Fbxo43 (F-box protein 43) - Rat Genome Database

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Gene: Fbxo43 (F-box protein 43) Rattus norvegicus
Analyze
Symbol: Fbxo43
Name: F-box protein 43
RGD ID: 1310225
Description: Predicted to enable zinc ion binding activity. Involved in cellular response to nerve growth factor stimulus. Predicted to be located in female germ cell nucleus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure 64. Orthologous to human FBXO43 (F-box protein 43); INTERACTS WITH acrylamide; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: endogenous meiotic inhibitor 2; F-box only protein 43; LOC315034
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8769,218,298 - 69,231,873 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl769,218,299 - 69,230,310 (-)EnsemblGRCr8
mRatBN7.2767,333,161 - 67,346,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl767,333,162 - 67,346,751 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx769,221,626 - 69,235,193 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0771,424,242 - 71,437,811 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0771,292,102 - 71,305,672 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0774,925,091 - 74,938,796 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl774,925,092 - 74,938,663 (-)Ensemblrn6Rnor6.0
Rnor_5.0775,081,329 - 75,094,991 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4771,670,329 - 71,683,901 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera764,414,991 - 64,428,564 (-)NCBICelera
RGSC_v3.1771,691,059 - 71,704,631 (-)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cytostatic factor proteins are present in male meiotic cells and beta-nerve growth factor increases mos levels in rat late spermatocytes. Perrard MH, etal., PLoS One. 2009 Oct 5;4(10):e7237. doi: 10.1371/journal.pone.0007237.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16456547   PMID:16966421   PMID:20724447  


Genomics

Comparative Map Data
Fbxo43
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8769,218,298 - 69,231,873 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl769,218,299 - 69,230,310 (-)EnsemblGRCr8
mRatBN7.2767,333,161 - 67,346,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl767,333,162 - 67,346,751 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx769,221,626 - 69,235,193 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0771,424,242 - 71,437,811 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0771,292,102 - 71,305,672 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0774,925,091 - 74,938,796 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl774,925,092 - 74,938,663 (-)Ensemblrn6Rnor6.0
Rnor_5.0775,081,329 - 75,094,991 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4771,670,329 - 71,683,901 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera764,414,991 - 64,428,564 (-)NCBICelera
RGSC_v3.1771,691,059 - 71,704,631 (-)NCBI
Cytogenetic Map7q22NCBI
FBXO43
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388100,133,351 - 100,150,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8100,133,351 - 100,145,817 (-)Ensemblhg38GRCh38
GRCh378101,145,579 - 101,158,045 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368101,214,835 - 101,227,252 (-)NCBIBuild 36Build 36hg18NCBI36
Celera897,330,985 - 97,343,496 (-)NCBICelera
Cytogenetic Map8q22.2NCBI
HuRef896,348,421 - 96,360,932 (-)NCBIHuRef
CHM1_18101,185,882 - 101,198,393 (-)NCBICHM1_1
T2T-CHM13v2.08101,258,131 - 101,275,344 (-)NCBIT2T-CHM13v2.0
Fbxo43
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391536,150,206 - 36,170,086 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1536,150,206 - 36,165,030 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381536,150,060 - 36,169,940 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1536,150,060 - 36,164,884 (-)Ensemblmm10GRCm38
MGSCv371536,079,815 - 36,094,639 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361536,094,649 - 36,109,473 (-)NCBIMGSCv36mm8
Celera1536,777,573 - 36,792,407 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
cM Map1514.46NCBI
Fbxo43
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541715,390,969 - 15,406,751 (-)Ensembl
ChiLan1.0NW_00495541715,394,481 - 15,406,751 (-)NCBIChiLan1.0ChiLan1.0
FBXO43
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27117,474,806 - 117,498,887 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1893,013,613 - 93,037,589 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0896,774,246 - 96,786,933 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1898,948,145 - 98,960,382 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl898,948,145 - 98,960,382 (-)EnsemblpanPan2panpan1.1
FBXO43
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1132,037,270 - 2,057,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl132,038,408 - 2,052,741 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha132,035,158 - 2,054,848 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0132,189,300 - 2,210,531 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl132,191,213 - 2,203,034 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1132,033,543 - 2,054,732 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0132,145,577 - 2,166,765 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0132,148,055 - 2,167,777 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fbxo43
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530335,662,044 - 35,674,874 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647043,088,714 - 43,100,973 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647043,091,516 - 43,100,973 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO43
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl436,856,937 - 36,871,618 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1436,856,662 - 36,872,753 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2439,772,435 - 39,787,507 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO43
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1894,983,189 - 94,996,480 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl894,983,640 - 94,994,672 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603945,685,902 - 45,699,132 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo43
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11209,682,751 - 209,696,404 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fbxo43
57 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:32
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000014333
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 6 52 121 65 65 35 23 35 2 209 101 7 106 61 77 30 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000014333   ⟹   ENSRNOP00000014333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl769,218,299 - 69,230,310 (-)Ensembl
mRatBN7.2 Ensembl767,333,162 - 67,346,751 (-)Ensembl
Rnor_6.0 Ensembl774,925,092 - 74,938,663 (-)Ensembl
RefSeq Acc Id: NM_001012117   ⟹   NP_001012117
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8769,218,298 - 69,231,873 (-)NCBI
mRatBN7.2767,333,161 - 67,346,751 (-)NCBI
Rnor_6.0774,925,091 - 74,938,663 (-)NCBI
Rnor_5.0775,081,329 - 75,094,991 (-)NCBI
RGSC_v3.4771,670,329 - 71,683,901 (-)RGD
Celera764,414,991 - 64,428,564 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012117 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH82107 (Get FASTA)   NCBI Sequence Viewer  
  EDM16401 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014333
  ENSRNOP00000014333.4
GenBank Protein Q66H04 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012117   ⟸   NM_001012117
- UniProtKB: Q66H04 (UniProtKB/Swiss-Prot),   A6HR21 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014333   ⟸   ENSRNOT00000014333
Protein Domains
F-box   ZBR-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66H04-F1-model_v2 AlphaFold Q66H04 1-664 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310225 AgrOrtholog
BioCyc Gene G2FUF-33653 BioCyc
Ensembl Genes ENSRNOG00000010459 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014333 ENTREZGENE
  ENSRNOT00000014333.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot
  2.20.25.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134870 IMAGE-MGC_LOAD
InterPro FBX5_43 UniProtKB/Swiss-Prot
  IBR_dom UniProtKB/Swiss-Prot
  ZF_ZBR UniProtKB/Swiss-Prot
KEGG Report rno:315034 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95305 IMAGE-MGC_LOAD
NCBI Gene 315034 ENTREZGENE
PANTHER F-BOX ONLY PROTEIN 43 UniProtKB/Swiss-Prot
  F-BOX ONLY PROTEIN 5 AND 43 UniProtKB/Swiss-Prot
PhenoGen Fbxo43 PhenoGen
PROSITE ZF_ZBR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010459 RatGTEx
SMART IBR UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
UniProt A6HR21 ENTREZGENE, UniProtKB/TrEMBL
  FBX43_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Fbxo43  F-box protein 43  Fbxo43_predicted  F-box protein 43 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fbxo43_predicted  F-box protein 43 (predicted)      Symbol and Name status set to approved 70820 APPROVED