Isg15 (ISG15 ubiquitin-like modifier) - Rat Genome Database

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Gene: Isg15 (ISG15 ubiquitin-like modifier) Rattus norvegicus
Analyze
Symbol: Isg15
Name: ISG15 ubiquitin-like modifier
RGD ID: 1310312
Description: Predicted to enable integrin binding activity; protein tag activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including ISG15-protein conjugation; integrin-mediated signaling pathway; and positive regulation of cytokine production. Predicted to act upstream of or within response to bacterium. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 38. Orthologous to human ISG15 (ISG15 ubiquitin like modifier); PARTICIPATES IN Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G1p2; interferon, alpha-inducible protein (clone IFI-15K); LOC298693; ubiquitin-like protein ISG15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85172,066,369 - 172,067,656 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5172,066,369 - 172,067,656 (-)EnsemblGRCr8
mRatBN7.25166,784,148 - 166,785,435 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,784,148 - 166,785,435 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5169,486,258 - 169,487,543 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05171,307,649 - 171,308,934 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05171,270,210 - 171,271,495 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,624,862 - 173,629,124 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,624,310 - 173,626,248 (-)Ensemblrn6Rnor6.0
Rnor_5.05177,098,640 - 177,102,838 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45173,034,479 - 173,035,766 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5164,983,801 - 164,985,088 (-)NCBICelera
RGSC_v3.15173,031,293 - 173,045,496 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
Actein  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bromuconazole  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chlorophyllin  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethyl malate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fentanyl  (EXP)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
furfural  (ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 4064  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
lipoteichoic acid  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metam  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nicotine  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
prednisolone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP,ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
XL147  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin. Chu Q, etal., Clin Experiment Ophthalmol. 2011 Mar;39(2):142-51. doi: 10.1111/j.1442-9071.2010.02437.x.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients. Murakawa M, etal., J Med Virol. 2017 Jul;89(7):1241-1247. doi: 10.1002/jmv.24763. Epub 2017 Feb 27.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15485925   PMID:16122702   PMID:16139798   PMID:17227866   PMID:18305167   PMID:19357168   PMID:21402791   PMID:21543490   PMID:22022510   PMID:22859821   PMID:23012479   PMID:29100055  
PMID:30826466   PMID:31505169  


Genomics

Comparative Map Data
Isg15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85172,066,369 - 172,067,656 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5172,066,369 - 172,067,656 (-)EnsemblGRCr8
mRatBN7.25166,784,148 - 166,785,435 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,784,148 - 166,785,435 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5169,486,258 - 169,487,543 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05171,307,649 - 171,308,934 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05171,270,210 - 171,271,495 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,624,862 - 173,629,124 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,624,310 - 173,626,248 (-)Ensemblrn6Rnor6.0
Rnor_5.05177,098,640 - 177,102,838 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45173,034,479 - 173,035,766 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5164,983,801 - 164,985,088 (-)NCBICelera
RGSC_v3.15173,031,293 - 173,045,496 (-)NCBI
Cytogenetic Map5q36NCBI
ISG15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811,013,497 - 1,014,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11,001,138 - 1,014,540 (+)Ensemblhg38GRCh38
GRCh371948,877 - 949,920 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361938,742 - 939,782 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341988,945 - 989,986NCBI
Celera11,639,488 - 1,640,561 (-)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1220,321 - 221,394 (+)NCBIHuRef
CHM1_11935,863 - 936,936 (+)NCBICHM1_1
T2T-CHM13v2.01443,628 - 444,671 (+)NCBIT2T-CHM13v2.0
Isg15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394156,283,881 - 156,285,275 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4156,283,912 - 156,285,253 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384156,199,424 - 156,200,818 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4156,199,455 - 156,200,796 (-)Ensemblmm10GRCm38
MGSCv374155,573,533 - 155,574,927 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364155,573,561 - 155,574,905 (-)NCBIMGSCv36mm8
Celera17158,455,903 - 158,457,244 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map488.61NCBI
Isg15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554869,706,703 - 9,707,949 (-)Ensembl
ChiLan1.0NW_0049554869,706,878 - 9,707,876 (-)NCBIChiLan1.0ChiLan1.0
ISG15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21227,238,490 - 227,239,793 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11225,934,379 - 225,935,499 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1927,418 - 928,491 (+)EnsemblpanPan2panpan1.1
ISG15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,230,879 - 56,237,354 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,236,318 - 56,404,695 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha556,314,175 - 56,315,328 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0556,439,681 - 56,440,834 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,439,798 - 56,607,588 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,430,725 - 56,431,878 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,322,629 - 56,323,782 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0556,712,681 - 56,713,834 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Isg15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,421,189 - 27,422,563 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367372,043,383 - 2,044,761 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISG15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,363,173 - 63,364,208 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1663,363,201 - 63,364,211 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ISG15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120130,419,909 - 130,421,409 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20130,419,782 - 130,421,380 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605435,047,518 - 35,049,231 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Isg15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248188,510,657 - 8,511,749 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Isg15
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v114,467,767 - 4,469,156 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:33
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000039263
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat

Markers in Region
RH135070  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,784,161 - 166,784,343 (+)MAPPERmRatBN7.2
Rnor_6.05173,624,916 - 173,625,097NCBIRnor6.0
Rnor_5.05177,098,694 - 177,098,875UniSTSRnor5.0
RGSC_v3.45173,034,493 - 173,034,674UniSTSRGSC3.4
Celera5164,983,815 - 164,983,996UniSTS
RH 3.4 Map51171.5UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 91 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000039263   ⟹   ENSRNOP00000035405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5173,624,310 - 173,626,248 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096620   ⟹   ENSRNOP00000090709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5172,066,369 - 172,067,656 (-)Ensembl
mRatBN7.2 Ensembl5166,784,148 - 166,785,435 (-)Ensembl
RefSeq Acc Id: NM_001106700   ⟹   NP_001100170
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85172,066,369 - 172,067,656 (-)NCBI
mRatBN7.25166,784,148 - 166,785,435 (-)NCBI
Rnor_6.05173,624,902 - 173,626,189 (-)NCBI
Rnor_5.05177,098,640 - 177,102,838 (-)NCBI
RGSC_v3.45173,034,479 - 173,035,766 (-)RGD
Celera5164,983,801 - 164,985,088 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100170 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81366 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000090709
  ENSRNOP00000090709.1
RefSeq Acc Id: NP_001100170   ⟸   NM_001106700
- UniProtKB: D4A3X3 (UniProtKB/TrEMBL),   A6IUW5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035405   ⟸   ENSRNOT00000039263
Ensembl Acc Id: ENSRNOP00000090709   ⟸   ENSRNOT00000096620
Protein Domains
Ubiquitin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A3X3-F1-model_v2 AlphaFold D4A3X3 1-161 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694345
Promoter ID:EPDNEW_R4869
Type:multiple initiation site
Name:Isg15_1
Description:ISG15 ubiquitin-like modifier
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05173,626,140 - 173,626,200EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310312 AgrOrtholog
BioCyc Gene G2FUF-38859 BioCyc
Ensembl Genes ENSRNOG00000021802 Ensembl
  ENSRNOG00000069527 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000096620 ENTREZGENE
  ENSRNOT00000096620.2 UniProtKB/TrEMBL
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
InterPro Ubiquilin UniProtKB/TrEMBL
  Ubiquitin UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:298693 UniProtKB/TrEMBL
NCBI Gene 298693 ENTREZGENE
PANTHER FI07626P-RELATED UniProtKB/TrEMBL
  UBIQUILIN UniProtKB/TrEMBL
Pfam ubiquitin UniProtKB/TrEMBL
PhenoGen Isg15 PhenoGen
PROSITE UBIQUITIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021802 RatGTEx
  ENSRNOG00000069527 RatGTEx
SMART UBQ UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
UniProt A6IUW5 ENTREZGENE, UniProtKB/TrEMBL
  D4A3X3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-20 Isg15  ISG15 ubiquitin-like modifier  G1p2  interferon, alpha-inducible protein (clone IFI-15K)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 G1p2  interferon, alpha-inducible protein (clone IFI-15K)   G1p2_predicted  interferon, alpha-inducible protein (clone IFI-15K) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 G1p2_predicted  interferon, alpha-inducible protein (clone IFI-15K) (predicted)      Symbol and Name status set to approved 70820 APPROVED