Tfap2a (transcription factor AP-2 alpha) - Rat Genome Database

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Gene: Tfap2a (transcription factor AP-2 alpha) Rattus norvegicus
Analyze
Symbol: Tfap2a
Name: transcription factor AP-2 alpha
RGD ID: 1310267
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and transcription coregulator activity. Involved in Schwann cell development; positive regulation of transcription by RNA polymerase II; and response to lipopolysaccharide. Predicted to be located in clathrin-coated pit. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in branchiooculofacial syndrome. Orthologous to human TFAP2A (transcription factor AP-2 alpha); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activating enhancer-binding protein 2 alpha; activating enhancer-binding protein 2-alpha; activator protein 2; AP-2 transcription factor; AP2-alpha; LOC306862; Tcfap2a; transcription factor AP-2, alpha; transcription factor AP-2-alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81724,230,064 - 24,253,219 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1724,229,910 - 24,253,219 (+)EnsemblGRCr8
mRatBN7.21724,028,716 - 24,047,507 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1724,024,432 - 24,047,507 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1723,913,439 - 23,929,006 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01725,516,916 - 25,532,497 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01723,854,421 - 23,869,994 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01724,653,342 - 24,670,457 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1724,654,902 - 24,670,457 (+)Ensemblrn6Rnor6.0
Rnor_5.01726,596,839 - 26,634,214 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41730,017,580 - 30,034,852 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1723,700,225 - 23,715,767 (+)NCBICelera
RGSC_v3.11730,020,346 - 30,035,192 (+)NCBI
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Arg-Gly-Asp  (ISO)
arotinoid acid  (ISO)
arsenite(3-)  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carboplatin  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clomiphene  (ISO)
cortisol  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenpropidin  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
hexestrol  (ISO)
ifosfamide  (ISO)
imidacloprid  (ISO)
indinavir  (ISO)
kahweol  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
mercury dibromide  (ISO)
mestranol  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mitomycin C  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
nickel subsulfide  (ISO)
Octicizer  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
paroxetine  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sertraline  (ISO)
sodium arsenite  (ISO)
spiroxamine  (ISO)
stavudine  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
XAV939  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior neuropore closure  (ISO)
basement membrane organization  (ISO)
bone morphogenesis  (ISO,ISS)
cellular response to iron ion  (ISO,ISS)
cornea development in camera-type eye  (ISO)
embryonic body morphogenesis  (ISO)
embryonic camera-type eye morphogenesis  (ISO)
embryonic cranial skeleton morphogenesis  (ISO,ISS)
embryonic forelimb morphogenesis  (ISO,ISS)
embryonic pattern specification  (ISO)
epidermis morphogenesis  (ISO)
eyelid development in camera-type eye  (ISO,ISS)
face morphogenesis  (ISO)
forebrain neuron development  (ISO)
forelimb morphogenesis  (ISO)
inner ear morphogenesis  (ISO,ISS)
keratinocyte development  (ISO)
kidney development  (IBA,ISO,ISS)
lens induction in camera-type eye  (ISO)
lens morphogenesis in camera-type eye  (ISO)
metanephric nephron development  (ISO)
negative regulation of apoptotic process  (IBA,ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epidermal growth factor receptor signaling pathway  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO,ISS)
negative regulation of transcription by competitive promoter binding  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
nervous system development  (IBA,ISO)
neural crest cell development  (ISO)
neural tube closure  (ISO)
oculomotor nerve formation  (ISO,ISS)
optic cup structural organization  (ISO,ISS)
optic vesicle morphogenesis  (ISO,ISS)
outflow tract morphogenesis  (ISO)
positive regulation of bone mineralization  (ISO,ISS)
positive regulation of cell migration  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of gene expression  (ISO,ISS)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of tooth mineralization  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IBA,IEA,IMP,ISO,ISS)
regulation of cell differentiation  (ISO)
regulation of cell population proliferation  (IBA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of neuron differentiation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to lipopolysaccharide  (IDA)
retina layer formation  (ISO)
roof of mouth development  (ISO,ISS)
Schwann cell development  (IEP)
sensory organ development  (ISO)
sensory perception of sound  (ISO,ISS)
skeletal system development  (IBA)
skeletal system morphogenesis  (ISO)
skin development  (ISO)
sympathetic nervous system development  (ISO)
trigeminal nerve development  (ISO,ISS)

Cellular Component
clathrin-coated pit  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. Braganca J, etal., J Biol Chem. 2003 May 2;278(18):16021-9. Epub 2003 Feb 12.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Effect of cysteamine on redox-sensitive thiol-containing proteins in the duodenal mucosa. Khomenko T, etal., Biochem Biophys Res Commun. 2003 Oct 3;309(4):910-6.
5. Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53. McPherson LA, etal., J Biol Chem. 2002 Nov 22;277(47):45028-33. Epub 2002 Sep 10.
6. Sustained increases in activating transcription factor-2 and activator protein-2 in the rat supraoptic nucleus during water deprivation. Meeker RB and Fernandes A, Neuroendocrinology. 2002 Aug;76(2):111-20.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes. Muller FU, etal., Cell Death Differ. 2004 May;11(5):485-93.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Chronic administration of carbamazepine down-regulates AP-2 DNA-binding activity and AP-2alpha protein expression in rat frontal cortex. Rao JS, etal., Biol Psychiatry. 2007 Jan 15;61(2):154-61. Epub 2006 Jun 27.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. The NECAP PHear domain increases clathrin accessory protein binding potential. Ritter B, etal., EMBO J. 2007 Sep 19;26(18):4066-77. Epub 2007 Aug 30.
15. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
16. Developmental regulation and overexpression of the transcription factor AP-2, a potential regulator of the timing of Schwann cell generation. Stewart HJ, etal., Eur J Neurosci. 2001 Jul;14(2):363-72.
17. PACAP-regulated phenylethanolamine N-methyltransferase gene expression. Tai TC, etal., J Neurochem. 2010 Dec;115(5):1195-205. doi: 10.1111/j.1471-4159.2010.07005.x. Epub 2010 Oct 12.
18. Lipopolysaccharide regulates constitutive and inducible transcription factor activities differentially in vivo in the rat. Ye X and Liu SF, Biochem Biophys Res Commun. 2001 Nov 9;288(4):927-32.
Additional References at PubMed
PMID:1998122   PMID:7555706   PMID:7559606   PMID:8321221   PMID:8622765   PMID:8622766   PMID:9520389   PMID:9811866   PMID:9858544   PMID:9918694   PMID:10068641   PMID:10571739  
PMID:10803593   PMID:10842061   PMID:10847586   PMID:11205881   PMID:11278550   PMID:11522791   PMID:11694877   PMID:11744375   PMID:12072434   PMID:15013802   PMID:15475956   PMID:16186342  
PMID:16236267   PMID:16449191   PMID:17670746   PMID:17984226   PMID:18224708   PMID:18718911   PMID:18723448   PMID:18824566   PMID:19115315   PMID:19463168   PMID:19578371   PMID:19750005  
PMID:19943855   PMID:20066163   PMID:20150232   PMID:20351096   PMID:20448150   PMID:20607706   PMID:20808827   PMID:21084835   PMID:21204207   PMID:21539825   PMID:21829553   PMID:22306374  
PMID:23393395   PMID:26437238   PMID:27053364   PMID:33264079  


Genomics

Comparative Map Data
Tfap2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81724,230,064 - 24,253,219 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1724,229,910 - 24,253,219 (+)EnsemblGRCr8
mRatBN7.21724,028,716 - 24,047,507 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1724,024,432 - 24,047,507 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1723,913,439 - 23,929,006 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01725,516,916 - 25,532,497 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01723,854,421 - 23,869,994 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01724,653,342 - 24,670,457 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1724,654,902 - 24,670,457 (+)Ensemblrn6Rnor6.0
Rnor_5.01726,596,839 - 26,634,214 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41730,017,580 - 30,034,852 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1723,700,225 - 23,715,767 (+)NCBICelera
RGSC_v3.11730,020,346 - 30,035,192 (+)NCBI
Cytogenetic Map17p12NCBI
TFAP2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38610,396,677 - 10,419,659 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl610,393,186 - 10,419,659 (-)Ensemblhg38GRCh38
GRCh37610,396,910 - 10,419,892 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36610,504,902 - 10,527,783 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34610,506,384 - 10,523,252NCBI
Celera611,625,394 - 11,648,276 (-)NCBICelera
Cytogenetic Map6p24.3NCBI
HuRef610,272,671 - 10,295,552 (-)NCBIHuRef
CHM1_1610,399,160 - 10,422,046 (-)NCBICHM1_1
T2T-CHM13v2.0610,264,407 - 10,287,386 (-)NCBIT2T-CHM13v2.0
Tfap2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391340,867,278 - 40,891,715 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1340,868,778 - 40,891,852 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381340,713,802 - 40,738,238 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1340,715,302 - 40,738,376 (-)Ensemblmm10GRCm38
MGSCv371340,811,044 - 40,829,192 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361340,727,706 - 40,745,894 (-)NCBIMGSCv36mm8
Celera1341,797,334 - 41,815,714 (-)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1320.01NCBI
Tfap2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554653,882,549 - 3,898,929 (+)Ensembl
ChiLan1.0NW_0049554653,877,896 - 3,900,259 (+)NCBIChiLan1.0ChiLan1.0
TFAP2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2525,046,932 - 25,064,748 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1621,036,711 - 21,053,926 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0610,237,834 - 10,260,843 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1610,519,625 - 10,541,898 (-)NCBIPanPan1.1PanPan1.1panPan2
TFAP2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13510,157,043 - 10,180,484 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3510,157,882 - 10,180,270 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3510,170,458 - 10,197,631 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03510,260,835 - 10,284,005 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3510,261,674 - 10,283,869 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13510,091,163 - 10,114,276 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03510,131,471 - 10,154,557 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03511,458,363 - 11,481,509 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tfap2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494614,212,794 - 14,243,177 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365342,481,806 - 2,499,317 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365342,481,804 - 2,518,573 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TFAP2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl77,221,656 - 7,244,612 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.177,221,654 - 7,244,626 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.277,534,956 - 7,556,586 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TFAP2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11761,750,757 - 61,769,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604410,406,413 - 10,425,011 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tfap2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475615,418,260 - 15,436,379 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475615,413,950 - 15,436,037 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tfap2a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11459,703,253 - 59,721,386 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tfap2a
209 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:359
Count of miRNA genes:194
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000041960
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171553702528637951Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat

Markers in Region
TFAP2A  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21724,031,723 - 24,032,003 (+)MAPPERmRatBN7.2
Rnor_6.01724,654,659 - 24,654,938NCBIRnor6.0
Rnor_5.01726,596,596 - 26,596,875UniSTSRnor5.0
RGSC_v3.41730,017,337 - 30,017,616UniSTSRGSC3.4
Celera1723,699,982 - 23,700,261UniSTS
Cytogenetic Map17p12UniSTS
AI013304  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81724,252,242 - 24,252,359 (+)Marker Load Pipeline
mRatBN7.21724,046,528 - 24,046,645 (+)MAPPERmRatBN7.2
Rnor_6.01724,669,462 - 24,669,578NCBIRnor6.0
Rnor_5.01726,611,399 - 26,611,515UniSTSRnor5.0
RGSC_v3.41730,032,198 - 30,032,314UniSTSRGSC3.4
Celera1723,714,785 - 23,714,901UniSTS
RH 3.4 Map17280.8UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 1 47 127 34 36 16 8 16 6 180 74 7 117 80 86 20 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000041960   ⟹   ENSRNOP00000040925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1724,237,683 - 24,253,219 (+)Ensembl
mRatBN7.2 Ensembl1724,031,967 - 24,047,507 (+)Ensembl
Rnor_6.0 Ensembl1724,654,902 - 24,670,457 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102035   ⟹   ENSRNOP00000078814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1724,229,950 - 24,253,219 (+)Ensembl
mRatBN7.2 Ensembl1724,024,432 - 24,047,507 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103008   ⟹   ENSRNOP00000082537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1724,229,910 - 24,253,219 (+)Ensembl
mRatBN7.2 Ensembl1724,029,869 - 24,047,507 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105131   ⟹   ENSRNOP00000076636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1724,230,061 - 24,253,219 (+)Ensembl
mRatBN7.2 Ensembl1724,029,746 - 24,047,507 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107954   ⟹   ENSRNOP00000088142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1724,236,489 - 24,253,219 (+)Ensembl
mRatBN7.2 Ensembl1724,030,646 - 24,047,507 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109680   ⟹   ENSRNOP00000081532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1724,234,303 - 24,253,219 (+)Ensembl
mRatBN7.2 Ensembl1724,028,667 - 24,047,507 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110879   ⟹   ENSRNOP00000094618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1724,239,073 - 24,253,219 (+)Ensembl
mRatBN7.2 Ensembl1724,033,357 - 24,047,507 (+)Ensembl
RefSeq Acc Id: NM_001107345   ⟹   NP_001100815
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81724,237,683 - 24,253,219 (+)NCBI
mRatBN7.21724,031,967 - 24,047,507 (+)NCBI
Rnor_6.01724,654,902 - 24,670,457 (+)NCBI
Rnor_5.01726,596,839 - 26,634,214 (+)NCBI
RGSC_v3.41730,017,580 - 30,034,852 (+)RGD
Celera1723,700,225 - 23,715,767 (+)RGD
Sequence:
RefSeq Acc Id: XM_039095687   ⟹   XP_038951615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81724,234,208 - 24,252,850 (+)NCBI
mRatBN7.21724,028,716 - 24,046,727 (+)NCBI
RefSeq Acc Id: XM_063276385   ⟹   XP_063132455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81724,235,744 - 24,252,850 (+)NCBI
RefSeq Acc Id: XM_063276386   ⟹   XP_063132456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81724,230,064 - 24,252,850 (+)NCBI
RefSeq Acc Id: NP_001100815   ⟸   NM_001107345
- UniProtKB: G3V9A8 (UniProtKB/TrEMBL),   A6J784 (UniProtKB/TrEMBL),   A0A8I6AMM5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040925   ⟸   ENSRNOT00000041960
RefSeq Acc Id: XP_038951615   ⟸   XM_039095687
- Peptide Label: isoform X2
- UniProtKB: P58197 (UniProtKB/Swiss-Prot),   A0A8I5ZSF0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094618   ⟸   ENSRNOT00000110879
Ensembl Acc Id: ENSRNOP00000081532   ⟸   ENSRNOT00000109680
Ensembl Acc Id: ENSRNOP00000082537   ⟸   ENSRNOT00000103008
Ensembl Acc Id: ENSRNOP00000088142   ⟸   ENSRNOT00000107954
Ensembl Acc Id: ENSRNOP00000078814   ⟸   ENSRNOT00000102035
Ensembl Acc Id: ENSRNOP00000076636   ⟸   ENSRNOT00000105131
RefSeq Acc Id: XP_063132456   ⟸   XM_063276386
- Peptide Label: isoform X3
- UniProtKB: P58197 (UniProtKB/Swiss-Prot),   A0A8I6G3W2 (UniProtKB/TrEMBL),   A6J782 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132455   ⟸   XM_063276385
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GGS6 (UniProtKB/TrEMBL),   A0A8I6AMM5 (UniProtKB/TrEMBL)
Protein Domains
Transcription factor AP-2 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P58197-F1-model_v2 AlphaFold P58197 1-437 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310267 AgrOrtholog
BioCyc Gene G2FUF-9712 BioCyc
Ensembl Genes ENSRNOG00000015522 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000041960 ENTREZGENE
  ENSRNOT00000102035 ENTREZGENE
  ENSRNOT00000107954 ENTREZGENE
  ENSRNOT00000109680 ENTREZGENE
InterPro TF_AP2 UniProtKB/Swiss-Prot
  TF_AP2_alpha_N UniProtKB/Swiss-Prot
  TF_AP2_C UniProtKB/Swiss-Prot
NCBI Gene 306862 ENTREZGENE
PANTHER PTHR10812 UniProtKB/Swiss-Prot
  TRANSCRIPTION FACTOR AP-2-ALPHA UniProtKB/Swiss-Prot
Pfam TF_AP-2 UniProtKB/Swiss-Prot
PhenoGen Tfap2a PhenoGen
PRINTS AP2ATNSCPFCT UniProtKB/Swiss-Prot
  AP2TNSCPFCT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015522 RatGTEx
UniProt A0A8I5Y4U0_RAT UniProtKB/TrEMBL
  A0A8I5ZSF0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G3W2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G9K6_RAT UniProtKB/TrEMBL
  A0A8I6GGS6 ENTREZGENE, UniProtKB/TrEMBL
  A6J782 ENTREZGENE, UniProtKB/TrEMBL
  A6J784 ENTREZGENE, UniProtKB/TrEMBL
  AP2A_RAT UniProtKB/Swiss-Prot
  G3V9A8 ENTREZGENE, UniProtKB/TrEMBL
  P58197 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-06-09 Tfap2a  transcription factor AP-2 alpha  Tcfap2a  transcription factor AP-2, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tcfap2a  transcription factor AP-2, alpha   Tcfap2a_predicted  transcription factor AP-2, alpha (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tcfap2a_predicted  transcription factor AP-2, alpha (predicted)      Symbol and Name status set to approved 70820 APPROVED