Pcdhb22 (protocadherin beta 22) - Rat Genome Database

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Gene: Pcdhb22 (protocadherin beta 22) Rattus norvegicus
Analyze
Symbol: Pcdhb22
Name: protocadherin beta 22
RGD ID: 1310328
Description: Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to be located in photoreceptor connecting cilium. Predicted to be active in plasma membrane. Orthologous to human PCDHB15 (protocadherin beta 15); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC307486; pcdh-T5; protocadherin beta-15; protocadherin-T5
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81829,497,038 - 29,503,142 (+)NCBIGRCr8
mRatBN7.21829,223,028 - 29,229,132 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1829,223,149 - 29,225,536 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01830,590,864 - 30,595,456 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1830,592,794 - 30,595,181 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01830,298,048 - 30,302,651 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41830,327,386 - 30,330,048 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11830,354,031 - 30,356,418 (+)NCBI
Celera1828,918,568 - 28,921,569 (+)NCBICelera
Cytogenetic Map18p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pcdhb22Ratautosomal dominant intellectual developmental disorder 31  ISOPCDHB15 (Homo sapiens)8554872ClinVar Annotator: match by term: NEURODEVELOPMENTAL DISORDER WITH NEONATAL RESPIRATORY INSUFFICIENCY more ...ClinVarPMID:28492532
Pcdhb22Ratfamilial adenomatous polyposis 1  ISOPCDHB15 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial adenomatous polyposis 1ClinVarPMID:17963004 more ...
Pcdhb22RatHereditary Neoplastic Syndromes  ISOPCDHB15 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromeClinVarPMID:17963004 more ...
Pcdhb22RatNeurodevelopmental Disorders  ISOPCDHB15 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868

1 to 20 of 53 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pcdhb22Rat1,2-dichloroethane decreases expressionISOPcdhb22 (Mus musculus)6480464ethylene dichloride results in decreased expression of PCDHB15 mRNACTDPMID:28960355
Pcdhb22Rat1,2-dimethylhydrazine decreases expressionISOPcdhb22 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of PCDHB15 mRNACTDPMID:22206623
Pcdhb22Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPcdhb22 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PCDHB22 mRNACTDPMID:21570461 and PMID:26377647
Pcdhb22Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PCDHB22 mRNACTDPMID:33387578
Pcdhb22Rat2,4-diaminotoluene decreases expressionISOPcdhb22 (Mus musculus)64804642 and 4-diaminotoluene results in decreased expression of PCDHB22 mRNACTDPMID:20713471
Pcdhb22Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of PCDHB22 mRNACTDPMID:21346803
Pcdhb22Rat4,4'-sulfonyldiphenol increases expressionISOPcdhb22 (Mus musculus)6480464bisphenol S results in increased expression of PCDHB22 mRNACTDPMID:30951980
Pcdhb22Rat4,4'-sulfonyldiphenol affects methylationISOPcdhb22 (Mus musculus)6480464bisphenol S affects the methylation of PCDHB15 geneCTDPMID:31683443
Pcdhb22Ratacrylamide affects expressionEXP 6480464Acrylamide affects the expression of PCDHB22 mRNACTDPMID:28959563
Pcdhb22Rataflatoxin B1 affects expressionISOPCDHB15 (Homo sapiens)6480464Aflatoxin B1 affects the expression of PCDHB15 proteinCTDPMID:20106945
Pcdhb22Rataflatoxin B1 increases methylationISOPCDHB15 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of PCDHB15 exonCTDPMID:30157460
Pcdhb22Rataflatoxin B1 decreases methylationISOPCDHB15 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of PCDHB15 geneCTDPMID:27153756
Pcdhb22Ratbenzo[a]pyrene increases expressionISOPCDHB15 (Homo sapiens)6480464Benzo(a)pyrene results in increased expression of PCDHB15 mRNACTDPMID:22178795
Pcdhb22Ratbenzo[a]pyrene decreases methylationISOPCDHB15 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of PCDHB15 promoterCTDPMID:27901495
Pcdhb22Ratbenzo[a]pyrene affects methylationISOPCDHB15 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of PCDHB15 exonCTDPMID:27901495
Pcdhb22Ratbis(2-ethylhexyl) phthalate multiple interactionsEXP 6480464[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PCDHB15 promoterCTDPMID:23359474
Pcdhb22Ratbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PCDHB15 promoterCTDPMID:23359474
Pcdhb22Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of PCDHB15 mRNACTDPMID:25181051
Pcdhb22Ratbisphenol F increases expressionISOPcdhb22 (Mus musculus)6480464bisphenol F results in increased expression of PCDHB22 mRNACTDPMID:30951980
Pcdhb22RatCGP 52608 multiple interactionsISOPCDHB15 (Homo sapiens)6480464CGP 52608 promotes the reaction [RORA protein binds to PCDHB15 gene]CTDPMID:28238834

1 to 20 of 53 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pcdhb22Ratcell adhesion involved_inIEAInterPro:IPR0208941600115GO_REF:0000002InterProGO_REF:0000002
Pcdhb22Ratcell adhesion involved_inIBAMGI:106671 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pcdhb22Ratcell adhesion involved_inIEAUniProtKB-KW:KW-01301600115GO_REF:0000043UniProtGO_REF:0000043
Pcdhb22Rathomophilic cell adhesion via plasma membrane adhesion molecules involved_inIEAInterPro:IPR0021261600115GO_REF:0000002InterProGO_REF:0000002

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pcdhb22Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Pcdhb22Ratmembrane located_inIEAInterPro:IPR002126 and InterPro:IPR0159191600115GO_REF:0000002InterProGO_REF:0000002
Pcdhb22Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Pcdhb22Ratphotoreceptor connecting cilium located_inISOPcdhb22 (Mus musculus)1624291 PMID:18279309RGDPMID:18279309
Pcdhb22Ratplasma membrane located_inIEAInterPro:IPR0208941600115GO_REF:0000002InterProGO_REF:0000002
Pcdhb22Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Pcdhb22Ratplasma membrane is_active_inIBAMGI:106671 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pcdhb22Ratcalcium ion binding enablesIEAUniRule:UR0004134501600115GO_REF:0000104UniProtGO_REF:0000104
Pcdhb22Ratcalcium ion binding enablesIEAInterPro:IPR002126 and InterPro:IPR0159191600115GO_REF:0000002InterProGO_REF:0000002


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Multiple cadherin superfamily members with unique expression profiles are produced in rat testis. Johnson KJ, etal., Endocrinology 2000 Feb;141(2):675-83.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, etal., Genome Res 2004 Jan;14(1):79-89. Epub 2003 Dec 12.
PMID:15744052   PMID:18279309  



Pcdhb22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81829,497,038 - 29,503,142 (+)NCBIGRCr8
mRatBN7.21829,223,028 - 29,229,132 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1829,223,149 - 29,225,536 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01830,590,864 - 30,595,456 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1830,592,794 - 30,595,181 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01830,298,048 - 30,302,651 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41830,327,386 - 30,330,048 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11830,354,031 - 30,356,418 (+)NCBI
Celera1828,918,568 - 28,921,569 (+)NCBICelera
Cytogenetic Map18p11NCBI
PCDHB15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385141,245,395 - 141,249,365 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5141,245,395 - 141,249,365 (+)EnsemblGRCh38hg38GRCh38
GRCh375140,624,963 - 140,628,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365140,605,331 - 140,607,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 345140,605,330 - 140,607,983NCBI
Celera5136,701,975 - 136,704,630 (+)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5135,770,205 - 135,772,860 (+)NCBIHuRef
CHM1_15140,058,351 - 140,061,006 (+)NCBICHM1_1
T2T-CHM13v2.05141,770,701 - 141,774,671 (+)NCBIT2T-CHM13v2.0
Pcdhb22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391837,651,402 - 37,657,532 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1837,650,924 - 37,657,532 (+)EnsemblGRCm39 Ensembl
GRCm381837,518,353 - 37,521,419 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1837,517,871 - 37,524,479 (+)EnsemblGRCm38mm10GRCm38
MGSCv371837,678,007 - 37,681,073 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361837,644,327 - 37,647,393 (+)NCBIMGSCv36mm8
Celera1838,869,674 - 38,872,740 (+)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1819.51NCBI
LOC100987426
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24136,490,132 - 136,499,118 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15134,629,915 - 134,638,670 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05136,605,233 - 136,611,147 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15142,721,180 - 142,724,785 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5142,721,472 - 142,723,835 (+)Ensemblpanpan1.1panPan2
LOC487178
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1236,251,313 - 36,271,637 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha233,302,959 - 33,323,542 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0236,705,659 - 36,716,774 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl236,705,911 - 36,710,593 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1233,779,722 - 33,800,301 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0234,590,711 - 34,611,298 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0235,398,365 - 35,418,957 (+)NCBIUU_Cfam_GSD_1.0
LOC100514339
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.12142,803,760 - 142,808,886 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22148,873,511 - 148,888,495 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCDHB15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12343,866,100 - 43,877,344 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2343,866,966 - 43,869,329 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603433,979,915 - 33,988,150 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Pcdhb22
14 total Variants

