Dusp29 (dual specificity phosphatase 29) - Rat Genome Database

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Gene: Dusp29 (dual specificity phosphatase 29) Rattus norvegicus
Analyze
Symbol: Dusp29
Name: dual specificity phosphatase 29
RGD ID: 1310229
Description: Predicted to enable MAP kinase phosphatase activity; protein homodimerization activity; and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in several processes, including glucose homeostasis; negative regulation of ERK1 and ERK2 cascade; and protein dephosphorylation. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human DUSP29 (dual specificity phosphatase 29); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dual specificity phosphatase and pro isomerase domain containing 1; dual specificity phosphatase DUPD1; Dupd1; LOC361003
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,642,809 - 2,682,850 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl152,655,923 - 2,689,538 (+)EnsemblGRCr8
mRatBN7.2152,593,473 - 2,634,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,593,578 - 2,633,503 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx152,600,319 - 2,640,195 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0153,986,768 - 4,026,642 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0152,599,117 - 2,638,989 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0152,766,929 - 2,806,573 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,766,710 - 2,806,536 (+)Ensemblrn6Rnor6.0
Rnor_5.0152,747,987 - 2,787,603 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4152,648,702 - 2,688,973 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera151,950,504 - 1,989,573 (-)NCBICelera
RGSC_v3.1152,648,703 - 2,688,616 (+)NCBI
Cytogenetic Map15p16NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)
protein-containing complex  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17498703   PMID:21543850  


