Fbxo43 (F-box protein 43) - Rat Genome Database

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Gene: Fbxo43 (F-box protein 43) Rattus norvegicus
Analyze
Symbol: Fbxo43
Name: F-box protein 43
RGD ID: 1310225
Description: Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of meiotic nuclear division and regulation of mitotic nuclear division. Predicted to act upstream of or within negative regulation of protein catabolic process and regulation of meiotic nuclear division. Predicted to be located in female germ cell nucleus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure 64. Orthologous to human FBXO43 (F-box protein 43); INTERACTS WITH acrylamide; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: endogenous meiotic inhibitor 2; F-box only protein 43; LOC315034
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8769,218,298 - 69,231,873 (-)NCBIGRCr8
mRatBN7.2767,333,161 - 67,346,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl767,333,162 - 67,346,751 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx769,221,626 - 69,235,193 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0771,424,242 - 71,437,811 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0771,292,102 - 71,305,672 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0774,925,091 - 74,938,796 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl774,925,092 - 74,938,663 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0775,081,329 - 75,094,991 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4771,670,329 - 71,683,901 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1771,691,059 - 71,704,631 (-)NCBI
Celera764,414,991 - 64,428,564 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16456547   PMID:16966421   PMID:20724447  


Genomics

Comparative Map Data
Fbxo43
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8769,218,298 - 69,231,873 (-)NCBIGRCr8
mRatBN7.2767,333,161 - 67,346,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl767,333,162 - 67,346,751 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx769,221,626 - 69,235,193 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0771,424,242 - 71,437,811 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0771,292,102 - 71,305,672 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0774,925,091 - 74,938,796 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl774,925,092 - 74,938,663 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0775,081,329 - 75,094,991 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4771,670,329 - 71,683,901 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1771,691,059 - 71,704,631 (-)NCBI
Celera764,414,991 - 64,428,564 (-)NCBICelera
Cytogenetic Map7q22NCBI
FBXO43
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388100,133,351 - 100,150,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8100,133,351 - 100,145,817 (-)EnsemblGRCh38hg38GRCh38
GRCh378101,145,579 - 101,158,045 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368101,214,835 - 101,227,252 (-)NCBINCBI36Build 36hg18NCBI36
Celera897,330,985 - 97,343,496 (-)NCBICelera
Cytogenetic Map8q22.2NCBI
HuRef896,348,421 - 96,360,932 (-)NCBIHuRef
CHM1_18101,185,882 - 101,198,393 (-)NCBICHM1_1
T2T-CHM13v2.08101,258,131 - 101,275,344 (-)NCBIT2T-CHM13v2.0
Fbxo43
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391536,150,206 - 36,170,086 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1536,150,206 - 36,165,030 (-)EnsemblGRCm39 Ensembl
GRCm381536,150,060 - 36,169,940 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1536,150,060 - 36,164,884 (-)EnsemblGRCm38mm10GRCm38
MGSCv371536,079,815 - 36,094,639 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361536,094,649 - 36,109,473 (-)NCBIMGSCv36mm8
Celera1536,777,573 - 36,792,407 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1514.46NCBI
Fbxo43
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541715,390,969 - 15,406,751 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541715,394,481 - 15,406,751 (-)NCBIChiLan1.0ChiLan1.0
FBXO43
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27117,474,806 - 117,498,887 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1893,013,613 - 93,037,589 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0896,774,246 - 96,786,933 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1898,948,145 - 98,960,382 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl898,948,145 - 98,960,382 (-)Ensemblpanpan1.1panPan2
FBXO43
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1132,037,270 - 2,057,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl132,038,408 - 2,052,741 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha132,035,158 - 2,054,848 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0132,189,300 - 2,210,531 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl132,191,213 - 2,203,034 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1132,033,543 - 2,054,732 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0132,145,577 - 2,166,765 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0132,148,055 - 2,167,777 (-)NCBIUU_Cfam_GSD_1.0
Fbxo43
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530335,662,044 - 35,674,874 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647043,088,714 - 43,100,973 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647043,091,516 - 43,100,973 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl436,856,937 - 36,871,618 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1436,856,662 - 36,872,753 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2439,772,435 - 39,787,507 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO43
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1894,983,189 - 94,996,480 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl894,983,640 - 94,994,672 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603945,685,902 - 45,699,132 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Fbxo43
52 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:32
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000014333
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 10 15
Below cutoff 35 35 21 9 21 5 6 58 31 18 11 5

Sequence


RefSeq Acc Id: ENSRNOT00000014333   ⟹   ENSRNOP00000014333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl767,333,162 - 67,346,751 (-)Ensembl
Rnor_6.0 Ensembl774,925,092 - 74,938,663 (-)Ensembl
RefSeq Acc Id: NM_001012117   ⟹   NP_001012117
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8769,218,298 - 69,231,873 (-)NCBI
mRatBN7.2767,333,161 - 67,346,751 (-)NCBI
Rnor_6.0774,925,091 - 74,938,663 (-)NCBI
Rnor_5.0775,081,329 - 75,094,991 (-)NCBI
RGSC_v3.4771,670,329 - 71,683,901 (-)RGD
Celera764,414,991 - 64,428,564 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012117 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH82107 (Get FASTA)   NCBI Sequence Viewer  
  EDM16401 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014333
  ENSRNOP00000014333.4
  ENSRNOP00055038821
  ENSRNOP00060013116
  ENSRNOP00065020978
GenBank Protein Q66H04 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012117   ⟸   NM_001012117
- UniProtKB: Q66H04 (UniProtKB/Swiss-Prot),   A6HR21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014333   ⟸   ENSRNOT00000014333
Protein Domains
F-box   ZBR-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66H04-F1-model_v2 AlphaFold Q66H04 1-664 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310225 AgrOrtholog
BioCyc Gene G2FUF-33653 BioCyc
Ensembl Genes ENSRNOG00000010459 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055027285 UniProtKB/Swiss-Prot
  ENSRNOG00060009928 UniProtKB/Swiss-Prot
  ENSRNOG00065016081 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014333 ENTREZGENE
  ENSRNOT00000014333.5 UniProtKB/Swiss-Prot
  ENSRNOT00055047208 UniProtKB/Swiss-Prot
  ENSRNOT00060016771 UniProtKB/Swiss-Prot
  ENSRNOT00065026731 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.20.25.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134870 IMAGE-MGC_LOAD
InterPro FBX5_43 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IBR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_ZBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:315034 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:95305 IMAGE-MGC_LOAD
NCBI Gene 315034 ENTREZGENE
PANTHER F-BOX ONLY PROTEIN 43 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F-BOX ONLY PROTEIN 5 AND 43 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fbxo43 PhenoGen
PROSITE ZF_ZBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010459 RatGTEx
  ENSRNOG00055027285 RatGTEx
  ENSRNOG00060009928 RatGTEx
  ENSRNOG00065016081 RatGTEx
SMART IBR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HR21 ENTREZGENE, UniProtKB/TrEMBL
  FBX43_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Fbxo43  F-box protein 43  Fbxo43_predicted  F-box protein 43 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fbxo43_predicted  F-box protein 43 (predicted)      Symbol and Name status set to approved 70820 APPROVED