Predicted Target Of
Summary Value
Count of predictions:16
Count of miRNA genes:16
Interacting mature miRNAs:16
Transcripts:ENSRNOT00000027133
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 36 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat

1 to 10 of 36 rows
RH134768  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21829,225,526 - 29,225,738 (+)MAPPERmRatBN7.2
Rnor_6.01830,595,172 - 30,595,383NCBIRnor6.0
Rnor_5.01830,302,367 - 30,302,578UniSTSRnor5.0
RGSC_v3.41830,329,764 - 30,329,975UniSTSRGSC3.4
Celera1828,921,285 - 28,921,496UniSTS
RH 3.4 Map18422.4UniSTS
Cytogenetic Map18p11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 89 88 57 25 57 6 216 97 93 45 59 31



Ensembl Acc Id: ENSRNOT00000027133   ⟹   ENSRNOP00000027133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1829,223,149 - 29,225,536 (+)Ensembl
Rnor_6.0 Ensembl1830,592,794 - 30,595,181 (+)Ensembl
RefSeq Acc Id: NM_001416815   ⟹   NP_001403744
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81829,497,038 - 29,503,142 (+)NCBI
mRatBN7.21829,223,028 - 29,229,132 (+)NCBI
Protein RefSeqs NP_001403744 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF87074 (Get FASTA)   NCBI Sequence Viewer  
  EDL76360 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027133.1
  ENSRNOP00000100796
Ensembl Acc Id: ENSRNOP00000027133   ⟸   ENSRNOT00000027133
RefSeq Acc Id: NP_001403744   ⟸   NM_001416815
- UniProtKB: G3V8N1 (UniProtKB/TrEMBL),   A6J378 (UniProtKB/TrEMBL)
Cadherin

Name Modeler Protein Id AA Range Protein Structure
AF-G3V8N1-F1-model_v2 AlphaFold G3V8N1 1-795 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 25 of 25 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSRNOG00000020028 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027133.3 UniProtKB/TrEMBL
  ENSRNOT00000128127 ENTREZGENE
Gene3D-CATH Cadherins UniProtKB/TrEMBL
InterPro Cadherin UniProtKB/TrEMBL
  Cadherin-like UniProtKB/TrEMBL
  Cadherin_C UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  Cadherin_N UniProtKB/TrEMBL
  Protocadherin/Cadherin-CA UniProtKB/TrEMBL
NCBI Gene 307486 ENTREZGENE
PANTHER CADHERIN-87A UniProtKB/TrEMBL
  PTHR24028:SF97 UniProtKB/TrEMBL
Pfam Cadherin UniProtKB/TrEMBL
  Cadherin_2 UniProtKB/TrEMBL
  Cadherin_C_2 UniProtKB/TrEMBL
PhenoGen Pcdhb22 PhenoGen
PRINTS CADHERIN UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020028 RatGTEx
SMART SM00112 UniProtKB/TrEMBL
Superfamily-SCOP Cadherin UniProtKB/TrEMBL
UniProt A6J378 ENTREZGENE, UniProtKB/TrEMBL
  G3V8N1 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Pcdhb22  protocadherin beta 22  Pcdhb22_predicted  protocadherin beta 22 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Pcdhb22_predicted  protocadherin beta 22 (predicted)      Symbol and Name status set to approved 70820 APPROVED