Genomics

Comparative Map Data
Dusp29
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,642,809 - 2,682,850 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl152,655,923 - 2,689,538 (+)EnsemblGRCr8
mRatBN7.2152,593,473 - 2,634,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,593,578 - 2,633,503 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx152,600,319 - 2,640,195 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0153,986,768 - 4,026,642 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0152,599,117 - 2,638,989 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0152,766,929 - 2,806,573 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,766,710 - 2,806,536 (+)Ensemblrn6Rnor6.0
Rnor_5.0152,747,987 - 2,787,603 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4152,648,702 - 2,688,973 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera151,950,504 - 1,989,573 (-)NCBICelera
RGSC_v3.1152,648,703 - 2,688,616 (+)NCBI
Cytogenetic Map15p16NCBI
DUSP29
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381075,037,472 - 75,073,642 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1075,037,472 - 75,073,655 (-)Ensemblhg38GRCh38
GRCh371076,797,230 - 76,833,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361076,467,600 - 76,488,278 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1070,085,843 - 70,106,521 (-)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1070,796,168 - 70,816,830 (-)NCBIHuRef
CHM1_11077,079,339 - 77,100,017 (-)NCBICHM1_1
T2T-CHM13v2.01075,911,002 - 75,947,146 (-)NCBIT2T-CHM13v2.0
Dusp29
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391421,726,605 - 21,764,644 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1421,726,605 - 21,764,644 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381421,676,565 - 21,714,576 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1421,676,537 - 21,714,576 (-)Ensemblmm10GRCm38
MGSCv371422,495,794 - 22,533,798 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361420,465,124 - 20,503,128 (-)NCBIMGSCv36mm8
Celera1418,059,519 - 18,097,591 (-)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.82NCBI
Dusp29
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543717,002,190 - 17,040,786 (+)Ensembl
ChiLan1.0NW_00495543717,002,269 - 17,037,750 (+)NCBIChiLan1.0ChiLan1.0
DUSP29
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2887,194,286 - 87,215,555 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11087,199,611 - 87,220,880 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01071,566,439 - 71,587,499 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11074,230,684 - 74,252,072 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1074,230,734 - 74,266,565 (-)EnsemblpanPan2panpan1.1
DUSP29
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1425,307,786 - 25,341,772 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha425,443,089 - 25,475,662 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0425,590,511 - 25,623,040 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl425,590,877 - 25,623,362 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1425,485,685 - 25,518,247 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0425,686,330 - 25,718,866 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0426,041,770 - 26,074,362 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dusp29
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721355,774,753 - 55,812,762 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365214,267,613 - 4,305,563 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365214,267,619 - 4,305,481 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP29
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1477,602,871 - 77,643,114 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11477,602,871 - 77,643,109 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21483,728,094 - 83,768,026 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP29
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1956,299,535 - 56,335,745 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl956,300,105 - 56,335,764 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604816,802,988 - 16,823,552 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp29
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247548,392,804 - 8,421,831 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247548,393,663 - 8,427,867 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dusp29
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11291,454,227 - 91,494,294 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dusp29
282 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:240
Count of miRNA genes:155
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000017483
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
1300142Bp191Blood pressure QTL 1913.14arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)15115177511Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 11 49 89 33 40 14 71 14 6 214 144 9 72 37 77 26 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000017483   ⟹   ENSRNOP00000017483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl152,655,923 - 2,684,711 (+)Ensembl
mRatBN7.2 Ensembl152,593,578 - 2,633,503 (+)Ensembl
Rnor_6.0 Ensembl152,766,710 - 2,806,536 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109231   ⟹   ENSRNOP00000093158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl152,655,923 - 2,674,118 (+)Ensembl
mRatBN7.2 Ensembl152,593,578 - 2,624,795 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124521   ⟹   ENSRNOP00000110191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl152,655,923 - 2,676,161 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129388   ⟹   ENSRNOP00000106899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl152,655,923 - 2,689,538 (+)Ensembl
RefSeq Acc Id: NM_001108368   ⟹   NP_001101838
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,642,906 - 2,682,826 (+)NCBI
mRatBN7.2152,593,578 - 2,633,503 (+)NCBI
Rnor_6.0152,766,929 - 2,806,556 (+)NCBI
Rnor_5.0152,747,987 - 2,787,603 (+)NCBI
RGSC_v3.4152,648,702 - 2,688,973 (+)RGD
Celera151,950,504 - 1,989,573 (-)RGD
Sequence:
RefSeq Acc Id: XM_017599732   ⟹   XP_017455221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,655,745 - 2,682,850 (+)NCBI
mRatBN7.2152,606,445 - 2,634,019 (+)NCBI
Rnor_6.0152,778,006 - 2,806,573 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063274366   ⟹   XP_063130436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,642,818 - 2,682,850 (+)NCBI
RefSeq Acc Id: XM_063274367   ⟹   XP_063130437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,655,748 - 2,682,233 (+)NCBI
RefSeq Acc Id: XM_063274368   ⟹   XP_063130438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,642,809 - 2,674,924 (+)NCBI
RefSeq Acc Id: NP_001101838   ⟸   NM_001108368
- UniProtKB: P0C595 (UniProtKB/Swiss-Prot),   A6KKS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455221   ⟸   XM_017599732
- Peptide Label: isoform X1
- UniProtKB: P0C595 (UniProtKB/Swiss-Prot),   A6KKS6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017483   ⟸   ENSRNOT00000017483
Ensembl Acc Id: ENSRNOP00000093158   ⟸   ENSRNOT00000109231
RefSeq Acc Id: XP_063130438   ⟸   XM_063274368
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AGT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130436   ⟸   XM_063274366
- Peptide Label: isoform X1
- UniProtKB: P0C595 (UniProtKB/Swiss-Prot),   A6KKS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130437   ⟸   XM_063274367
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000106899   ⟸   ENSRNOT00000129388
Ensembl Acc Id: ENSRNOP00000110191   ⟸   ENSRNOT00000124521
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C595-F1-model_v2 AlphaFold P0C595 1-215 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310229 AgrOrtholog
BioCyc Gene G2FUF-14589 BioCyc
Ensembl Genes ENSRNOG00000013034 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017483 ENTREZGENE
  ENSRNOT00000017483.6 UniProtKB/Swiss-Prot
  ENSRNOT00000124521 ENTREZGENE
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot
InterPro Atypical_DUSP_famA UniProtKB/Swiss-Prot
  Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  Tyr_Pase_AS UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot
KEGG Report rno:361003 UniProtKB/Swiss-Prot
NCBI Gene 361003 ENTREZGENE
PANTHER DUAL SPECIFICITY PHOSPHATASE 29 UniProtKB/Swiss-Prot
  PTHR45682 UniProtKB/Swiss-Prot
Pfam DSPc UniProtKB/Swiss-Prot
PhenoGen Dusp29 PhenoGen
PRINTS ADSPHPHTASE UniProtKB/Swiss-Prot
  ADSPHPHTASEA UniProtKB/Swiss-Prot
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013034 RatGTEx
SMART DSPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot
UniProt A0A8I6AGT7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M0H1_RAT UniProtKB/TrEMBL
  A0ABK0M0Q5_RAT UniProtKB/TrEMBL
  A6KKS6 ENTREZGENE, UniProtKB/TrEMBL
  DUPD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-22 Dusp29  dual specificity phosphatase 29  Dupd1  dual specificity phosphatase and pro isomerase domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dupd1  dual specificity phosphatase and pro isomerase domain containing 1   Dupd1_predicted  dual specificity phosphatase and pro isomerase domain containing 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dupd1_predicted  dual specificity phosphatase and pro isomerase domain containing 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED