Dusp29 (dual specificity phosphatase 29) - Rat Genome Database

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Gene: Dusp29 (dual specificity phosphatase 29) Rattus norvegicus
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Symbol: Dusp29
Name: dual specificity phosphatase 29
RGD ID: 1310229
Description: Predicted to enable MAP kinase phosphatase activity; protein homodimerization activity; and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in glucose homeostasis; muscle cell differentiation; and negative regulation of ERK1 and ERK2 cascade. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human DUSP29 (dual specificity phosphatase 29); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dual specificity phosphatase and pro isomerase domain containing 1; dual specificity phosphatase DUPD1; Dupd1; LOC361003
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,642,809 - 2,682,850 (+)NCBIGRCr8
mRatBN7.2152,593,473 - 2,634,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,593,578 - 2,633,503 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx152,600,319 - 2,640,195 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0153,986,768 - 4,026,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0152,599,117 - 2,638,989 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0152,766,929 - 2,806,573 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,766,710 - 2,806,536 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0152,747,987 - 2,787,603 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4152,648,702 - 2,688,973 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1152,648,703 - 2,688,616 (+)NCBI
Celera151,950,504 - 1,989,573 (-)NCBICelera
Cytogenetic Map15p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
nucleus  (ISO,ISS)
protein-containing complex  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17498703   PMID:21543850  


Genomics

Comparative Map Data
Dusp29
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,642,809 - 2,682,850 (+)NCBIGRCr8
mRatBN7.2152,593,473 - 2,634,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,593,578 - 2,633,503 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx152,600,319 - 2,640,195 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0153,986,768 - 4,026,642 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0152,599,117 - 2,638,989 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0152,766,929 - 2,806,573 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl152,766,710 - 2,806,536 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0152,747,987 - 2,787,603 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4152,648,702 - 2,688,973 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1152,648,703 - 2,688,616 (+)NCBI
Celera151,950,504 - 1,989,573 (-)NCBICelera
Cytogenetic Map15p16NCBI
DUSP29
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381075,037,472 - 75,073,642 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1075,037,472 - 75,073,642 (-)EnsemblGRCh38hg38GRCh38
GRCh371076,797,230 - 76,833,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361076,467,600 - 76,488,278 (-)NCBINCBI36Build 36hg18NCBI36
Celera1070,085,843 - 70,106,521 (-)NCBICelera
Cytogenetic Map10q22.2NCBI
HuRef1070,796,168 - 70,816,830 (-)NCBIHuRef
CHM1_11077,079,339 - 77,100,017 (-)NCBICHM1_1
T2T-CHM13v2.01075,911,002 - 75,947,146 (-)NCBIT2T-CHM13v2.0
Dusp29
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391421,726,605 - 21,764,644 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1421,726,605 - 21,764,644 (-)EnsemblGRCm39 Ensembl
GRCm381421,676,565 - 21,714,576 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1421,676,537 - 21,714,576 (-)EnsemblGRCm38mm10GRCm38
MGSCv371422,495,794 - 22,533,798 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361420,465,124 - 20,503,128 (-)NCBIMGSCv36mm8
Celera1418,059,519 - 18,097,591 (-)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1411.82NCBI
Dusp29
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543717,002,190 - 17,040,786 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543717,002,269 - 17,037,750 (+)NCBIChiLan1.0ChiLan1.0
DUSP29
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2887,194,286 - 87,215,555 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11087,199,611 - 87,220,880 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01071,566,439 - 71,587,499 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11074,230,684 - 74,252,072 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1074,230,734 - 74,266,565 (-)Ensemblpanpan1.1panPan2
DUSP29
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1425,307,786 - 25,341,772 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha425,443,089 - 25,475,662 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0425,590,511 - 25,623,040 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl425,590,877 - 25,623,362 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1425,485,685 - 25,518,247 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0425,686,330 - 25,718,866 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0426,041,770 - 26,074,362 (-)NCBIUU_Cfam_GSD_1.0
Dusp29
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721355,774,753 - 55,812,762 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365214,267,613 - 4,305,563 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365214,267,619 - 4,305,481 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP29
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1477,602,871 - 77,643,114 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11477,602,871 - 77,643,109 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21483,728,094 - 83,768,026 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP29
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1956,299,535 - 56,335,745 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl956,300,105 - 56,335,764 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604816,802,988 - 16,823,552 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp29
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247548,392,804 - 8,421,831 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247548,393,663 - 8,427,867 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dusp29
107 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:240
Count of miRNA genes:155
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000017483
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15105825014481294Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15226636822711984Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 10 1 7
Low 6 2 1 1 1 6 3 1
Below cutoff 1 25 7 4 10 4 40 11 23 8

Sequence


RefSeq Acc Id: ENSRNOT00000017483   ⟹   ENSRNOP00000017483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,593,578 - 2,633,503 (+)Ensembl
Rnor_6.0 Ensembl152,766,710 - 2,806,536 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109231   ⟹   ENSRNOP00000093158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,593,578 - 2,624,795 (+)Ensembl
RefSeq Acc Id: NM_001108368   ⟹   NP_001101838
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,642,906 - 2,682,826 (+)NCBI
mRatBN7.2152,593,578 - 2,633,503 (+)NCBI
Rnor_6.0152,766,929 - 2,806,556 (+)NCBI
Rnor_5.0152,747,987 - 2,787,603 (+)NCBI
RGSC_v3.4152,648,702 - 2,688,973 (+)RGD
Celera151,950,504 - 1,989,573 (-)RGD
Sequence:
RefSeq Acc Id: XM_017599732   ⟹   XP_017455221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,655,745 - 2,682,850 (+)NCBI
mRatBN7.2152,606,445 - 2,634,019 (+)NCBI
Rnor_6.0152,778,006 - 2,806,573 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063274366   ⟹   XP_063130436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,642,818 - 2,682,850 (+)NCBI
RefSeq Acc Id: XM_063274367   ⟹   XP_063130437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,655,748 - 2,682,233 (+)NCBI
RefSeq Acc Id: XM_063274368   ⟹   XP_063130438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8152,642,809 - 2,674,924 (+)NCBI
RefSeq Acc Id: NP_001101838   ⟸   NM_001108368
- UniProtKB: P0C595 (UniProtKB/Swiss-Prot),   A6KKS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455221   ⟸   XM_017599732
- Peptide Label: isoform X1
- UniProtKB: P0C595 (UniProtKB/Swiss-Prot),   A6KKS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017483   ⟸   ENSRNOT00000017483
RefSeq Acc Id: ENSRNOP00000093158   ⟸   ENSRNOT00000109231
RefSeq Acc Id: XP_063130438   ⟸   XM_063274368
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063130436   ⟸   XM_063274366
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063130437   ⟸   XM_063274367
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C595-F1-model_v2 AlphaFold P0C595 1-215 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310229 AgrOrtholog
BioCyc Gene G2FUF-14589 BioCyc
Ensembl Genes ENSRNOG00000013034 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018924 UniProtKB/Swiss-Prot
  ENSRNOG00060012328 UniProtKB/Swiss-Prot
  ENSRNOG00065010213 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017483 ENTREZGENE
  ENSRNOT00000017483.6 UniProtKB/Swiss-Prot
  ENSRNOT00000109231.1 UniProtKB/TrEMBL
  ENSRNOT00055032269 UniProtKB/Swiss-Prot
  ENSRNOT00060020895 UniProtKB/Swiss-Prot
  ENSRNOT00065016461 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Atypical_DUSP_famA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:361003 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 361003 ENTREZGENE
PANTHER DUAL SPECIFICITY PHOSPHATASE 29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45682 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dusp29 PhenoGen
PRINTS ADSPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADSPHPHTASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013034 RatGTEx
  ENSRNOG00055018924 RatGTEx
  ENSRNOG00060012328 RatGTEx
  ENSRNOG00065010213 RatGTEx
SMART DSPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AGT7_RAT UniProtKB/TrEMBL
  A6KKS6 ENTREZGENE, UniProtKB/TrEMBL
  DUPD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-22 Dusp29  dual specificity phosphatase 29  Dupd1  dual specificity phosphatase and pro isomerase domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dupd1  dual specificity phosphatase and pro isomerase domain containing 1   Dupd1_predicted  dual specificity phosphatase and pro isomerase domain containing 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Dupd1_predicted  dual specificity phosphatase and pro isomerase domain containing 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED