
Rnor_6.0 Ensembl1154,377,374 - 54,404,612 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101749   ⟹   ENSRNOP00000084633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1165,255,123 - 65,285,914 (-)Ensembl
mRatBN7.2 Ensembl1151,795,024 - 51,822,938 (-)Ensembl
RefSeq Acc Id: NM_001427687   ⟹   NP_001414616
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,255,123 - 65,285,914 (-)NCBI
RefSeq Acc Id: XM_039088875   ⟹   XP_038944803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,258,005 - 65,278,332 (-)NCBI
mRatBN7.21151,792,143 - 51,815,342 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414616 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944803 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11105 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031394
  ENSRNOP00000031394.4
  ENSRNOP00000084633.1
Ensembl Acc Id: ENSRNOP00000031394   ⟸   ENSRNOT00000033837
RefSeq Acc Id: XP_038944803   ⟸   XM_039088875
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000084633   ⟸   ENSRNOT00000101749
RefSeq Acc Id: NP_001414616   ⟸   NM_001427687
- UniProtKB: D3ZF50 (UniProtKB/TrEMBL),   A0A8I5ZXN3 (UniProtKB/TrEMBL)
Protein Domains
CIP2A N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZF50-F1-model_v2 AlphaFold D3ZF50 1-909 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698127
Promoter ID:EPDNEW_R8649
Type:multiple initiation site
Name:Cip2a_1
Description:cell proliferation regulating inhibitor of protein phosphatase2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01154,404,658 - 54,404,718EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310335 AgrOrtholog
BioCyc Gene G2FUF-21425 BioCyc
Ensembl Genes ENSRNOG00000039183 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033837 ENTREZGENE
  ENSRNOT00000033837.6 UniProtKB/TrEMBL
  ENSRNOT00000101749.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  CIP2A UniProtKB/TrEMBL
  CIP2A_N UniProtKB/TrEMBL
NCBI Gene 360711 ENTREZGENE
PANTHER PROTEIN CIP2A UniProtKB/TrEMBL
  PTHR23161 UniProtKB/TrEMBL
Pfam CIP2A_N UniProtKB/TrEMBL
PhenoGen Cip2a PhenoGen
RatGTEx ENSRNOG00000039183 RatGTEx
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A0A8I5ZXN3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZF50 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Cip2a  cellular inhibitor of PP2A  Cip2a  cell proliferation regulating inhibitor of protein phosphatase 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-07-18 Cip2a  cell proliferation regulating inhibitor of protein phosphatase 2A  RGD1310335  similar to RIKEN cDNA C330027C09  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1310335  similar to RIKEN cDNA C330027C09   RGD1310335_predicted  similar to RIKEN cDNA C330027C09 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1310335_predicted  similar to RIKEN cDNA C330027C09 (predicted)  LOC360711_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC360711_predicted  similar to RIKEN cDNA C330027C09 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL