Tfap2a (transcription factor AP-2 alpha) - Rat Genome Database

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Gene: Tfap2a (transcription factor AP-2 alpha) Rattus norvegicus
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Symbol: Tfap2a
Name: transcription factor AP-2 alpha
RGD ID: 1310267
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and transcription coregulator activity. Involved in Schwann cell development; positive regulation of transcription by RNA polymerase II; and response to lipopolysaccharide. Predicted to be located in clathrin-coated pit and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in branchiooculofacial syndrome. Orthologous to human TFAP2A (transcription factor AP-2 alpha); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activating enhancer-binding protein 2 alpha; activating enhancer-binding protein 2-alpha; activator protein 2; AP-2 transcription factor; AP2-alpha; LOC306862; Tcfap2a; transcription factor AP-2, alpha; transcription factor AP-2-alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81724,230,064 - 24,253,219 (+)NCBIGRCr8
mRatBN7.21724,028,716 - 24,047,507 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1724,024,432 - 24,047,507 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1723,913,439 - 23,929,006 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01725,516,916 - 25,532,497 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01723,854,421 - 23,869,994 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01724,653,342 - 24,670,457 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1724,654,902 - 24,670,457 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01726,596,839 - 26,634,214 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41730,017,580 - 30,034,852 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11730,020,346 - 30,035,192 (+)NCBI
Celera1723,700,225 - 23,715,767 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Tfap2aRatdilated cardiomyopathy  ISOTFAP2A (Homo sapiens)1578494protein:increased expression:myocardiumRGD 
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Tfap2aRatamblyopia  ISOTFAP2A (Homo sapiens)8554872ClinVar Annotator: match by term: AmblyopiaClinVarPMID:25741868
Tfap2aRatbranchiooculofacial syndrome  ISOTFAP2A (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10767004 more ...
Tfap2aRatbranchiootorenal syndrome  ISOTFAP2A (Homo sapiens)8554872ClinVar Annotator: match by term: Melnick-Fraser syndromeClinVarPMID:30311386
Tfap2aRatcataract 13 with adult i phenotype  ISOTFAP2A (Homo sapiens)8554872ClinVar Annotator: match by term: Cataract 13 with adult I phenotypeClinVarPMID:28492532
Tfap2aRatesotropia  ISOTFAP2A (Homo sapiens)8554872ClinVar Annotator: match by term: EsotropiaClinVarPMID:25741868
Tfap2aRatgenetic disease  ISOTFAP2A (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:18423521 more ...
Tfap2aRatHypertelorism  ISOTFAP2A (Homo sapiens)8554872ClinVar Annotator: match by term: HypertelorismClinVarPMID:25741868
Tfap2aRatIRIS COLOBOMA  ISOTFAP2A (Homo sapiens)8554872ClinVar Annotator: match by term: Iris colobomaClinVarPMID:25741868
Tfap2aRatlens subluxation  ISOTFAP2A (Homo sapiens)8554872ClinVar Annotator: match by term: Lens subluxationClinVarPMID:25741868
Tfap2aRatmicrophthalmia  ISOTFAP2A (Homo sapiens)8554872ClinVar Annotator: match by term: MicrophthalmosClinVarPMID:25741868
Tfap2aRatNeurodevelopmental Disorders  ISOTFAP2A (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental abnormalityClinVar 
Tfap2aRatpathologic nystagmus  ISOTFAP2A (Homo sapiens)8554872ClinVar Annotator: match by term: NystagmusClinVarPMID:25741868
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Original Reference(s)
Tfap2aRatbranchiootorenal syndrome  ISOTFAP2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19685247
Tfap2aRatBreast Neoplasms  ISOTFAP2A (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:16204029
Tfap2aRatCraniofacial Abnormalities  ISOTFAP2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14534133 and PMID:19685247
Tfap2aRatEye Abnormalities  ISOTFAP2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19685247
Tfap2aRatkidney disease  ISOTFAP2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19685247
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Tfap2aRatorofacial cleft  ISSTfap2a (Mus musculus)13592920OMIM:119530 more ...MouseDO 
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Original Reference(s)
Tfap2aRatbranchiooculofacial syndrome  ISOTFAP2A (Homo sapiens)7240710 OMIM 

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Tfap2aRat(-)-demecolcine decreases expressionISOTFAP2A (Homo sapiens)6480464Demecolcine results in decreased expression of TFAP2A mRNACTDPMID:23649840
Tfap2aRat1,2-dimethylhydrazine increases expressionISOTfap2a (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of TFAP2A mRNACTDPMID:22206623
Tfap2aRat14-Deoxy-11,12-didehydroandrographolide increases expressionISOTFAP2A (Homo sapiens)648046414-deoxy-11 and 12-didehydroandrographolide results in increased expression of TFAP2A mRNACTDPMID:22101062
Tfap2aRat15-acetyldeoxynivalenol increases expressionISOTFAP2A (Homo sapiens)648046415-acetyldeoxynivalenol results in increased expression of TFAP2A mRNACTDPMID:23792671
Tfap2aRat17beta-estradiol decreases expressionISOTFAP2A (Homo sapiens)6480464Estradiol results in decreased expression of TFAP2A mRNACTDPMID:26865669 and PMID:28711546
Tfap2aRat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOTFAP2A (Homo sapiens)64804642 more ...CTDPMID:31326446
Tfap2aRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTfap2a (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TFAP2A mRNACTDPMID:21570461 and PMID:24058054
Tfap2aRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of TFAP2A mRNACTDPMID:33387578
Tfap2aRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOTFAP2A (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of TFAP2A mRNACTDPMID:19901195 more ...
Tfap2aRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOTfap2a (Mus musculus)6480464TFAP2A mRNA affects the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]CTDPMID:16085934
Tfap2aRat3,3',5,5'-tetrabromobisphenol A increases expressionISOTFAP2A (Homo sapiens)6480464tetrabromobisphenol A results in increased expression of TFAP2A mRNACTDPMID:31326446
Tfap2aRat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOTfap2a (Mus musculus)6480464[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of TFAP2A mRNA and Acrylamide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of TFAP2A mRNA]CTDPMID:30409764
Tfap2aRat4,4'-sulfonyldiphenol decreases expressionISOTfap2a (Mus musculus)6480464bisphenol S results in decreased expression of TFAP2A mRNACTDPMID:30951980
Tfap2aRat4,4'-sulfonyldiphenol decreases methylationISOTfap2a (Mus musculus)6480464bisphenol S results in decreased methylation of TFAP2A promoterCTDPMID:33297965
Tfap2aRat4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine increases expressionISOTfap2a (Mus musculus)6480464fenpropimorph results in increased expression of TFAP2A proteinCTDPMID:34737147
Tfap2aRat4-hydroxyphenyl retinamide increases expressionISOTfap2a (Mus musculus)6480464Fenretinide results in increased expression of TFAP2A mRNACTDPMID:28973697
Tfap2aRat5-aza-2'-deoxycytidine increases expressionISOTFAP2A (Homo sapiens)6480464Decitabine results in increased expression of TFAP2A mRNA and Decitabine results in increased expression of TFAP2A proteinCTDPMID:16204029
Tfap2aRat5-aza-2'-deoxycytidine multiple interactionsISOTFAP2A (Homo sapiens)6480464[Decitabine results in increased expression of TFAP2A protein] which results in increased susceptibility to Cisplatin and [Decitabine results in increased expression of TFAP2A protein] which results in increased susceptibility to DoxorubicinCTDPMID:16204029
Tfap2aRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of TFAP2A mRNACTDPMID:24780913
Tfap2aRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of TFAP2A mRNACTDPMID:30047161

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Biological Process
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Original Reference(s)
Tfap2aRatanterior neuropore closure acts_upstream_of_or_withinISOTfap2a (Mus musculus)1624291MGI:1888387 PMID:8622765RGDPMID:8622765
Tfap2aRatbasement membrane organization acts_upstream_of_or_withinISOTfap2a (Mus musculus)1624291MGI:2183192 PMID:16186342RGDPMID:16186342
Tfap2aRatbone morphogenesis involved_inISSUniProtKB:P340561600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2aRatbone morphogenesis involved_inISOTfap2a (Mus musculus)1624291 PMID:8622766RGDPMID:8622766
Tfap2aRatcell population proliferation acts_upstream_ofISOTfap2a (Mus musculus)1624291MGI:3038304 PMID:16449191RGDPMID:16449191
Tfap2aRatcellular response to iron ion involved_inISSUniProtKB:P055491600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2aRatcellular response to iron ion involved_inISOTFAP2A (Homo sapiens)1624291 PMID:20808827RGDPMID:20808827
Tfap2aRatcornea development in camera-type eye acts_upstream_of_or_withinISOTfap2a (Mus musculus)1624291MGI:2183192 PMID:16186342RGDPMID:16186342
Tfap2aRatembryonic body morphogenesis acts_upstream_of_or_withinISOTfap2a (Mus musculus)1624291MGI:2183192 PMID:15013802RGDPMID:15013802
Tfap2aRatembryonic camera-type eye morphogenesis acts_upstream_of_or_withinISOTfap2a (Mus musculus)1624291MGI:2176682 PMID:9811866RGDPMID:9811866
Tfap2aRatembryonic cranial skeleton morphogenesis involved_inISSUniProtKB:P340561600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2aRatembryonic cranial skeleton morphogenesis involved_inISOTfap2a (Mus musculus)1624291 PMID:8622766RGDPMID:8622766
Tfap2aRatembryonic cranial skeleton morphogenesis acts_upstream_of_or_withinISOTfap2a (Mus musculus)1624291MGI:1888387 PMID:8622765RGDPMID:8622765
Tfap2aRatembryonic forelimb morphogenesis involved_inISSUniProtKB:P340561600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2aRatembryonic forelimb morphogenesis involved_inISOTfap2a (Mus musculus)1624291 PMID:9811866RGDPMID:9811866
Tfap2aRatembryonic pattern specification acts_upstream_of_or_withinISOTfap2a (Mus musculus)1624291MGI:3769332 PMID:17984226RGDPMID:17984226
Tfap2aRatepidermal growth factor receptor signaling pathway acts_upstream_ofISOTfap2a (Mus musculus)1624291MGI:3038304 PMID:16449191RGDPMID:16449191
Tfap2aRatepidermis morphogenesis acts_upstream_of_or_withinISOTfap2a (Mus musculus)1624291MGI:3038304 PMID:16449191RGDPMID:16449191
Tfap2aRateyelid development in camera-type eye involved_inISOTfap2a (Mus musculus)1624291 PMID:9811866RGDPMID:9811866
Tfap2aRateyelid development in camera-type eye involved_inISSUniProtKB:P340561600115GO_REF:0000024UniProtGO_REF:0000024
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Cellular Component
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Original Reference(s)
Tfap2aRatclathrin-coated pit located_inISOTfap2a (Mus musculus)1624291 PMID:26437238RGDPMID:26437238
Tfap2aRatnucleoplasm located_inIEAUniProtKB:A0A6E1XE14 and ensembl:ENSP000003689331600115GO_REF:0000107EnsemblGO_REF:0000107
Tfap2aRatnucleoplasm located_inISOTFAP2A (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Tfap2aRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Tfap2aRatnucleus located_inISOTfap2a (Mus musculus)1624291 PMID:10842061 more ...RGDPMID:10842061 more ...
Tfap2aRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Tfap2aRatnucleus located_inIEAInterPro:IPR004979 and InterPro:IPR0081211600115GO_REF:0000002InterProGO_REF:0000002
Tfap2aRatnucleus located_inISOTFAP2A (Homo sapiens)1624291 PMID:12586840 more ...RGDPMID:12586840 more ...
Tfap2aRatnucleus is_active_inIBAFB:FBgn0261953 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function
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Tfap2aRatchromatin binding enablesISSUniProtKB:P340561600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2aRatchromatin binding enablesISOTfap2a (Mus musculus)1624291 PMID:15475956 and PMID:18224708RGDPMID:15475956 and PMID:18224708
Tfap2aRatcis-regulatory region sequence-specific DNA binding enablesISOTfap2a (Mus musculus)1624291 PMID:19943855RGDPMID:19943855
Tfap2aRatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Tfap2aRatDNA binding enablesISOTFAP2A (Homo sapiens)1624291 PMID:16236267RGDPMID:16236267
Tfap2aRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOTfap2a (Mus musculus)1624291 PMID:19463168 more ...RGDPMID:19463168 more ...
Tfap2aRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIBAMGI:104671 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Tfap2aRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISSUniProtKB:P055491600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2aRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOTFAP2A (Homo sapiens)1624291 PMID:11278550 and PMID:20808827RGDPMID:11278550 and PMID:20808827
Tfap2aRatDNA-binding transcription factor activity enablesIEAInterPro:IPR004979 and InterPro:IPR0081211600115GO_REF:0000002InterProGO_REF:0000002
Tfap2aRatDNA-binding transcription factor activity enablesISOTfap2a (Mus musculus)1624291 PMID:11522791 and PMID:15475956RGDPMID:11522791 and PMID:15475956
Tfap2aRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISSUniProtKB:P055491600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2aRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOTFAP2A (Homo sapiens)1624291 PMID:12586840 more ...RGDPMID:12586840 more ...
Tfap2aRatDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISSUniProtKB:P055491600115GO_REF:0000024UniProtGO_REF:0000024
Tfap2aRatDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISOTfap2a (Mus musculus)1624291 PMID:16449191 and PMID:19943855RGDPMID:16449191 and PMID:19943855
Tfap2aRatDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISOTFAP2A (Homo sapiens)1624291 PMID:11278550 more ...RGDPMID:11278550 more ...
Tfap2aRatidentical protein binding enablesISOTFAP2A (Homo sapiens)1624291UniProtKB:P05549 and PMID:1998122RGDPMID:1998122
Tfap2aRatprotein binding enablesISOTFAP2A (Homo sapiens)1624291UniProtKB:P06748 more ...RGDPMID:10987820 more ...
Tfap2aRatprotein binding enablesISOTfap2a (Mus musculus)1624291PR:Q8CDJ8 more ...RGDPMID:11522791 more ...
Tfap2aRatprotein binding enablesISOTFAP2A (Homo sapiens) and UniProtKB:P05549-51624291UniProtKB:Q0VD86 more ...RGDPMID:25910212 and PMID:32296183
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Reference Title
Reference Citation
1. Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. Braganca J, etal., J Biol Chem. 2003 May 2;278(18):16021-9. Epub 2003 Feb 12.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Effect of cysteamine on redox-sensitive thiol-containing proteins in the duodenal mucosa. Khomenko T, etal., Biochem Biophys Res Commun. 2003 Oct 3;309(4):910-6.
5. Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53. McPherson LA, etal., J Biol Chem. 2002 Nov 22;277(47):45028-33. Epub 2002 Sep 10.
6. Sustained increases in activating transcription factor-2 and activator protein-2 in the rat supraoptic nucleus during water deprivation. Meeker RB and Fernandes A, Neuroendocrinology. 2002 Aug;76(2):111-20.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes. Muller FU, etal., Cell Death Differ. 2004 May;11(5):485-93.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Chronic administration of carbamazepine down-regulates AP-2 DNA-binding activity and AP-2alpha protein expression in rat frontal cortex. Rao JS, etal., Biol Psychiatry. 2007 Jan 15;61(2):154-61. Epub 2006 Jun 27.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. The NECAP PHear domain increases clathrin accessory protein binding potential. Ritter B, etal., EMBO J. 2007 Sep 19;26(18):4066-77. Epub 2007 Aug 30.
15. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
16. Developmental regulation and overexpression of the transcription factor AP-2, a potential regulator of the timing of Schwann cell generation. Stewart HJ, etal., Eur J Neurosci. 2001 Jul;14(2):363-72.
17. PACAP-regulated phenylethanolamine N-methyltransferase gene expression. Tai TC, etal., J Neurochem. 2010 Dec;115(5):1195-205. doi: 10.1111/j.1471-4159.2010.07005.x. Epub 2010 Oct 12.
18. Lipopolysaccharide regulates constitutive and inducible transcription factor activities differentially in vivo in the rat. Ye X and Liu SF, Biochem Biophys Res Commun. 2001 Nov 9;288(4):927-32.
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PMID:1998122   PMID:7555706   PMID:7559606   PMID:8321221   PMID:8622765   PMID:8622766   PMID:9520389   PMID:9811866   PMID:9858544   PMID:9918694   PMID:10068641   PMID:10571739  
PMID:10803593   PMID:10842061   PMID:10847586   PMID:11205881   PMID:11278550   PMID:11522791   PMID:11694877   PMID:11744375   PMID:12072434   PMID:15013802   PMID:15475956   PMID:16186342  
PMID:16236267   PMID:16449191   PMID:17670746   PMID:17984226   PMID:18224708   PMID:18718911   PMID:18723448   PMID:18824566   PMID:19115315   PMID:19463168   PMID:19578371   PMID:19750005  
PMID:19943855   PMID:20066163   PMID:20150232   PMID:20351096   PMID:20448150   PMID:20607706   PMID:20808827   PMID:21084835   PMID:21204207   PMID:21539825   PMID:21829553   PMID:22306374  
PMID:23393395   PMID:26437238   PMID:27053364   PMID:33264079  



Tfap2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81724,230,064 - 24,253,219 (+)NCBIGRCr8
mRatBN7.21724,028,716 - 24,047,507 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1724,024,432 - 24,047,507 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1723,913,439 - 23,929,006 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01725,516,916 - 25,532,497 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01723,854,421 - 23,869,994 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01724,653,342 - 24,670,457 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1724,654,902 - 24,670,457 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01726,596,839 - 26,634,214 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41730,017,580 - 30,034,852 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11730,020,346 - 30,035,192 (+)NCBI
Celera1723,700,225 - 23,715,767 (+)NCBICelera
Cytogenetic Map17p12NCBI
TFAP2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38610,396,677 - 10,419,659 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl610,393,186 - 10,419,659 (-)EnsemblGRCh38hg38GRCh38
GRCh37610,396,910 - 10,419,892 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36610,504,902 - 10,527,783 (-)NCBINCBI36Build 36hg18NCBI36
Build 34610,506,384 - 10,523,252NCBI
Celera611,625,394 - 11,648,276 (-)NCBICelera
Cytogenetic Map6p24.3NCBI
HuRef610,272,671 - 10,295,552 (-)NCBIHuRef
CHM1_1610,399,160 - 10,422,046 (-)NCBICHM1_1
T2T-CHM13v2.0610,264,407 - 10,287,386 (-)NCBIT2T-CHM13v2.0
Tfap2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391340,867,278 - 40,891,715 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1340,868,778 - 40,891,852 (-)EnsemblGRCm39 Ensembl
GRCm381340,713,802 - 40,738,238 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1340,715,302 - 40,738,376 (-)EnsemblGRCm38mm10GRCm38
MGSCv371340,811,044 - 40,829,192 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361340,727,706 - 40,745,894 (-)NCBIMGSCv36mm8
Celera1341,797,334 - 41,815,714 (-)NCBICelera
Cytogenetic Map13A3.3NCBI
cM Map1320.01NCBI
Tfap2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554653,882,549 - 3,898,929 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554653,877,896 - 3,900,259 (+)NCBIChiLan1.0ChiLan1.0
TFAP2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2525,046,932 - 25,064,748 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1621,036,711 - 21,053,926 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0610,237,834 - 10,260,843 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1610,519,625 - 10,541,898 (-)NCBIpanpan1.1PanPan1.1panPan2
TFAP2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13510,157,043 - 10,180,484 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3510,157,882 - 10,180,270 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3510,170,458 - 10,197,631 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03510,260,835 - 10,284,005 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3510,261,674 - 10,283,869 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13510,091,163 - 10,114,276 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03510,131,471 - 10,154,557 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03511,458,363 - 11,481,509 (-)NCBIUU_Cfam_GSD_1.0
Tfap2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494614,212,794 - 14,243,177 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365342,481,806 - 2,499,317 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365342,481,804 - 2,518,573 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TFAP2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl77,221,656 - 7,244,612 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.177,221,654 - 7,244,626 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.277,534,956 - 7,556,586 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TFAP2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11761,750,757 - 61,769,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604410,406,413 - 10,425,011 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tfap2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475615,418,260 - 15,436,379 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475615,413,950 - 15,436,037 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tfap2a
114 total Variants

Predicted Target Of
Summary Value
Count of predictions:359
Count of miRNA genes:194
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000041960
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 36 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat

1 to 10 of 36 rows
TFAP2A  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21724,031,723 - 24,032,003 (+)MAPPERmRatBN7.2
Rnor_6.01724,654,659 - 24,654,938NCBIRnor6.0
Rnor_5.01726,596,596 - 26,596,875UniSTSRnor5.0
RGSC_v3.41730,017,337 - 30,017,616UniSTSRGSC3.4
Celera1723,699,982 - 23,700,261UniSTS
Cytogenetic Map17p12UniSTS
AI013304  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81724,252,242 - 24,252,359 (+)Marker Load Pipeline
mRatBN7.21724,046,528 - 24,046,645 (+)MAPPERmRatBN7.2
Rnor_6.01724,669,462 - 24,669,578NCBIRnor6.0
Rnor_5.01726,611,399 - 26,611,515UniSTSRnor5.0
RGSC_v3.41730,032,198 - 30,032,314UniSTSRGSC3.4
Celera1723,714,785 - 23,714,901UniSTS
RH 3.4 Map17280.8UniSTS
Cytogenetic Map17p12UniSTS




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 35 101 34 36 16 8 16 6 124 55 89 45 54 20



Ensembl Acc Id: ENSRNOT00000041960   ⟹   ENSRNOP00000040925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1724,031,967 - 24,047,507 (+)Ensembl
Rnor_6.0 Ensembl1724,654,902 - 24,670,457 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102035   ⟹   ENSRNOP00000078814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1724,024,432 - 24,047,507 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103008   ⟹   ENSRNOP00000082537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1724,029,869 - 24,047,507 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105131   ⟹   ENSRNOP00000076636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1724,029,746 - 24,047,507 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107954   ⟹   ENSRNOP00000088142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1724,030,646 - 24,047,507 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109680   ⟹   ENSRNOP00000081532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1724,028,667 - 24,047,507 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110879   ⟹   ENSRNOP00000094618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1724,033,357 - 24,047,507 (+)Ensembl
RefSeq Acc Id: NM_001107345   ⟹   NP_001100815
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81724,237,683 - 24,253,219 (+)NCBI
mRatBN7.21724,031,967 - 24,047,507 (+)NCBI
Rnor_6.01724,654,902 - 24,670,457 (+)NCBI
Rnor_5.01726,596,839 - 26,634,214 (+)NCBI
RGSC_v3.41730,017,580 - 30,034,852 (+)RGD
Celera1723,700,225 - 23,715,767 (+)RGD
Sequence:
RefSeq Acc Id: XM_039095687   ⟹   XP_038951615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81724,234,208 - 24,252,850 (+)NCBI
mRatBN7.21724,028,716 - 24,046,727 (+)NCBI
RefSeq Acc Id: XM_063276385   ⟹   XP_063132455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81724,235,744 - 24,252,850 (+)NCBI
RefSeq Acc Id: XM_063276386   ⟹   XP_063132456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81724,230,064 - 24,252,850 (+)NCBI
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: NP_001100815   ⟸   NM_001107345
- UniProtKB: G3V9A8 (UniProtKB/TrEMBL),   A6J784 (UniProtKB/TrEMBL),   A0A8I6AMM5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040925   ⟸   ENSRNOT00000041960
RefSeq Acc Id: XP_038951615   ⟸   XM_039095687
- Peptide Label: isoform X2
- UniProtKB: P58197 (UniProtKB/Swiss-Prot),   A0A8I5ZSF0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094618   ⟸   ENSRNOT00000110879
Ensembl Acc Id: ENSRNOP00000081532   ⟸   ENSRNOT00000109680
Name Modeler Protein Id AA Range Protein Structure
AF-P58197-F1-model_v2 AlphaFold P58197 1-437 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-9712 BioCyc
Ensembl Genes ENSRNOG00000015522 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000041960 ENTREZGENE
  ENSRNOT00000102035 ENTREZGENE
  ENSRNOT00000107954 ENTREZGENE
  ENSRNOT00000109680 ENTREZGENE
InterPro TF_AP2 UniProtKB/Swiss-Prot
  TF_AP2_alpha_N UniProtKB/Swiss-Prot
  TF_AP2_C UniProtKB/Swiss-Prot
NCBI Gene 306862 ENTREZGENE
PANTHER PTHR10812 UniProtKB/Swiss-Prot
  TRANSCRIPTION FACTOR AP-2-ALPHA UniProtKB/Swiss-Prot
Pfam TF_AP-2 UniProtKB/Swiss-Prot
PhenoGen Tfap2a PhenoGen
PRINTS AP2ATNSCPFCT UniProtKB/Swiss-Prot
  AP2TNSCPFCT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015522 RatGTEx
UniProt A0A8I5Y4U0_RAT UniProtKB/TrEMBL
  A0A8I5ZSF0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G3W2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G9K6_RAT UniProtKB/TrEMBL
  A0A8I6GGS6 ENTREZGENE, UniProtKB/TrEMBL
  A6J782 ENTREZGENE, UniProtKB/TrEMBL
  A6J784 ENTREZGENE, UniProtKB/TrEMBL
  AP2A_RAT UniProtKB/Swiss-Prot
  G3V9A8 ENTREZGENE, UniProtKB/TrEMBL
  P58197 ENTREZGENE
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-06-09 Tfap2a  transcription factor AP-2 alpha  Tcfap2a  transcription factor AP-2, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Tcfap2a  transcription factor AP-2, alpha   Tcfap2a_predicted  transcription factor AP-2, alpha (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tcfap2a_predicted  transcription factor AP-2, alpha (predicted)      Symbol and Name status set to approved 70820 APPROVED